E-3 Visa Translator Jobs
Translator roles qualify for E-3 visa sponsorship when the position requires a bachelor's degree in linguistics, translation, or a related field. Australian nationals can secure employer-sponsored E-3 status with no lottery and indefinite two-year renewals, making this one of the most stable paths into U.S. language services work.
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Get Access To All JobsINTRODUCTION
The Translational Science and Early Clinical Development (TSECD) department delivers seamless, end-to-end translational evidence for our Respiratory & Immunology (R&I) portfolio: robust human target validation, development and execution of early clinical development plans with clear evidence of target engagement and pharmacology, and deeper understanding of the mechanism of action for programs in clinical development via biomarker-driven insights.
The Translational Science Lead (TSL) is a key role within TSECD, accountable for the development and execution of the translational strategies for portfolio projects, underpinned by a deep understanding of disease relevant pathways and drivers. This includes human target validation plans at the time of target selection, strategies for target engagement and delivering evidence for proof-of-mechanism (PoM) in early clinical trials and deepening our understanding of the mechanism of action and patient selection during clinical development.
The Translational Science Lead is a project facing role, collaborating closely with biosciences during preclinical development to support human target validation packages, and leading biomarker data exploration in non-interventional cohorts and via back-translated clinical trials. As the program moves into the clinic, the TSL contributes significantly to clinical development including but not limited to application of target engagement assays, developing and executing an appropriate biomarker sampling strategy, and enabling the evaluation of key novel biomarkers by facilitating assay transfer and execution in the clinical trial setting. As a program progresses in clinical development, TSLs are the key scientific voice on project teams, enabling product development and launch through generation of the mechanistic differentiation and scientific evidence package for our assets, and providing robust scientific reasons to believe for lifecycle opportunities.
Accountabilities and responsibilities:
- Develop and integrate translational science strategies for R&I projects and clinical studies, including accountability for human target validation, target engagement and precision medicine.
- Build mechanistic understanding of the target and disease through designing and leading innovative application of experimental methods and technologies.
- Establish the translational evidence package for new targets utilizing public and proprietary biobanks to better understand responding sub populations, biomarkers and the biology of our drug targets.
- Integrate and interpret clinical, biomarker, and multi-omics data to generate mechanistic and translational insights that enhance patient outcomes.
- Partnering with data science to enable AI/ML strategies to discover mechanisms, biomarkers and patient phenotypes.
- Identifying and enabling PoM biomarkers to demonstrate target engagement at First-Time-In-Human clinical trials.
- Delivering precision medicine strategies to identify the patients most likely to benefit from our medicines, including early molecular biomarker assay development planning if common clinical features are not sufficient for precision medicine.
- Represent TSECD’s translational strategy through investment decisions and governance interactions and facilitate cross-functional communication to enable accurate execution.
- Integrate translational strategy into key clinical documents.
- Clinical Study Protocols, Informed Consent Forms, Sample Life Cycle Plans, Case Report Forms, local Health Authority applications, Human Genetic Resources, Clinical Study Reports.
- Contribute to regulatory and health authority responses, author Submission document sections relating to Mode of Action, PK/PD, precision medicine.
- Prepare and review scientific publications to support publication and marketing strategies.
MINIMUM REQUIREMENTS – EDUCATION AND EXPERIENCE:
- PhD or MD equivalent with a strong experimental drive and background in relevant scientific field
- Post-doc experience or otherwise relevant scientific research experience
- Minimum 5 years of experience in a Biomedical or Pharmaceutical role
- Experience in an academic and/or industry setting
- Strong publication record
DESIRABLE SKILLS/EXPERIENCE:
- 8+ years of experience in a Scientific role within the Biomedical or Pharmaceutical Industry
- Experience leading projects
- Experience from clinical trials
EXPERIENCE AND SKILLS
- Proven ability to deliver translational readouts and human target validation and their application to drug discovery.
- Excellent understanding of the Respiratory therapy area including but not limited to COPD, Asthma, NCFBE and IPF/ILDs, and disease biology, including related molecular pathways and mechanisms.
- Experience and knowledge of the biological basis for target engagement biomarkers and familiar with PoM biomarker invention and implementation.
- Experience and knowledge of the biological basis for patient stratification and precision medicine, and familiar with patient selection biomarker invention and implementation.
- Broad understanding of relevant technologies and methodologies along with excellent scientific skills and ability to design experiments to address key scientific questions.
- Excellent skills in hypothesis forming and testing and able to draw conclusions and suggest next steps based on the experimental data.
- Shown experience and solid understanding of pharmacology, translational medicine and clinical sciences as well as clinical development with pre-eminence in at least one of these areas.
