Applied Scientist Jobs in San Francisco, CA
Applied Scientist jobs in San Francisco are concentrated in SoMa, Mission Bay, and the Financial District, with demand driven by AI infrastructure, biotech platforms, and enterprise software. Employers hiring right now include Amazon, Amazon Web Services, and Lyft. Scan the live roles below and apply to whichever ones fit.
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San Francisco, CA · On-site (5 days/week) · Full-time
Compensation: $170,000–$300,000 base
About the Company
Our client is a Series B company building purpose-built AI systems that forecast and optimize how physical products are manufactured, stored, and distributed around the world. Instead of layering a general-purpose model on top of existing tools, the team trains a custom frontier model for each customer and treats supply chain forecasting as a fundamental computer science problem. They are already live with multi-billion-dollar enterprises and high-growth businesses, backed by top-tier venture investors, and led by a founding team with prior successful exits and deep research backgrounds.
Founded 2024 · ~20 people · Industry: AI, B2B, Enterprise, Logistics, Manufacturing
The Role
Our client is hiring an Applied AI Scientist to join a brand-new Applied AI team being built out around its VP of Applied AI. This is a technical, customer-facing role for someone coming from data science, forward deployed engineering, or solutions architecture who is equally comfortable in a Jupyter notebook and in front of an enterprise stakeholder. You'd be the trusted technical partner to customers from the very first demo through full production deployment, with customer demand growing quickly enough that there is real room to shape how the team operates.
What you'll be doing
- Meeting with enterprise customers to understand their operational challenges and framing those problems clearly for technical and non-technical audiences alike
- Leading technical and value-focused demos, and building custom demos and prototypes that support sales and go-to-market efforts
- Working directly in customer data with Python and SQL to surface and demonstrate real business value
- Acting as the technical point person through evaluations, pilots, and implementations
- Supporting live customer deployments so each customer gets the full value of the platform
Tech stack: Python, SQL, Machine Learning, Data Science
Requirements
- Direct experience working with enterprise customers on deployments, pilots, demos, or messy operational data problems (retail or CPG settings are a strong plus)
- A track record of building custom demos and proofs-of-concept in code, primarily Python and SQL
- Roughly 3–8 years as a data scientist, forward deployed engineer, solutions architect, or similar
- Background at an enterprise ML/data platform company, an early-stage startup, or a top-tier consulting firm
- A bachelor's degree in a STEM or other quantitative field
- Experience in a selling or pre-sales motion for a product where you needed a genuine grounding in machine learning to be credible
- Ability to run demos that land with both engineers and business leaders
Nice to Haves
- A hands-on, builder's approach and real enthusiasm for picking up unfamiliar technologies and domains as the work requires
Why Join
- Work on real AI: custom frontier models trained per customer, not a wrapper around someone else's LLM
- Ground floor of a new team at a well-funded Series B: you'll help define the function as the company deploys with some of the world's largest supply chains
- Founders with prior exits and a team drawn from leading universities, big tech, and top data and analytics companies
- Competitive base plus health, dental, and vision coverage, 401(k), commuter benefits, and unlimited PTO
Details
- Location: San Francisco, CA
- Work policy: 5 days in-office
- Compensation: $170,000–$300,000 base; no equity component at this time
- Visa sponsorship: Open to visa transfers (e.g. OPT, H-1B transfers)
- Employment type: Full-time
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Find Applied Scientist JobsApplied Scientist Job Market in San Francisco
Who's Hiring
- Amazon29

- Amazon Web Services19

- Lyft10

- SentiLink10

- Braze5

Top Industries Hiring
- Technology & Software34
- Retail5
- E-Commerce & Online Marketplaces5
Applied Scientist Jobs in San Francisco: Frequently Asked Questions
How do I get a applied scientist job in San Francisco?
Focus your search on San Francisco's three strongest hiring clusters: AI and machine learning platforms in SoMa, biotech and computational biology firms in Mission Bay, and fintech and data infrastructure companies in the Financial District. Candidates who can demonstrate production ML experience, published research, or strong open-source contributions stand out in this market. Targeting mid-stage startups alongside large tech employers broadens your options considerably.
Which companies hire applied scientists in San Francisco?
Employers hiring applied scientists in San Francisco right now include Amazon, Amazon Web Services, and Lyft, based on current listings on Migrate Mate as of November 2026. San Francisco's hiring mix skews toward AI-native startups, established tech platforms, and life sciences companies with computational research arms.
Are there remote applied scientist jobs in San Francisco?
Yes, though it depends heavily on the role: purely analytical and modeling work is frequently remote, while positions involving lab systems, on-site data infrastructure, or embedded product teams tend to require in-person presence. About 85% of applied scientist openings tied to San Francisco are remote or hybrid as of November 2026. The most remote-friendly specialties locally are NLP, recommendation systems, and forecasting.
How can I get a applied scientist job in San Francisco with little or no experience?
The most realistic entry path in San Francisco is through a research engineering or junior ML engineer role at a mid-stage startup, where scope is broader and teams are smaller. AI-focused companies in SoMa and Mission Bay frequently hire candidates with strong graduate research backgrounds even without industry experience. Contributing to open-source projects used by San Francisco employers and attending local ML meetups builds visibility with hiring managers directly.
Which industries hire the most applied scientists in San Francisco?
Most applied scientist openings in San Francisco sit in Technology & Software, Retail, and E-Commerce & Online Marketplaces, per current listings on Migrate Mate as of November 2026. San Francisco's density of AI-first companies, biotech research platforms, and fintech infrastructure firms creates sustained demand for applied scientists with specialized modeling and experimentation skills.
Related Jobs in California
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