Senior Level Principal Clinical Research Associate Jobs

Senior level principal clinical research associate jobs place experienced professionals in charge of trial oversight, protocol strategy, and the cross-functional teams that deliver study outcomes. Roles are concentrated in Technology & Software, Gaming & Esports, and Media & Entertainment, with a mix of on-site, hybrid, and remote positions available, and employers like Riot Games, Chicago Trading Company, and GitLab hiring at this level now.

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Overview

Open roles9
Top stateCalifornia
Top employerRiot Games
Top cityLos Angeles, CA
Work type63% Hybrid
Top industryTechnology

Showing 5 of 9+ Senior Level Principal Clinical Research Associate jobs

Principal Security Researcher
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New 5h ago
Principal Security Researcher
Oracle
Nashville, Tennessee
Cybersecurity
Research & Academia
Technical Product & Program Management
On-Site
Bachelor's
10,000+

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Principal Cloud Security Researcher
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Added 1d ago
Principal Cloud Security Researcher
CrowdStrike
Wyoming
Cybersecurity
Software Engineering
Cloud & DevOps
Technical Product & Program Management
Cloud Engineering
$195k - $310k/yr
Remote (US)
None
1,001-5,000

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Principal Security Researcher
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Added 2mo ago
Principal Security Researcher
GitLab
Remote
Cybersecurity
Technical Product & Program Management
Security Engineering
Technical Program Management
$275k/yr
Remote (US)
None

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Principal Quantitative Researcher
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Added 5mo ago
Principal Quantitative Researcher
Chicago Trading Company
New York, New York
Data Science & Analytics
Data Science
$250k - $300k/yr
Hybrid
Doctorate

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Principal Quantitative Researcher
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Added 5mo ago
Principal Quantitative Researcher
Chicago Trading Company
Chicago, Illinois
Data Science & Analytics
Data Science
$250k - $300k/yr
Hybrid
Doctorate

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Senior Level Principal Clinical Research Associate Job Market

Who's Hiring

Riot Games2 open roles
Chicago Trading Company2 open roles
GitLab1 open role

Top Industries Hiring

  • Technology & Software
  • Gaming & Esports
  • Media & Entertainment
  • Investment & Asset Management
  • Science & Research

Senior Level Principal Clinical Research Associate Jobs: Frequently Asked Questions

How do I get a senior level principal clinical research associate job?

Employers at this level expect a demonstrated record of independent site management, protocol deviation resolution, and regulatory inspection readiness. What gives candidates an edge is experience mentoring junior CRAs, owning complex multi-site studies end to end, and fluency with ICH-GCP compliance across therapeutic areas. Tailoring your application to show cross-functional leadership and outcome ownership makes the strongest impression.

Which companies hire senior level principal clinical research associates?

Companies hiring senior level principal clinical research associates right now include Riot Games, Chicago Trading Company, and GitLab, based on current listings on Migrate Mate as of November 2026. Hiring at this level comes primarily from large contract research organizations, biopharma sponsors, and medical device companies running late-phase or global trials.

Are there remote senior level principal clinical research associate jobs?

Yes, though availability depends on therapeutic area and sponsor requirements. About 88% of senior level principal clinical research associate openings are remote or hybrid as of November 2026, reflecting the industry's broader adoption of remote monitoring models for experienced professionals who can manage site relationships independently.

What makes a principal clinical research associate role senior level?

Senior level principal clinical research associate roles carry full ownership of trial execution rather than task completion. That means setting site strategy, resolving escalated compliance issues without manager guidance, mentoring junior and mid-level CRAs, and contributing to process improvement across the clinical operations function. The scope is strategic and cross-functional, not just site-specific.

Which industries hire the most senior level principal clinical research associates?

Senior Level principal clinical research associate roles concentrate in Technology & Software, Gaming & Esports, and Media & Entertainment, based on current listings on Migrate Mate as of November 2026. These sectors drive demand because they run the highest volumes of regulated clinical trials and require experienced oversight professionals who can operate with minimal supervision across complex study portfolios.