Machine Learning Jobs in San Francisco, CA
Machine learning jobs in San Francisco concentrate in AI research, fintech, healthcare tech, and enterprise software, with the heaviest hiring in SoMa, Mission Bay, and the Financial District. Employers posting roles right now include Pinterest, Genentech, and OpenAI. Scan the live roles below and apply to whichever ones fit.
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INTRODUCTION
The Senior Principal AI Agent / ML Software Engineer is a Senior Staff-level, hands-on technical leadership role responsible for defining, building, and operating next-generation AI systems on Oracle Cloud Infrastructure (OCI). This person will set architecture and engineering direction for production-grade agentic AI platforms, autonomous workflows, scalable inference infrastructure, and enterprise AI applications used in large-scale, business-critical environments.
This role requires a proven engineer who can translate ambiguous product and platform goals into durable technical strategy, lead multi-team execution without direct authority, and remain deeply hands-on in design, code, reviews, operations, and incident follow-up. The ideal candidate combines deep distributed systems experience with practical AI-native engineering, including orchestration of LLMs, tools, APIs, memory, retrieval, evaluation, guardrails, and cloud services. The expectation is to ship, scale, and operate reliable, secure, observable, and cost-aware AI platform systems while raising the technical bar for engineers across the organization.
Responsibilities
- Serve as a senior technical owner for OCI AI platform capabilities, including agent execution, inference systems, model serving, AI workflow orchestration, evaluation, and observability.
- Design, architect, and deliver scalable agentic AI systems capable of reasoning, planning, tool use, workflow execution, multi-step task orchestration, and safe human-in-the-loop escalation.
- Build production-grade services for tool calling, agent memory, context management, Model Context Protocol (MCP) integration, vector retrieval, multi-agent coordination, policy enforcement, and evaluation.
- Lead architecture across distributed services optimized for low latency, high throughput, GPU efficiency, reliability, cost, operability, and secure multi-tenant operation.
- Define service boundaries, APIs, data models, state management, consistency tradeoffs, failure modes, SLIs/SLOs, rollout strategies, and operational readiness criteria for AI platform services.
- Drive technical strategy across infrastructure, platform, security, data, and application engineering teams, converting broad goals into executable multi-quarter plans and measurable milestones.
- Integrate AI agents securely and reliably with enterprise APIs, cloud services, databases, identity systems, secrets management, and external systems.
- Establish AgentOps and LLMOps practices for tracing, monitoring, eval suites, regression testing, experimentation, safety guardrails, prompt/tool versioning, and production reliability.
- Evaluate and operationalize emerging technologies in generative AI, agentic workflows, inference optimization, long-context systems, reasoning models, AI developer tooling, and agentic-first development.
- Drive engineering excellence through code reviews, design reviews, test strategy, deployment automation, incident analysis, documentation, and AI-assisted development practices using tools such as Codex, Claude Code, Cursor, Copilot, or similar systems.
- Mentor Staff and senior engineers, raise architectural standards, and influence engineering practices across OCI without requiring direct management authority.
- Own critical production outcomes, including reliability, performance, security posture, cost efficiency, and supportability for the systems delivered.
REQUIRED QUALIFICATIONS
- Bachelor's, Master's, or Ph.D. in Computer Science, AI/ML, Engineering, or a related field, or equivalent practical experience.
- 12+ years of professional software engineering experience, including significant ownership of production systems; or equivalent experience demonstrating Senior Staff / Principal-level impact.
- Proven track record as a Staff, Senior Staff, Principal, or equivalent technical leader influencing architecture and execution across multiple teams.
- Deep experience designing, building, and operating high-scale distributed systems, cloud services, infrastructure platforms, or AI/ML platform services.
- Hands-on experience with production AI systems, agentic AI applications, autonomous workflows, tool-using agents, multi-step orchestration, or multi-agent systems.
- Practical experience with orchestration frameworks such as LangGraph, LangChain, CrewAI, AutoGen, LlamaIndex, or similar ecosystems.
- Deep understanding of LLM application patterns, including prompt design, structured outputs, function/tool calling, context management, RAG, memory, tool safety, and evaluation.
- Strong programming skills in Python and ability to contribute high-quality production code, reviews, tests, and debugging in complex distributed environments.
- Strong expertise with Kubernetes, Docker, cloud-native infrastructure, service-to-service communication, scalability, fault tolerance, observability, and performance analysis.
- Experience defining SLIs/SLOs, production readiness criteria, incident response practices, monitoring, tracing, experiments, and reliability programs for AI or distributed systems.
- Strong understanding of AI safety, governance, security, and operational risks for autonomous or semi-autonomous systems, including data handling, access control, auditability, and human accountability.
- Excellent written and verbal communication, with demonstrated ability to lead technical direction, resolve ambiguity, and influence senior stakeholders.
PREFERRED QUALIFICATIONS
- Experience optimizing large-scale GPU inference or training workloads for latency, throughput, utilization, availability, and cost.
- Experience building or operating model serving, inference gateways, agent runtimes, workflow engines, developer platforms, or internal AI productivity platforms.
- Experience integrating AI systems with enterprise APIs, databases, cloud services, vector databases, embeddings, retrieval systems, identity systems, and policy enforcement layers.
- Experience with LLM fine-tuning, long-context systems, reasoning models, model routing, caching, batching, quantization, or emerging generative AI research.
- Experience building evaluation frameworks for agentic systems, including offline evals, online experiments, golden tasks, adversarial testing, regression gates, and observability dashboards.
- Experience using AI-assisted software development tools such as Codex, Claude Code, Cursor, Copilot, or similar systems in large-scale engineering environments.
- Track record of defining architectural standards, platform capabilities, or engineering practices adopted across multiple teams or organizations.
- Experience in enterprise, cloud infrastructure, regulated, security-sensitive, or mission-critical environments.
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Find Machine Learning JobsMachine Learning Job Market in San Francisco
Who's Hiring
- Pinterest39

