Senior Staff Data Scientist Jobs in St. Louis, MO

Senior Staff Data Scientist jobs in St. Louis are concentrated across healthcare analytics, financial services, and enterprise technology, with employers clustered in the Central West End, Clayton, and downtown's financial district. Employers hiring right now include Washington University in St. Louis, The DarkStar, and Merck KGaA. Find a role that fits below and apply directly.

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Overview

Open roles57
Top employerWashington University in St. Louis
Work type80% On-site
Top credentialMaster's degree
Companies hiring29

Showing 5 of 57+ Senior Staff Data Scientist jobs

Merck KGaA
Senior Analytical Scientist
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Merck KGaA
New 16h ago
Senior Analytical Scientist
Merck KGaA
St. Louis, Missouri
AI (Artificial Intelligence)
Data Analytics
Data Science
$76k - $114k/yr
Doctoral degree in chemistry
10,000+

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HCLTech
Senior Data Scientist
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HCLTech
Added 1d ago
Senior Data Scientist
HCLTech
St. Louis, Missouri
AI (Artificial Intelligence)
Software Engineering
Technical Program Management
Master's degree in information technology
10,000+

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Washington University in St. Louis
Senior Scientist - Neurology
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Washington University in St. Louis
Added 1d ago
Senior Scientist - Neurology
Washington University in St. Louis
St. Louis, Missouri
IT Support
Project Management
Technical Program Management
$63k - $115k/yr
10,000+

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Washington University in St. Louis
Staff Scientist - Neurosurgery
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Washington University in St. Louis
Added 2d ago
Staff Scientist - Neurosurgery
Washington University in St. Louis
St. Louis, Missouri
Biotech & Life Sciences
Environmental & Physical Sciences
Laboratory Research
Research & Academia
$48k - $87k/yr
Master's degree
10,000+

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Curium Pharmaceuticals
Principal Drug Safety Scientist
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Curium Pharmaceuticals
Added 3d ago
Principal Drug Safety Scientist
Curium Pharmaceuticals
St. Louis, Missouri
Account Management
Business Development
Partnerships & Business Development
Sales
Master's degree in epidemiology

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See All 57 Senior Staff Data Scientist Jobs in St. Louis

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Senior Staff Data Scientist Job Market in St. Louis

Who's Hiring

Washington University in St. Louis
Washington University in St. Louis9 open roles
The DarkStar
The DarkStar6 open roles
Merck KGaA
Merck KGaA4 open roles

Top Industries Hiring

  • Education
  • Consulting & Professional Services
  • Healthcare & Medical Services
  • Biotechnology & Pharmaceuticals
  • Medical Devices

Senior Staff Data Scientist Jobs in St. Louis: Frequently Asked Questions

How do I get a senior staff data scientist job in St. Louis?

Focus on the sectors driving the most St. Louis hiring: large health systems, regional banks and insurance carriers, and the growing agribusiness analytics corridor anchored near Creve Coeur and West County. Candidates who combine deep ML or statistical modeling expertise with domain knowledge in healthcare or finance stand out locally. Networking through Washington University or Saint Louis University data science programs also opens doors that online applications alone don't.

Which companies hire senior staff data scientists in St. Louis?

Employers hiring senior staff data scientists in St. Louis right now include Washington University in St. Louis, The DarkStar, and Merck KGaA, based on current listings on Migrate Mate as of July 2026. St. Louis hiring is spread across major health systems, financial institutions, and mid-size technology firms that have established analytics centers in the metro area.

Are there remote senior staff data scientist jobs in St. Louis?

Yes, senior staff data scientist work is well-suited to remote arrangements given its analytical and modeling focus. About 20% of senior staff data scientist openings tied to St. Louis are remote or hybrid as of July 2026, reflecting broader industry norms for this role. Model development, research, and cross-team collaboration tasks are the functions most commonly performed remotely by St. Louis-based teams.

How can I get a senior staff data scientist job in St. Louis with little or no experience?

The most realistic entry path in St. Louis is through a data analyst or junior data scientist role at one of the city's large health systems or regional insurance companies, which regularly hire entry-level analytics talent and promote from within. Building experience with clinical or actuarial data sets is a genuine edge here. Washington University's data science programs and local tech meetups in the Cortex Innovation Community also provide direct connections to hiring managers at St. Louis employers.

Which industries hire the most senior staff data scientists in St. Louis?

St. Louis senior staff data scientist roles concentrate in Education, Consulting & Professional Services, and Healthcare & Medical Services, based on current listings on Migrate Mate as of July 2026. St. Louis's long-established base of healthcare providers, agricultural and food industry corporations, and regional financial institutions creates consistent demand for senior-level data science expertise across those sectors.

See All 57 Senior Staff Data Scientist Jobs in St. Louis

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