Real World Evidence Jobs in USA with Visa Sponsorship
Real World Evidence roles sit at the intersection of epidemiology, data science, and regulatory strategy, making them strong candidates for H-1B visa and O-1 visa sponsorship. Most positions require a graduate degree in a quantitative or health science field, and employers in pharma and biotech sponsor regularly. For detailed occupation requirements, see the O*NET profile.
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Get Access To All JobsINTRODUCTION
Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone. Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor. Mineralys is headquartered in Radnor, Pennsylvania. Mineralys is a fully remote company.
Position Summary
The Associate Director, HEOR / Real-World Evidence (RWE) plays a strategic and scientific leadership role in developing and executing evidence strategies that support the clinical and economic value of our innovative therapy. This position is responsible for designing and delivering real-world and outcomes research evidence to support medical affairs, market access, and regulatory objectives. The role focuses on generating high-quality, decision-relevant evidence, including observational studies, external control arms, and economic models, and indirect treatment comparisons, to contextualize clinical outcomes, demonstrate value, and support stakeholder decision-making. The Associate Director collaborates cross-functionally with Medical Affairs, biostatistics, and commercial teams, while also engaging external partners such as academic researchers, key opinion leaders, and data vendors. This role contributes to strategic evidence planning, scientific communication, and advancing real-world data capabilities within a matrixed organization.
Key Responsibilities
- Lead the design, execution, and oversight of HEOR and RWE studies, including observational studies (retrospective/prospective cohorts), economic models, external control arms and indirect treatment comparisons.
- Oversee data analysis ensuring methodological rigor and contribute to research reports for internal and external consumption.
- Develop and execute integrated HEOR strategies aligned with product development and market access needs.
- Identify evidence gaps and define research strategies to address unmet needs, burden of disease, and treatment pathways.
- Support development of value messaging tools (e.g., cost-effectiveness models, budget impact models).
Cross-functional Collaboration & Stakeholder Engagement
- Partner cross-functionally with Medical Affairs, Clinical Development, Market Value & Access and Commercial teams to align with data needs.
- Build and manage relationships with external experts, academic collaborators, and vendors.
- Provide HEOR/RWE expertise to support interactions with HTA agencies.
- Lead publication planning and development of HEOR/RWE abstracts, manuscripts, and presentations for scientific congresses and peer-reviewed journals.
Operational Leadership & Governance
- Oversee vendor selection and management, ensuring timely, high-quality study execution.
- Manage timelines, budgets, and deliverables across multiple projects.
- Ensure all HEOR activities adhere to compliance guidelines, internal SOPs, regulatory standards, and ethical guidelines for RWD and economic modeling.
Qualifications
- Advanced degree required (PhD, PharmD, MD, MPH, or similar) in health economics, outcomes research, biostatistics, epidemiology or related field.
- Minimum of 8 years of relevant experience in HEOR, RWE, or outcomes research in pharmaceutical, biotech, consulting, or academic settings.
- Strong analytical skills and strong understanding of observational study design, real-world data sources (claims, EMR, registries), and health economic modeling.
- Experience with burden of illness studies, and comparative effectiveness research.
- Familiarity HTA requirements and RWE regulatory landscape.
- Demonstrated ability to successfully lead complex research projects independently and collaboratively.
- Strong communication, and scientific writing skills, including publication track record.
- Proven cross-functional collaboration and stakeholder engagement capabilities.
Travel
This position requires up to 20% travel. Frequently travel is outside the local area and overnight.
US Salary Range: $175,000 - $200,000
INTRODUCTION
Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone. Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor. Mineralys is headquartered in Radnor, Pennsylvania. Mineralys is a fully remote company.
Position Summary
The Associate Director, HEOR / Real-World Evidence (RWE) plays a strategic and scientific leadership role in developing and executing evidence strategies that support the clinical and economic value of our innovative therapy. This position is responsible for designing and delivering real-world and outcomes research evidence to support medical affairs, market access, and regulatory objectives. The role focuses on generating high-quality, decision-relevant evidence, including observational studies, external control arms, and economic models, and indirect treatment comparisons, to contextualize clinical outcomes, demonstrate value, and support stakeholder decision-making. The Associate Director collaborates cross-functionally with Medical Affairs, biostatistics, and commercial teams, while also engaging external partners such as academic researchers, key opinion leaders, and data vendors. This role contributes to strategic evidence planning, scientific communication, and advancing real-world data capabilities within a matrixed organization.
Key Responsibilities
- Lead the design, execution, and oversight of HEOR and RWE studies, including observational studies (retrospective/prospective cohorts), economic models, external control arms and indirect treatment comparisons.
- Oversee data analysis ensuring methodological rigor and contribute to research reports for internal and external consumption.
- Develop and execute integrated HEOR strategies aligned with product development and market access needs.
- Identify evidence gaps and define research strategies to address unmet needs, burden of disease, and treatment pathways.
- Support development of value messaging tools (e.g., cost-effectiveness models, budget impact models).
Cross-functional Collaboration & Stakeholder Engagement
- Partner cross-functionally with Medical Affairs, Clinical Development, Market Value & Access and Commercial teams to align with data needs.
