Senior Level Director of Compliance Jobs
Senior level director of compliance jobs place seasoned professionals in charge of enterprise-wide compliance programs, regulatory strategy, and the cross-functional teams that carry those mandates into practice. Openings concentrate in Education, Insurance, and Manufacturing, with a mix of on-site, hybrid, and remote roles, and employers like KARDIGAN, Lumafield, and Capital One hiring at this level now.
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About us
Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world.
It is Kardigan's mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve.
Led by Tassos Gianakakos, Jay Edelberg, M.D., Ph.D., and Bob McDowell, Ph.D., Kardigan's co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020.
We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients.
At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families, we are deeply committed to improving the lives of patients and prioritizing their needs above all else. We believe in being authentic—leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn, we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit. Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries.
These values are the foundation of our work, empowering us to make a real difference, every day.
Location: Princeton, NJ (preferred) or South San Francisco, CA
Job Overview
Kardigan is seeking a Head of GxP Compliance to support the company's growth toward becoming a global, multi-product commercial-stage biopharmaceutical company. This position will be responsible for overseeing the development, implementation, and management of GxP compliance activities, including internal and external audits, inspection readiness and management, regulatory surveillance, and other compliance programs and initiatives as needed. This position will play a critical role in maintaining regulatory compliance, fostering a culture of quality, and ensuring that our products and clinical trial activities are compliant with applicable regulations. This position will report to the Chief Quality Officer.
Key Responsibilities:
- Provide direction and planning for build out of the GxP Compliance team in alignment with business objectives to ensure that appropriate staffing and capabilities are in place to protect patient safety and product quality through phased development and commercialization
- Lead, working in collaboration with Quality stakeholders, the establishment and iterative improvement of GxP Compliance processes and systems, including:
- GxP Audit Program: develop and execute annual risk-based internal and external audit schedule across all GxP areas (GCP, GLP, GDP/GMP, GVP); manage external audits from regulatory agencies and other stakeholders, coordinating responses and follow-up actions; analyze audit findings to identify trends and drive continuous improvement
- Inspection Readiness and Management: develop training programs for GxP compliance; ensure the organization is prepared for regulatory inspections by establishing inspection readiness programs and conducting mock inspections; establish tools and processes for on-site and remote inspection management
- External Monitoring and Engagement: working with cross-functional stakeholders establish processes for regulatory surveillance to ensure the organization stays abreast of GxP regulatory requirements and trends; coordinate external engagement activities enabling Kardigan to have a "seat at the table" in key industry forums
- GxP Compliance Processes and Reporting: direct the development and maintenance of GxP compliance documentation (policies, procedures, records), processes and metrics; prepare regular reports for management review and senior leadership on compliance status
- Contribute to cross-functional and enterprise level initiatives, for example:
- Compliance Governance: in conjunction with Legal, provide support for the establishment of enterprise level practices
- Quality Management System: support continuous improvement of the Kardigan QMS by providing regulatory intelligence and audit insights
- Promote a culture of quality and compliance mindset, continuous improvement and cross-functional problem-solving.
- Represent company in external forums to advocate company positions and facilitate adoption of evolving expectations and state of the art practices
- Maintain flexibility to perform other functional or company-wide or industry-related activities or projects as assigned
Basic Qualifications:
- Bachelor's degree in a life science or healthcare field
- Minimum of 10 years of experience in GxP Compliance, quality assurance and/or clinical operations within the pharma/biotech industry
- Proven track record establishing and developing high performing teams, including strong experience with people management and talent development
- Strong knowledge of FDA/EU/ICH requirements across GxP areas. Ability to assess compliance to regulations and industry expectations, including phase appropriate controls and readiness
- Experience in leading regulatory inspections (running front and back rooms) and setting up inspection readiness programs
- Proven track record of establishing excellent relationships and partnerships within Quality and across Development and Technical Operations to proactively build quality and compliance into standard practices and mindsets
- Able to apply a risk-based analysis to quality and compliance issues with a demonstrated creativity and flexibility in developing solutions that satisfy both business requirements and legal obligations
- Able to collaborate and communicate well with all levels of employees, including peers, executives and cross-functionally
Preferred Qualifications:
- Advanced degree in a life science or healthcare field
- Experience in all clinical phases through commercialization
About us
Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world.
It is Kardigan's mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve.
Led by Tassos Gianakakos, Jay Edelberg, M.D., Ph.D., and Bob McDowell, Ph.D., Kardigan's co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020.
We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients.
At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families, we are deeply committed to improving the lives of patients and prioritizing their needs above all else. We believe in being authentic—leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn, we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit. Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries.
These values are the foundation of our work, empowering us to make a real difference, every day.