- Demonstrated leadership skills, ability to be a self-starter.
- Strong team working skills with a proven track record of working collaboratively to ensure scientific excellence and robust delivery to projects.
- Excellent written, oral, presentation and interpersonal skills.
COMPENSATION
- The annual base pay for this position ranges from $175,498.40 - $263,247.60 USD Annual. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
At AstraZeneca, we champion a perspective of excellence. Our environment is driven by a belief that good can always be better. We continuously seek opportunities to contribute by harnessing science and evidence to foresee risks. It's a place where innovation thrives as we find new ways to improve outcomes for patients. With a focus on growth and innovation, there are always exciting products to quality assure as we go to market globally.
Ready to make a difference? Apply now to join our team!
LI-Hybrid
INTRODUCTION
The Translational Science and Early Clinical Development (TSECD) department delivers seamless, end-to-end translational evidence for our Respiratory & Immunology (R&I) portfolio: robust human target validation, development and execution of early clinical development plans with clear evidence of target engagement and pharmacology, and deeper understanding of the mechanism of action for programs in clinical development via biomarker-driven insights.
The Translational Science Lead (TSL) is a key role within TSECD, accountable for the development and execution of the translational strategies for portfolio projects, underpinned by a deep understanding of disease relevant pathways and drivers. This includes human target validation plans at the time of target selection, strategies for target engagement and delivering evidence for proof-of-mechanism (PoM) in early clinical trials and deepening our understanding of the mechanism of action and patient selection during clinical development.
The Translational Science Lead is a project facing role, collaborating closely with biosciences during preclinical development to support human target validation packages, and leading biomarker data exploration in non-interventional cohorts and via back-translated clinical trials. As the program moves into the clinic, the TSL contributes significantly to clinical development including but not limited to application of target engagement assays, developing and executing an appropriate biomarker sampling strategy, and enabling the evaluation of key novel biomarkers by facilitating assay transfer and execution in the clinical trial setting. As a program progresses in clinical development, TSLs are the key scientific voice on project teams, enabling product development and launch through generation of the mechanistic differentiation and scientific evidence package for our assets, and providing robust scientific reasons to believe for lifecycle opportunities.
Accountabilities and responsibilities:
- Develop and integrate translational science strategies for R&I projects and clinical studies, including accountability for human target validation, target engagement and precision medicine.
- Build mechanistic understanding of the target and disease through designing and leading innovative application of experimental methods and technologies.
- Establish the translational evidence package for new targets utilizing public and proprietary biobanks to better understand responding sub populations, biomarkers and the biology of our drug targets.
- Integrate and interpret clinical, biomarker, and multi-omics data to generate mechanistic and translational insights that enhance patient outcomes.
- Partnering with data science to enable AI/ML strategies to discover mechanisms, biomarkers and patient phenotypes.
- Identifying and enabling PoM biomarkers to demonstrate target engagement at First-Time-In-Human clinical trials.
- Delivering precision medicine strategies to identify the patients most likely to benefit from our medicines, including early molecular biomarker assay development planning if common clinical features are not sufficient for precision medicine.
- Represent TSECD’s translational strategy through investment decisions and governance interactions and facilitate cross-functional communication to enable accurate execution.
- Integrate translational strategy into key clinical documents.
- Clinical Study Protocols, Informed Consent Forms, Sample Life Cycle Plans, Case Report Forms, local Health Authority applications, Human Genetic Resources, Clinical Study Reports.
- Contribute to regulatory and health authority responses, author Submission document sections relating to Mode of Action, PK/PD, precision medicine.
- Prepare and review scientific publications to support publication and marketing strategies.
MINIMUM REQUIREMENTS – EDUCATION AND EXPERIENCE:
- PhD or MD equivalent with a strong experimental drive and background in relevant scientific field
- Post-doc experience or otherwise relevant scientific research experience
- Minimum 5 years of experience in a Biomedical or Pharmaceutical role
- Experience in an academic and/or industry setting
- Strong publication record
DESIRABLE SKILLS/EXPERIENCE:
- 8+ years of experience in a Scientific role within the Biomedical or Pharmaceutical Industry
- Experience leading projects
- Experience from clinical trials
EXPERIENCE AND SKILLS
- Proven ability to deliver translational readouts and human target validation and their application to drug discovery.
- Excellent understanding of the Respiratory therapy area including but not limited to COPD, Asthma, NCFBE and IPF/ILDs, and disease biology, including related molecular pathways and mechanisms.
- Experience and knowledge of the biological basis for target engagement biomarkers and familiar with PoM biomarker invention and implementation.
