Sr Staff Machine Learning Engineer Jobs in San Francisco, CA
Sr Staff Machine Learning Engineer jobs in San Francisco are heavily concentrated in SoMa, Mission Bay, and the Financial District, driven by demand from Pinterest, Genentech, and OpenAI across AI infrastructure, fintech, and enterprise software. Competition is intense but openings are active year-round at the senior-principal level. See the openings below and apply to the ones that match your experience.
Find JobsOverview
Showing 5 of 329+ Sr Staff Machine Learning Engineer jobs











Hi, We're AppFolio
We're innovators, changemakers, and collaborators. We're more than just a software company — we're building the AI-native platform where the real estate industry comes to do business. We're transforming property management: how properties are leased, how residents find their homes, and how intelligence flows across an entire portfolio.
Realm-X is AppFolio's AI-native platform powering this transformation. Within it, Realm-X Leasing Performer is an autonomous AI agent that handles the end-to-end leasing lifecycle — lead management, tour scheduling, follow-up, application processing, etc. — on behalf of property managers and leasing teams. It's one of AppFolio's most ambitious bets on autonomous AI, and it needs ML engineering worthy of that ambition.
Who We Are Looking For
We're hiring a Staff Machine Learning Engineer to own the ML strategy and execution that makes the Realm-X Leasing Performer production-grade, observable, and continuously improving. You'll sit at the intersection of applied ML, agent systems, and leasing domain expertise — working directly with Leasing Engineering, Voice & Agents, and Research ML to translate prototypes into systems our customers can depend on every day.
This isn't a platform-only role. You'll be close enough to the product to shape how the Leasing Performer reasons, acts, and learns — and close enough to infrastructure to make sure it's reliable, cost-efficient, and safe at scale.
Your Impact
- Own the ML Strategy for Leasing: Define and drive the machine learning roadmap across Leasing products — identifying where ML creates the most leverage, making the right model and architecture bets, and working closely with Product and Engineering leadership to align the team around a coherent technical vision that reflects real customer outcomes.
- Drive the Development & Architecture for Autonomous AI Agents: Be the ML lead for AppFolio's autonomous leasing agent — shaping how it communicates with prospective tenants and helps streamline leasing operations. You'll own the model quality, evaluation framework, and continuous improvement loop that makes the Performer better over time.
- Translate Research into Product: Partner with Voice & Agents and Research ML to evaluate new capabilities — fine-tuning approaches, retrieval strategies, agentic patterns — and make the call on what's ready to ship and what needs more hardening before it reaches customers.
- Drive Model Quality and Evaluation: Build the evaluation and experimentation infrastructure that lets the Leasing team ship ML changes with confidence — defining what "better" looks like for leasing-specific tasks and owning the metrics that reflect real customer outcomes.
- Set the ML Bar for Leasing Engineering: Establish the patterns, standards, and practices that the broader Leasing Engineering team follows when integrating ML — from prompt engineering and RAG to fine-tuning and model selection. Be the person the team comes to when the ML question is hard.
- Operate with Production Discipline: Ensure that ML systems powering the Leasing Performer meet the reliability bar that production SaaS demands — SLOs, observability, cost discipline, and a clear on-call posture. You don't have to build all of it, but you own the outcomes.
Qualifications
- Systems thinker: You think in terms of platforms and long-term leverage, not just features. You understand how ML infrastructure decisions compound over time.
- Production builder: You've built and scaled ML infrastructure in production with meaningful business impact — and you treat it like any other production system.
- Domain curiosity: You take time to understand the business workflows your systems serve — in this case, leasing — and use that understanding to make better technical bets.
- Ambiguity: You operate effectively in high ambiguity, turning unclear infra problems into clear direction.
- Owner-operator: You take ownership with a founder mindset, act with urgency, and focus on outcomes.
- Collaboration: You are humble, collaborative, and low-ego — you elevate those around you and work fluidly across ML, product, and engineering.
- Reliability mindset: You treat ML infra like any other production system: SLOs, on-call, observability, postmortems.
- Sustainability: You value work-life balance as a foundation for sustained high performance.
Must Have
- ML Development at scale: Has built and supported production ML systems at scale.
- Architectural Leadership: You have experience leading architectural discussions, defining system design, and guiding technical decision-making.
- Inference & Training: Has trained or fine-tuned language models end-to-end; comfortable with deep learning, evaluation, and inference.
- Training capability: Has trained or fine-tuned language models end-to-end; comfortable with deep learning, evaluation, and inference.
- RAG & agents: Hands-on experience with LangChain / LangGraph and modern RAG patterns over structured and unstructured data.
- AI safety & authorization: Hands-on experience operating AI guardrails, scoped tool permissions, and authorization layers for production AI systems — especially in agentic contexts.
Nice to Have
- Experience building ML systems for conversational AI, leasing, or CRM-adjacent workflows.
- GPU performance tuning (vLLM, TensorRT, Triton, or similar).
- Experience with ontology-driven systems or knowledge graphs supporting AI applications.
- Familiarity with real estate, property management, or leasing workflows.
- Contributions to open-source ML infrastructure or LLM tooling.
LI-KB1
See All 329+ Sr Staff Machine Learning Engineer Jobs in San Francisco
Find roles in San Francisco that match your experience and apply in just a few clicks.
Find JobsSr Staff Machine Learning Engineer Job Market in San Francisco
Who's Hiring
- Pinterest47

