ML Software Engineer Jobs in San Francisco, CA
ML Software Engineer jobs in San Francisco are concentrated in SoMa, Mission Bay, and the Financial District, driven by demand across AI infrastructure, autonomous systems, and enterprise software. Employers actively hiring include Pinterest, Genentech, and OpenAI. See the openings below and apply to the ones that match your experience.
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INTRODUCTION
The Senior Principal AI Agent / ML Software Engineer is a Senior Staff-level, hands-on technical leadership role responsible for defining, building, and operating next-generation AI systems on Oracle Cloud Infrastructure (OCI). This person will set architecture and engineering direction for production-grade agentic AI platforms, autonomous workflows, scalable inference infrastructure, and enterprise AI applications used in large-scale, business-critical environments.
This role requires a proven engineer who can translate ambiguous product and platform goals into durable technical strategy, lead multi-team execution without direct authority, and remain deeply hands-on in design, code, reviews, operations, and incident follow-up. The ideal candidate combines deep distributed systems experience with practical AI-native engineering, including orchestration of LLMs, tools, APIs, memory, retrieval, evaluation, guardrails, and cloud services. The expectation is to ship, scale, and operate reliable, secure, observable, and cost-aware AI platform systems while raising the technical bar for engineers across the organization.
Responsibilities
- Serve as a senior technical owner for OCI AI platform capabilities, including agent execution, inference systems, model serving, AI workflow orchestration, evaluation, and observability.
- Design, architect, and deliver scalable agentic AI systems capable of reasoning, planning, tool use, workflow execution, multi-step task orchestration, and safe human-in-the-loop escalation.
- Build production-grade services for tool calling, agent memory, context management, Model Context Protocol (MCP) integration, vector retrieval, multi-agent coordination, policy enforcement, and evaluation.
- Lead architecture across distributed services optimized for low latency, high throughput, GPU efficiency, reliability, cost, operability, and secure multi-tenant operation.
- Define service boundaries, APIs, data models, state management, consistency tradeoffs, failure modes, SLIs/SLOs, rollout strategies, and operational readiness criteria for AI platform services.
- Drive technical strategy across infrastructure, platform, security, data, and application engineering teams, converting broad goals into executable multi-quarter plans and measurable milestones.
- Integrate AI agents securely and reliably with enterprise APIs, cloud services, databases, identity systems, secrets management, and external systems.
- Establish AgentOps and LLMOps practices for tracing, monitoring, eval suites, regression testing, experimentation, safety guardrails, prompt/tool versioning, and production reliability.
- Evaluate and operationalize emerging technologies in generative AI, agentic workflows, inference optimization, long-context systems, reasoning models, AI developer tooling, and agentic-first development.
- Drive engineering excellence through code reviews, design reviews, test strategy, deployment automation, incident analysis, documentation, and AI-assisted development practices using tools such as Codex, Claude Code, Cursor, Copilot, or similar systems.
- Mentor Staff and senior engineers, raise architectural standards, and influence engineering practices across OCI without requiring direct management authority.
- Own critical production outcomes, including reliability, performance, security posture, cost efficiency, and supportability for the systems delivered.
REQUIRED QUALIFICATIONS
- Bachelor's, Master's, or Ph.D. in Computer Science, AI/ML, Engineering, or a related field, or equivalent practical experience.
- 12+ years of professional software engineering experience, including significant ownership of production systems; or equivalent experience demonstrating Senior Staff / Principal-level impact.
- Proven track record as a Staff, Senior Staff, Principal, or equivalent technical leader influencing architecture and execution across multiple teams.
- Deep experience designing, building, and operating high-scale distributed systems, cloud services, infrastructure platforms, or AI/ML platform services.
- Hands-on experience with production AI systems, agentic AI applications, autonomous workflows, tool-using agents, multi-step orchestration, or multi-agent systems.
- Practical experience with orchestration frameworks such as LangGraph, LangChain, CrewAI, AutoGen, LlamaIndex, or similar ecosystems.
- Deep understanding of LLM application patterns, including prompt design, structured outputs, function/tool calling, context management, RAG, memory, tool safety, and evaluation.
- Strong programming skills in Python and ability to contribute high-quality production code, reviews, tests, and debugging in complex distributed environments.
- Strong expertise with Kubernetes, Docker, cloud-native infrastructure, service-to-service communication, scalability, fault tolerance, observability, and performance analysis.
- Experience defining SLIs/SLOs, production readiness criteria, incident response practices, monitoring, tracing, experiments, and reliability programs for AI or distributed systems.
- Strong understanding of AI safety, governance, security, and operational risks for autonomous or semi-autonomous systems, including data handling, access control, auditability, and human accountability.
- Excellent written and verbal communication, with demonstrated ability to lead technical direction, resolve ambiguity, and influence senior stakeholders.
PREFERRED QUALIFICATIONS
- Experience optimizing large-scale GPU inference or training workloads for latency, throughput, utilization, availability, and cost.
- Experience building or operating model serving, inference gateways, agent runtimes, workflow engines, developer platforms, or internal AI productivity platforms.
- Experience integrating AI systems with enterprise APIs, databases, cloud services, vector databases, embeddings, retrieval systems, identity systems, and policy enforcement layers.
- Experience with LLM fine-tuning, long-context systems, reasoning models, model routing, caching, batching, quantization, or emerging generative AI research.
- Experience building evaluation frameworks for agentic systems, including offline evals, online experiments, golden tasks, adversarial testing, regression gates, and observability dashboards.
- Experience using AI-assisted software development tools such as Codex, Claude Code, Cursor, Copilot, or similar systems in large-scale engineering environments.
- Track record of defining architectural standards, platform capabilities, or engineering practices adopted across multiple teams or organizations.
- Experience in enterprise, cloud infrastructure, regulated, security-sensitive, or mission-critical environments.
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Find ML Software Engineer JobsML Software Engineer Job Market in San Francisco
Who's Hiring
- Pinterest39

