Clinical Operations Lead Jobs
Clinical Operations Lead jobs are open across pharmaceutical, biotech, medical device, and contract research organizations, at levels from associate lead to senior and director, with specializations in clinical trials, site management, and regulatory compliance. Find a role that fits from the openings below and apply directly.
Find Clinical Operations Lead JobsOverview
Showing 5 of 19+ Clinical Operations Lead jobs
Why Sarepta? Why Now?
The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.
We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.
What Sarepta Offers
At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:
- Physical and Emotional Wellness
- Financial Wellness
- Support for Caregivers
For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us
The Importance of the Role
The Associate Director, Clinical Operations Program Lead, Study Start-up and Feasibility will report to the Director, Patient Recruitment and Start-Up Strategy and lead a team to drive the strategy and implementation of feasibility and study start-up across all clinical programs.
The Opportunity to Make a Difference
We are seeking an associate director-level candidate with clinical operations experience, with specific expertise in feasibility and study start-up, who is interested in applying their experience to develop, build out, and implement innovative feasibility and study start-up activities within Sarepta that positively impact our clinical programs.
The Associate Director, Clinical Operations Program Lead, Study Start-up and Feasibility will report to the Director, Patient Recruitment and Start-Up Strategy and will lead a team to drive the strategy and implementation of country and site feasibility for our studies and support the internalization of country and site feasibility. The candidate will drive study start-up activities and be responsible for oversight of timelines and goals with respect to our clinical studies. The candidate will be responsible for directing and overseeing the success of Sarepta’s clinical trial feasibility process, leading the development of feasibility and start-up strategies, including study-specific plans, and directing and overseeing the success of Sarepta’s clinical trial start-up activities.
This is a highly cross-functional position, requiring collaboration with internal teams, CROs, and vendors. The candidate must be comfortable working directly with clinical trial sites.
The contribution of the candidate directly supports the goals of the Development Operations organization under R&D.
This is a great opportunity for an individual with an operational background and innovative mindset to help us accelerate study execution to support Sarepta’s goal of Patient’s First.
More about You
Primary Responsibilities Include:
- Develop and implement feasibility and start-up strategies to support the success of Sarepta’s clinical studies.
- Oversee study feasibility activities, including country, site, and investigator selection for participation in Sarepta clinical studies.
- Gather cross-functional, country-level input to inform robust feasibility strategies.
- Develop and manage integrated feasibility and site start-up timelines, and report on progress, including plans to address potential timing risks or gaps.
- Establish study-specific meetings to review clinical trial feasibility data and start-up activities with study leads, MSLs, and the CRO; report metrics to broader teams, including senior management.
- Lead calls with Sarepta and CRO partners to manage feasibility and study start-up activities and ensure study timelines are achieved.
- Foster a culture of innovation by developing new ideas and programs to advance feasibility and support departmental growth.
- Provide guidance and mentorship to junior members of the Study Start-up and Feasibility team.
- Create reporting tools to measure ongoing activities, as well as key performance, quality, and effectiveness indicators.
- Partner with Clinical Operations, CRO teams, and other key stakeholders to implement innovative feasibility initiatives, including data collection within CTMS.
- Support and/or lead the development of charters and SOPs related to Study Start-up and Feasibility.
- May have direct reports.
Desired Education and Skills:
- BA/BS degree in a related field; 10+ years related experience in the pharmaceutical or biotech industry within a clinical operations or project management role or similar
- Experience in clinical study budget planning, and program implementation
- Experience with both direct line management and dotted line reporting
- Experience in developing feasibility questionnaires
- Experience with protocol and ICF development and review
- Experience in clinical study start-up
- Experience with rare disease / difficult to recruit populations a plus
- Experience identifying and managing multiple CROs, vendors, budgets, KPIs
- Comprehensive regulatory knowledge, including ICH and GCPs
- Exceptional organizational skills and ability to deal with competing priorities
- Strong analytical reasoning and problem-solving ability
- Excellent PowerPoint slide development and presentation skills
- Ability to multi-task, work independently and as part of a multidisciplinary team, exercise sound judgement and escalate issues when necessary
What Now?
We’re always looking for solution-oriented, critical thinkers.
So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.
LI-Hybrid
This position is hybrid, you will be expected to work on site at one of Sarepta’s facilities in the United States and/or attend Company-sponsored in-person events from time to time.
The targeted salary range for this position is $160,800 - $201,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.
Candidates must be authorized to work in the U.S.
