Clinical Nurse Jobs in Irvine, CA
Clinical Nurse jobs in Irvine are concentrated in the Irvine Spectrum and Woodbridge medical corridors, as well as the Health Sciences campus near UCI, across hospital systems, outpatient clinics, and specialty care centers. Employers hiring right now include UC Irvine Health, City of Hope, and Hoag Health System. Find a role that fits below and apply directly.
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Work Location
Irvine, California
Work Shift
Why CHOC?
At CHOC, we strive to be the leading destination of children’s health by providing exceptional and innovative care. We are responsible for the overall health of our community’s pediatric population in our hospitals, clinics, and practices. And because of our breadth of care, your career at CHOC can be as diverse and fulfilling as you determine. CHOC’s compensation structure, benefits offerings, and career development programs are geared to helping you achieve your professional and personal goals. Apply now to see where your career at CHOC can take you.
Environmental Sustainability Statement
Driven by the connection between children's health and a healthy environment, we commit to creating a healthcare model that incorporates environmental sustainability aligned with our mission to protect children's health and patient safety.
Job Summary
The Clinical Nurse is responsible for the planning and delivery of family-centered patient care utilizing the nursing process: assessment, diagnosis, planning, implementation, and evaluation. Responsible for directing and coordinating nursing care for patients based on established clinical nursing practice standards. Collaborate with patient/family and other professional disciplines. Create a partnership to ensure effective and efficient patient care delivery for the achievement of mutually desired patient outcomes. Support the organization’s vision and mission. Promote and provide excellence in nursing care.Pay Range
Minimum $52.93 Midpoint $70.13 Maximum $87.32Rate of pay is determined by various factors, including but not limited to knowledge, skills, competencies, experience, education, as well as position requirements.
Experience
- R equired: Minimum one (1) year acute care nursing experience.
- Preferred: Prefer 2-3 year experience as a RN in Pediatric care. Experience in Education. Care coordination, public health or community clinic.
Education
- Required: Graduation from an accredited school of Registered Nursing; Bachelor of Science degree in Nursing (BSN).
Training
- Required: Basic Life Support (BLS); Ped Emerg Assess, Recog & Stabil (PEARS); Registered Nurse - California (RN).
- Preferred: Certified Pediatric Nurse (CPN).
Specialized Skills
- Required: Knowledge of and ability to provide appropriate family-centered patient care based upon age appropriateness and cultural and spiritual needs; Excellent customer satisfaction skills; Effective communication skills; Ability to prioritize and complete duties in a timely and organized manner; Ability to work collaboratively and in a positive manner with others; Ability to prepare timely and accurate documentation and reports; Ability to perform work according to CHOC policies and procedures, professional standards of care, and applicable laws; Demonstrate flexibility and creativity in response to unexpected changes in work load/staffing; Ability to set goals and judge results in accordance with the highest standards; care with sensitivity and respect; advance care through development of new ideas and technology; promote teamwork to achieve CHOC's mission; and understand and exceed customer expectations.
Licensure
- Required: Basic Life Support (BLS); Ped Emerg Assess, Recog & Stabil (PEARS); Registered Nurse - California (RN).
- Preferred: Certified Pediatric Nurse (CPN).
Work Environments - Functional Demand:
Light - Moderate energy level Lift and carry 25-35 lbs. Push/pull 50-100 lbs. (ie. empty bed, stretcher).Physical Activity Requirements:
Bending, Carry Objects, Climbing, Keyboard use/repetitive motion, Pinching/fine motor activities, Push/Pull, Reaching forward, Reaching overhead, Sitting, Squat/kneel/crawl (Squad & Knee), Standing, Talk or hear, Taste or smell, Twisting, Walking, Wrist position deviationPhysical Activity Lifting
Lifting (Floor to waist level) - Constant 67 or more%, Lifting (Floor to waist level) - Frequent 36-66%, Lifting (Floor to waist level) - Occasional 0-35%, Lifting (Waist level and above) - Constant 67 or more%, Lifting (Waist level and above) - Frequent 36-66%, Lifting (Waist level and above) - Occasional 0-35%Sensory Requirements:
Color Discrimination, Depth Perception, Far Vision, Hearing, Near VisionEnvironment Requirements:
Airborn Communicable Disease, Bloodborne Pathogens, Chemical, Dust Particular Matter, Extreme Noise Levels, Extreme Temperatures, Radiation, Uneven Surfaces or ElevationsNon-Discrimination Statement:
CHOC does not discriminate on the basis of age, race, color, religion, national origin, ancestry, marital status, genetic information, disability, sex, gender (including pregnancy, breastfeeding, childbirth, lactation or related medical conditions), gender identity or expression, medical condition, sexual orientation, veteran status, military or uniformed service member status, or other protected characteristics in accordance with state and federal laws. CHOC will consider for employment qualified applicants with criminal histories, in accordance with the Fair Chance Initiative for Hiring.
We encourage individuals from all backgrounds to apply for positions at CHOC, even if your experience doesn’t align perfectly with the listed qualifications for a particular role, as your unique experience may be a great addition to our culture for another one of our opportunities.
If you desire support or accommodations throughout the Talent Acquisition process, please inform your Talent Acquisition Partner.
See All 277+ Clinical Nurse Jobs in Irvine
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Find Clinical Nurse JobsClinical Nurse Job Market in Irvine
Who's Hiring
- UC Irvine Health123

- City of Hope92

- Hoag Health System46

- CHOC Children's15

Top Industries Hiring
- Science & Research
- Healthcare & Medical Services
Clinical Nurse Jobs in Irvine: Frequently Asked Questions
How do I get a clinical nurse job in Irvine?
Focus your search on Irvine's hospital systems, multi-specialty outpatient clinics, and the dense concentration of medical groups near the UCI Health corridor and Irvine Spectrum. Employers in this market strongly favor candidates with acute care or specialty unit experience, current BLS and ACLS certifications, and familiarity with Epic or Cerner. Applying directly to health systems and large physician groups rather than through staffing agencies tends to yield faster responses in this market.
Which companies hire clinical nurses in Irvine?
Employers hiring clinical nurses in Irvine right now include UC Irvine Health, City of Hope, and Hoag Health System, based on current listings on Migrate Mate as of August 2026. Irvine's employer mix leans heavily toward integrated health systems, specialty outpatient centers, and large corporate-owned medical groups, reflecting the city's strong healthcare infrastructure.
How can I get a clinical nurse job in Irvine with little or no experience?
The most realistic entry path in Irvine is through a new-graduate residency or nurse externship at one of the area's hospital systems, which regularly recruit from regional nursing programs including those tied to UCI. Large outpatient groups and urgent care centers in the Spectrum and Woodbridge districts also hire new graduates for lower-acuity roles that build toward full clinical positions. Highlighting clinical rotation hours in med-surg or telemetry and holding current certifications before applying strengthens your candidacy significantly.
Which industries hire the most clinical nurses in Irvine?
The sectors hiring the most clinical nurses in Irvine are Science & Research and Healthcare & Medical Services, based on current listings on Migrate Mate as of August 2026. Irvine's position as a regional healthcare hub, anchored by a major academic medical center and a high density of specialty and ambulatory care facilities, drives consistent demand across those sectors.
Related Jobs in California
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