Scientist Jobs in Philadelphia, PA
Scientist jobs in Philadelphia are in strong demand, concentrated in University City, Center City, and the Navy Yard across life sciences, pharmaceutical research, and environmental services, with employers ranging from research hospitals to biotech firms. Companies actively hiring include Penn Medicine, Exponent, and Legend Biotech. Scan the live roles below and apply to whichever ones fit.
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Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.
Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.
Legend Biotech is seeking a Sr. Scientist as part of the Research & Development team based in Philadelphia, Pennsylvania.
Role Overview
We are seeking an initiative-taking and creative scientist to grow our pipeline efforts. The candidate will be part of Legend Biotech, a leading cell therapy company with a commercial CAR drug product CARVYKTI and an attractive pipeline portfolio. The candidate will be an integral part of our Philadelphia R&D team, whose aim is to research, develop and advance the next generation of cell therapies using innovative in vivo delivery technologies and create novel CAR therapy to treat a wide range of cancer and autoimmune disease indications. This position will focus on in-vivo CAR. The position requires enthusiasm, passion, outstanding skills in the art, diligence, and a desire to create new medicines for patients.
Expertise in immunology and/or oncology is required. The ideal candidate will be a highly motivated individual who enjoys fast paced biotech environment. You thrive in a collaborative work environment and are skilled at advancing multiple projects concurrently. Knowledge of state-of-art immunotherapy and its applications. As part of the Legend Biotech R&D team and under minimal supervision, you will be responsible for timely execution and delivery of projects in our discovery pipeline.
Key Responsibilities
- Lead, design and optimize research with aims of exploring next generation cell therapies using in-vivo CAR-T.
- Contribute to project creation and formation through dissection of published literature to find novel solutions to in-vivo cell therapy problems.
- Isolate immune cells from leukopak or blood of healthy donors or patients and execute the evaluation of in-vivo CAR virus using a battery of in-vitro assays and in-vivo mice models.
- Perform treatment of solid tumor research requiring cell biology techniques including cell culture, transfection, FACS, and cell-based functional assays.
- Package and titer engineered viruses to infect immune cells in vitro and in vivo; Characterize virus particles with protein and PCR based assays; Measure transduction rate using flow and VCN analysis.
- Generate, manage, evaluate, and maintain critical data in a highly organized manner, including the use of ELN.
- Deliver result to meet timeline with accountability through presentation to a wide range of audiences of internal group meetings and other forums.
- Maintain compliance with GLP and EHS protocols.
Requirements
- PhD in Immunology or related discipline.
- 4 years of experience in the field of cell and gene therapy, in vivo CAR-T experience preferred.
- Extensive experience in immune cell-based analytics and assay development including but not limited to advanced multi-parameter flow-cytometry, immunogenicity assay such as cytotoxicity assay, cytokine release ELISA/MSD multiplex assays.
- Experience with lentivirus particle characterization and quantification using molecular (VCN) and flow-based assays.
- Experience with solid tumor models and in vivo cell-specific gene delivery is a plus.
- Track record of productivity is evidenced by publications or patents.
- Be able to work independently to plan and timely execute research projects
- Deep knowledge of immunology and immunotherapy; a deep understanding of solid tumor models is preferred
- Proficient in advanced gene delivery methods using LVV, VLP or LNP technologies
- Strong experience with lentivirus production, tittering and transduction.
- Working molecular biology and cellular biology knowledge in design and evaluation of modified viral vectors
- Strong multitasking, problem-solving and collaborative skills
- Excellent verbal and written communication skills
#Li-JR1
#Li-Onsite
Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.
EEO Statement
It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.
Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.
Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.
Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.
Legend Biotech is seeking a Sr. Scientist as part of the Research & Development team based in Philadelphia, Pennsylvania.
Role Overview
We are seeking an initiative-taking and creative scientist to grow our pipeline efforts. The candidate will be part of Legend Biotech, a leading cell therapy company with a commercial CAR drug product CARVYKTI and an attractive pipeline portfolio. The candidate will be an integral part of our Philadelphia R&D team, whose aim is to research, develop and advance the next generation of cell therapies using innovative in vivo delivery technologies and create novel CAR therapy to treat a wide range of cancer and autoimmune disease indications. This position will focus on in-vivo CAR. The position requires enthusiasm, passion, outstanding skills in the art, diligence, and a desire to create new medicines for patients.
Expertise in immunology and/or oncology is required. The ideal candidate will be a highly motivated individual who enjoys fast paced biotech environment. You thrive in a collaborative work environment and are skilled at advancing multiple projects concurrently. Knowledge of state-of-art immunotherapy and its applications. As part of the Legend Biotech R&D team and under minimal supervision, you will be responsible for timely execution and delivery of projects in our discovery pipeline.