Sarepta Therapeutics offers a competitive compensation and benefit package.
Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.
Why Sarepta? Why Now?
The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.
We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.
What Sarepta Offers
At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:
- Physical and Emotional Wellness
- Financial Wellness
- Support for Caregivers
For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us
The Importance of the Role
The Associate Director, Clinical Operations Program Lead, Study Start-up and Feasibility will report to the Director, Patient Recruitment and Start-Up Strategy and lead a team to drive the strategy and implementation of feasibility and study start-up across all clinical programs.
The Opportunity to Make a Difference
We are seeking an associate director-level candidate with clinical operations experience, with specific expertise in feasibility and study start-up, who is interested in applying their experience to develop, build out, and implement innovative feasibility and study start-up activities within Sarepta that positively impact our clinical programs.
The Associate Director, Clinical Operations Program Lead, Study Start-up and Feasibility will report to the Director, Patient Recruitment and Start-Up Strategy and will lead a team to drive the strategy and implementation of country and site feasibility for our studies and support the internalization of country and site feasibility. The candidate will drive study start-up activities and be responsible for oversight of timelines and goals with respect to our clinical studies. The candidate will be responsible for directing and overseeing the success of Sarepta’s clinical trial feasibility process, leading the development of feasibility and start-up strategies, including study-specific plans, and directing and overseeing the success of Sarepta’s clinical trial start-up activities.
This is a highly cross-functional position, requiring collaboration with internal teams, CROs, and vendors. The candidate must be comfortable working directly with clinical trial sites.
The contribution of the candidate directly supports the goals of the Development Operations organization under R&D.
This is a great opportunity for an individual with an operational background and innovative mindset to help us accelerate study execution to support Sarepta’s goal of Patient’s First.
More about You
Primary Responsibilities Include:
- Develop and implement feasibility and start-up strategies to support the success of Sarepta’s clinical studies.
- Oversee study feasibility activities, including country, site, and investigator selection for participation in Sarepta clinical studies.
- Gather cross-functional, country-level input to inform robust feasibility strategies.
- Develop and manage integrated feasibility and site start-up timelines, and report on progress, including plans to address potential timing risks or gaps.
- Establish study-specific meetings to review clinical trial feasibility data and start-up activities with study leads, MSLs, and the CRO; report metrics to broader teams, including senior management.
- Lead calls with Sarepta and CRO partners to manage feasibility and study start-up activities and ensure study timelines are achieved.
- Foster a culture of innovation by developing new ideas and programs to advance feasibility and support departmental growth.
- Provide guidance and mentorship to junior members of the Study Start-up and Feasibility team.
- Create reporting tools to measure ongoing activities, as well as key performance, quality, and effectiveness indicators.
- Partner with Clinical Operations, CRO teams, and other key stakeholders to implement innovative feasibility initiatives, including data collection within CTMS.
- Support and/or lead the development of charters and SOPs related to Study Start-up and Feasibility.
- May have direct reports.
Desired Education and Skills:
- BA/BS degree in a related field; 10+ years related experience in the pharmaceutical or biotech industry within a clinical operations or project management role or similar
- Experience in clinical study budget planning, and program implementation
- Experience with both direct line management and dotted line reporting
- Experience in developing feasibility questionnaires
- Experience with protocol and ICF development and review
- Experience in clinical study start-up
- Experience with rare disease / difficult to recruit populations a plus
- Experience identifying and managing multiple CROs, vendors, budgets, KPIs
- Comprehensive regulatory knowledge, including ICH and GCPs
- Exceptional organizational skills and ability to deal with competing priorities
- Strong analytical reasoning and problem-solving ability
- Excellent PowerPoint slide development and presentation skills
- Ability to multi-task, work independently and as part of a multidisciplinary team, exercise sound judgement and escalate issues when necessary
What Now?
We’re always looking for solution-oriented, critical thinkers.
So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.
LI-Hybrid
This position is hybrid, you will be expected to work on site at one of Sarepta’s facilities in the United States and/or attend Company-sponsored in-person events from time to time.
The targeted salary range for this position is $160,800 - $201,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.
Candidates must be authorized to work in the U.S.
Sarepta Therapeutics offers a competitive compensation and benefit package.
Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.
See All Clinical Operations Lead Jobs
Jump back to the full list of openings and apply to any clinical operations lead role that fits.
Find Clinical Operations Lead JobsClinical Operations Lead Job Market
A snapshot from current openings nationwide, updated as new roles post.
