Senior Data Science Engineer Jobs in Missouri
Senior Data Science Engineer jobs in Missouri are open across O'Fallon, St Louis, and Creve Coeur and other Missouri metros, with employers like Mastercard, Cushman & Wakefield, and Bass Pro Shops hiring at every experience level. Find a role that fits below and apply directly.
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Job Title
Senior Director Data Science and AI
Job Description Summary
The Senoir Director, Data Science & AI is a senior technical leader responsible for executing the organization's AI strategy. This role leads a multidisciplinary team of data scientists, ML engineers, and AI practitioners to build, deploy at scale, operate, and govern AI solutions across the enterprise. The Director champions AI innovation across the enterprise — spanning traditional machine learning, generative AI, and agentic systems — while maintaining the operational rigor, governance frameworks, and ethical standards required of a modern AI-driven organization.
Job Description
AI Model Development
- Lead the end-to-end architecture, development, and deployment of AI, including machine learning, GenAI, and Agentic models that are tailored to business use cases.
- Drive the development of agentic AI systems — including multi-agent orchestration, tool-use, and autonomous task-execution pipelines — to automate complex enterprise workflows.
- Establish model development standards encompassing data preprocessing, feature engineering, model selection, hyperparameter tuning, evaluation, and documentation.
- Partner with data engineering teams to ensure robust, scalable, and high-quality data pipelines that support model training and inference.
AI Operations (MLOps / LLMOps)
- Mature the organization's AIOps (MLOps & LLMOps) capabilities, including CI/CD pipelines for model training, evaluation, deployment, and monitoring.
- Define and enforce standards for model versioning, experiment tracking, reproducibility, and model registry management.
- Implement robust model monitoring frameworks to detect performance degradation, data drift, concept drift, and bias in production systems, with automated alerting and retraining triggers.
- Manage cloud AI/ML platform costs and optimize infrastructure utilization across training, fine-tuning, and inference workloads.
AI Innovation
- Serve as an internal AI innovation champion — identifying high-value use cases across business functions and translating them into AI-powered solutions.
- Build and maintain an enterprise AI roadmap aligned with strategic business objectives, balancing quick wins with long-term capability building.
- Foster a culture of experimentation through structured ideation programs, hackathons, and proof-of-concept sprints, ensuring rapid validation and responsible scaling of AI initiatives.
- Collaborate with product and technology leadership to embed AI capabilities into core enterprise capabilities and customer-facing products.
AI Governance
- Partner, support, and execute the organization's AI governance framework, including policies for model risk management, fairness, explainability, privacy, and security.
- Lead AI risk assessments and ensure all models in production meet internal standards and applicable regulatory requirements.
- Partner with Legal, Compliance, and Risk teams to manage data privacy obligations (GDPR, CCPA), intellectual property considerations for generative AI outputs, and third-party AI vendor due diligence.
- Champion sound AI principles organization-wide, ensuring that human oversight and accountability are embedded in every stage of the AI development lifecycle.
Team Leadership & Talent Development
- Recruit, develop, and retain a high-performing team of AI practitioners.
- Establish clear team structure, career paths, and performance frameworks that reward both technical excellence and collaborative impact.
- Foster a team culture that values intellectual curiosity, rigorous experimentation, continuous learning, and collaboration.
- Serve as a technical mentor and thought leader for technical and business teams in Technology and across the business.
Stakeholder Engagement
- Build strong cross-functional partnerships with technology and business unit leaders to ensure AI initiatives are well-defined and aligned with business priorities.
- Define and track KPIs and OKRs for the Data Science & AI function, providing regular reporting on model performance, operational health, and business impact to teams and leaders across the organization.
Education
- Bachelor's degree in a quantitative field (Finance, Economics, Mathematics, Engineering, Computer Science, etc.) or a bachelor’s degree with related applied quantitative experience.
- Master's degree in quantitative, arts, or business field preferred.
Experience
- 6-8 years of progressive experience in data science, AI/ML engineering & data, 1+ years of experience with generative AI and Agentic systems, with at least 4+ years in a people leadership role.
- Demonstrated track record of delivering production AI/ML systems at enterprise scale, from inception through deployment and ongoing operations.
- Hands-on experience with generative AI, large language models, and prompt engineering in an enterprise context.
- Experience building or scaling agentic AI systems.
- Proven experience establishing MLOps/LLMOps practices.
- Background in AI governance, model risk management, or responsible AI frameworks is highly desirable.
Cushman & Wakefield also provides eligible employees with an opportunity to enroll in a variety of benefit programs, generally including health, vision, and dental insurance, flexible spending accounts, health savings accounts, retirement savings plans, life, and disability insurance programs, and paid and unpaid time away from work. In addition to a comprehensive benefits package, Cushman and Wakefield provide eligible employees with competitive pay, which may vary depending on eligibility factors such as geographic location, date of hire, total hours worked, job type, business line, and applicability of collective bargaining agreements.
The compensation that will be offered to the successful candidate will depend on factors such as whether the position is covered by a collective bargaining agreement, the geographic area in which the work will be performed, market pay rates in that area, and the candidate’s experience and qualifications.
The company will not pay less than minimum wage for this role.
The compensation for the position is: $204,000.00 - $240,000.00
Cushman & Wakefield is an Equal Opportunity employer to all protected groups, including protected veterans and individuals with disabilities. Discrimination of any type will not be tolerated.
In compliance with the Americans with Disabilities Act Amendments Act (ADAAA), if you have a disability and would like to request an accommodation in order to apply for a position at Cushman & Wakefield, please call the ADA line at 1-888-365-5406 or email Accommodations@cushwake.com. Please refer to the job title and job location when you contact us.
See All 15 Senior Data Science Engineer Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
Find JobsSenior Data Science Engineer Jobs by City in Missouri
Where Missouri roles are concentrated, by current openings.
Senior Data Science Engineer Job Market in Missouri
A snapshot from current Missouri openings, updated as new roles post.
Who's Hiring
- Mastercard5