- Genentech14

- OpenAI13

- Lyft11

- DoorDash11

Top Industries Hiring
- Technology & Software203
- Science & Research20
- Artificial Intelligence20
- Retail15
- Fintech13
ML Software Engineer Jobs in San Francisco: Frequently Asked Questions
How do I get a ml software engineer job in San Francisco?
The strongest path into a ml software engineer role in San Francisco is targeting the city's AI-native startups in SoMa and Mission Bay, as well as the larger tech firms headquartered in the Financial District and South of Market. Candidates who can demonstrate experience with production ML systems, model deployment, and MLOps tooling stand out in this market. Contributing to open-source ML projects and engaging with San Francisco's dense AI research community also give applicants a concrete edge.
Which companies hire ml software engineers in San Francisco?
Companies currently hiring ml software engineers in San Francisco include Pinterest, Genentech, and OpenAI, per current listings on Migrate Mate as of June 2026. San Francisco's hiring base ranges from well-funded AI startups and autonomous vehicle companies to large-scale cloud and enterprise software firms with dedicated machine learning divisions.
Are there remote ml software engineer jobs in San Francisco?
Yes, though many ml software engineer roles require on-site access to GPU clusters, proprietary datasets, or cross-functional research teams. About 53% of ml software engineer openings tied to San Francisco are remote or hybrid as of June 2026, with the fully remote share concentrated in inference engineering, ML platform development, and applied research roles that rely primarily on code and experimentation rather than hardware access.
How can I get a ml software engineer job in San Francisco with little or no experience?
The most realistic entry path in San Francisco is securing a junior ML engineer or ML platform associate role at a mid-stage startup in SoMa or Mission Bay, where smaller teams give early-career engineers broader exposure than large firms. San Francisco employers often value demonstrable project work, such as Kaggle competition results, published model benchmarks, or contributions to frameworks like Hugging Face, over formal credentials. Targeting AI infrastructure roles or data engineering positions at growth-stage companies is a practical way to build the production experience that senior ml software engineer openings require.
Which industries hire the most ml software engineers in San Francisco?
Most ml software engineer openings in San Francisco sit in Technology & Software, Science & Research, and Artificial Intelligence, per current listings on Migrate Mate as of June 2026. San Francisco's concentration of AI-first companies, autonomous systems developers, and enterprise software firms makes it one of the densest markets for applied machine learning work in the country.
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