Clinical Operations Lead Jobs

Clinical Operations Lead jobs are open across pharmaceutical, biotech, medical device, and contract research organizations, at levels from associate lead to senior and director, with specializations in clinical trials, site management, and regulatory compliance. Find a role that fits from the openings below and apply directly.

Find Clinical Operations Lead Jobs

Overview

Open roles29
Top stateCalifornia
Top employerMannKind Corporation
Top citySan Francisco, CA
Work type45% On-site
Top industryScience

Showing 5 of 29+ Clinical Operations Lead jobs

El Camino Health
Clinical Data Specialist - 0.5 - Days - Heart and Vascular Institute OPS @ MV
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El Camino Health
Added 3d ago
Clinical Data Specialist - 0.5 - Days - Heart and Vascular Institute OPS @ MV
El Camino Health
Mountain View, California
Program Management
Project & Program Management
Project Management
$57.75 - $86.62/hr
Bachelor of Science
1,001-5,000

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Southeast Permanente Medical Group
Consultant Clinical Ops Analytics
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Southeast Permanente Medical Group
Added 2w ago
Consultant Clinical Ops Analytics
Southeast Permanente Medical Group
Georgia
Business Analysis
Data Analytics
Data Science
Master's degree in business

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KBR
Special Ops Licensed Clinical Social Worker (NAB, Coronado, CA)
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KBR
Added 3w ago
Special Ops Licensed Clinical Social Worker (NAB, Coronado, CA)
KBR
San Diego, California
Clinical Support
Consulting & Professional Services
Healthcare Administration
$96k - $107k/yr
Master's degree in social work
10,000+

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C
RN Clinical Operations & Strategy Lead
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C
Added 3w ago
RN Clinical Operations & Strategy Lead
CuraFi
San Francisco, California
Clinical Support
Healthcare Administration
Medical Coding & Billing
$140k - $160k/yr
Hybrid
Managed Registered Nurses (RNs)

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St. Elizabeth Healthcare
Specialist Oncology Clinical Ops - Cancer Center
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St. Elizabeth Healthcare
Added 3w ago
Specialist Oncology Clinical Ops - Cancer Center
St. Elizabeth Healthcare
Edgewood, Kentucky
Clinical Support
Healthcare Administration
Medical Specialists
High school diploma or GED
5,001-10,000

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Clinical Operations Lead Job Market

Who's Hiring

MannKind Corporation
MannKind Corporation3 open roles
Takeda Pharmaceuticals
Takeda Pharmaceuticals2 open roles
Southeast Permanente Medical
Southeast Permanente Medical2 open roles

Top Industries Hiring

  • Science & Research
  • Healthcare & Medical Services
  • Biotechnology & Pharmaceuticals
  • Medical Devices

What Employers Look For

The qualifications that appear most often in clinical operations lead jobs.

  • Bachelor's degree in life sciences, nursing, or a related field required
  • Minimum five years of clinical trial management or site oversight experience
  • Demonstrated knowledge of ICH E6 GCP guidelines and FDA regulations
  • Proficiency with clinical trial management systems such as Medidata Rave or Veeva Vault
  • Experience managing cross-functional teams across CROs and sponsor organizations
  • Project Management Professional or Clinical Research Associate certification preferred

Tips for Your Clinical Operations Lead Job Search

Quantify your trial oversight on your resume

Hiring managers want to see the scope of your clinical work, not just your job duties. List the number of sites you managed, therapeutic areas covered, and whether you led Phase I through III trials. Concrete scope signals credibility faster than titles alone.

Highlight your regulatory documentation experience

Clinical operations leads are expected to own TMF maintenance, protocol deviations, and audit readiness. Call out specific systems you've used, like Veeva Vault or eTMF platforms, and any FDA or ICH E6 GCP audit experience. Vague mentions of 'regulatory knowledge' won't cut it.

Apply early to roles that fit

Migrate Mate lists clinical operations lead openings from across the United States in one place, so you can find roles that match and apply directly to each listing.

Target openings by therapeutic area match

Oncology, rare disease, and neurology trials have distinct operational demands. Filter for postings that match your therapeutic background, since hiring teams consistently prioritize candidates who've worked in the same indication over those with broader but shallower experience.

Prepare case studies for your interview panel

Most clinical operations lead interviews include a scenario round covering site escalations, enrollment delays, or vendor management failures. Walk into it with two or three real examples that show how you identified the issue, what you decided, and what the outcome was.

Negotiate beyond base salary at offer stage

Clinical operations leads frequently overlook sign-on bonuses, remote flexibility, and conference budgets when reviewing offers. Ask specifically about trial travel expectations and reimbursement policy, since site visit frequency varies widely and affects your actual take-home value.

Clinical Operations Lead Jobs: Frequently Asked Questions

Which companies are hiring the most clinical operations leads?

The companies hiring the most clinical operations leads right now include MannKind Corporation, Takeda Pharmaceuticals, and Southeast Permanente Medical, with the largest share of openings in California, Massachusetts, and Florida, based on current listings on Migrate Mate as of August 2026. Large CROs, mid-size biotech sponsors, and integrated health systems tend to post the most consistently throughout the year.

How many clinical operations lead jobs are remote?

About 55% of clinical operations lead openings are fully remote or hybrid as of August 2026, with the balance requiring on-site or travel-heavy schedules. Roles focused on oversight, vendor management, and central monitoring tend to offer the most remote flexibility, while site-based and early-phase positions typically require in-person presence.

How do you become a clinical operations lead?

You typically start as a clinical research associate or trial coordinator, building direct site management experience across multiple phases and therapeutic areas. From there, you move into a senior CRA or lead CRA role before stepping into operational leadership. Earning GCP certification and demonstrating cross-functional project ownership, including budget and vendor management, accelerates the progression.

Can you get a clinical operations lead role with limited experience?

Breaking in with limited experience is possible if you've managed at least one trial from startup through closeout, even in a supporting capacity. Emphasize any protocol deviation management, site escalation ownership, or cross-functional coordination you've led. Targeting smaller sponsors or niche CROs in less competitive therapeutic areas gives you the best entry point into a lead title.

What does the clinical operations lead interview process look like?

Most processes run three to four rounds. The first is a recruiter screen covering your trial background and leadership scope. A hiring manager interview follows, focused on operational decision-making and regulatory knowledge. You'll likely face a scenario-based panel with cross-functional stakeholders, and some organizations add a final presentation or case study on a mock trial challenge before extending an offer.

Where can I find and apply to clinical operations lead jobs?

You can find and apply to clinical operations lead jobs on Migrate Mate, which lists current openings from across the United States. Search the listings to find roles that match your therapeutic background and experience level, then apply directly to each one that fits.

See All 29 Clinical Operations Lead Jobs

Find roles that match your experience and apply in just a few clicks.

Find Clinical Operations Lead Jobs