- Build and manage relationships with external experts, academic collaborators, and vendors.
- Provide HEOR/RWE expertise to support interactions with HTA agencies.
- Lead publication planning and development of HEOR/RWE abstracts, manuscripts, and presentations for scientific congresses and peer-reviewed journals.
Operational Leadership & Governance
- Oversee vendor selection and management, ensuring timely, high-quality study execution.
- Manage timelines, budgets, and deliverables across multiple projects.
- Ensure all HEOR activities adhere to compliance guidelines, internal SOPs, regulatory standards, and ethical guidelines for RWD and economic modeling.
Qualifications
- Advanced degree required (PhD, PharmD, MD, MPH, or similar) in health economics, outcomes research, biostatistics, epidemiology or related field.
- Minimum of 8 years of relevant experience in HEOR, RWE, or outcomes research in pharmaceutical, biotech, consulting, or academic settings.
- Strong analytical skills and strong understanding of observational study design, real-world data sources (claims, EMR, registries), and health economic modeling.
- Experience with burden of illness studies, and comparative effectiveness research.
- Familiarity HTA requirements and RWE regulatory landscape.
- Demonstrated ability to successfully lead complex research projects independently and collaboratively.
- Strong communication, and scientific writing skills, including publication track record.
- Proven cross-functional collaboration and stakeholder engagement capabilities.
Travel
This position requires up to 20% travel. Frequently travel is outside the local area and overnight.
US Salary Range: $175,000 - $200,000
See all Real World Evidence Jobs
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Get Access To All JobsTips for Finding Real World Evidence Jobs
Target pharma and biotech employers directly
Large pharmaceutical companies and contract research organizations file hundreds of LCAs annually for RWE roles. Filtering by employer type narrows your search to organizations with established immigration infrastructure and legal teams already familiar with sponsoring this specialty.
Lead with your degree field, not just your title
H-1B specialty occupation approval hinges on whether your degree directly relates to the role. Epidemiology, biostatistics, health economics, and public health degrees map cleanly to RWE job descriptions, make that connection explicit in every application.
Know that a master's degree strengthens your case
While some RWE positions accept a bachelor's degree, a master's in epidemiology or biostatistics significantly improves both your sponsorship odds and your H-1B petition's strength. USCIS scrutinizes specialty occupation claims more closely when the degree requirement isn't a strict minimum.
Understand the H-1B cap timeline before you apply
Most RWE roles at for-profit employers are subject to the H-1B annual cap and lottery. Registration opens in March for an October 1 start date. Building your timeline around this cycle, not against it, is essential for negotiating realistic start dates with hiring managers.
Highlight regulatory experience when possible
RWE work that supports FDA submissions or health technology assessments signals high-value output to employers. Candidates with regulatory touchpoints are easier to justify through the sponsorship process because the business case for the role, and the degree requirement, is clear and defensible.
Ask about sponsorship policy before the final interview round
Not all employers who hire RWE analysts sponsor international candidates. Raising sponsorship early, after demonstrating technical fit but before the offer stage, avoids wasted time on both sides and surfaces whether the employer has sponsored similar roles before.
Frequently Asked Questions
Is Real World Evidence a specialty occupation for H-1B purposes?
Yes, in most cases. RWE roles typically require a bachelor's degree or higher in a specific field such as epidemiology, biostatistics, health economics, or a related quantitative discipline. USCIS generally accepts these as specialty occupations. The key is that the job description explicitly requires a degree in a specific field, not just any bachelor's degree, which most RWE positions do.
Which employers sponsor H-1B visas for Real World Evidence analysts?
Pharma companies like Pfizer, Merck, AstraZeneca, and Johnson & Johnson regularly sponsor RWE professionals. Contract research organizations such as IQVIA and Parexel also file substantial LCA volumes for these roles. To find currently open, sponsorship-friendly positions, browse Migrate Mate, which filters specifically for employers actively hiring international candidates in this field.
Does a PhD give me an advantage over a master's degree for sponsorship?
For sponsorship approval, a master's in a directly related field is usually sufficient to satisfy specialty occupation requirements. A PhD strengthens your petition if the role involves independent research design or scientific leadership, but it isn't required by most employer-sponsored RWE positions. Where a PhD helps most is in senior or principal-level roles where the complexity of the work justifies the higher credential.
Can I get sponsored for an RWE role on OPT before the H-1B lottery?
Yes. Many RWE employers hire international candidates on OPT and then sponsor them for the H-1B lottery the following March. STEM OPT gives candidates in biostatistics, epidemiology, and data science fields up to 36 months of work authorization, which provides a meaningful runway through at least one, sometimes two, lottery cycles before a cap-subject H-1B visa is required.
What if my degree is in a related but not exact field, like public health or health informatics?
USCIS evaluates whether there's a direct and logical connection between your degree field and the duties of the role, not an exact title match. A degree in public health or health informatics can support an RWE petition if the job description emphasizes data analysis, study design, or outcomes research. Employers with experienced immigration counsel know how to frame these petitions, which is why targeting firms with a track record of sponsorship matters.
What is the prevailing wage requirement for sponsored Real World Evidence jobs?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.