Senior Staff Data Scientist Jobs in Kansas City, MO
Senior Staff Data Scientist jobs in Kansas City are concentrated in the Crossroads Tech District, the Power and Light business core, and the growing Overland Park corridor, with demand running highest across financial services, healthcare, and logistics analytics. Employers actively hiring right now include Catalent Pharma Solutions, Kansas City National Security Campus, and KCAS BIO. Scan the live roles below and apply to whichever ones fit.
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The Kansas City National Security Campus (KCNSC), managed and operated by Honeywell Federal Manufacturing & Technologies, is a premier advanced manufacturing facility that supports the safety, security, reliability and effectiveness of our nation's nuclear deterrent. With nearly 7,000 employees combined in Kansas City, Missouri, and Albuquerque, New Mexico, KCNSC protects our nation and allies by producing trusted national security products and services for the U.S. Department of Energy's National Nuclear Security Administration.
We create innovative solutions to complex national security challenges, and lead with accountability, collaboration and an unwavering dedication to our mission and core values.
Are you ready to do work that matters?
Summary
The Sr Data Scientist - Applied AI role leads moderately complex end-to-end design, development, operationalization, and ongoing support of advanced artificial intelligence solutions for manufacturing or business applications, ensuring models are scalable, reliable, and seamlessly integrated into frontend and backend systems.
Duties and Responsibilities
- Lead the development of AI/ML models and algorithms using disciplined software‑engineering practices, including version control, automated testing, and thorough documentation.
- Lead teams to design, build, and maintain production‑grade pipelines for model training, validation, deployment, and monitoring, applying CI/CD and containerization principles.
- Architect and expose model inference services via robust APIs, integrating them with stakeholder applications and user interfaces.
- Optimize model performance for latency, throughput, and resource utilization to meet real‑time manufacturing or business requirements.
- Collaborate with multiple stakeholders to translate business needs into AI system specifications, define service‑level objectives, and provide technical guidance to data‑science partners.
- Mentor and support continuous improvement of other engineers, scientists, and interns.
You Must Have
- At least five years relevant experience in data science or related technical activities.
- BS in engineering from ABET accredited institution or Bachelor of Science degree in data science or related field, OR two additional years of relevant experience.
- Ability to travel as determined by the needs of the business.
- Ability to work remote, hybrid, or on-site as directed by management and is determined by the needs of the business.
- Regular and reliable attendance is an essential function of this job.
- United States Citizenship.
- Ability to obtain and maintain, if required for position, a U.S. Department of Energy (DOE) security clearance (some positions require additional DOE designations).
We Value
- Experience leading a technical team to deliver business or manufacturing focused solutions.
- Ability to grasp complex technical and business problems, prioritize tasks, and devise innovative, production‑ready AI solutions that align with manufacturing or enterprise objectives.
- Expert‑level proficiency in a modern programming language (e.g., JavaScript, Python, Java, C++) and strong command of database/query languages (e.g., SQL) for building scalable data pipelines and services.
- Demonstrated software‑engineering discipline: version control, unit/integration testing, continuous integration‑continuous deployment (CI/CD), and documentation of code and system architecture.
- Strong communication skills (verbal, written, presentation) to convey technical concepts to stakeholders, collaborate with cross‑functional teams, and produce clear technical specifications and run‑books.
- Deep knowledge of machine‑learning and deep‑learning concepts, including model design, training, evaluation, and optimization for performance, latency, and
- Familiarity with distributed data‑processing frameworks and big‑data ecosystems (e.g., Spark, Kafka) to support high‑throughput training and real‑time inference pipelines.
- Proven ability to create actionable visualizations or dashboards that show model performance, data quality, and operational metrics for end‑users and decision‑makers.
- Hands-on experience deploying AI applications on cloud platforms such as Azure or AWS.
- Expert understanding of Large Language Models (LLMs), Natural Language Processing (NLP), and Retrieval-Augmented Generation (RAG).
This job description/job posting is not all inclusive and other duties may be assigned.
What We Offer
We are focused on attracting, hiring and retaining talented people who power our mission. Our robust total rewards package recognizes performance, fuels development and supports flexibility. Key features include:
- Medical, dental and vision insurance
- Health Savings Account (HSA)
- Industry leading 401(k) match
- Generous paid time off
- Flexible work schedule
- Tuition Reimbursement
- Professional Certification & License Programs
- Mission driven culture
Click here to learn more about our benefits and culture.
Connect with us on social media: Facebook, LinkedIn and X.
Additional Information:
- Job ID: 5032
- Category: Engineering
- Level of Experience: Experienced Professional
- Posting Location: KCNSC North 9221 Ward Parkway Kansas City, MO, 64114
- Remote Eligibility: On-Site
- Travel Required: 0-10%
- Approved Work States: MO; KS
- Hourly/Salary: Salary
- Division: 800
- Department: E65
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Who's Hiring



Top Industries Hiring
- Biotechnology & Pharmaceuticals
- Science & Research
- Technology & Software
- Consulting & Professional Services
- Education
Senior Staff Data Scientist Jobs in Kansas City: Frequently Asked Questions
How do I get a senior staff data scientist job in Kansas City?
Focus on the sectors doing the most hiring locally: financial services firms clustered downtown, healthcare systems anchored in the medical corridor, and supply chain and logistics companies drawn by Kansas City's freight hub position. Candidates with experience in cloud-based modeling platforms, ML pipeline ownership, and cross-functional stakeholder influence stand out here. Targeting employers in Overland Park and Lenexa, where tech offices have expanded, also widens your options considerably.
Which companies hire senior staff data scientists in Kansas City?
Employers hiring senior staff data scientists in Kansas City right now include Catalent Pharma Solutions, Kansas City National Security Campus, and KCAS BIO, based on current listings on Migrate Mate as of July 2026. Kansas City's hiring mix leans toward established financial institutions, regional health systems, and mid-to-large logistics and insurance companies, many of which have built out in-house data science functions over the past several years.
Are there remote senior staff data scientist jobs in Kansas City?
Yes, senior staff data scientist work is broadly analytical and platform-based, making it one of the more remote-compatible senior technical roles. About 33% of senior staff data scientist openings tied to Kansas City are remote or hybrid as of July 2026, though fully on-site positions still exist at healthcare and financial services employers that require data governance oversight in person. Modeling, research, and strategy-focused tracks tend to carry the most remote flexibility.
How can I get a senior staff data scientist job in Kansas City with little or no experience?
The most realistic path in Kansas City is moving up through a data analyst or data engineer role at one of the city's mid-size financial services or insurance firms, which regularly hire junior talent and promote internally. UMKC and KU Edwards Campus both have local data science and analytics programs with ties to KC employers. Building a portfolio with time-series or geospatial work relevant to logistics or healthcare, which dominate local hiring, gives you a concrete edge when applying for step-up roles.
Which industries hire the most senior staff data scientists in Kansas City?
Kansas City senior staff data scientist roles concentrate in Biotechnology & Pharmaceuticals, Science & Research, and Technology & Software, based on current listings on Migrate Mate as of July 2026. Kansas City's position as a regional financial hub, a national freight and logistics center, and home to several major health systems creates sustained, recurring demand for senior data science talent across all three sectors.
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