Senior AI Software Engineer Jobs in San Francisco, CA

Senior AI Software Engineer jobs in San Francisco are concentrated in SoMa, Mission Bay, and the Financial District, with strong demand from AI labs, cloud infrastructure companies, and enterprise software firms represented by Rippling, Innovaccer, and Lyft. Large language models, MLOps, and autonomous systems engineering are among the most sought-after specialties right now. Scan the live roles below and apply to whichever ones fit.

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Overview

Open roles26
Top employerRippling
Work type67% Hybrid
Top credentialBachelor of Science
Companies hiring22

Showing 5 of 26+ Senior AI Software Engineer jobs

Senior Software Engineer, Claims & AI Billing
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Added 1d ago
Senior Software Engineer, Claims & AI Billing
Commure
San Francisco, California
AI (Artificial Intelligence)
Data Science
$180k - $230k/yr

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Senior Staff Software Engineer, Agentic AI for XR
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Added 3d ago
Senior Staff Software Engineer, Agentic AI for XR
Google
San Francisco, California
Compliance & Risk
Cybersecurity
Security Engineering
$262k - $364k/yr
Doctoral degree in Computer Science
10,000+

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Senior Software Engineer (AI Agents)
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Added 4d ago
Senior Software Engineer (AI Agents)
Traba
San Francisco, California
Cloud Engineering
DevOps
Software Engineering
$200k - $240k/yr
2-10

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Senior Software Engineer, Backend (AI Platform)
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Added 2w ago
Senior Software Engineer, Backend (AI Platform)
Affirm
San Francisco, California
Creative & Design
Product Management
UI/UX Design
$173k - $255k/yr
Remote (US)
Bachelor's degree
1,001-5,000

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Senior Software Engineer, Backend Full Stack - Rippling AI
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Added 2w ago
Senior Software Engineer, Backend Full Stack - Rippling AI
Rippling
San Francisco, California
AI (Artificial Intelligence)
Data Science
Software Engineering
$168k - $280k/yr
Hybrid
51-200

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See All 26 Senior AI Software Engineer Jobs in San Francisco

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Senior AI Software Engineer Job Market in San Francisco

Who's Hiring

Rippling3 open roles
Innovaccer3 open roles
Lyft1 open role

Top Industries Hiring

  • Technology & Software
  • Biotechnology & Pharmaceuticals

Senior AI Software Engineer Jobs in San Francisco: Frequently Asked Questions

How do I get a senior ai software engineer job in San Francisco?

Target the clusters where San Francisco hiring concentrates: AI research labs and model companies in SoMa, biotech-adjacent ML teams in Mission Bay, and infrastructure-focused engineering groups in the Financial District. Candidates with hands-on experience deploying large language models, building ML pipelines at scale, or contributing to open-source AI frameworks stand out in this market. Networking through SF-based AI meetups and research conferences adds a measurable edge over cold applications.

Which companies hire senior ai software engineers in San Francisco?

Employers hiring senior ai software engineers in San Francisco right now include Rippling, Innovaccer, and Lyft, based on current listings on Migrate Mate as of November 2026. San Francisco's hiring mix leans heavily toward AI-native startups, foundation model labs, and large tech companies with dedicated AI divisions.

Are there remote senior ai software engineer jobs in San Francisco?

Yes, though remote access depends on the role's focus: research and applied ML engineering positions tend to be more remote-friendly than hands-on infrastructure or on-site lab work. About 89% of senior ai software engineer openings tied to San Francisco are remote or hybrid as of November 2026, reflecting how broadly distributed AI teams have become. Model evaluation, fine-tuning, and data pipeline work are the functions most commonly offered fully remote.

How can I get a senior ai software engineer job in San Francisco with little or no experience?

The most realistic entry path is through AI research internships or associate machine learning engineer roles at San Francisco-based startups, where smaller teams give junior candidates broader ownership faster. Companies building vertical AI products in healthcare and fintech in Mission Bay and SoMa often hire candidates who bring strong Python, PyTorch, or Hugging Face experience even without a long resume. Contributing to visible open-source AI projects and presenting at local AI meetups accelerates recognition in this tight-knit community.

Which industries hire the most senior ai software engineers in San Francisco?

Most senior ai software engineer openings in San Francisco sit in Technology & Software and Biotechnology & Pharmaceuticals, per current listings on Migrate Mate as of November 2026. San Francisco's density of foundation model companies, enterprise SaaS platforms, and venture-backed AI startups makes it one of the most concentrated hiring markets for this role anywhere in the country.

See All 26 Senior AI Software Engineer Jobs in San Francisco

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