Sr Staff Machine Learning Engineer Jobs in San Francisco, CA

Sr Staff Machine Learning Engineer jobs in San Francisco are heavily concentrated in SoMa, Mission Bay, and the Financial District, driven by demand from DoorDash, Uber, and Grindr across AI infrastructure, fintech, and enterprise software. Competition is intense but openings are active year-round at the senior-principal level. See the openings below and apply to the ones that match your experience.

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Overview

Open roles152+
Top employerDoorDash
Work type64% Hybrid
Companies hiring27

Showing 5 of 152+ Sr Staff Machine Learning Engineer jobs

Braze
Staff Machine Learning Engineer, ML Platform
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Braze
Added 1d ago
Staff Machine Learning Engineer, ML Platform
Braze
San Francisco, California
Customer Support
IT Support
IT Support & Systems Administration
Technical Program Management
$184k - $314k/yr
1,001-5,000

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Cognizant
Staff Machine Learning Infrastructure Engineer
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Cognizant
Added 2d ago
Staff Machine Learning Infrastructure Engineer
Cognizant
San Francisco, California
Program Management
Project & Program Management
Project Management
$130k - $145k/yr
Hybrid
Master's degree in computer science
10,000+

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Kikoff
Staff Machine Learning Engineer
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Kikoff
Added 1w ago
Staff Machine Learning Engineer
Kikoff
San Francisco, California
Business Strategy
Data Analytics
Data Science
$307k - $352k/yr
Bachelor's degree in statistics

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Chemify Ltd
Senior / Staff Machine Learning Scientist
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Chemify Ltd
Added 1mo ago
Senior / Staff Machine Learning Scientist
Chemify Ltd
San Francisco, California
Business Development
Growth Marketing
Marketing
Doctoral degree in Computer Science
201-500

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DoorDash
Staff Machine Learning Engineer, Causal Inference
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DoorDash
Added 1mo ago
Staff Machine Learning Engineer, Causal Inference
DoorDash
San Francisco, California
Engineering (Non-Software)
Mechanical Engineering
Product Management
$204k - $299k/yr
Military encouraged
10,000+

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See All 152+ Sr Staff Machine Learning Engineer Jobs in San Francisco

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Sr Staff Machine Learning Engineer Job Market in San Francisco

Who's Hiring

  • DoorDash
    DoorDash25
  • Uber
    Uber12
  • Grindr
    Grindr8
  • Liquid AI
    Liquid AI8
  • Together AI
    Together AI8

Top Industries Hiring

  • Technology & Software62
  • Electronics & Hardware8
  • Banking & Financial Services8
  • Automotive4
  • Hospitality & Tourism4

Sr Staff Machine Learning Engineer Jobs in San Francisco: Frequently Asked Questions

How do I get a sr staff machine learning engineer job in San Francisco?

The strongest path into a sr staff machine learning engineer role in San Francisco runs through the city's dense AI and enterprise software ecosystem, particularly in SoMa and Mission Bay. Companies here prioritize candidates with demonstrated ownership of large-scale ML systems, publication records or open-source contributions, and cross-functional leadership. Engaging directly with the SF ML community through local meetups and industry events also gives candidates a measurable edge in this market.

Which companies hire sr staff machine learning engineers in San Francisco?

Companies currently hiring sr staff machine learning engineers in San Francisco include DoorDash, Uber, and Grindr, per current listings on Migrate Mate as of September 2026. The San Francisco market skews heavily toward AI-native startups, large consumer tech platforms, and fintech firms, many of which maintain flagship engineering offices in the city rather than operating from suburban campuses.

Are there remote sr staff machine learning engineer jobs in San Francisco?

Yes, though at the sr staff level many roles require periodic on-site collaboration given the strategic and cross-functional scope. About 73% of sr staff machine learning engineer openings tied to San Francisco are remote or hybrid as of September 2026, with the most flexibility showing up in research-oriented and platform infrastructure roles rather than product-embedded ML positions that demand close coordination with San Francisco-based engineering and product teams.

How can I get a sr staff machine learning engineer job in San Francisco with little or no experience?

The most realistic entry path in San Francisco is through a machine learning engineer or senior ML engineer role at one of the city's many AI startups or growth-stage fintech companies, where promotion tracks to the staff and sr staff levels move faster than at large incumbents. Contributing to open-source ML projects, building a public portfolio on GitHub, and targeting companies in Mission Bay's biotech corridor or SoMa's AI cluster that run structured ML residency or new grad programs can open the door without prior sr staff-level credentials.

Which industries hire the most sr staff machine learning engineers in San Francisco?

Most sr staff machine learning engineer openings in San Francisco sit in Technology & Software, Electronics & Hardware, and Banking & Financial Services, per current listings on Migrate Mate as of September 2026. San Francisco's concentration of AI-first companies, major consumer tech platforms, and venture-backed fintech firms creates sustained demand at this level well above what comparable metros produce outside of Seattle and New York.

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