Laboratory Jobs at Calico Life Sciences with Visa Sponsorship
Calico Life Sciences hires for Laboratory roles across research, wet lab, and investigative science functions, and has a track record of sponsoring work visas for qualified candidates in this space. If you're building a career in longevity or biomedical research, Calico is an employer worth targeting.
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Get Access To All JobsWho We Are
Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.
Position Description
Calico is seeking an experienced and highly motivated Principal Associate Scientist to join the Biomarker Group and lead the discovery and validation of pharmacodynamic, prognostic and predictive biomarker assays to support a wide range of clinical programs. Our group is responsible for developing biomarkers for programs in Neuroscience, Oncology and Aging-related diseases. We are looking for a collaborative leader with over 15 years of experience in translational biology, molecular and cellular biology, and hands-on assay development. You will bridge the gap between early discovery and clinical development, ensuring our therapeutic candidates are supported by robust biomarker strategies to derisk clinical development.
Position Responsibilities
- Discovery & Validation: Discover and validate pharmacodynamic biomarkers to support the clinical development of drugs with novel MoAs utilizing pre-clinical models (in vivo and in vitro) and human specimens
- Assay Development: Lead the development, optimization, and qualification of biomarker assays using various platform
- Data Analysis & Interpretation: Perform rigorous analysis to establish PK/PD relationships and benchmark program compounds
- Utilize statistical and specialized tools to interpret results from ex-vivo and in-vitro studies, delivering actionable insights for clinical dose selection
- Synthesize complex biological data into clear reports and strategic guidance for senior management
- Clinical Translation: Oversee the technical transfer of validated assays to CROs or internal bioanalysis teams for Phase I/II studies
- Strategic Intelligence: Curate and analyze competitive intelligence to inform discovery strategy and provide scenario assessments of high-priority clinical assets
- Mentorship: Manage and mentor junior scientists, fostering a culture of technical excellence and scientific curiosity
Position Requirements
- BS or MS degree in cell biology, molecular biology, neuroscience, or a related field, with 14+ years of industry experience
- Well-versed in a wide range of molecular biology, biochemistry, and cell biology techniques, including RNA isolation, qPCR, Western blotting, and immunoprecipitation
- Significant experience in the extraction of soluble, insoluble, and aggregated proteins and subcellular fractionation
- Extensive hands-on experience in primary and immortalized cell culture, including the processing of human whole blood for PBMC and specific immune cell isolation as well as ex-vivo stimulation of whole blood or PBMCs
- Expert-level proficiency in high-sensitivity and multiplex platforms such as Olink, MSD, SIMOA, NULISA, and SOMAscan
- Strong data analysis proficiencies with strong preference for proficiency in data science programming languages such as R or Python for both statistical analysis and visualization
- Self-motivated with a "can-do" attitude, able to troubleshoot experiments independently, and possessing strong teamwork and communication skills
- Must be willing to work onsite 5 days a week
The estimated base salary range for this role is $163,000 - $172,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.
Who We Are
Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.
Position Description
Calico is seeking an experienced and highly motivated Principal Associate Scientist to join the Biomarker Group and lead the discovery and validation of pharmacodynamic, prognostic and predictive biomarker assays to support a wide range of clinical programs. Our group is responsible for developing biomarkers for programs in Neuroscience, Oncology and Aging-related diseases. We are looking for a collaborative leader with over 15 years of experience in translational biology, molecular and cellular biology, and hands-on assay development. You will bridge the gap between early discovery and clinical development, ensuring our therapeutic candidates are supported by robust biomarker strategies to derisk clinical development.
