Technical Lead Jobs in San Francisco, CA
Technical Lead jobs in San Francisco are concentrated in SoMa, the Financial District, and Mission Bay, driven by demand from enterprise software, fintech, AI infrastructure, and biotech companies. Employers actively hiring include OpenAI, REFLECTION, and HERCULES. Find a role that fits below and apply directly.
Find Technical Lead JobsOverview
Showing 5 of 204+ Technical Lead jobs











The Position
Technical Product Owner, RDT Lead – 3PD (Personalized, Predictive Patient Data)
The Opportunity
The Technical Product Owner, RDT Lead – 3PD drives the technical product strategy and delivery for Roche’s Patient Strategy data ecosystem. Combining strategic product ownership and delivery leadership, this role unifies internal and external data streams into a scalable, compliant engine that powers personalized healthcare experiences.
About the Ecosystem
3PD connects patients, providers, and operations through unified data, predictive analytics, and AI/ML capabilities. Spanning ingestion, integration, governance, and advanced decisioning, it empowers timely interventions to optimize patient treatment journeys.
The Technical Product Owner/RDT Lead evolves 3PD as an integrated enterprise platform—balancing immediate Patient Strategy needs with long-term scalability, interoperability, reliability, and reuse.
Key Responsibilities
- Product Vision & Strategy: Define and execute the 3PD strategy, roadmap, and backlog, translating business needs into scalable data capabilities and AI/ML enablement.
- Data Lifecycle Ownership: Provide technical leadership across acquisition, ingestion, processing, storage, and consumption to support end-user and downstream system needs.
- Vendor Data Acquisition: Lead technical onboarding of external data sources, including mapping, validation, reconciliation, quality, and operational readiness.
- System Integration & Enablement: Drive upstream and downstream integrations, making patient data available for operational systems, analytics, reporting, AI/ML, and decisioning platforms.
- Delivery Management: Lead end-to-end technical delivery across workstreams, managing scope, milestones, dependencies, risks, and cross-team handoffs.
- Data Quality & Reliability: Establish standards for data accuracy, timeliness, and completeness; implement monitoring, observability, and issue-remediation with engineering teams.
- Architecture & Strategy: Partner with architects to guide integration patterns, scalability, interoperability, and long-term sustainability while managing technical debt.
- Governance & Compliance: Embed data governance, lineage, privacy, consent, security, and regulatory requirements into product design and delivery.
- Dependency Management: Maintain an end-to-end view of dependencies across consuming products to prevent delivery bottlenecks.
- Stakeholder & Vendor Leadership: Build partnerships across Patient Strategy, business, DDA, architecture, engineering, and external vendors to drive alignment and resolve conflicts.
- Product Health & Improvement: Define metrics for product health, data quality, adoption, and operational stability to guide continuous improvement.
Who You Are
- Bachelor’s degree in IT, Computer Science, Data/Analytics, or a related field; an advanced degree or certifications (PMP/PgMP/Product) preferred.
- 10+ years leading complex technical integrations, enterprise data products, and cross-functional product delivery within large-scale IT environments.
- Demonstrated expertise owning data ecosystems—including vendor ingestion, data quality, governance, lineage, and enablement for analytics, AI/ML, and decisioning platforms.
- Strong technical fluency in cloud platforms, APIs, batch/event integrations, data pipelines, data modeling, and enterprise architecture patterns.
- Proven track record translating business needs into product roadmaps, navigating complex stakeholder environments, and driving cross-team execution.
- Solid background in data privacy, consent, security, and regulatory compliance for sensitive patient data environments.
Technical / Business Skills
- Strong knowledge of the end-to-end data lifecycle, including acquisition, ingestion, integration, transformation, quality, and consumption.
- Experience translating business and end-user needs into technical requirements, product roadmaps, and scalable data capabilities.
- Strong understanding of data quality, governance, lineage, privacy, consent, security, and regulatory requirements for sensitive patient data.
- Strong product and delivery management skills, including roadmap and backlog management, prioritization, dependency and risk management, and end-to-end delivery.
- Advanced analytical and problem-solving skills with the ability to evaluate technical options and drive decisions across complex, cross-functional environments.
Additional Qualifications
- Exceptional communication, facilitation, and negotiation skills, with the ability to drive consensus across business and technical stakeholders.
- Demonstrated ability to influence without direct authority and navigate complex cross-functional and vendor relationships.
- Strong leadership, coaching, and mentoring capabilities across product and delivery teams.
- Experience with Agile/product operating models and complex, multi-team technical delivery.
- Experience in pharmaceutical, healthcare, patient services, or other regulated data environments preferred.
- Experience enabling data for analytics, AI/ML, predictive capabilities, decisioning, or personalization is highly desirable.
The expected salary range for this position based on the primary location of South San Francisco, CA is $142,200 - $264,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Relocation benefits are not available for this job posting.
#RDT2026
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
See All 204+ Technical Lead Jobs in San Francisco
Find roles in San Francisco that match your experience and apply in just a few clicks.
Find Technical Lead JobsTechnical Lead Job Market in San Francisco
Who's Hiring
- OpenAI25

- REFLECTION20

- HERCULES10

- Ironclad10

- Checkr5

Top Industries Hiring
- Technology & Software20
- Science & Research10
- Agriculture & Farming5
- Artificial Intelligence5
- Banking & Financial Services5
Technical Lead Jobs in San Francisco: Frequently Asked Questions
How do I get a technical lead job in San Francisco?
The clearest path is targeting San Francisco's dense cluster of enterprise software, fintech, and AI companies in SoMa and the Financial District, where technical lead roles open most frequently. Candidates who demonstrate hands-on experience with distributed systems, cross-functional team leadership, and production-scale engineering stand out. Contributing to open-source projects and building a visible portfolio on GitHub strengthens applications considerably in this market.
Which companies hire technical leads in San Francisco?
Companies currently hiring technical leads in San Francisco include OpenAI, REFLECTION, and HERCULES, per current listings on Migrate Mate as of September 2026. San Francisco's employer base ranges from late-stage startups in SoMa to established technology firms and financial institutions headquartered in the Financial District and Mission Bay.
Are there remote technical lead jobs in San Francisco?
Yes, though technical lead roles often require regular on-site collaboration given their team coordination and architecture review responsibilities. About 73% of technical lead openings tied to San Francisco are remote or hybrid as of September 2026, with hybrid schedules being especially common among fintech and enterprise software employers headquartered in the city.
How can I get a technical lead job in San Francisco with little or no experience?
The most realistic entry point is moving into a senior individual contributor role at a San Francisco startup, where smaller engineering teams give engineers earlier exposure to architectural decisions and informal leadership. Employers in SoMa and Mission Bay frequently promote from within when candidates demonstrate ownership of a feature or system. Volunteering for on-call rotations and mentoring junior teammates builds the leadership record that technical lead hiring managers look for.
Which industries hire the most technical leads in San Francisco?
Most technical lead openings in San Francisco sit in Technology & Software, Science & Research, and Agriculture & Farming, per current listings on Migrate Mate as of September 2026. San Francisco's concentration of venture-backed technology companies, global financial institutions, and emerging AI research labs makes these sectors the primary drivers of local technical lead demand.
Related Jobs in California
See All 204+ Technical Lead Jobs in San Francisco
Find roles in San Francisco that match your experience and apply in just a few clicks.
Find Technical Lead Jobs