Senior Mainframe Systems Programmer Jobs in South Carolina
Senior Mainframe Systems Programmer jobs in South Carolina are open across Greenville, Columbia, and Charleston and other South Carolina metros, with employers like ALG Senior, LPL Financial, and Truist hiring at every experience level. Find a role that fits below and apply directly.
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Job Summary
The IT SR Systems Engineer provides hands-on technical leadership for enterprise infrastructure and software systems. This role serves as a resource to staff, leads deployments and disaster recovery efforts, and ensures secure, reliable, and high-performing server, network, and database environments aligned with organizational standards.
Key Responsibilities
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Maintains a high standard of professionalism and customer service, consistently representing the organization’s Service Excellence Standards and Core Values when interacting with patients, visitors, physicians, and colleagues.
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Serves as an intermediate-level resource to support staff by providing technical direction, overseeing task execution, and ensuring high-quality service delivery.
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Performs cross-functional collaboration to analyze software and workflow needs, aligning technical solutions with operational goals.
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Oversees software distribution systems, ensuring secure, scalable, and efficient enterprise-wide deployment.
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Leads evaluation, testing, and coordinated deployment of software updates, patches, and service packs to minimize downtime.
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Manages software licensing and inventory compliance, ensuring proactive renewal and usage oversight.
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Performs advanced Network and Server Administration (Windows Server, VMware, Unix/Linux, Citrix), including capacity planning, performance optimization, and infrastructure forecasting.
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Provides Database Administration, including performance monitoring, integrity validation, and point-in-time recovery testing using SQL diagnostic tools.
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Participates in Disaster Recovery planning, testing, and documentation to ensure business continuity and audit readiness.
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Ensures compliance with change control, security, and risk management policies; contributes to the development of security standards and procedures.
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Leads server application installations and standard build development.
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Participates in on-call rotation.
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Other duties may be assigned, dependent upon business need.
Education
Minimum of a bachelor’s degree in Information Management, Computer Science, Business Administration, or a related field from an accredited school.
Degree equivalency: Four (4) years of directly related experience may be considered in lieu of the degree.
Experience
A minimum of four (4) years of experience is required as follows:
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Advanced experience administering complex virtual server environments, including Windows Server, Linux, SQL, Citrix, and web server technologies.
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Proven expertise in enterprise backup, recovery, and disaster recovery planning and execution.
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Hands-on experience configuring and supporting Storage Area Network (SAN) infrastructure.
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Advanced knowledge of Microsoft patch management, vulnerability remediation, and update deployment processes.
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Demonstrated experience implementing and maintaining server security best practices, including endpoint detection and response (EDR) solutions such as CrowdStrike.
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Experience managing and optimizing Linux systems and container-based applications in production environments.
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Practical experience designing and supporting cloud-based infrastructure, including Microsoft Azure.
Education/Experience: A combination of eight (8) years of education and experience may be considered.
If you would enjoy working in a dynamic environment and are looking for an opportunity to become part of a stellar team of professionals, we invite you to apply online today. We are an equal opportunity employer.
Founded in 1906, McLeod Health is a locally owned and managed, not for profit organization supported by the strength of more than 900 members on its medical staff and more than 2,900 licensed nurses. McLeod Health is also composed of approximately 15,000 team members and more than 90 physician practices throughout its 18-county service area. With seven hospitals, McLeod Health operates three Health and Fitness Centers, a Sports Medicine and Outpatient Rehabilitation Center, Hospice and Home Health Services. The system currently has 988 licensed beds, including Hospice and Behavioral Health. The hospitals within McLeod Health include: McLeod Regional Medical Center, McLeod Health Dillon, McLeod Health Loris, McLeod Health Seacoast, McLeod Health Cheraw, McLeod Health Clarendon and McLeod Behavioral Health.
See All 463+ Senior Mainframe Systems Programmer Jobs in South Carolina
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Find JobsSenior Mainframe Systems Programmer Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Senior Mainframe Systems Programmer Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
- ALG Senior16

- LPL Financial13

- Truist13

- American Eagle Outfitters12

- Fluor12

Top Industries Hiring
- Consulting & Professional Services93
- Construction & Real Estate55
- Manufacturing52
- Healthcare & Medical Services45
- Banking & Financial Services40
What South Carolina Employers Look For
The qualifications that appear most often in senior mainframe systems programmer jobs across South Carolina.
- 5 or more years of hands-on z/OS systems programming experience in a production environment
- Proficiency with IBM system software installation and maintenance using SMP/E
- Experience configuring and supporting JES2 or JES3, VTAM, and TCP/IP on z/OS
- Working knowledge of RACF, ACF2, or Top Secret for mainframe security administration
- Familiarity with DFSMS, DASD management, and storage subsystem configuration
- Bachelor's degree in computer science, information systems, or a related technical field
Senior Mainframe Systems Programmer Jobs in South Carolina: Frequently Asked Questions
How many senior mainframe systems programmer jobs are there in South Carolina?
There are 463+ senior mainframe systems programmer openings in South Carolina on Migrate Mate as of June 2026, with the most roles in Greenville, Columbia, and Charleston. New positions post regularly as employers across South Carolina hire.
How much do senior mainframe systems programmers make in South Carolina?
Senior mainframe systems programmers in South Carolina earn a median of about $99,740 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $63,130 for the lowest 10% to over $135,250 for the top 10%. Pay rises with experience, specialty, and employer.
Which South Carolina cities have the most senior mainframe systems programmer jobs?
Greenville, Columbia, and Charleston have the most senior mainframe systems programmer openings in South Carolina right now, with additional roles spread across smaller metros statewide.
Which companies hire senior mainframe systems programmers in South Carolina?
Employers hiring senior mainframe systems programmers in South Carolina include ALG Senior, LPL Financial, and Truist, based on current listings on Migrate Mate as of June 2026.
Are there remote senior mainframe systems programmer jobs in South Carolina?
Yes. About 14% of senior mainframe systems programmer openings tied to South Carolina are remote or hybrid as of June 2026. The rest are on-site roles based in South Carolina metros.
How do I apply for senior mainframe systems programmer jobs in South Carolina?
You can apply to senior mainframe systems programmer jobs in South Carolina directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Carolina location, then apply to each one that fits.
See All 463+ Senior Mainframe Systems Programmer Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
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