Position Responsibilities
- Discovery & Validation: Discover and validate pharmacodynamic biomarkers to support the clinical development of drugs with novel MoAs utilizing pre-clinical models (in vivo and in vitro) and human specimens
- Assay Development: Lead the development, optimization, and qualification of biomarker assays using various platform
- Data Analysis & Interpretation: Perform rigorous analysis to establish PK/PD relationships and benchmark program compounds
- Utilize statistical and specialized tools to interpret results from ex-vivo and in-vitro studies, delivering actionable insights for clinical dose selection
- Synthesize complex biological data into clear reports and strategic guidance for senior management
- Clinical Translation: Oversee the technical transfer of validated assays to CROs or internal bioanalysis teams for Phase I/II studies
- Strategic Intelligence: Curate and analyze competitive intelligence to inform discovery strategy and provide scenario assessments of high-priority clinical assets
- Mentorship: Manage and mentor junior scientists, fostering a culture of technical excellence and scientific curiosity
Position Requirements
- BS or MS degree in cell biology, molecular biology, neuroscience, or a related field, with 14+ years of industry experience
- Well-versed in a wide range of molecular biology, biochemistry, and cell biology techniques, including RNA isolation, qPCR, Western blotting, and immunoprecipitation
- Significant experience in the extraction of soluble, insoluble, and aggregated proteins and subcellular fractionation
- Extensive hands-on experience in primary and immortalized cell culture, including the processing of human whole blood for PBMC and specific immune cell isolation as well as ex-vivo stimulation of whole blood or PBMCs
- Expert-level proficiency in high-sensitivity and multiplex platforms such as Olink, MSD, SIMOA, NULISA, and SOMAscan
- Strong data analysis proficiencies with strong preference for proficiency in data science programming languages such as R or Python for both statistical analysis and visualization
- Self-motivated with a "can-do" attitude, able to troubleshoot experiments independently, and possessing strong teamwork and communication skills
- Must be willing to work onsite 5 days a week
The estimated base salary range for this role is $163,000 - $172,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.
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Get Access To All JobsTips for Finding Laboratory Jobs at Calico Life Sciences Jobs
Align your credentials to biomedical research standards
Calico's Laboratory roles sit at the intersection of aging biology and translational research. Make sure your CV reflects lab techniques relevant to that domain, such as CRISPR, proteomics, or metabolomics, rather than listing generic bench skills.
Verify your degree field matches the posted role
H-1B eligibility for Laboratory positions requires a degree in a specific specialty occupation field. A biology or biochemistry degree typically qualifies, but a general science degree may face USCIS scrutiny. Confirm the match before applying.
Target roles that align with Calico's research pipeline
Calico recruits heavily around longevity science and drug discovery. Laboratory openings tied to those programs tend to move faster through internal approvals. Search for postings that reference aging pathways, model organisms, or therapeutic development.
Browse open Laboratory roles at Calico using Migrate Mate
Filter by Laboratory roles at Calico Life Sciences on Migrate Mate to see current openings alongside verified sponsorship history. That saves you the step of screening employers manually before you apply.
Laboratory at Calico Life Sciences jobs are hiring across the US. Find yours.
Find Laboratory at Calico Life Sciences JobsFrequently Asked Questions
Does Calico Life Sciences sponsor H-1B visas for Laboratorys?
Yes, Calico Life Sciences sponsors H-1B visas for Laboratory roles. The company has a consistent track record of supporting work authorization for research and lab staff, including both cap-subject H-1B petitions and H-1B1 filings for eligible nationals. If you're interviewing for a Laboratory position, raise visa sponsorship early so the HR team can confirm the timeline.
How do I apply for Laboratory jobs at Calico Life Sciences?
You can find current Laboratory openings at Calico Life Sciences through their careers page or by browsing Migrate Mate, which lists verified sponsorship employers in one place. Tailor your application to Calico's focus areas in longevity and biomedical research. Highlight relevant wet lab skills and any publications or research experience in aging biology, as those directly match the company's scientific priorities.
Which visa types does Calico Life Sciences commonly use for Laboratory roles?
Calico Life Sciences sponsors H-1B and H-1B1 visas for Laboratory positions, along with F-1 OPT and CPT for students currently enrolled or recently graduated. TN status is available for Canadian and Mexican nationals in qualifying life sciences roles. J-1 visas are also supported for researchers on exchange programs. The right visa depends on your nationality, degree field, and current immigration status.
What qualifications does Calico Life Sciences expect for Laboratory roles?
Most Laboratory positions at Calico require at least a bachelor's degree in a life sciences field such as biochemistry, molecular biology, or cell biology, with many senior roles expecting a master's or Ph.D. Hands-on bench experience is weighted heavily, particularly in techniques relevant to aging research. Familiarity with model organisms, high-throughput screening, or omics platforms strengthens your application significantly.
How do I plan my timeline if I need visa sponsorship for a Laboratory role at Calico?
Timeline depends on your current status. F-1 OPT students can start immediately if OPT is active, with an H-1B filed before expiration. Cap-subject H-1B petitions are filed in April with an October 1 start date, so any offer accepted before March needs to account for that window. TN and H-1B1 filings move faster and aren't tied to the annual cap, giving those applicants more scheduling flexibility.
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