Real World Evidence Jobs in USA with Visa Sponsorship
Real World Evidence roles sit at the intersection of epidemiology, data science, and regulatory strategy, making them strong candidates for H-1B visa and O-1 visa sponsorship. Most positions require a graduate degree in a quantitative or health science field, and employers in pharma and biotech sponsor regularly. For detailed occupation requirements, see the O*NET profile.
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General Summary:
The Real World Evidence Manager is an integral member of the RWE team who leverages expertise in epidemiology, real world data, and other relevant disciplines to assess the natural history and real world outcomes for Vertex’s pipeline and portfolio products. The position will support cross-functional global observational research by providing methodological and analytical support for internal stakeholders, including Clinical Development, Global Medical Affairs, Global Patient Safety, and Government Affairs and Public Policy. The Manager will also execute on tactics related to the collection and/or analysis of real world data to inform relevant stakeholders such as regulatory affairs and clinical development.
Key Duties and Responsibilities:
- Support focused/targeted epidemiologic research in support of Vertex’s pipeline and established portfolios, including Natural History (NH) of disease and systematic literature reviews
- Ensure scientific rigor for real world data analyses
- Conduct feasibility assessment of relevant data sources for disease areas and research questions
- Provide insights and experience to design and defend fit-for-purpose epidemiologic observational research; Identify appropriate analytic methods aligned to research needs
- Collaborate with and manage vendors, to ensure meeting project timelines and goals
- Support Study Execution Teams for observational studies
- Contribute to development of performance metrics and dashboards for RWE projects
- Able to balance multiple projects in a fast-paced environment
- Utilize strong oral and visual communication skills and understanding of Vertex strategies to promote and translate value of RWD/RWE methods and studies across the company
- Excellent communication skills (oral and written) with internal and external audiences
- Contribute to company publications strategy via development of conference abstracts, presentations, peer-reviewed manuscripts based on the findings of RWE studies
Knowledge and Skills:
- Working knowledge of relevant RWE regulatory agency guidance and position papers and the opportunities to use RWE to inform regulatory decision making
- Demonstrated ability to design and execute observational research
- Strong interpersonal communication and study management skills
- Ability to take detailed observational study results and communicate them in a clear, non-technical manner to internal cross-functional teams, using language that resonates with the teams, while maintaining the integrity of key findings
- Ability to work collaboratively in a constantly changing, diverse, and matrix environment
Education and Experience:
- PhD (preferred) or MS/MPH in epidemiology, biostatistics, health economics and outcomes research, or similar required
- Formal graduate training in Epidemiology/Health Services Research required
- Minimum 2 years of experience working in observational research within the life sciences industry or relevant academic, government, or consulting environment
At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Pay Range:
$132,100 - $198,100
Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation:
Hybrid-Eligible Or On-Site Eligible
Flex Eligibility Status:
In this Hybrid-Eligible role, you can choose to be designated as:
- Hybrid: work remotely up to two days per week; or select
- On-Site: work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
LI-Hybrid
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
Job Description
General Summary:
The Real World Evidence Manager is an integral member of the RWE team who leverages expertise in epidemiology, real world data, and other relevant disciplines to assess the natural history and real world outcomes for Vertex’s pipeline and portfolio products. The position will support cross-functional global observational research by providing methodological and analytical support for internal stakeholders, including Clinical Development, Global Medical Affairs, Global Patient Safety, and Government Affairs and Public Policy. The Manager will also execute on tactics related to the collection and/or analysis of real world data to inform relevant stakeholders such as regulatory affairs and clinical development.
