Clinical Registered Nurse Jobs in Chicago, IL

Clinical Registered Nurse jobs in Chicago are concentrated across major academic medical centers and specialty hospital systems in the Medical District, Streeterville, and Hyde Park, with strong demand in critical care, oncology, and emergency settings. Employers actively hiring include Northwestern Medicine, Rush University Medical Center, and SAINT MARY OF NAZARETH HOSPITAL. Find a role that fits below and apply directly.

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Overview

Open roles81
Top employerNorthwestern Medicine
Work type98% On-site
Top credentialHigh School
Companies hiring25

Showing 5 of 81+ Clinical Registered Nurse jobs

Advocate Aurora Health
RN Clinical Lead
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Advocate Aurora Health
Added 1d ago
RN Clinical Lead
Advocate Aurora Health
Chicago, Illinois
On-Site
Bachelor's
10,000+

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Rush University Medical Center
Clinical Faculty RN NEx
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Rush University Medical Center
Added 3d ago
Clinical Faculty RN NEx
Rush University Medical Center
Chicago, Illinois
Nursing
Teaching & Instruction
Healthcare Administration
$43 - $61/hr
On-Site
Master's

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Optum
InterQual Senior Clinical Education Consultant (RN) - Remote
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Optum
Added 1w ago
InterQual Senior Clinical Education Consultant (RN) - Remote
Optum
Chicago, Illinois
Nursing
Healthcare Administration
Patient Services & Wellbeing
$92k - $164k/yr
On-Site
Bachelor's
10,000+

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Gift of Hope Organ & Tissue Donor Network
RN - Clinical Coordinator
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Gift of Hope Organ & Tissue Donor Network
Added 1w ago
RN - Clinical Coordinator
Gift of Hope Organ & Tissue Donor Network
Chicago, Illinois
Nursing
Healthcare Administration
Patient Services & Wellbeing
$39.9 - $44.71/hr
201-500

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Advocate Aurora Health
RN Clinical Lead - ICU
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Advocate Aurora Health
Added 1w ago
RN Clinical Lead - ICU
Advocate Aurora Health
Chicago, Illinois
Nursing
Healthcare Administration
Patient Services & Wellbeing
$41.1 - $61.65/hr
High School
10,000+

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See All 81 Clinical Registered Nurse Jobs in Chicago

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Clinical Registered Nurse Job Market in Chicago

Who's Hiring

  • Northwestern Medicine
    Northwestern Medicine16
  • Rush University Medical Center
    Rush University Medical Center16
  • S
    SAINT MARY OF NAZARETH HOSPITAL11
  • Advocate Aurora Health
    Advocate Aurora Health9
  • Endeavor Health
    Endeavor Health3

Top Industries Hiring

  • Healthcare & Medical Services54
  • Education10
  • Consulting & Professional Services2
  • Science & Research1
  • Transportation & Logistics1

Clinical Registered Nurse Jobs in Chicago: Frequently Asked Questions

How do I get a clinical registered nurse job in Chicago?

The strongest path into Chicago's clinical registered nurse market runs through its large academic hospital systems, Level I trauma centers, and specialty care networks, which dominate hiring across the Medical District, Streeterville, and the Near North Side. Candidates with acute care experience, specialty certifications such as CCRN or OCN, and familiarity with Epic clinical systems have a clear edge. Applying directly to hospital system career portals and targeting units with known staffing pressure, like ICU, emergency, and oncology, moves applications forward fastest.

Which companies hire clinical registered nurses in Chicago?

Companies currently hiring clinical registered nurses in Chicago include Northwestern Medicine, Rush University Medical Center, and SAINT MARY OF NAZARETH HOSPITAL, per current listings on Migrate Mate as of June 2026. Chicago's market is anchored by large integrated health systems and nationally ranked academic medical centers that hire across inpatient, outpatient, and specialty care settings year-round.

Are there remote clinical registered nurse jobs in Chicago?

Yes, but only for a narrow subset of roles, since most clinical registered nurse positions require direct patient contact and on-site presence. About 2% of clinical registered nurse openings tied to Chicago are remote or hybrid as of June 2026, concentrated in utilization review, case management, and telehealth triage functions. Chicago-based managed care organizations and insurance carriers are the primary employers offering those arrangements.

How can I get a clinical registered nurse job in Chicago with little or no experience?

The most realistic entry point in Chicago is a new graduate residency or nurse externship program offered by the city's large academic hospital systems, which are structured specifically to bring ADN and BSN graduates into acute care with supervised clinical progression. Community hospitals on Chicago's South and West Sides often have more accessible hiring pipelines for new grads than the flagship downtown campuses. Building experience in a med-surg or step-down unit first, then pursuing a specialty certification, is the standard trajectory local nurse managers recognize.

Which industries hire the most clinical registered nurses in Chicago?

Most clinical registered nurse openings in Chicago sit in Healthcare & Medical Services, Education, and Consulting & Professional Services, per current listings on Migrate Mate as of June 2026. Chicago's density of nationally ranked academic medical centers, large integrated hospital systems, and a growing ambulatory and specialty clinic network collectively sustain consistent demand across inpatient and outpatient settings.

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