Clinical Nurse Jobs in Irvine, CA

Clinical Nurse jobs in Irvine are concentrated in the Irvine Spectrum and Woodbridge medical corridors, as well as the Health Sciences campus near UCI, across hospital systems, outpatient clinics, and specialty care centers. Employers hiring right now include City of Hope and UC Irvine Health. Find a role that fits below and apply directly.

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Overview

Open roles303+
Top employerCity of Hope
Work type100% On-site
Top credentialBLS Certification
Companies hiring2

Showing 5 of 303+ Clinical Nurse jobs

UC Irvine Health
Clinical Nurse II
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UC Irvine Health
New 23h ago
Clinical Nurse II
UC Irvine Health
Irvine, California
Nursing
Healthcare Administration
Patient Services & Wellbeing
$67 - $92/hr
On-Site
Bachelor's
1,001-5,000

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UC Irvine Health
Clinical Nurse II (IR/Cath) - Periop Float Pool - FT, Days
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UC Irvine Health
Added 2d ago
Clinical Nurse II (IR/Cath) - Periop Float Pool - FT, Days
UC Irvine Health
Irvine, California
Healthcare Administration
Nursing
Patient Services & Wellbeing
$67.55 - $92.72/hr
Bachelor of Science
1,001-5,000

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UC Irvine Health
Clinical Nurse II (OR) - Periop Float Pool - FT, Days
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UC Irvine Health
Added 3d ago
Clinical Nurse II (OR) - Periop Float Pool - FT, Days
UC Irvine Health
Irvine, California
Healthcare Administration
Nursing
Patient Services & Wellbeing
$67.55 - $92.72/hr
Bachelor of Science
1,001-5,000

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City of Hope
Clinical Nurse III - Medical Surgical Floor, Nights
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City of Hope
Added 2w ago
Clinical Nurse III - Medical Surgical Floor, Nights
City of Hope
Irvine, California
Healthcare Administration
Nursing
Patient Services & Wellbeing
BLS Certification
10,000+

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City of Hope
Clinical Nurse III - Medical Surgical 3rd Floor, FT, Nights
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City of Hope
Added 1mo ago
Clinical Nurse III - Medical Surgical 3rd Floor, FT, Nights
City of Hope
Irvine, California
Healthcare Administration
Nursing
Patient Services & Wellbeing
$63.81 - $92.53/hr
BLS Certification
10,000+

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See All 303+ Clinical Nurse Jobs in Irvine

Find roles in Irvine that match your experience and apply in just a few clicks.

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Clinical Nurse Job Market in Irvine

Who's Hiring

City of Hope
City of Hope152 open roles
UC Irvine Health
UC Irvine Health152 open roles

Top Industries Hiring

  • Education

Clinical Nurse Jobs in Irvine: Frequently Asked Questions

How do I get a clinical nurse job in Irvine?

Focus your search on Irvine's hospital systems, multi-specialty outpatient clinics, and the dense concentration of medical groups near the UCI Health corridor and Irvine Spectrum. Employers in this market strongly favor candidates with acute care or specialty unit experience, current BLS and ACLS certifications, and familiarity with Epic or Cerner. Applying directly to health systems and large physician groups rather than through staffing agencies tends to yield faster responses in this market.

Which companies hire clinical nurses in Irvine?

Employers hiring clinical nurses in Irvine right now include City of Hope and UC Irvine Health, based on current listings on Migrate Mate as of September 2026. Irvine's employer mix leans heavily toward integrated health systems, specialty outpatient centers, and large corporate-owned medical groups, reflecting the city's strong healthcare infrastructure.

Are there remote clinical nurse jobs in Irvine?

Yes, though they are rare since most clinical nurse roles require direct patient care in a facility. About 0% of clinical nurse openings tied to Irvine are remote or hybrid as of September 2026, skewing toward utilization review, case management, and telephonic triage positions. Irvine's health insurance and managed care employers are the most active source of those remote-eligible roles locally.

How can I get a clinical nurse job in Irvine with little or no experience?

The most realistic entry path in Irvine is through a new-graduate residency or nurse externship at one of the area's hospital systems, which regularly recruit from regional nursing programs including those tied to UCI. Large outpatient groups and urgent care centers in the Spectrum and Woodbridge districts also hire new graduates for lower-acuity roles that build toward full clinical positions. Highlighting clinical rotation hours in med-surg or telemetry and holding current certifications before applying strengthens your candidacy significantly.

Which industries hire the most clinical nurses in Irvine?

The sectors hiring the most clinical nurses in Irvine are Education, based on current listings on Migrate Mate as of September 2026. Irvine's position as a regional healthcare hub, anchored by a major academic medical center and a high density of specialty and ambulatory care facilities, drives consistent demand across those sectors.

See All 303+ Clinical Nurse Jobs in Irvine

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