Senior Data Science Engineer Jobs in Missouri

Senior Data Science Engineer jobs in Missouri are open across O'Fallon, St Louis, and Creve Coeur and other Missouri metros, with employers like Mastercard, Cushman & Wakefield, and Bass Pro Shops hiring at every experience level. Find a role that fits below and apply directly.

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Overview

Open roles15+
Top employerMastercard
Top cityO'Fallon, MO
Cities hiring7
Work type80% On-site
Top industryTechnology

Showing 5 of 15+ Senior Data Science Engineer jobs

Cushman & Wakefield
Senior Director Data Science and AI
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Cushman & Wakefield
Added 1mo ago
Senior Director Data Science and AI
Cushman & Wakefield
Creve Coeur, Missouri
Data Science & Analytics
Software Engineering
Technical Product & Program Management
Project & Program Management
Data Science
AI (Artificial Intelligence)
ML (Machine Learning)
Technical Program Management
Project Management
$204k - $240k/yr
On-Site
Bachelor's
10,000+

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Mastercard
Senior Software Engineer II
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Mastercard
Added 3d ago
Senior Software Engineer II
Mastercard
O'Fallon, Missouri
Software Engineering
Data Engineering
Data Science & Analytics
Data Science
Data Analytics
Backend Engineering
$115k - $184k/yr
On-Site
Bachelor's
10,000+

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Mastercard
Senior Data Engineer
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Mastercard
Added 1w ago
Senior Data Engineer
Mastercard
O'Fallon, Missouri
Data Engineering
Data Science & Analytics
Data Science
Data Analytics
$115k - $184k/yr
On-Site
Bachelor's
10,000+

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YASH Technologies
Senior Machine Learning Engineer
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YASH Technologies
Added 3w ago
Senior Machine Learning Engineer
YASH Technologies
St Louis, Missouri
Data Science & Analytics
Software Engineering
Technical Product & Program Management
Data Science
AI (Artificial Intelligence)
ML (Machine Learning)
Hybrid
Bachelor's

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Mastercard
Senior Software Engineer
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Mastercard
Added 3w ago
Senior Software Engineer
Mastercard
O'Fallon, Missouri
Software Engineering
Data Science & Analytics
Cloud & DevOps
Data Science
Backend Engineering
$115k - $184k/yr
On-Site
None
10,000+

Have you applied for this role?

See All 15 Senior Data Science Engineer Jobs in Missouri

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Senior Data Science Engineer Jobs by City in Missouri

Where Missouri roles are concentrated, by current openings.

O'Fallon
5 jobs
St Louis
3 jobs
Creve Coeur
2 jobs
St. Louis
2 jobs
Gray Summit
1 jobs
Kansas City
1 jobs
Springfield
1 jobs

Senior Data Science Engineer Job Market in Missouri

A snapshot from current Missouri openings, updated as new roles post.

Who's Hiring

  • Mastercard
    Mastercard5
  • Cushman & Wakefield
    Cushman & Wakefield2
  • Bass Pro Shops
    Bass Pro Shops1
  • CLA (CliftonLarsonAllen)
    CLA (CliftonLarsonAllen)1
  • Clayco
    Clayco1

Top Industries Hiring

  • Technology & Software5
  • Consulting & Professional Services4
  • Construction & Real Estate3
  • Food & Beverage1
  • Retail1

What Missouri Employers Look For

The qualifications that appear most often in senior data science engineer jobs across Missouri.

  • 5 or more years of experience in data science, machine learning, or a related engineering discipline
  • Proficiency in Python and experience with ML frameworks such as TensorFlow, PyTorch, or scikit-learn
  • Hands-on experience designing and deploying production-grade machine learning pipelines
  • Strong command of distributed computing tools including Spark, Databricks, or equivalent platforms
  • Experience with cloud platforms such as AWS, Google Cloud, or Azure for data and model infrastructure
  • Bachelor's or master's degree in computer science, statistics, mathematics, or a closely related field

Senior Data Science Engineer Jobs in Missouri: Frequently Asked Questions

How many senior data science engineer jobs are there in Missouri?

There are 15+ senior data science engineer openings in Missouri on Migrate Mate as of June 2026, with the most roles in O'Fallon, St Louis, and Creve Coeur. New positions post regularly as employers across Missouri hire.

How much do senior data science engineers make in Missouri?

Senior data science engineers in Missouri earn a median of about $97,090 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $58,960 for the lowest 10% to over $151,380 for the top 10%. Pay rises with experience, specialty, and employer.

Which Missouri cities have the most senior data science engineer jobs?

O'Fallon, St Louis, and Creve Coeur have the most senior data science engineer openings in Missouri right now, with additional roles spread across smaller metros statewide.

Which companies hire senior data science engineers in Missouri?

Employers hiring senior data science engineers in Missouri include Mastercard, Cushman & Wakefield, and Bass Pro Shops, based on current listings on Migrate Mate as of June 2026.

Are there remote senior data science engineer jobs in Missouri?

Yes. About 20% of senior data science engineer openings tied to Missouri are remote or hybrid as of June 2026. The rest are on-site roles based in Missouri metros.

How do I apply for senior data science engineer jobs in Missouri?

You can apply to senior data science engineer jobs in Missouri directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred Missouri location, then apply to each one that fits.

See All 15 Senior Data Science Engineer Jobs in Missouri

Find roles in Missouri that match your experience and apply in just a few clicks.

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