- Genentech14

- OpenAI12

- DoorDash10

Top Industries Hiring
- Technology & Software187
- Science & Research20
- Artificial Intelligence19
- Retail14
- Medical Devices13
Sr Staff Machine Learning Engineer Jobs in San Francisco: Frequently Asked Questions
How do I get a sr staff machine learning engineer job in San Francisco?
The strongest path into a sr staff machine learning engineer role in San Francisco runs through the city's dense AI and enterprise software ecosystem, particularly in SoMa and Mission Bay. Companies here prioritize candidates with demonstrated ownership of large-scale ML systems, publication records or open-source contributions, and cross-functional leadership. Engaging directly with the SF ML community through local meetups and industry events also gives candidates a measurable edge in this market.
Which companies hire sr staff machine learning engineers in San Francisco?
Companies currently hiring sr staff machine learning engineers in San Francisco include Pinterest, Genentech, and OpenAI, per current listings on Migrate Mate as of June 2026. The San Francisco market skews heavily toward AI-native startups, large consumer tech platforms, and fintech firms, many of which maintain flagship engineering offices in the city rather than operating from suburban campuses.
Are there remote sr staff machine learning engineer jobs in San Francisco?
Yes, though at the sr staff level many roles require periodic on-site collaboration given the strategic and cross-functional scope. About 52% of sr staff machine learning engineer openings tied to San Francisco are remote or hybrid as of June 2026, with the most flexibility showing up in research-oriented and platform infrastructure roles rather than product-embedded ML positions that demand close coordination with San Francisco-based engineering and product teams.
How can I get a sr staff machine learning engineer job in San Francisco with little or no experience?
The most realistic entry path in San Francisco is through a machine learning engineer or senior ML engineer role at one of the city's many AI startups or growth-stage fintech companies, where promotion tracks to the staff and sr staff levels move faster than at large incumbents. Contributing to open-source ML projects, building a public portfolio on GitHub, and targeting companies in Mission Bay's biotech corridor or SoMa's AI cluster that run structured ML residency or new grad programs can open the door without prior sr staff-level credentials.
Which industries hire the most sr staff machine learning engineers in San Francisco?
Most sr staff machine learning engineer openings in San Francisco sit in Technology & Software, Science & Research, and Artificial Intelligence, per current listings on Migrate Mate as of June 2026. San Francisco's concentration of AI-first companies, major consumer tech platforms, and venture-backed fintech firms creates sustained demand at this level well above what comparable metros produce outside of Seattle and New York.
Related Jobs in California
See All 329+ Sr Staff Machine Learning Engineer Jobs in San Francisco
Find roles in San Francisco that match your experience and apply in just a few clicks.
Find Jobs