Clinical Registered Nurse Jobs in Chicago, IL

Clinical Registered Nurse jobs in Chicago are concentrated across major academic medical centers and specialty hospital systems in the Medical District, Streeterville, and Hyde Park, with strong demand in critical care, oncology, and emergency settings. Employers actively hiring include Rush University Medical Center, SAINT MARY OF NAZARETH HOSPITAL, and Sinai Chicago. Find a role that fits below and apply directly.

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Overview

Open roles111+
Top employerRush University Medical Center
Work type82% On-site
Top credentialManaged Registered Nurses (RNs)
Companies hiring17

Showing 5 of 111+ Clinical Registered Nurse jobs

Endeavor Health
RN - Clinical Decisional Unit - Nights
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Endeavor Health
Added 1d ago
RN - Clinical Decisional Unit - Nights
Endeavor Health
Chicago, Illinois
Clinical Trials
Healthcare Administration
Nursing
Patient Services & Wellbeing
$36 - $55.8/hr
Managed Registered Nurses (RNs)
10,000+

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Resurrection Medical Center
Clinical Supervisor RN- Medical Surgical - Oncology
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Resurrection Medical Center
Added 1d ago
Clinical Supervisor RN- Medical Surgical - Oncology
Resurrection Medical Center
Chicago, Illinois
Corporate Training
Learning & Development
Project Management
$36.75 - $55.7/hr
Managed Registered Nurses (RNs)

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AMG, Integrated Healthcare Management
CLINICAL LIAISON (RN, LPN, RT, or PT) FULL TIME
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AMG, Integrated Healthcare Management
Added 3d ago
CLINICAL LIAISON (RN, LPN, RT, or PT) FULL TIME
AMG, Integrated Healthcare Management
Chicago, Illinois
Business Operations
Customer Service
Customer Success
51-200

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Humboldt Park Health
RN Clinical Coordinator
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Humboldt Park Health
Added 5d ago
RN Clinical Coordinator
Humboldt Park Health
Chicago, Illinois
Customer Service
Healthcare Administration
Human Resources
Managed Registered Nurses (RNs)
501-1,000

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Ascension
Registered Nurse Clinical Lead Med Surg
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Ascension
Added 5d ago
Registered Nurse Clinical Lead Med Surg
Ascension
Chicago, Illinois
Business Operations
Program Management
Project Management
$45.3 - $63.95/hr
Managed Registered Nurses (RNs)
10,000+

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See All 111+ Clinical Registered Nurse Jobs in Chicago

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Clinical Registered Nurse Job Market in Chicago

Who's Hiring

  • Rush University Medical Center
    Rush University Medical Center29
  • SAINT MARY OF NAZARETH HOSPITAL
    SAINT MARY OF NAZARETH HOSPITAL18
  • Sinai Chicago
    Sinai Chicago7
  • Advocate Aurora Health
    Advocate Aurora Health7
  • Gift of Hope Organ & Tissue Donor Network
    Gift of Hope Organ & Tissue Donor Network7

Top Industries Hiring

  • Healthcare & Medical Services21
  • Education11
  • Transportation & Logistics4

Clinical Registered Nurse Jobs in Chicago: Frequently Asked Questions

How do I get a clinical registered nurse job in Chicago?

The strongest path into Chicago's clinical registered nurse market runs through its large academic hospital systems, Level I trauma centers, and specialty care networks, which dominate hiring across the Medical District, Streeterville, and the Near North Side. Candidates with acute care experience, specialty certifications such as CCRN or OCN, and familiarity with Epic clinical systems have a clear edge. Applying directly to hospital system career portals and targeting units with known staffing pressure, like ICU, emergency, and oncology, moves applications forward fastest.

Which companies hire clinical registered nurses in Chicago?

Companies currently hiring clinical registered nurses in Chicago include Rush University Medical Center, SAINT MARY OF NAZARETH HOSPITAL, and Sinai Chicago, per current listings on Migrate Mate as of August 2026. Chicago's market is anchored by large integrated health systems and nationally ranked academic medical centers that hire across inpatient, outpatient, and specialty care settings year-round.

Are there remote clinical registered nurse jobs in Chicago?

Yes, but only for a narrow subset of roles, since most clinical registered nurse positions require direct patient contact and on-site presence. About 18% of clinical registered nurse openings tied to Chicago are remote or hybrid as of August 2026, concentrated in utilization review, case management, and telehealth triage functions. Chicago-based managed care organizations and insurance carriers are the primary employers offering those arrangements.

How can I get a clinical registered nurse job in Chicago with little or no experience?

The most realistic entry point in Chicago is a new graduate residency or nurse externship program offered by the city's large academic hospital systems, which are structured specifically to bring ADN and BSN graduates into acute care with supervised clinical progression. Community hospitals on Chicago's South and West Sides often have more accessible hiring pipelines for new grads than the flagship downtown campuses. Building experience in a med-surg or step-down unit first, then pursuing a specialty certification, is the standard trajectory local nurse managers recognize.

Which industries hire the most clinical registered nurses in Chicago?

Most clinical registered nurse openings in Chicago sit in Healthcare & Medical Services, Education, and Transportation & Logistics, per current listings on Migrate Mate as of August 2026. Chicago's density of nationally ranked academic medical centers, large integrated hospital systems, and a growing ambulatory and specialty clinic network collectively sustain consistent demand across inpatient and outpatient settings.

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