Clinical Manager Jobs in South Carolina
Clinical Manager jobs in South Carolina are open across Charleston, Columbia, and Florence and other South Carolina metros, with employers like Medical University of South Carolina, PruittHealth, and COLLEGE OF CHARLESTON hiring at every experience level. Find a role that fits below and apply directly.
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INTRODUCTION
RN Clinical Manager – Home Health Services
Full Time
Location: Aiken
Home is Where the Care Begins.
Are you a passionate nursing leader ready to make a meaningful impact in home health? Join PruittHealth @ Home, where we believe “home is where the heart is”—and where your career can thrive.
We’re seeking a Registered Nurse (RN) – Clinical Manager to oversee clinical operations and patient care services in our home health division. This is your opportunity to lead with compassion, drive excellence, and be part of a team that treats each other like family.
Key Responsibilities:
- Provide daily clinical oversight of patient care services.
- Coordinate referrals and admissions with internal and external sources.
- Evaluate patient needs and agency capabilities before admission.
- Supervise care planning, partner assignments, and care delivery.
- Ensure compliance with regulatory standards and agency policies.
- Mentor and coach clinical staff to promote morale and retention.
- Utilize MatrixCare and Strategic Healthcare Partner systems for workflow and reporting.
Why Join PruittHealth @ Home?
We invest in our employee-partners with:
- Competitive pay structures with unlimited income potential
- Flexible schedules and additional pay incentives
- Mileage reimbursement
- Progressive benefits
- Career growth opportunities
- Supportive, family-like team culture
Our Commitment to You:
At PruittHealth, we’re committed to your success, safety, and satisfaction. We support our clinicians with the tools and resources they need to thrive—because when you care for others, we care for you.
Ready to Lead with Purpose?
We’re eager to connect with compassionate leaders like you.
BASIC QUALIFICATIONS
Required:
- Active, unrestricted RN license in the state of practice.
- Minimum of two years RN experience (preferred)
- At least one year of Home Health experience (preferred)
- Current CPR certification.
Family Makes Us Stronger. Our family, your family, one family. Committed to loving, giving, and caring. United in making a difference.
We are eager to connect with you! Apply Now to get started at PruittHealth!
As an Equal Employment Opportunity employer, all qualified applicants will receive consideration without regard to race, color, religion, sex, national origin, disability, or veteran status.
For Florida Job Postings Only:
For more information regarding Florida’s Care Provider Background Screening Clearinghouse Education and Awareness, please visit https://info.flclearinghouse.com
See All 16 Clinical Manager Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Clinical Manager JobsClinical Manager Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Clinical Manager Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
- Medical University of South Carolina5

- PruittHealth2

- COLLEGE OF CHARLESTON1

- Ceribell1

- Fresenius Medical Care1

Top Industries Hiring
- Healthcare & Medical Services9
- Education4
- Biotechnology & Pharmaceuticals2
- Medical Devices1
What South Carolina Employers Look For
The qualifications that appear most often in clinical manager jobs across South Carolina.
- Active RN license or relevant clinical licensure required in state of practice
- Bachelor's degree in nursing, healthcare administration, or a related clinical field
- Minimum of three to five years of progressive clinical leadership or supervisory experience
- Demonstrated experience with regulatory compliance including Joint Commission or state health department standards
- Proficiency with electronic health record systems such as Epic, Cerner, or Meditech
- Experience managing departmental budgets, staffing schedules, and operational workflows
Clinical Manager Jobs in South Carolina: Frequently Asked Questions
How many clinical manager jobs are there in South Carolina?
There are 16+ clinical manager openings in South Carolina on Migrate Mate as of June 2026, with the most roles in Charleston, Columbia, and Florence. New positions post regularly as employers across South Carolina hire.
Which South Carolina cities have the most clinical manager jobs?
Charleston, Columbia, and Florence have the most clinical manager openings in South Carolina right now, with additional roles spread across smaller metros statewide.
Which companies hire clinical managers in South Carolina?
Employers hiring clinical managers in South Carolina include Medical University of South Carolina, PruittHealth, and COLLEGE OF CHARLESTON, based on current listings on Migrate Mate as of June 2026.
Are there remote clinical manager jobs in South Carolina?
Yes. About 0% of clinical manager openings tied to South Carolina are remote or hybrid as of June 2026. The rest are on-site roles based in South Carolina metros.
How do I apply for clinical manager jobs in South Carolina?
You can apply to clinical manager jobs in South Carolina directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Carolina location, then apply to each one that fits.
See All 16 Clinical Manager Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Clinical Manager Jobs