- Genentech14

- OpenAI13

- Lyft11

- DoorDash11

Top Industries Hiring
- Technology & Software203
- Science & Research20
- Artificial Intelligence20
- Retail15
- Fintech13
Machine Learning Jobs in San Francisco: Frequently Asked Questions
How do I get a machine learning job in San Francisco?
The strongest path into San Francisco's machine learning market is through its AI-first tech companies, early-stage startups in SoMa and Mission Bay, and the large fintech and healthcare tech firms anchored downtown. Candidates with hands-on experience in model deployment, MLOps, or applied NLP stand out locally. Contributing to open-source projects and building a visible portfolio on GitHub helps significantly in a market where hiring teams move fast and technical screens come early.
Which companies hire machine learnings in San Francisco?
San Francisco machine learning roles are posted by Pinterest, Genentech, and OpenAI and others right now, based on current listings on Migrate Mate as of June 2026. The local market is a mix of established tech giants with dedicated AI divisions, fast-growing startups building foundation models, and financial services firms investing heavily in ML infrastructure.
Are there remote machine learning jobs in San Francisco?
Yes, though it depends on the role: research and data-focused positions tend to be more remote-friendly, while MLOps and on-site infrastructure roles typically require in-person work. About 53% of machine learning openings tied to San Francisco are remote or hybrid as of June 2026, reflecting the city's strong hybrid culture. Model experimentation and research work are the functions most commonly offered with location flexibility.
How can I get a machine learning job in San Francisco with little or no experience?
The most realistic entry point in San Francisco is an ML engineer associate or data analyst role at a mid-size startup, where teams are small enough that junior contributors take on meaningful work early. San Francisco's dense startup ecosystem in SoMa and Dogpatch regularly hires candidates who demonstrate project-based learning, Kaggle competition results, or research experience from local universities such as UC San Francisco or San Francisco State. Roles in data labeling, ML quality assurance, and analytics engineering often serve as direct stepping stones.
Which industries hire the most machine learnings in San Francisco?
San Francisco machine learning roles concentrate in Technology & Software, Science & Research, and Artificial Intelligence, based on current listings on Migrate Mate as of June 2026. San Francisco's position as the hub of foundation model development, combined with its large fintech corridor and growing health tech cluster in Mission Bay, drives sustained demand across all three sectors.
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