Clinical Operations Lead Jobs in Columbia, SC

Clinical Operations Lead jobs in Columbia, South Carolina are concentrated in the health sciences corridor near the University of South Carolina, the Midlands medical district, and the Forest Acres and Harbison employer clusters, with strong demand from Circle K, AgFirst Farm Credit Bank, and Speechify across hospital systems, contract research, and life sciences. Find a role that fits below and apply directly.

Find Clinical Operations Lead Jobs

Overview

Open roles30
Top employerCircle K
Work type38% Hybrid
Top credentialHigh school diploma or GED
Companies hiring17

Showing 5 of 30+ Clinical Operations Lead jobs

CVS Health
Lead Director - Software Development Engineering
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CVS Health
New 1m ago
Lead Director - Software Development Engineering
CVS Health
Columbia, South Carolina
Engineering (Non-Software)
Project Management
Technical Program Management
$144k - $288k/yr
High school diploma or GED
10,000+

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Speechify
Tech Lead, Web Core Product & Chrome Extension - Columbia, SC, USA
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Speechify
New 1m ago
Tech Lead, Web Core Product & Chrome Extension - Columbia, SC, USA
Speechify
Columbia, South Carolina
Backend Engineering
Full-stack Engineering
Software Engineering
Remote (US)

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US Department of Veterans Affairs
Physician - Lead Primary Care
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US Department of Veterans Affairs
New 1m ago
Physician - Lead Primary Care
US Department of Veterans Affairs
Columbia, South Carolina
Healthcare Administration
Patient Services & Wellbeing
Physicians
On-Site
Military encouraged
10,000+

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Doctors Care
Certified Coding Specialist/Auditor Team Lead
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Doctors Care
New 1m ago
Certified Coding Specialist/Auditor Team Lead
Doctors Care
Columbia, South Carolina
Business Operations
Project & Program Management
Project Management
High school diploma or GED
1,001-5,000

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Speechify
Tech Lead, Android Core Product - Columbia, SC, USA
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Speechify
New 1m ago
Tech Lead, Android Core Product - Columbia, SC, USA
Speechify
Columbia, South Carolina
Backend Engineering
Full-stack Engineering
Software Engineering
$140k - $200k/yr
Remote (US)

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See All 30 Clinical Operations Lead Jobs in Columbia

Find roles in Columbia that match your experience and apply in just a few clicks.

Find Clinical Operations Lead Jobs

Clinical Operations Lead Job Market in Columbia

Who's Hiring

  • Circle K
    Circle K8
  • AgFirst Farm Credit Bank
    AgFirst Farm Credit Bank3
  • Speechify
    Speechify2
  • CVS Health
    CVS Health2
  • City of Columbia, SC
    City of Columbia, SC2

Top Industries Hiring

  • Retail5
  • Technology & Software5
  • Healthcare & Medical Services4
  • Banking & Financial Services3
  • Government & Public Sector2

Clinical Operations Lead Jobs in Columbia: Frequently Asked Questions

How do I get a clinical operations lead job in Columbia?

Focus on Columbia's dominant hiring sectors: hospital systems tied to the Midlands health corridor, contract research organizations operating near the University of South Carolina, and life sciences firms clustered in the Harbison and Forest Acres areas. Candidates with hands-on protocol management, IRB coordination, or site activation experience stand out here. Familiarity with academic medical center workflows and regional health system culture gives a clear edge in Columbia's market.

Which companies hire clinical operations leads in Columbia?

Employers hiring clinical operations leads in Columbia right now include Circle K, AgFirst Farm Credit Bank, and Speechify, based on current listings on Migrate Mate as of July 2026. Columbia's hiring is driven by a mix of regional hospital networks, contract research organizations, and growing life sciences operations tied to the university medical ecosystem.

Are there remote clinical operations lead jobs in Columbia?

Yes, but with limits. Clinical operations lead roles vary widely, with site-facing and protocol oversight functions almost always requiring on-site presence, while data coordination and vendor management tasks can shift remote. About 69% of clinical operations lead openings tied to Columbia are remote or hybrid as of July 2026, skewing toward roles in data operations and sponsor-facing coordination rather than hands-on site management.

How can I get a clinical operations lead job in Columbia with little or no experience?

The most realistic entry path in Columbia is moving through a clinical coordinator or research assistant role at one of the Midlands hospital systems or University of South Carolina-affiliated research programs. Employers in Columbia's academic medical and CRO sector regularly promote from within, and entry-level site coordinator positions at regional health networks offer direct exposure to trial operations. Certifications in clinical research and local volunteer experience with IRB processes strengthen your candidacy.

Which industries hire the most clinical operations leads in Columbia?

The sectors hiring the most clinical operations leads in Columbia are Retail, Technology & Software, and Healthcare & Medical Services, based on current listings on Migrate Mate as of July 2026. Columbia's concentration of regional hospital systems, university-affiliated research programs, and expanding contract research operations makes the Midlands a consistent source of clinical operations demand across those sectors.

See All 30 Clinical Operations Lead Jobs in Columbia

Find roles in Columbia that match your experience and apply in just a few clicks.

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