Sr Staff Machine Learning Engineer Jobs in San Francisco, CA

Sr Staff Machine Learning Engineer jobs in San Francisco are heavily concentrated in SoMa, Mission Bay, and the Financial District, driven by demand from Uber, DoorDash, and Anthropic across AI infrastructure, fintech, and enterprise software. Competition is intense but openings are active year-round at the senior-principal level. See the openings below and apply to the ones that match your experience.

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Overview

Open roles146+
Top employerUber
Work type63% Hybrid
Companies hiring29

Showing 5 of 146+ Sr Staff Machine Learning Engineer jobs

Staff Machine Learning Engineer, Homefeed
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New 5h ago
Staff Machine Learning Engineer, Homefeed
Pinterest
San Francisco, California
Engineering (Non-Software)
Software Engineering
Technical Program Management
$189k - $390k/yr
Bachelor's degree
1,001-5,000

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Member of Technical Staff - ML Research Engineer, Pre-Training Data
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Added 3d ago
Member of Technical Staff - ML Research Engineer, Pre-Training Data
Liquid AI
San Francisco, California
Business Development
Procurement & Purchasing
Supply Chain
Hybrid
Bachelor of Science

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Staff Machine Learning Engineer
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Added 5d ago
Staff Machine Learning Engineer
Integral Ad Science
San Francisco, California
Electrical Engineering
Engineering (Non-Software)
Quality Assurance & Testing (QA Testing)
Specialized Engineering
$135k - $232k/yr
Master's degree
501-1,000

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Staff Machine Learning Engineer
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Added 6d ago
Staff Machine Learning Engineer
Pinterest
San Francisco, California
Software Engineering
Data Science & Analytics
Technical Product & Program Management
AI (Artificial Intelligence)
Data Science
Technical Program Management
$189k - $390k/yr
Hybrid
Master's
1,001-5,000

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Staff Machine Learning Engineer
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Added 1w ago
Staff Machine Learning Engineer
Uber
San Francisco, California
AI (Artificial Intelligence)
Data Science
ML (Machine Learning)
$232k - $258k/yr
Doctoral degree in Computer Science
10,000+

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See All 146+ Sr Staff Machine Learning Engineer Jobs in San Francisco

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Sr Staff Machine Learning Engineer Job Market in San Francisco

Who's Hiring

  • Uber23
  • DoorDash13
  • Anthropic10
  • Grindr6
  • Liquid AI6

Top Industries Hiring

  • Technology & Software39
  • Electronics & Hardware6
  • Banking & Financial Services6
  • Biotechnology & Pharmaceuticals6
  • Automotive3

Sr Staff Machine Learning Engineer Jobs in San Francisco: Frequently Asked Questions

How do I get a sr staff machine learning engineer job in San Francisco?

The strongest path into a sr staff machine learning engineer role in San Francisco runs through the city's dense AI and enterprise software ecosystem, particularly in SoMa and Mission Bay. Companies here prioritize candidates with demonstrated ownership of large-scale ML systems, publication records or open-source contributions, and cross-functional leadership. Engaging directly with the SF ML community through local meetups and industry events also gives candidates a measurable edge in this market.

Which companies hire sr staff machine learning engineers in San Francisco?

Companies currently hiring sr staff machine learning engineers in San Francisco include Uber, DoorDash, and Anthropic, per current listings on Migrate Mate as of November 2026. The San Francisco market skews heavily toward AI-native startups, large consumer tech platforms, and fintech firms, many of which maintain flagship engineering offices in the city rather than operating from suburban campuses.

Are there remote sr staff machine learning engineer jobs in San Francisco?

Yes, though at the sr staff level many roles require periodic on-site collaboration given the strategic and cross-functional scope. About 71% of sr staff machine learning engineer openings tied to San Francisco are remote or hybrid as of November 2026, with the most flexibility showing up in research-oriented and platform infrastructure roles rather than product-embedded ML positions that demand close coordination with San Francisco-based engineering and product teams.

How can I get a sr staff machine learning engineer job in San Francisco with little or no experience?

The most realistic entry path in San Francisco is through a machine learning engineer or senior ML engineer role at one of the city's many AI startups or growth-stage fintech companies, where promotion tracks to the staff and sr staff levels move faster than at large incumbents. Contributing to open-source ML projects, building a public portfolio on GitHub, and targeting companies in Mission Bay's biotech corridor or SoMa's AI cluster that run structured ML residency or new grad programs can open the door without prior sr staff-level credentials.

Which industries hire the most sr staff machine learning engineers in San Francisco?

Most sr staff machine learning engineer openings in San Francisco sit in Technology & Software, Electronics & Hardware, and Banking & Financial Services, per current listings on Migrate Mate as of November 2026. San Francisco's concentration of AI-first companies, major consumer tech platforms, and venture-backed fintech firms creates sustained demand at this level well above what comparable metros produce outside of Seattle and New York.

See All 146+ Sr Staff Machine Learning Engineer Jobs in San Francisco

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