Clinical Nurse Jobs in San Diego, CA

Clinical Nurse jobs in San Diego are in strong demand, concentrated in Mission Valley, Kearny Mesa, and the medical corridor around Hillcrest and Balboa Park, across hospital systems, outpatient clinics, and specialty care centers. Employers hiring right now include Sharp HealthCare, Sharp Healthcare, and UC San Diego Health. Find a role that fits below and apply directly.

Find Clinical Nurse Jobs

Overview

Open roles277+
Top employerSharp HealthCare
Work type100% On-site
Top credentialBLS Certification
Companies hiring8

Showing 5 of 277+ Clinical Nurse jobs

Sharp HealthCare
Clinical Nurse RN - ICU and Procedural Areas Float Pool - Sharp Metro Campus - Variable shifts - FT
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Sharp HealthCare
Added 1d ago
Clinical Nurse RN - ICU and Procedural Areas Float Pool - Sharp Metro Campus - Variable shifts - FT
Sharp HealthCare
San Diego, California
Business Operations
Consulting & Professional Services
Healthcare Administration
Quality Assurance & Testing (QA Testing)
$61.74 - $90.16/hr
BLS Certification
10,000+

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Sharp HealthCare
Clinical Nurse RN - 1W Oncology unit - Sharp Memorial Hospital - Night - FT
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Sharp HealthCare
Added 3d ago
Clinical Nurse RN - 1W Oncology unit - Sharp Memorial Hospital - Night - FT
Sharp HealthCare
San Diego, California
Healthcare Administration
Mental & Behavioral Health
Social Work & Counseling
$61.74 - $90.16/hr
BLS Certification
10,000+

Have you applied for this role?

Sharp HealthCare
Clinical Nurse RN - 4West Trauma/Neuro/H&N PCU - Sharp Memorial Hospital - Night - FT
We won't show you this job again
Sharp HealthCare
Added 3d ago
Clinical Nurse RN - 4West Trauma/Neuro/H&N PCU - Sharp Memorial Hospital - Night - FT
Sharp HealthCare
San Diego, California
Healthcare Administration
Mental & Behavioral Health
Social Work & Counseling
$61.74 - $90.16/hr
BLS Certification
10,000+

Have you applied for this role?

Sharp HealthCare
Clinical Nurse RN - 4West Trauma Neuro Head & Neck PCU - Sharp Memorial Hospital - Night - FT
We won't show you this job again
Sharp HealthCare
Added 3d ago
Clinical Nurse RN - 4West Trauma Neuro Head & Neck PCU - Sharp Memorial Hospital - Night - FT
Sharp HealthCare
San Diego, California
Healthcare Administration
Mental & Behavioral Health
Social Work & Counseling
$61.74 - $90.16/hr
BLS Certification
10,000+

Have you applied for this role?

Sharp HealthCare
Clinical Nurse RN - 1West Oncology unit - Sharp Memorial Hospital - Night - FT
We won't show you this job again
Sharp HealthCare
Added 3d ago
Clinical Nurse RN - 1West Oncology unit - Sharp Memorial Hospital - Night - FT
Sharp HealthCare
San Diego, California
Healthcare Administration
Mental & Behavioral Health
Social Work & Counseling
$61.74 - $90.16/hr
BLS Certification
10,000+

Have you applied for this role?

See All 277+ Clinical Nurse Jobs in San Diego

Find roles in San Diego that match your experience and apply in just a few clicks.

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Clinical Nurse Job Market in San Diego

Who's Hiring

  • Sharp HealthCare
    Sharp HealthCare175
  • UC San Diego Health
    UC San Diego Health29
  • AccentCare
    AccentCare15
  • Journey Clinical
    Journey Clinical15

Top Industries Hiring

  • Healthcare & Medical Services117
  • Medical Devices15
  • Electronics & Hardware15

Clinical Nurse Jobs in San Diego: Frequently Asked Questions

How do I get a clinical nurse job in San Diego?

The strongest path is targeting San Diego's large integrated health systems, which staff acute care, surgical, and specialty units across the city, along with the cluster of outpatient and ambulatory care centers in Mission Valley and Kearny Mesa. Candidates with experience in high-acuity settings, bilingual Spanish proficiency, or a specialty certification in critical care or emergency nursing stand out in this competitive coastal market.

Which companies hire clinical nurses in San Diego?

San Diego clinical nurse roles are posted by Sharp HealthCare, Sharp Healthcare, and UC San Diego Health and others right now, based on current listings on Migrate Mate as of August 2026. The local market is driven by large academic medical centers, regional hospital networks, and a growing number of specialty and multispecialty outpatient groups serving San Diego's diverse population.

Are there remote clinical nurse jobs in San Diego?

Yes, though hands-on bedside and procedural roles are by nature on-site, making fully remote work uncommon for most clinical nurse positions. About 0% of clinical nurse openings tied to San Diego are remote or hybrid as of August 2026, with those opportunities most often found in utilization review, case management, and telehealth triage roles tied to San Diego-based health plans and managed care organizations.

How can I get a clinical nurse job in San Diego with little or no experience?

The most realistic entry path is applying to new graduate residency programs offered by San Diego's larger hospital systems, which are designed specifically for RNs completing their first year of practice. Community hospitals and federally qualified health centers serving neighborhoods like City Heights and National City also hire early-career nurses for medical-surgical and primary care roles. Completing a preceptorship or clinical rotation at a San Diego facility and obtaining Basic Life Support and ACLS certification before applying gives candidates a practical edge.

Which industries hire the most clinical nurses in San Diego?

San Diego clinical nurse roles concentrate in Healthcare & Medical Services, Medical Devices, and Electronics & Hardware, based on current listings on Migrate Mate as of August 2026. San Diego's large military and veterans health infrastructure, research-driven biotech sector, and network of community health centers all generate consistent clinical nurse demand alongside the city's major hospital systems.

See All 277+ Clinical Nurse Jobs in San Diego

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