Clinical Nurse Jobs in Irvine, CA

Join the transformative team at City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. City of Hope’s growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, and treatment facilities in Atlanta, Chicago and Phoenix. Our dedicated and compassionate employees are driven by a common mission: To deliver the cures of tomorrow to the people who need them today.

In this clinic-based RN role, you will support multiple providers caring for complex breast surgery patients across specialties such as breast oncology, infectious disease, and plastic surgery. In a fast-paced, high-acuity outpatient setting, you will coordinate care for patients requiring advanced therapies by explaining treatment plans, monitoring lab results, and arranging transfusions as needed. You will partner with physicians and Advanced Practice Providers to triage patient needs, follow up on orders, provide cross-coverage, and manage in-basket messages to ensure timely, comprehensive, high-quality care. Preferred experience is in surgical oncology, followed by medical oncology or other outpatient specialties.

As a successful candidate, you will:

• Strong oncology clinical expertise.

• Advanced critical thinking and clinical judgment in managing complex patient conditions

• Proficiency in interpreting lab results and identifying early signs of complications

• Excellent care coordination and organizational skills in a fast-paced environment

• Effective communication and collaboration with multidisciplinary teams

• Confidence in patient education, including explaining complex therapies and treatment plans

• Ability to prioritize, triage, and manage high-volume patient needs

• Strong attention to detail and follow-through in managing orders and in-basket messaging

• A compassionate, patient-centered approach with a focus on quality and safety

Your qualifications should include:

• Bachelor’s degree in nursing or master’s degree in nursing

• Three to five years related experience
• Current California Registered Nurse license
• Current BLS certification from American Heart Association
• National certification (must obtain within three years and must be maintained thereafter to retain Clin III status)
• If applicable to your site Chemotherapy/biotherapy certification.

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.

To learn more about our Comprehensive Benefits, please CLICK HERE.

Please note: City of Hope is committed to a safe and transparent hiring experience. Please be aware that scammers may attempt to impersonate our organization through fake job postings, emails or interviews.

• Apply only through our official website or trusted partner platforms.
• City of Hope will never request payment or fees at any stage of the hiring process.
• We will not request sensitive personal or financial information prior to the acceptance of a formal offer.
• All communications will come from official @coh.org email addresses.
• Interviews are conducted only through approved, professional channels.
• Be cautious of unsolicited communications, urgent requests or opportunities that seem inconsistent with standard hiring practices.
• If you receive any suspicious communication, please report it to careers@coh.org.