Biotech Jobs at Calico Life Sciences with Visa Sponsorship
Calico Life Sciences hires Biotech professionals to advance its research into the biology of aging, and the company has a consistent track record of sponsoring work visas for qualified candidates in this function. If you're targeting a Biotech role here, visa sponsorship is a realistic part of the conversation.
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Get Access To All JobsWho We Are
Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.
Position Description
Calico is seeking an experienced and highly motivated Principal Associate Scientist to join the Biomarker Group and lead the discovery and validation of pharmacodynamic, prognostic and predictive biomarker assays to support a wide range of clinical programs. Our group is responsible for developing biomarkers for programs in Neuroscience, Oncology and Aging-related diseases. We are looking for a collaborative leader with over 15 years of experience in translational biology, molecular and cellular biology, and hands-on assay development. You will bridge the gap between early discovery and clinical development, ensuring our therapeutic candidates are supported by robust biomarker strategies to derisk clinical development.
Position Responsibilities
- Discovery & Validation: Discover and validate pharmacodynamic biomarkers to support the clinical development of drugs with novel MoAs utilizing pre-clinical models (in vivo and in vitro) and human specimens
- Assay Development: Lead the development, optimization, and qualification of biomarker assays using various platform
- Data Analysis & Interpretation: Perform rigorous analysis to establish PK/PD relationships and benchmark program compounds
- Utilize statistical and specialized tools to interpret results from ex-vivo and in-vitro studies, delivering actionable insights for clinical dose selection
- Synthesize complex biological data into clear reports and strategic guidance for senior management
- Clinical Translation: Oversee the technical transfer of validated assays to CROs or internal bioanalysis teams for Phase I/II studies
- Strategic Intelligence: Curate and analyze competitive intelligence to inform discovery strategy and provide scenario assessments of high-priority clinical assets
- Mentorship: Manage and mentor junior scientists, fostering a culture of technical excellence and scientific curiosity
Position Requirements
- BS or MS degree in cell biology, molecular biology, neuroscience, or a related field, with 14+ years of industry experience
- Well-versed in a wide range of molecular biology, biochemistry, and cell biology techniques, including RNA isolation, qPCR, Western blotting, and immunoprecipitation
- Significant experience in the extraction of soluble, insoluble, and aggregated proteins and subcellular fractionation
- Extensive hands-on experience in primary and immortalized cell culture, including the processing of human whole blood for PBMC and specific immune cell isolation as well as ex-vivo stimulation of whole blood or PBMCs
- Expert-level proficiency in high-sensitivity and multiplex platforms such as Olink, MSD, SIMOA, NULISA, and SOMAscan
- Strong data analysis proficiencies with strong preference for proficiency in data science programming languages such as R or Python for both statistical analysis and visualization
- Self-motivated with a "can-do" attitude, able to troubleshoot experiments independently, and possessing strong teamwork and communication skills
- Must be willing to work onsite 5 days a week
The estimated base salary range for this role is $163,000 - $172,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.
Who We Are
Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.
Position Description
Calico is seeking an experienced and highly motivated Principal Associate Scientist to join the Biomarker Group and lead the discovery and validation of pharmacodynamic, prognostic and predictive biomarker assays to support a wide range of clinical programs. Our group is responsible for developing biomarkers for programs in Neuroscience, Oncology and Aging-related diseases. We are looking for a collaborative leader with over 15 years of experience in translational biology, molecular and cellular biology, and hands-on assay development. You will bridge the gap between early discovery and clinical development, ensuring our therapeutic candidates are supported by robust biomarker strategies to derisk clinical development.
