Senior Level Python Developer Jobs
Senior level python developer jobs put experienced engineers in charge of architecture decisions, system design, and the technical direction of the teams and projects that depend on them. The mix is heavily remote and hybrid, with openings concentrated in Technology & Software, Energy, and Science & Research and employers like Photon, Synechron, and CoreTek Labs hiring at this level now.
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Role: Python API Lead Developer
Location: Chicago, IL (Hybrid)
Duration: Long Term
Role Summary:
Seeking an experienced Python API Lead Developer to lead the design, development, security, and deployment of enterprise-grade REST APIs in an AWS cloud environment. The ideal candidate will possess deep expertise in Python/FastAPI, cloud-native API architecture, and modern API security standards.
Top Skills:
- Python
- FastAPI
- AWS API Gateway
- OAuth2/JWT
- API Security
- AWS Cloud
Key Responsibilities:
- Design and develop high-performance REST APIs using Python and FastAPI.
- Define and maintain API specifications using OpenAPI/Swagger.
- Implement secure authentication and authorization using OAuth2, JWT, and mTLS.
- Deploy, manage, and secure APIs using AWS API Gateway and related AWS services.
- Configure and support AWS security components including ACM, Private CA, WAF, and Shield.
- Perform API testing, validation, monitoring, and troubleshooting.
- Ensure compliance with healthcare security requirements, including HIPAA and secure handling of PHI.
- Support CI/CD pipelines and source control best practices.
Required Skills:
- Strong experience in Python, FastAPI, and REST API development.
- Expertise in OAuth2, JWT, mTLS, and API security best practices.
- Hands-on experience with AWS API Gateway, Lambda, S3, EKS, CloudWatch, ACM, and WAF.
- Experience with OpenAPI/Swagger, Postman, and API testing tools.
- 3-5+ years of AWS cloud development and deployment experience.
- Experience with Git and CI/CD practices.
- Prior experience working in HIPAA-compliant environments.
Preferred Qualifications
- AWS Certified Developer Associate.
- Experience integrating APIs with identity providers such as Okta.
Years of Experience:
12.00 Years of Experience
Role: Python API Lead Developer
Location: Chicago, IL (Hybrid)
Duration: Long Term
Role Summary:
Seeking an experienced Python API Lead Developer to lead the design, development, security, and deployment of enterprise-grade REST APIs in an AWS cloud environment. The ideal candidate will possess deep expertise in Python/FastAPI, cloud-native API architecture, and modern API security standards.
Top Skills:
- Python
- FastAPI
- AWS API Gateway
- OAuth2/JWT
- API Security
- AWS Cloud
Key Responsibilities:
- Design and develop high-performance REST APIs using Python and FastAPI.
- Define and maintain API specifications using OpenAPI/Swagger.
- Implement secure authentication and authorization using OAuth2, JWT, and mTLS.
- Deploy, manage, and secure APIs using AWS API Gateway and related AWS services.
- Configure and support AWS security components including ACM, Private CA, WAF, and Shield.
- Perform API testing, validation, monitoring, and troubleshooting.
- Ensure compliance with healthcare security requirements, including HIPAA and secure handling of PHI.
- Support CI/CD pipelines and source control best practices.
Required Skills:
- Strong experience in Python, FastAPI, and REST API development.
- Expertise in OAuth2, JWT, mTLS, and API security best practices.
- Hands-on experience with AWS API Gateway, Lambda, S3, EKS, CloudWatch, ACM, and WAF.
- Experience with OpenAPI/Swagger, Postman, and API testing tools.
- 3-5+ years of AWS cloud development and deployment experience.
- Experience with Git and CI/CD practices.
- Prior experience working in HIPAA-compliant environments.
Preferred Qualifications
- AWS Certified Developer Associate.
- Experience integrating APIs with identity providers such as Okta.
Years of Experience:
12.00 Years of Experience
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Top Industries Hiring
- Technology & Software
- Energy
- Science & Research
- Electronics & Hardware
Senior Level Python Developer Jobs: Frequently Asked Questions
How do I get a senior level python developer job?
Employers hiring at the senior level look for engineers who can own a system end to end, not just complete tickets. Demonstrating that you have led a migration, designed a service from scratch, or made architectural calls under real constraints matters more than years alone. Strong candidates also show they have mentored others and can communicate technical tradeoffs to non-engineering stakeholders.
Which companies hire senior level python developers?
Companies hiring senior level python developers right now include Photon, Synechron, and CoreTek Labs, based on current listings on Migrate Mate as of September 2026. Hiring at this level comes from a wide range of organizations, from established tech companies and financial institutions to growth-stage startups that need engineers who can build and scale without close supervision.
Are there remote senior level python developer jobs?
Yes, remote and hybrid options are common at this level. About 43% of senior level python developer openings are remote or hybrid as of September 2026, reflecting how much employers value experienced engineers regardless of location. Senior roles often come with greater flexibility because the expectation is that you can operate independently and lead without needing daily in-person oversight.
What makes a python developer role senior level?
Senior level roles are defined by scope and ownership rather than task completion. A senior python developer is expected to design systems, evaluate architectural tradeoffs, set technical standards, and make decisions that affect the whole team or product. Mentoring junior and mid-level engineers is a routine part of the work, and the expectation is that you drive outcomes rather than wait for direction.
Which industries hire the most senior level python developers?
Senior level python developer roles concentrate in Technology & Software, Energy, and Science & Research, based on current listings on Migrate Mate as of September 2026. These sectors drive hiring at this level because they rely on complex, high-stakes systems where experienced engineers who can own architecture and guide teams are far more valuable than additional headcount at earlier career stages.