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Department Overview:

The Teresa Zimmers and Leonidas Koniaris laboratory uses human biospecimens, cell culture models, and mouse models to interrogate and understand the physiological response to injury or illness including liver injury, kidney injury, burn injury, and cancer. We seek novel targetable mechanisms to block adipose and muscle wasting in cachexia in order to promote function, quality of life, healing, and survival. The laboratory is highly collaborative, working closely with other labs and centers at OHSU and around the world. Funding is derived from OHSU, the Brenden Colson Center, the Knight Cancer Institute, NIH, and the Veterans Administration.

The Senior Research Associate will work jointly under PI’s Zimmers and Koniaris and will execute various murine injury models, in vitro studies, and analyses of human biospecimens. The position requires expertise in mouse modeling including surgery, common cell and molecular biology techniques, including cell and tissue processing, cell culture, tissue dissociation, DNA/RNA isolation, PCR, Western blotting, ELISAs, and gel electrophoresis. The candidate must possess exceptional organizational skills and a detail-oriented management style. An ability to work independently, as well as collaboratively, and to help train and supervise entry-level staff, students, and interns is required. The SRA will lead projects and lead or contribute to manuscripts and presentations, and like all members of the laboratory, will contribute to shared laboratory chores, record keeping, ordering, compliance, etc. The SRA, like all full-time lab members, will contribute to training of rotation students and summer students and will present at laboratory meetings and other research meetings. The SRA will have the opportunity to receive professional development and mentoring, including attendance at external training opportunities and national and international conferences.

Function/Duties of Position:

• Managing junior lab members: on-boarding and introduction to essential lab functions.
• Designing and executing experiments; identifying, testing, and implementing novel experimental and organizational procedures in the lab, collecting, analyzing, and quantifying data.
• Assist with IACUC/IRB renewals, submitting amendments as needed for ongoing research in the laboratory. Ensure laboratory compliance with EHS policies.
• Co-author manuscripts for peer reviewed publication. Support grant applications for funding of the research laboratory.
• Attending and presenting research at lab meetings, seminars and conferences.

Required Qualifications:

• PhD in relevant field AND 1 year of relevant experience OR
• Master's Degree in relevant field AND 5 years of relevant experience OR
• Bachelor's Degree in relevant field AND 9 years of relevant experience
• Experience in an academic biomedical research laboratory using mouse models and advanced analyses including omics approaches.
• Demonstrated ability to lead a project with agency and independence.
• Demonstrated facility with mouse modeling, mouse genetics, colony management.
• Demonstrated ability in analysis of high dimensional data, e.g. transcriptomics, genomics, proteomics.
• Demonstrated competence in analysis of biological pathways using human and/or murine biospecimens (histology, ELISA, preparation of samples for advanced omics analysis) and complementary studies using in vitro systems including genetic manipulation of primary cells, tissues, and cell lines.
• Ability to design, execute, troubleshoot and interpret experiments.
• Ability to master OHSU specific administrative systems for laboratory functions including IACUC, IRB, IBC, ordering, compliance, etc.
• Ability to organize the laboratory records and inventory.
• Ability to work independently as well as collaboratively. Ability to work in a team environment.
• Ability to perform the job duties with or without accommodation.

Preferred Qualifications:

Monday - Friday, 8:00am - 4:30pm. Work is generally 40 hours per week during normal working hours, however, some evening and weekend work will be necessary. Additional safety training will be required to work with cell lines/ infectious bacteria or viruses/ working with in a BSL-2 environment.

Why apply to OHSU?: We are Oregon's only public academic health center. In addition to caring for patients, we lead groundbreaking research. We also train the next generation of health care professionals. As Portland's largest employer, we give you opportunities to learn and advance in a system of hospitals and clinics across Oregon and Southwest Washington. All are welcome. OHSU welcomes people of all ages, ethnicities, genders, national origins, religions and sexual orientations. We are striving to build an anti-racist, multicultural institution and encourage people with diverse backgrounds to apply. To request reasonable accommodation, contact askhr@ohsu.edu.