CPT Senior Clinical Research Scientist Jobs
Senior Clinical Research Scientist roles in pharma, biotech, and CROs involve protocol design, data analysis, and regulatory submissions, work that maps directly to graduate-level life sciences curricula. CPT authorization requires your DSO to confirm the position is an integral part of your degree program before you start.
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Get Access To All JobsAbout BOSTONGENE: BostonGene is redefining cancer patient care and drug development through the integration of omnimodal data and artificial intelligence. Built and validated through an extensive real-world clinical testing network, BostonGene’s Foundation Model of cancer and the immune system integrates genomic, transcriptomic, and immune data with clinical outcomes to generate biologically grounded, actionable insights. These insights enable biopharma partners to design and de-risk trials, identify novel targets, and optimize therapeutic response prediction across all stages of development while simultaneously improving patient care through clinically integrated innovation.
Position Overview
BostonGene is seeking a bench Scientist to join our R&D next-generation sequencing (NGS) team in our laboratory located in Waltham, MA. This candidate will support assay development and technical transfer in collaboration with immunology, production, and bioinformatics teams. The candidate will be expected to support NGS protocols, such as RNA and DNA isolation from tissue, cell-free DNA isolation from plasma, library preparation, QC, and other lab processes. The role will primarily require laboratory bench work (70-80%) in a BSL-2 laboratory.
Key Responsibilities:
- Perform assay and product development experiments of NGS workflows, including WGS, WES, and liquid biopsy assays for internal and external collaborators
- Troubleshoot and support the technical transfer of workflows to the production lab
- Maintain detailed and accurate records in LIMS, ELN, and in compliance with laboratory protocols and regulatory requirements
- Assist in the development of laboratory SOPs and batch records
- Execute and assist with validation studies, bridging studies, and technical reports
- Stay informed on emerging technologies and trends in NGS to support innovation in assay development
Qualifications
- Ph.D. in life sciences or related discipline with 0–3 years of relevant experience, OR M.S. with 3–6 years, OR B.S. with 6–10 years of hands-on experience. (The job title will be commensurate with experience.)
- Strong experience in nucleic acid extraction (DNA/RNA) from FFPE, blood, or other clinical samples
- Proficiency in NGS library prep (short-read and/or long-read), including WGS and WES
- Excellent problem-solving and troubleshooting skills
- Strong organizational skills with the ability to manage sample tracking, documentation, and inventory
Preferred Skills & Experience:
- Experience working with liquid biopsy samples (cfDNA/ctDNA, cfRNA, or exosomes)
- Familiarity with NGS QC metrics and analysis tools
- Understanding of assay validation in regulated environments (GCLP, ISO)
- Demonstrated experience in SOP development and process documentation
- Strong verbal and written communication skills, with the ability to work effectively in cross-functional teams
- Proven ability to work in a dynamic, fast-paced environment with shifting priorities
- Self-motivated and accountable, with a collaborative mindset
Additional Information
- Ability to stand for prolonged periods and perform repetitive tasks inherent to laboratory work.
About BOSTONGENE: BostonGene is redefining cancer patient care and drug development through the integration of omnimodal data and artificial intelligence. Built and validated through an extensive real-world clinical testing network, BostonGene’s Foundation Model of cancer and the immune system integrates genomic, transcriptomic, and immune data with clinical outcomes to generate biologically grounded, actionable insights. These insights enable biopharma partners to design and de-risk trials, identify novel targets, and optimize therapeutic response prediction across all stages of development while simultaneously improving patient care through clinically integrated innovation.
Position Overview
BostonGene is seeking a bench Scientist to join our R&D next-generation sequencing (NGS) team in our laboratory located in Waltham, MA. This candidate will support assay development and technical transfer in collaboration with immunology, production, and bioinformatics teams. The candidate will be expected to support NGS protocols, such as RNA and DNA isolation from tissue, cell-free DNA isolation from plasma, library preparation, QC, and other lab processes. The role will primarily require laboratory bench work (70-80%) in a BSL-2 laboratory.
Key Responsibilities:
- Perform assay and product development experiments of NGS workflows, including WGS, WES, and liquid biopsy assays for internal and external collaborators
- Troubleshoot and support the technical transfer of workflows to the production lab
- Maintain detailed and accurate records in LIMS, ELN, and in compliance with laboratory protocols and regulatory requirements
- Assist in the development of laboratory SOPs and batch records
- Execute and assist with validation studies, bridging studies, and technical reports
- Stay informed on emerging technologies and trends in NGS to support innovation in assay development
Qualifications
- Ph.D. in life sciences or related discipline with 0–3 years of relevant experience, OR M.S. with 3–6 years, OR B.S. with 6–10 years of hands-on experience. (The job title will be commensurate with experience.)
- Strong experience in nucleic acid extraction (DNA/RNA) from FFPE, blood, or other clinical samples
- Proficiency in NGS library prep (short-read and/or long-read), including WGS and WES
- Excellent problem-solving and troubleshooting skills
- Strong organizational skills with the ability to manage sample tracking, documentation, and inventory
Preferred Skills & Experience:
- Experience working with liquid biopsy samples (cfDNA/ctDNA, cfRNA, or exosomes)
- Familiarity with NGS QC metrics and analysis tools
- Understanding of assay validation in regulated environments (GCLP, ISO)
- Demonstrated experience in SOP development and process documentation
- Strong verbal and written communication skills, with the ability to work effectively in cross-functional teams
- Proven ability to work in a dynamic, fast-paced environment with shifting priorities
- Self-motivated and accountable, with a collaborative mindset
Additional Information
- Ability to stand for prolonged periods and perform repetitive tasks inherent to laboratory work.
Senior Clinical Research Scientist CPT: Frequently Asked Questions
Does a Senior Clinical Research Scientist role qualify for CPT?
Yes, if your degree program includes research methods, clinical trial design, biostatistics, or regulatory affairs coursework that the role directly applies. Your DSO must confirm the connection between the specific job duties and your curriculum. Roles in protocol development, data monitoring, or IND submission work are typically strong matches for graduate life sciences programs.
Can I do full-time CPT as a Senior Clinical Research Scientist?
You can, but full-time CPT of 12 months or more eliminates your OPT eligibility entirely. Many F-1 students in clinical research pursue part-time CPT during semesters and switch to full-time during breaks to protect OPT. Discuss the tradeoff with your DSO before accepting a full-time offer, especially if you plan to pursue H-1B sponsorship after graduation.
What documents do I need for CPT authorization in this field?
You'll need a formal offer letter with your title, start date, hours per week, and supervisor details; a written statement from your academic advisor linking the role to your degree requirements; and your current I-20. Some DSOs also require a course registration showing the CPT is tied to a specific academic credit. Get these ready before contacting your DSO so the process moves quickly.
Which employers regularly hire F-1 students for clinical research roles?
Pharmaceutical companies, contract research organizations, academic medical centers, and mid-size biotech firms are the most active hirers for this role. Migrate Mate surfaces employers with documented DOL Labor Condition Application filing history for clinical research scientist positions, so you can identify which companies have a real track record of sponsoring F-1 and visa-sponsored hires rather than guessing from job postings alone.
How does CPT as a Senior Clinical Research Scientist affect my H-1B path?
CPT itself doesn't affect H-1B eligibility as long as you don't exceed 12 months of full-time CPT. After graduation, you'd transition to OPT or STEM OPT while your employer files an H-1B petition. Clinical research roles typically qualify as specialty occupations under USCIS standards, since the position requires a directly related bachelor's degree or higher in a life sciences field.
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