- Experience and knowledge of the biological basis for patient stratification and precision medicine, and familiar with patient selection biomarker invention and implementation.
- Broad understanding of relevant technologies and methodologies along with excellent scientific skills and ability to design experiments to address key scientific questions.
- Excellent skills in hypothesis forming and testing and able to draw conclusions and suggest next steps based on the experimental data.
- Shown experience and solid understanding of pharmacology, translational medicine and clinical sciences as well as clinical development with pre-eminence in at least one of these areas.
- Demonstrated leadership skills, ability to be a self-starter.
- Strong team working skills with a proven track record of working collaboratively to ensure scientific excellence and robust delivery to projects.
- Excellent written, oral, presentation and interpersonal skills.
COMPENSATION
- The annual base pay for this position ranges from $175,498.40 - $263,247.60 USD Annual. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
At AstraZeneca, we champion a perspective of excellence. Our environment is driven by a belief that good can always be better. We continuously seek opportunities to contribute by harnessing science and evidence to foresee risks. It's a place where innovation thrives as we find new ways to improve outcomes for patients. With a focus on growth and innovation, there are always exciting products to quality assure as we go to market globally.
Ready to make a difference? Apply now to join our team!
LI-Hybrid
See all 19+ Translator jobs
Sign up for free to unlock all listings, filter by visa type, and get alerts for new Translator roles.
Get Access To All JobsTips for Finding E-3 Visa Sponsorship as a Translator
Translate your Australian credentials for U.S. employers
A three-year Australian bachelor's degree in linguistics or translation is generally accepted as equivalent to a U.S. four-year degree for E-3 purposes. Get a credential evaluation letter ready before you apply so employers aren't left guessing.
Target industries with ongoing multilingual compliance needs
Legal, healthcare, and federal contractor employers maintain standing translation needs and are familiar with sponsoring specialty occupation visas. These sectors file LCAs regularly and are less likely to treat sponsorship as an obstacle.
Confirm the job description requires a specific degree field
E-3 sponsorship hinges on specialty occupation status. A posting that accepts any bachelor's degree won't support your visa. Ask hiring managers to confirm the role requires a degree in linguistics, translation, or a directly related discipline before you advance.
Use Migrate Mate's E-3 filing service to handle your LCA and visa paperwork
The LCA must be DOL-certified before your consulate appointment, and the sequencing matters. Migrate Mate's E-3 filing service manages the entire process from offer to consulate appointment, so neither you nor your employer misses a step.
Prepare language proficiency evidence before the consulate interview
Consular officers assess whether your qualifications genuinely support the role. Bring degree transcripts, any professional certification in your language pair, and a brief written explanation of how your specific language combination maps to the job duties.
Clarify remote and on-site work locations with your employer early
The LCA locks in a specific worksite address. If your translation role could shift between locations or include remote work across states, your employer needs to file additional LCA certifications with DOL before you begin working at each new site.
Translator jobs are hiring across the US. Find yours.
Find Translator JobsTranslator E-3 Visa: Frequently Asked Questions
How do I find Translator jobs that offer E-3 visa sponsorship?
Migrate Mate is built specifically for Australian professionals searching for E-3 sponsorship roles. It filters Translator positions by employers who already understand specialty occupation requirements, saving you from cold-pitching companies unfamiliar with the E-3 process. Start your search there before reaching out to individual employers.
How much does it cost to get an E-3 visa?
Migrate Mate's E-3 filing service covers the entire process for $499, including the Labor Condition Application, visa document preparation, and consulate appointment guidance. Traditional immigration lawyers charge $2,000–$5,000+ for the same work. The E-3 has less paperwork than most work visas, so paying thousands for legal help is usually unnecessary.
Does a Translator role qualify as a specialty occupation for the E-3?
Yes, provided the employer requires a bachelor's degree in linguistics, translation, or a closely related field as a genuine minimum for the position. Roles that accept any degree or substitute experience freely may not satisfy the specialty occupation standard. The job description language matters, and vague postings can create problems at the consulate.
How does the E-3 compare to the H-1B for Australian translators?
The E-3 is available only to Australian citizens and has no lottery, no annual cap pressure, and a faster path to starting work. The H-1B requires entering a randomized lottery with roughly a one-in-four selection rate. For Australians, the E-3 is the more direct and reliable route into U.S. translation roles.
Can I switch translation specialisations or employers after starting on an E-3?
You can change employers, but your new employer must file a fresh LCA with DOL and you'll need a new E-3 visa stamp if you travel internationally after the change. Switching language pairs or subject matter specialisations within the same employer is generally fine, as long as the core role still qualifies as a specialty occupation.
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