- Cushman & Wakefield2

- Bass Pro Shops1

- CLA (CliftonLarsonAllen)1

- Clayco1

Top Industries Hiring
- Technology & Software5
- Consulting & Professional Services4
- Construction & Real Estate3
- Food & Beverage1
- Retail1
What Missouri Employers Look For
The qualifications that appear most often in senior data science engineer jobs across Missouri.
- 5 or more years of experience in data science, machine learning, or a related engineering discipline
- Proficiency in Python and experience with ML frameworks such as TensorFlow, PyTorch, or scikit-learn
- Hands-on experience designing and deploying production-grade machine learning pipelines
- Strong command of distributed computing tools including Spark, Databricks, or equivalent platforms
- Experience with cloud platforms such as AWS, Google Cloud, or Azure for data and model infrastructure
- Bachelor's or master's degree in computer science, statistics, mathematics, or a closely related field
Senior Data Science Engineer Jobs in Missouri: Frequently Asked Questions
How many senior data science engineer jobs are there in Missouri?
There are 15+ senior data science engineer openings in Missouri on Migrate Mate as of June 2026, with the most roles in O'Fallon, St Louis, and Creve Coeur. New positions post regularly as employers across Missouri hire.
How much do senior data science engineers make in Missouri?
Senior data science engineers in Missouri earn a median of about $97,090 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $58,960 for the lowest 10% to over $151,380 for the top 10%. Pay rises with experience, specialty, and employer.
Which Missouri cities have the most senior data science engineer jobs?
O'Fallon, St Louis, and Creve Coeur have the most senior data science engineer openings in Missouri right now, with additional roles spread across smaller metros statewide.
Which companies hire senior data science engineers in Missouri?
Employers hiring senior data science engineers in Missouri include Mastercard, Cushman & Wakefield, and Bass Pro Shops, based on current listings on Migrate Mate as of June 2026.
Are there remote senior data science engineer jobs in Missouri?
Yes. About 20% of senior data science engineer openings tied to Missouri are remote or hybrid as of June 2026. The rest are on-site roles based in Missouri metros.
How do I apply for senior data science engineer jobs in Missouri?
You can apply to senior data science engineer jobs in Missouri directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred Missouri location, then apply to each one that fits.
See All 15 Senior Data Science Engineer Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
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