Position Responsibilities
- Discovery & Validation: Discover and validate pharmacodynamic biomarkers to support the clinical development of drugs with novel MoAs utilizing pre-clinical models (in vivo and in vitro) and human specimens
- Assay Development: Lead the development, optimization, and qualification of biomarker assays using various platform
- Data Analysis & Interpretation: Perform rigorous analysis to establish PK/PD relationships and benchmark program compounds
- Utilize statistical and specialized tools to interpret results from ex-vivo and in-vitro studies, delivering actionable insights for clinical dose selection
- Synthesize complex biological data into clear reports and strategic guidance for senior management
- Clinical Translation: Oversee the technical transfer of validated assays to CROs or internal bioanalysis teams for Phase I/II studies
- Strategic Intelligence: Curate and analyze competitive intelligence to inform discovery strategy and provide scenario assessments of high-priority clinical assets
- Mentorship: Manage and mentor junior scientists, fostering a culture of technical excellence and scientific curiosity
Position Requirements
- BS or MS degree in cell biology, molecular biology, neuroscience, or a related field, with 14+ years of industry experience
- Well-versed in a wide range of molecular biology, biochemistry, and cell biology techniques, including RNA isolation, qPCR, Western blotting, and immunoprecipitation
- Significant experience in the extraction of soluble, insoluble, and aggregated proteins and subcellular fractionation
- Extensive hands-on experience in primary and immortalized cell culture, including the processing of human whole blood for PBMC and specific immune cell isolation as well as ex-vivo stimulation of whole blood or PBMCs
- Expert-level proficiency in high-sensitivity and multiplex platforms such as Olink, MSD, SIMOA, NULISA, and SOMAscan
- Strong data analysis proficiencies with strong preference for proficiency in data science programming languages such as R or Python for both statistical analysis and visualization
- Self-motivated with a "can-do" attitude, able to troubleshoot experiments independently, and possessing strong teamwork and communication skills
- Must be willing to work onsite 5 days a week
The estimated base salary range for this role is $163,000 - $172,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.
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Get Access To All JobsTips for Finding Biotech Jobs at Calico Life Sciences Jobs
Align Your Credentials to Aging Research
Calico focuses on longevity and age-related disease, so framing your background around relevant disciplines like molecular biology, genomics, or computational biology strengthens your application before you ever reach the sponsorship conversation.
Confirm Your OPT or CPT Timeline Early
If you're on F-1 status, map your OPT expiration against Calico's typical hiring timeline. STEM OPT extension applications must be filed before your initial OPT ends, and a gap in authorization can stall an offer.
Search Calico's Open Roles on Migrate Mate
Filter by Biotech and Calico Life Sciences on Migrate Mate to see which positions are currently open and verified for visa sponsorship, so you're applying to roles where sponsorship is already confirmed rather than assumed.
Prepare for a Specialty Occupation Discussion
USCIS requires H-1B petitions to establish that the role qualifies as a specialty occupation. For Biotech positions at a research-focused company, having documentation that ties your specific degree field to the job duties helps your employer build a stronger petition.
Time Your H-1B Filing Around the Cap Lottery
If your role requires a cap-subject H-1B, USCIS accepts registrations only in March for an October 1 start date. Factor this into your job search so you're securing an offer well before the registration window opens.
Biotech at Calico Life Sciences jobs are hiring across the US. Find yours.
Find Biotech at Calico Life Sciences JobsFrequently Asked Questions
Does Calico Life Sciences sponsor H-1B visas for Biotechs?
Yes, Calico Life Sciences sponsors H-1B visas for Biotech roles. The company has an established pattern of filing H-1B petitions for research and scientific positions, which aligns with its focus on longevity biology. If you receive an offer, your employer will work with immigration counsel to file the petition with USCIS on your behalf.
How do I apply for Biotech jobs at Calico Life Sciences?
You can browse current Biotech openings at Calico Life Sciences directly through Migrate Mate, which filters for roles where visa sponsorship is confirmed. From there, applications typically go through Calico's own careers portal. Tailoring your resume to reflect experience in aging biology, genomics, or related fields gives you a stronger entry point.
Which visa types does Calico Life Sciences commonly use for Biotech roles?
Calico sponsors several visa categories for Biotech professionals, including H-1B, H-1B1 for Chilean and Singaporean nationals, F-1 OPT and CPT for current students and recent graduates, TN for Canadian and Mexican nationals, and J-1 for exchange visitors. The right category depends on your nationality, degree, and current immigration status.
What qualifications does Calico Life Sciences expect for Biotech positions?
Calico's Biotech roles typically require at least a bachelor's degree in a relevant scientific discipline, with many research positions preferring a master's or Ph.D. Hands-on lab experience in areas like molecular biology, cell biology, or bioinformatics is consistently valued. Because the company's mission centers on aging research, familiarity with longevity-related science strengthens your candidacy meaningfully.
How do I plan my timeline if I need H-1B sponsorship at Calico Life Sciences?
If you need a cap-subject H-1B, USCIS opens registration in March each year for an October 1 start. That means securing your offer well before March is critical. If you're on F-1 OPT, you may be able to start earlier and bridge to an H-1B. Discuss your status with Calico's HR team as early as possible so filing deadlines don't create gaps.
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