Senior Level COO Jobs

Senior level coo jobs put experienced operators in charge of organizational direction, cross-functional execution, and the leadership teams that deliver results. Openings concentrate across Biotechnology & Pharmaceuticals, Technology & Software, and Healthcare & Medical Services, with 32% remote or hybrid availability, and employers like Revolution Medicines, Jobot, and The Waters hiring at this level now.

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Overview

Open roles134+
Top stateCalifornia
Top employerRevolution Medicines
Top citySan Francisco, CA
Work type68% On-site
Top industryBiotechnology

Showing 4 of 134+ Senior Level COO jobs

Associate Director, Business Operations
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Associate Director, Business Operations
Revolution Medicines
San Francisco Bay Area
Project & Program Management
Business Operations
Project Management
$233k/yr
On-Site
Bachelor's

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Director of Pharmacy Operations - New York
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Added 3d ago
Director of Pharmacy Operations - New York
Optum
Albany, New York
Customer Service
Healthcare Administration
Human Resources
$135k - $231k/yr
10,000+

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Director DC Operations II
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Added 3d ago
Director DC Operations II
Bob's Discount Furniture
Solon, Ohio
Procurement & Supply Chain
Project & Program Management
Business Operations
Supply Chain
Logistics & Fleet Management
$141k - $176k/yr
On-Site
Bachelor's
5,001-10,000

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Regional Director of Operations
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Added 3d ago
Regional Director of Operations
PTS Advance
Denver, Colorado
Project & Program Management
Business Operations
Human Resources
Sales
Consulting & Professional Services
Project Management
On-Site
None

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Senior Level COO Job Market

Who's Hiring

  • Revolution Medicines11
  • Jobot4
  • The Waters4
  • Michels3
  • Bain & Company3

Top Industries Hiring

  • Biotechnology & Pharmaceuticals24
  • Technology & Software18
  • Healthcare & Medical Services11
  • Consulting & Professional Services11
  • Education9

Senior Level COO Jobs: Frequently Asked Questions

How do I get a senior level coo job?

Employers hiring at the senior level want candidates who have led large cross-functional teams, owned P&L or operational outcomes, and driven measurable organizational change. Tailor your resume to show scope, not just responsibilities. Highlight initiatives you originated and the business results that followed. Board-level communication experience and a history of building leadership pipelines consistently give candidates an edge at this stage.

Which companies hire senior level coos?

Companies hiring senior level coos right now include Revolution Medicines, Jobot, and The Waters, based on current listings on Migrate Mate as of November 2026. Hiring at this level covers growth-stage companies seeking their first dedicated operations executive and established organizations replacing or elevating the role as they scale.

Are there remote senior level coo jobs?

Yes, though remote availability at this level is more selective than in individual-contributor roles. About 32% of senior level coo openings are remote or hybrid as of November 2026, reflecting demand from distributed companies and private equity-backed organizations that prioritize operator talent over geography. On-site roles remain common where the position requires daily presence across facilities or teams.

What makes a coo role senior level?

Senior level coo roles are defined by enterprise-wide ownership rather than departmental execution. Expectations include setting operational strategy, managing a team of directors or VPs, and partnering directly with the CEO and board. These roles carry accountability for organizational health, capital allocation decisions, and long-term scalability, distinguishing them from mid-level operations roles focused on process management within a single function.

Which industries hire the most senior level coos?

Senior level coo roles concentrate in Biotechnology & Pharmaceuticals, Technology & Software, and Healthcare & Medical Services, based on current listings on Migrate Mate as of November 2026. These sectors tend to drive hiring at this level because rapid growth, regulatory complexity, or multi-site operations create a consistent need for dedicated operational leadership at the executive layer.