Key Responsibilities
- Lead, design and optimize research with aims of exploring next generation cell therapies using in-vivo CAR-T.
- Contribute to project creation and formation through dissection of published literature to find novel solutions to in-vivo cell therapy problems.
- Isolate immune cells from leukopak or blood of healthy donors or patients and execute the evaluation of in-vivo CAR virus using a battery of in-vitro assays and in-vivo mice models.
- Perform treatment of solid tumor research requiring cell biology techniques including cell culture, transfection, FACS, and cell-based functional assays.
- Package and titer engineered viruses to infect immune cells in vitro and in vivo; Characterize virus particles with protein and PCR based assays; Measure transduction rate using flow and VCN analysis.
- Generate, manage, evaluate, and maintain critical data in a highly organized manner, including the use of ELN.
- Deliver result to meet timeline with accountability through presentation to a wide range of audiences of internal group meetings and other forums.
- Maintain compliance with GLP and EHS protocols.
Requirements
- PhD in Immunology or related discipline.
- 4 years of experience in the field of cell and gene therapy, in vivo CAR-T experience preferred.
- Extensive experience in immune cell-based analytics and assay development including but not limited to advanced multi-parameter flow-cytometry, immunogenicity assay such as cytotoxicity assay, cytokine release ELISA/MSD multiplex assays.
- Experience with lentivirus particle characterization and quantification using molecular (VCN) and flow-based assays.
- Experience with solid tumor models and in vivo cell-specific gene delivery is a plus.
- Track record of productivity is evidenced by publications or patents.
- Be able to work independently to plan and timely execute research projects
- Deep knowledge of immunology and immunotherapy; a deep understanding of solid tumor models is preferred
- Proficient in advanced gene delivery methods using LVV, VLP or LNP technologies
- Strong experience with lentivirus production, tittering and transduction.
- Working molecular biology and cellular biology knowledge in design and evaluation of modified viral vectors
- Strong multitasking, problem-solving and collaborative skills
- Excellent verbal and written communication skills
#Li-JR1
#Li-Onsite
Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.
EEO Statement
It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.
Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.
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Who's Hiring
Top Industries Hiring
- Biotechnology & Pharmaceuticals
- Consulting & Professional Services
- Healthcare & Medical Services
- Technology & Software
- Fintech
Scientist Jobs in Philadelphia: Frequently Asked Questions
How do I get a scientist job in Philadelphia?
Focus your search on University City and the Navy Yard, where Philadelphia's pharmaceutical, biotech, and academic research employers concentrate most of their hiring. Candidates with hands-on laboratory experience, familiarity with GMP or GLP protocols, and connections through institutions like Penn or Drexel tend to move faster through hiring pipelines here. Attending local industry meetups through the Philadelphia Alliance for Capital and Technologies can also surface openings before they are widely posted.
Which companies hire scientists in Philadelphia?
Companies currently hiring scientists in Philadelphia include Penn Medicine, Exponent, and Legend Biotech, per current listings on Migrate Mate as of July 2026. Philadelphia's hiring base is a mix of major pharmaceutical manufacturers, independent contract research organizations, and research arms of its large academic medical centers.
Are there remote scientist jobs in Philadelphia?
Yes, though availability depends heavily on the type of scientist role, since bench and laboratory positions require on-site presence while data-intensive or regulatory affairs roles can often be done remotely. About 37% of scientist openings tied to Philadelphia are remote or hybrid as of July 2026, with hybrid arrangements more common for bioinformatics, clinical data management, and scientific writing positions linked to Philadelphia employers.
How can I get a scientist job in Philadelphia with little or no experience?
The most realistic entry path in Philadelphia is a research assistant or laboratory technician role at one of the city's academic medical centers or university-affiliated research institutes, which regularly hire entry-level candidates with a bachelor's degree. Contract research organizations clustered around University City also hire associate scientists for project-based work that builds credentials quickly. Strong candidates highlight any coursework-based lab skills, poster presentations, or co-op placements completed through Philadelphia-area programs at Drexel or Temple.
Which industries hire the most scientists in Philadelphia?
Most scientist openings in Philadelphia sit in Biotechnology & Pharmaceuticals, Consulting & Professional Services, and Healthcare & Medical Services, per current listings on Migrate Mate as of July 2026. Philadelphia's deep roots in pharmaceutical manufacturing and its cluster of nationally ranked research hospitals create sustained, year-round demand that distinguishes the city from other regional markets.
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