Location: Princeton, NJ (preferred) or South San Francisco, CA
Job Overview
Kardigan is seeking a Head of GxP Compliance to support the company's growth toward becoming a global, multi-product commercial-stage biopharmaceutical company. This position will be responsible for overseeing the development, implementation, and management of GxP compliance activities, including internal and external audits, inspection readiness and management, regulatory surveillance, and other compliance programs and initiatives as needed. This position will play a critical role in maintaining regulatory compliance, fostering a culture of quality, and ensuring that our products and clinical trial activities are compliant with applicable regulations. This position will report to the Chief Quality Officer.
Key Responsibilities:
- Provide direction and planning for build out of the GxP Compliance team in alignment with business objectives to ensure that appropriate staffing and capabilities are in place to protect patient safety and product quality through phased development and commercialization
- Lead, working in collaboration with Quality stakeholders, the establishment and iterative improvement of GxP Compliance processes and systems, including:
- GxP Audit Program: develop and execute annual risk-based internal and external audit schedule across all GxP areas (GCP, GLP, GDP/GMP, GVP); manage external audits from regulatory agencies and other stakeholders, coordinating responses and follow-up actions; analyze audit findings to identify trends and drive continuous improvement
- Inspection Readiness and Management: develop training programs for GxP compliance; ensure the organization is prepared for regulatory inspections by establishing inspection readiness programs and conducting mock inspections; establish tools and processes for on-site and remote inspection management
- External Monitoring and Engagement: working with cross-functional stakeholders establish processes for regulatory surveillance to ensure the organization stays abreast of GxP regulatory requirements and trends; coordinate external engagement activities enabling Kardigan to have a "seat at the table" in key industry forums
- GxP Compliance Processes and Reporting: direct the development and maintenance of GxP compliance documentation (policies, procedures, records), processes and metrics; prepare regular reports for management review and senior leadership on compliance status
- Contribute to cross-functional and enterprise level initiatives, for example:
- Compliance Governance: in conjunction with Legal, provide support for the establishment of enterprise level practices
- Quality Management System: support continuous improvement of the Kardigan QMS by providing regulatory intelligence and audit insights
- Promote a culture of quality and compliance mindset, continuous improvement and cross-functional problem-solving.
- Represent company in external forums to advocate company positions and facilitate adoption of evolving expectations and state of the art practices
- Maintain flexibility to perform other functional or company-wide or industry-related activities or projects as assigned
Basic Qualifications:
- Bachelor's degree in a life science or healthcare field
- Minimum of 10 years of experience in GxP Compliance, quality assurance and/or clinical operations within the pharma/biotech industry
- Proven track record establishing and developing high performing teams, including strong experience with people management and talent development
- Strong knowledge of FDA/EU/ICH requirements across GxP areas. Ability to assess compliance to regulations and industry expectations, including phase appropriate controls and readiness
- Experience in leading regulatory inspections (running front and back rooms) and setting up inspection readiness programs
- Proven track record of establishing excellent relationships and partnerships within Quality and across Development and Technical Operations to proactively build quality and compliance into standard practices and mindsets
- Able to apply a risk-based analysis to quality and compliance issues with a demonstrated creativity and flexibility in developing solutions that satisfy both business requirements and legal obligations
- Able to collaborate and communicate well with all levels of employees, including peers, executives and cross-functionally
Preferred Qualifications:
- Advanced degree in a life science or healthcare field
- Experience in all clinical phases through commercialization
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Senior Level Director of Compliance Jobs: Frequently Asked Questions
How do I get a senior level director of compliance job?
Employers at this level expect candidates who have owned compliance programs end to end, not just supported them. Demonstrating that you have built or redesigned a regulatory framework, led audits with board-level visibility, and mentored junior compliance staff gives you a clear edge. Certifications like a CHC, CCEP, or CRCM reinforce technical depth, and a history of cross-functional leadership signals readiness for the director role.
Which companies hire senior level director of compliances?
Companies hiring senior level director of compliances right now include KARDIGAN, Lumafield, and Capital One, based on current listings on Migrate Mate as of November 2026. Hiring at this level tends to come from large regulated enterprises in financial services, healthcare, and technology, as well as consulting firms that staff compliance leadership roles on behalf of clients.
Are there remote senior level director of compliance jobs?
Yes, though availability depends on the employer and industry. About 20% of senior level director of compliance openings are remote or hybrid as of November 2026, reflecting broader adoption of flexible arrangements for senior individual contributors and people managers alike. Highly regulated industries such as banking and healthcare still lean toward on-site or hybrid expectations for director-level roles.
What makes a director of compliance role senior level?
Senior level director of compliance roles carry ownership of the full compliance program rather than a slice of it. That means setting regulatory strategy, managing relationships with regulators and executive leadership, and being accountable for outcomes across business units. These roles also involve developing and mentoring compliance staff, driving policy design, and exercising independent judgment on complex risk and regulatory questions without close oversight.
Which industries hire the most senior level director of compliances?
Senior Level director of compliance roles concentrate in Education, Insurance, and Manufacturing, based on current listings on Migrate Mate as of November 2026. These sectors operate under dense regulatory environments where a dedicated senior compliance leader is a structural necessity rather than a discretionary hire, driving consistent demand at the director level.