Key Duties and Responsibilities:
- Support focused/targeted epidemiologic research in support of Vertex’s pipeline and established portfolios, including Natural History (NH) of disease and systematic literature reviews
- Ensure scientific rigor for real world data analyses
- Conduct feasibility assessment of relevant data sources for disease areas and research questions
- Provide insights and experience to design and defend fit-for-purpose epidemiologic observational research; Identify appropriate analytic methods aligned to research needs
- Collaborate with and manage vendors, to ensure meeting project timelines and goals
- Support Study Execution Teams for observational studies
- Contribute to development of performance metrics and dashboards for RWE projects
- Able to balance multiple projects in a fast-paced environment
- Utilize strong oral and visual communication skills and understanding of Vertex strategies to promote and translate value of RWD/RWE methods and studies across the company
- Excellent communication skills (oral and written) with internal and external audiences
- Contribute to company publications strategy via development of conference abstracts, presentations, peer-reviewed manuscripts based on the findings of RWE studies
Knowledge and Skills:
- Working knowledge of relevant RWE regulatory agency guidance and position papers and the opportunities to use RWE to inform regulatory decision making
- Demonstrated ability to design and execute observational research
- Strong interpersonal communication and study management skills
- Ability to take detailed observational study results and communicate them in a clear, non-technical manner to internal cross-functional teams, using language that resonates with the teams, while maintaining the integrity of key findings
- Ability to work collaboratively in a constantly changing, diverse, and matrix environment
Education and Experience:
- PhD (preferred) or MS/MPH in epidemiology, biostatistics, health economics and outcomes research, or similar required
- Formal graduate training in Epidemiology/Health Services Research required
- Minimum 2 years of experience working in observational research within the life sciences industry or relevant academic, government, or consulting environment
At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Pay Range:
$132,100 - $198,100
Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation:
Hybrid-Eligible Or On-Site Eligible
Flex Eligibility Status:
In this Hybrid-Eligible role, you can choose to be designated as:
- Hybrid: work remotely up to two days per week; or select
- On-Site: work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
LI-Hybrid
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
See all 4,168+ Real World Evidence Jobs
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Get Access To All JobsTips for Finding Real World Evidence Jobs
Target pharma and biotech employers directly
Large pharmaceutical companies and contract research organizations file hundreds of LCAs annually for RWE roles. Filtering by employer type narrows your search to organizations with established immigration infrastructure and legal teams already familiar with sponsoring this specialty.
Lead with your degree field, not just your title
H-1B specialty occupation approval hinges on whether your degree directly relates to the role. Epidemiology, biostatistics, health economics, and public health degrees map cleanly to RWE job descriptions, make that connection explicit in every application.
Know that a master's degree strengthens your case
While some RWE positions accept a bachelor's degree, a master's in epidemiology or biostatistics significantly improves both your sponsorship odds and your H-1B petition's strength. USCIS scrutinizes specialty occupation claims more closely when the degree requirement isn't a strict minimum.
Understand the H-1B cap timeline before you apply
Most RWE roles at for-profit employers are subject to the H-1B annual cap and lottery. Registration opens in March for an October 1 start date. Building your timeline around this cycle, not against it, is essential for negotiating realistic start dates with hiring managers.
Highlight regulatory experience when possible
RWE work that supports FDA submissions or health technology assessments signals high-value output to employers. Candidates with regulatory touchpoints are easier to justify through the sponsorship process because the business case for the role, and the degree requirement, is clear and defensible.
Ask about sponsorship policy before the final interview round
Not all employers who hire RWE analysts sponsor international candidates. Raising sponsorship early, after demonstrating technical fit but before the offer stage, avoids wasted time on both sides and surfaces whether the employer has sponsored similar roles before.
Frequently Asked Questions
Is Real World Evidence a specialty occupation for H-1B purposes?
Yes, in most cases. RWE roles typically require a bachelor's degree or higher in a specific field such as epidemiology, biostatistics, health economics, or a related quantitative discipline. USCIS generally accepts these as specialty occupations. The key is that the job description explicitly requires a degree in a specific field, not just any bachelor's degree, which most RWE positions do.
Which employers sponsor H-1B visas for Real World Evidence analysts?
Pharma companies like Pfizer, Merck, AstraZeneca, and Johnson & Johnson regularly sponsor RWE professionals. Contract research organizations such as IQVIA and Parexel also file substantial LCA volumes for these roles. To find currently open, sponsorship-friendly positions, browse Migrate Mate, which filters specifically for employers actively hiring international candidates in this field.
Does a PhD give me an advantage over a master's degree for sponsorship?
For sponsorship approval, a master's in a directly related field is usually sufficient to satisfy specialty occupation requirements. A PhD strengthens your petition if the role involves independent research design or scientific leadership, but it isn't required by most employer-sponsored RWE positions. Where a PhD helps most is in senior or principal-level roles where the complexity of the work justifies the higher credential.
Can I get sponsored for an RWE role on OPT before the H-1B lottery?
Yes. Many RWE employers hire international candidates on OPT and then sponsor them for the H-1B lottery the following March. STEM OPT gives candidates in biostatistics, epidemiology, and data science fields up to 36 months of work authorization, which provides a meaningful runway through at least one, sometimes two, lottery cycles before a cap-subject H-1B visa is required.
What if my degree is in a related but not exact field, like public health or health informatics?
USCIS evaluates whether there's a direct and logical connection between your degree field and the duties of the role, not an exact title match. A degree in public health or health informatics can support an RWE petition if the job description emphasizes data analysis, study design, or outcomes research. Employers with experienced immigration counsel know how to frame these petitions, which is why targeting firms with a track record of sponsorship matters.
What is the prevailing wage requirement for sponsored Real World Evidence jobs?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.