Clinical Nurse Jobs in Irvine, CA

Clinical Nurse jobs in Irvine are concentrated in the Irvine Spectrum and Woodbridge medical corridors, as well as the Health Sciences campus near UCI, across hospital systems, outpatient clinics, and specialty care centers. Employers hiring right now include UC Irvine Health, City of Hope, and Hoag Health System. Find a role that fits below and apply directly.

Find Clinical Nurse Jobs

Overview

Open roles277+
Top employerUC Irvine Health
Top credentialBLS Certification
Companies hiring4

Showing 5 of 277+ Clinical Nurse jobs

CHOC Children's
Clinical Nurse II, Dermatology
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CHOC Children's
Added 1d ago
Clinical Nurse II, Dermatology
CHOC Children's
Irvine, California
Healthcare Administration
Nursing
Patient Services & Wellbeing
$52.93 - $87.32/hr
Bachelor of Science
5,001-10,000

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UC Irvine Health
Clinical Nurse II - Stepdown - IRV (4N) - FT, Nights
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UC Irvine Health
Added 1d ago
Clinical Nurse II - Stepdown - IRV (4N) - FT, Nights
UC Irvine Health
Irvine, California
Business Operations
Business Strategy
Executive Leadership & C-Suite
Project & Program Management
$67.55 - $92.72/hr
Bachelor of Science
1,001-5,000

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UC Irvine Health
Clinical Nurse II - Med/SurgTelemetry - IRV (5) - FT Days
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UC Irvine Health
Added 1d ago
Clinical Nurse II - Med/SurgTelemetry - IRV (5) - FT Days
UC Irvine Health
Irvine, California
Business Operations
Business Strategy
Executive Leadership & C-Suite
Project & Program Management
$67.55 - $92.72/hr
Bachelor of Science
1,001-5,000

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UC Irvine Health
Clinical Nurse II - Stepdown IRV - PT, Nights
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UC Irvine Health
Added 1d ago
Clinical Nurse II - Stepdown IRV - PT, Nights
UC Irvine Health
Irvine, California
Business Operations
Business Strategy
Executive Leadership & C-Suite
Project & Program Management
$67.55 - $92.72/hr
Bachelor of Science
1,001-5,000

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UC Irvine Health
Clinical Nurse II - ACC - Infusion Center - FT Days
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UC Irvine Health
Added 2d ago
Clinical Nurse II - ACC - Infusion Center - FT Days
UC Irvine Health
Irvine, California
Corporate Training
Educational Administration
Learning & Development
$67.55 - $92.72/hr
Bachelor of Science
1,001-5,000

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See All 277+ Clinical Nurse Jobs in Irvine

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Clinical Nurse Job Market in Irvine

Who's Hiring

  • UC Irvine Health
    UC Irvine Health123
  • City of Hope
    City of Hope92
  • Hoag Health System
    Hoag Health System46
  • CHOC Children's
    CHOC Children's15

Top Industries Hiring

  • Science & Research
  • Healthcare & Medical Services

Clinical Nurse Jobs in Irvine: Frequently Asked Questions

How do I get a clinical nurse job in Irvine?

Focus your search on Irvine's hospital systems, multi-specialty outpatient clinics, and the dense concentration of medical groups near the UCI Health corridor and Irvine Spectrum. Employers in this market strongly favor candidates with acute care or specialty unit experience, current BLS and ACLS certifications, and familiarity with Epic or Cerner. Applying directly to health systems and large physician groups rather than through staffing agencies tends to yield faster responses in this market.

Which companies hire clinical nurses in Irvine?

Employers hiring clinical nurses in Irvine right now include UC Irvine Health, City of Hope, and Hoag Health System, based on current listings on Migrate Mate as of August 2026. Irvine's employer mix leans heavily toward integrated health systems, specialty outpatient centers, and large corporate-owned medical groups, reflecting the city's strong healthcare infrastructure.

How can I get a clinical nurse job in Irvine with little or no experience?

The most realistic entry path in Irvine is through a new-graduate residency or nurse externship at one of the area's hospital systems, which regularly recruit from regional nursing programs including those tied to UCI. Large outpatient groups and urgent care centers in the Spectrum and Woodbridge districts also hire new graduates for lower-acuity roles that build toward full clinical positions. Highlighting clinical rotation hours in med-surg or telemetry and holding current certifications before applying strengthens your candidacy significantly.

Which industries hire the most clinical nurses in Irvine?

The sectors hiring the most clinical nurses in Irvine are Science & Research and Healthcare & Medical Services, based on current listings on Migrate Mate as of August 2026. Irvine's position as a regional healthcare hub, anchored by a major academic medical center and a high density of specialty and ambulatory care facilities, drives consistent demand across those sectors.

See All 277+ Clinical Nurse Jobs in Irvine

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