Sr Staff Machine Learning Engineer Jobs in San Francisco, CA

Sr Staff Machine Learning Engineer jobs in San Francisco are heavily concentrated in SoMa, Mission Bay, and the Financial District, driven by demand from Pinterest, Genentech, and OpenAI across AI infrastructure, fintech, and enterprise software. Competition is intense but openings are active year-round at the senior-principal level. See the openings below and apply to the ones that match your experience.

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Overview

Open roles329+
Top employerPinterest
Work type48% On-site
Top credentialBachelor's
Companies hiring100+

Showing 5 of 329+ Sr Staff Machine Learning Engineer jobs

AppFolio
Staff Machine Learning Engineer
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AppFolio
Added 2d ago
Staff Machine Learning Engineer
AppFolio
San Francisco, California
Software Engineering
Data Science & Analytics
AI (Artificial Intelligence)
ML (Machine Learning)
Data Science
Property Management
On-Site
None
1,001-5,000

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Airbnb
Staff Machine Learning Engineer
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Airbnb
Added 3d ago
Staff Machine Learning Engineer
Airbnb
San Francisco, California
Software Engineering
Data Science & Analytics
AI (Artificial Intelligence)
ML (Machine Learning)
Data Science
$260k/yr
Remote (US)
Master's

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Lilt- Lega Italiana per la Lotta contro i Tumori
AI Researcher / ML Engineer (ASR & Speech Specialist)
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Lilt- Lega Italiana per la Lotta contro i Tumori
Added 1w ago
AI Researcher / ML Engineer (ASR & Speech Specialist)
Lilt- Lega Italiana per la Lotta contro i Tumori
San Francisco, California
Software Engineering
AI (Artificial Intelligence)
ML (Machine Learning)
Master's

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Warner Bros. Discovery
Staff Machine Learning Engineer - Search
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Warner Bros. Discovery
Added 1w ago
Staff Machine Learning Engineer - Search
Warner Bros. Discovery
San Francisco, California
Software Engineering
Data Science & Analytics
AI (Artificial Intelligence)
ML (Machine Learning)
Data Science
$193k - $358k/yr
10,000+

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Warner Bros. Discovery
Staff Machine Learning Engineer - Search
We won't show you this job again
Warner Bros. Discovery
Added 1w ago
Staff Machine Learning Engineer - Search
Warner Bros. Discovery
San Francisco, California
Software Engineering
Data Science & Analytics
AI (Artificial Intelligence)
ML (Machine Learning)
Data Science
$193k - $358k/yr
10,000+

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See All 329+ Sr Staff Machine Learning Engineer Jobs in San Francisco

Find roles in San Francisco that match your experience and apply in just a few clicks.

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Sr Staff Machine Learning Engineer Job Market in San Francisco

Who's Hiring

  • Pinterest
    Pinterest47
  • Genentech
    Genentech14
  • OpenAI
    OpenAI12
  • DoorDash
    DoorDash10

Top Industries Hiring

  • Technology & Software187
  • Science & Research20
  • Artificial Intelligence19
  • Retail14
  • Medical Devices13

Sr Staff Machine Learning Engineer Jobs in San Francisco: Frequently Asked Questions

How do I get a sr staff machine learning engineer job in San Francisco?

The strongest path into a sr staff machine learning engineer role in San Francisco runs through the city's dense AI and enterprise software ecosystem, particularly in SoMa and Mission Bay. Companies here prioritize candidates with demonstrated ownership of large-scale ML systems, publication records or open-source contributions, and cross-functional leadership. Engaging directly with the SF ML community through local meetups and industry events also gives candidates a measurable edge in this market.

Which companies hire sr staff machine learning engineers in San Francisco?

Companies currently hiring sr staff machine learning engineers in San Francisco include Pinterest, Genentech, and OpenAI, per current listings on Migrate Mate as of June 2026. The San Francisco market skews heavily toward AI-native startups, large consumer tech platforms, and fintech firms, many of which maintain flagship engineering offices in the city rather than operating from suburban campuses.

Are there remote sr staff machine learning engineer jobs in San Francisco?

Yes, though at the sr staff level many roles require periodic on-site collaboration given the strategic and cross-functional scope. About 52% of sr staff machine learning engineer openings tied to San Francisco are remote or hybrid as of June 2026, with the most flexibility showing up in research-oriented and platform infrastructure roles rather than product-embedded ML positions that demand close coordination with San Francisco-based engineering and product teams.

How can I get a sr staff machine learning engineer job in San Francisco with little or no experience?

The most realistic entry path in San Francisco is through a machine learning engineer or senior ML engineer role at one of the city's many AI startups or growth-stage fintech companies, where promotion tracks to the staff and sr staff levels move faster than at large incumbents. Contributing to open-source ML projects, building a public portfolio on GitHub, and targeting companies in Mission Bay's biotech corridor or SoMa's AI cluster that run structured ML residency or new grad programs can open the door without prior sr staff-level credentials.

Which industries hire the most sr staff machine learning engineers in San Francisco?

Most sr staff machine learning engineer openings in San Francisco sit in Technology & Software, Science & Research, and Artificial Intelligence, per current listings on Migrate Mate as of June 2026. San Francisco's concentration of AI-first companies, major consumer tech platforms, and venture-backed fintech firms creates sustained demand at this level well above what comparable metros produce outside of Seattle and New York.

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