Who's Hiring
- MannKind Corporation3
- Dyne Therapeutics2
- Ortho-Clinical Diagnostics2
- Ann & Robert H. Lurie Children's Hospital of Chicago1
- Apple1
Top Industries Hiring
- Biotechnology & Pharmaceuticals6
- Medical Devices4
- Science & Research4
- Healthcare & Medical Services2
- Agriculture & Farming1
What Employers Look For
The qualifications that appear most often in clinical operations lead jobs.
- Bachelor's degree in life sciences, nursing, or a related field required
- Minimum five years of clinical trial management or site oversight experience
- Demonstrated knowledge of ICH E6 GCP guidelines and FDA regulations
- Proficiency with clinical trial management systems such as Medidata Rave or Veeva Vault
- Experience managing cross-functional teams across CROs and sponsor organizations
- Project Management Professional or Clinical Research Associate certification preferred
Tips for Your Clinical Operations Lead Job Search
Quantify your trial oversight on your resume
Hiring managers want to see the scope of your clinical work, not just your job duties. List the number of sites you managed, therapeutic areas covered, and whether you led Phase I through III trials. Concrete scope signals credibility faster than titles alone.
Highlight your regulatory documentation experience
Clinical operations leads are expected to own TMF maintenance, protocol deviations, and audit readiness. Call out specific systems you've used, like Veeva Vault or eTMF platforms, and any FDA or ICH E6 GCP audit experience. Vague mentions of 'regulatory knowledge' won't cut it.
Apply early to roles that fit
Migrate Mate lists clinical operations lead openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Target openings by therapeutic area match
Oncology, rare disease, and neurology trials have distinct operational demands. Filter for postings that match your therapeutic background, since hiring teams consistently prioritize candidates who've worked in the same indication over those with broader but shallower experience.
Prepare case studies for your interview panel
Most clinical operations lead interviews include a scenario round covering site escalations, enrollment delays, or vendor management failures. Walk into it with two or three real examples that show how you identified the issue, what you decided, and what the outcome was.
Negotiate beyond base salary at offer stage
Clinical operations leads frequently overlook sign-on bonuses, remote flexibility, and conference budgets when reviewing offers. Ask specifically about trial travel expectations and reimbursement policy, since site visit frequency varies widely and affects your actual take-home value.
Clinical Operations Lead Jobs: Frequently Asked Questions
Which companies are hiring the most clinical operations leads?
The companies hiring the most clinical operations leads right now include MannKind Corporation, Dyne Therapeutics, and Ortho-Clinical Diagnostics, with the largest share of openings in Massachusetts, Florida, and California, based on current listings on Migrate Mate as of June 2026. Large CROs, mid-size biotech sponsors, and integrated health systems tend to post the most consistently throughout the year.
How many clinical operations lead jobs are remote?
About 26% of clinical operations lead openings are fully remote or hybrid as of June 2026, with the balance requiring on-site or travel-heavy schedules. Roles focused on oversight, vendor management, and central monitoring tend to offer the most remote flexibility, while site-based and early-phase positions typically require in-person presence.
How do you become a clinical operations lead?
You typically start as a clinical research associate or trial coordinator, building direct site management experience across multiple phases and therapeutic areas. From there, you move into a senior CRA or lead CRA role before stepping into operational leadership. Earning GCP certification and demonstrating cross-functional project ownership, including budget and vendor management, accelerates the progression.
Can you get a clinical operations lead role with limited experience?
Breaking in with limited experience is possible if you've managed at least one trial from startup through closeout, even in a supporting capacity. Emphasize any protocol deviation management, site escalation ownership, or cross-functional coordination you've led. Targeting smaller sponsors or niche CROs in less competitive therapeutic areas gives you the best entry point into a lead title.
What does the clinical operations lead interview process look like?
Most processes run three to four rounds. The first is a recruiter screen covering your trial background and leadership scope. A hiring manager interview follows, focused on operational decision-making and regulatory knowledge. You'll likely face a scenario-based panel with cross-functional stakeholders, and some organizations add a final presentation or case study on a mock trial challenge before extending an offer.
Where can I find and apply to clinical operations lead jobs?
You can find and apply to clinical operations lead jobs on Migrate Mate, which lists current openings from across the United States. Search the listings to find roles that match your therapeutic background and experience level, then apply directly to each one that fits.
See All Clinical Operations Lead Jobs
Jump back to the full list of openings and apply to any clinical operations lead role that fits.
Find Clinical Operations Lead Jobs