Senior Staff Data Scientist Jobs in St. Louis, MO
Senior Staff Data Scientist jobs in St. Louis are concentrated across healthcare analytics, financial services, and enterprise technology, with employers clustered in the Central West End, Clayton, and downtown's financial district. Employers hiring right now include Washington University in St. Louis, The DarkStar, and Merck KGaA. Find a role that fits below and apply directly.
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Work Your Magic with us! Start your next chapter and join MilliporeSigma.
Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.
This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.
Your Role
In this Sr. Analytical Scientist role you will be involved with problem solving, working within project timelines, and contributing to documentation for method qualification and transfer into GMP manufacturing. Key responsibilities include the following:
- Serve as a subject matter expert in analytical development, perform troubleshooting / provide efficient and innovative solutions, and support transfer of analytical methods to GMP QC labs
- Utilize customer-facing skills, document experimental results, communicate results to all stakeholders, author method development and qualification documents, contribute to information for customer proposals
- Serve as a project lead and ensure project deliverables are on quality and on time, develop multiple technical approach plans as needed to solve problems and mitigate risk, ensure process and methods are in place for efficient GMP start
- Lead project teams, influence exemplary work in other team members, lead process improvement initiatives, scout for new technologies / emerging trends, proactively consider the impact of quality, regulatory, manufacturing, and safety requirements when planning project activities
Who You Are
Minimum Qualifications:
- Bachelor’s degree in chemistry, Biochemistry, Biomedical Engineering, Chemical Engineering or other Life Science or Engineering discipline and 6+ years of research in an industrial or post-graduate setting
OR
- Master’s degree in chemistry, Biochemistry, Biomedical Engineering, Chemical Engineering or other Life Science or Engineering discipline and 2+ years of research in an industrial or post-graduate setting
OR
- PhD in Chemistry, Biochemistry, Biomedical Engineering, Chemical Engineering or other Life Science or Engineering discipline and 1+ years of research in an industrial or post-graduate setting
Preferred Qualifications:
- Experience with protein characterization via ELISA, SPR, Isoelectric Focusing, CE-based methods, UV-Vis, and/or chromatography (HPLC/GC/IC/UPLC/SEC/HILIC)
- Experience with advanced laboratory techniques; theory and practice to enable the development of novel approaches to solve complex process and analytical problems on fast-paced projects with changing priorities
- Knowledge of small molecule or bio-therapeutics drug development process
- Experience with antibody-drug conjugation
- Knowledge in Biochemistry or Organic Chemistry
- Experience in automation in analytical settings and instrument maintenance and troubleshooting
- Knowledge of Microsoft Word, Excel, and PowerPoint
- Experience with advanced data acquisition and/or statistical software systems
- Ability to coordinate information exchange and manage data generated by contract testing labs
Pay Range for this position: $75,700 - $113,500 annually
The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites. For more information click here.
What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!
Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!
See All 57 Senior Staff Data Scientist Jobs in St. Louis
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Find JobsSenior Staff Data Scientist Job Market in St. Louis
Who's Hiring



Top Industries Hiring
- Education
- Consulting & Professional Services
- Healthcare & Medical Services
- Biotechnology & Pharmaceuticals
- Medical Devices
Senior Staff Data Scientist Jobs in St. Louis: Frequently Asked Questions
How do I get a senior staff data scientist job in St. Louis?
Focus on the sectors driving the most St. Louis hiring: large health systems, regional banks and insurance carriers, and the growing agribusiness analytics corridor anchored near Creve Coeur and West County. Candidates who combine deep ML or statistical modeling expertise with domain knowledge in healthcare or finance stand out locally. Networking through Washington University or Saint Louis University data science programs also opens doors that online applications alone don't.
Which companies hire senior staff data scientists in St. Louis?
Employers hiring senior staff data scientists in St. Louis right now include Washington University in St. Louis, The DarkStar, and Merck KGaA, based on current listings on Migrate Mate as of July 2026. St. Louis hiring is spread across major health systems, financial institutions, and mid-size technology firms that have established analytics centers in the metro area.
Are there remote senior staff data scientist jobs in St. Louis?
Yes, senior staff data scientist work is well-suited to remote arrangements given its analytical and modeling focus. About 20% of senior staff data scientist openings tied to St. Louis are remote or hybrid as of July 2026, reflecting broader industry norms for this role. Model development, research, and cross-team collaboration tasks are the functions most commonly performed remotely by St. Louis-based teams.
How can I get a senior staff data scientist job in St. Louis with little or no experience?
The most realistic entry path in St. Louis is through a data analyst or junior data scientist role at one of the city's large health systems or regional insurance companies, which regularly hire entry-level analytics talent and promote from within. Building experience with clinical or actuarial data sets is a genuine edge here. Washington University's data science programs and local tech meetups in the Cortex Innovation Community also provide direct connections to hiring managers at St. Louis employers.
Which industries hire the most senior staff data scientists in St. Louis?
St. Louis senior staff data scientist roles concentrate in Education, Consulting & Professional Services, and Healthcare & Medical Services, based on current listings on Migrate Mate as of July 2026. St. Louis's long-established base of healthcare providers, agricultural and food industry corporations, and regional financial institutions creates consistent demand for senior-level data science expertise across those sectors.
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