Green Card Clinical Operations Lead Jobs
Clinical Operations Lead roles at U.S. clinical research organizations, biotech firms, and hospital networks regularly qualify for EB-2 and EB-3 green card sponsorship through PERM labor certification. Employers file on your behalf, certifying the role requires a specialized degree and that no qualified U.S. worker is available for the position.
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Get Access To All JobsWhy Sarepta? Why Now?
The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.
We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.
What Sarepta Offers
At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:
- Physical and Emotional Wellness
- Financial Wellness
- Support for Caregivers
For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us
The Importance of the Role
The Associate Director, Clinical Operations Program Lead, Study Start-up and Feasibility will report to the Director, Patient Recruitment and Start-Up Strategy and lead a team to drive the strategy and implementation of feasibility and study start-up across all clinical programs.
The Opportunity to Make a Difference
We are seeking an associate director-level candidate with clinical operations experience, with specific expertise in feasibility and study start-up, who is interested in applying their experience to develop, build out, and implement innovative feasibility and study start-up activities within Sarepta that positively impact our clinical programs.
The Associate Director, Clinical Operations Program Lead, Study Start-up and Feasibility will report to the Director, Patient Recruitment and Start-Up Strategy and will lead a team to drive the strategy and implementation of country and site feasibility for our studies and support the internalization of country and site feasibility. The candidate will drive study start-up activities and be responsible for oversight of timelines and goals with respect to our clinical studies. The candidate will be responsible for directing and overseeing the success of Sarepta’s clinical trial feasibility process, leading the development of feasibility and start-up strategies, including study-specific plans, and directing and overseeing the success of Sarepta’s clinical trial start-up activities.
This is a highly cross-functional position, requiring collaboration with internal teams, CROs, and vendors. The candidate must be comfortable working directly with clinical trial sites.
The contribution of the candidate directly supports the goals of the Development Operations organization under R&D.
This is a great opportunity for an individual with an operational background and innovative mindset to help us accelerate study execution to support Sarepta’s goal of Patient’s First.
More about You
Primary Responsibilities Include:
- Develop and implement feasibility and start-up strategies to support the success of Sarepta’s clinical studies.
- Oversee study feasibility activities, including country, site, and investigator selection for participation in Sarepta clinical studies.
- Gather cross-functional, country-level input to inform robust feasibility strategies.
- Develop and manage integrated feasibility and site start-up timelines, and report on progress, including plans to address potential timing risks or gaps.
- Establish study-specific meetings to review clinical trial feasibility data and start-up activities with study leads, MSLs, and the CRO; report metrics to broader teams, including senior management.
- Lead calls with Sarepta and CRO partners to manage feasibility and study start-up activities and ensure study timelines are achieved.
- Foster a culture of innovation by developing new ideas and programs to advance feasibility and support departmental growth.
- Provide guidance and mentorship to junior members of the Study Start-up and Feasibility team.
- Create reporting tools to measure ongoing activities, as well as key performance, quality, and effectiveness indicators.
- Partner with Clinical Operations, CRO teams, and other key stakeholders to implement innovative feasibility initiatives, including data collection within CTMS.
- Support and/or lead the development of charters and SOPs related to Study Start-up and Feasibility.
- May have direct reports.
Desired Education and Skills:
- BA/BS degree in a related field; 10+ years related experience in the pharmaceutical or biotech industry within a clinical operations or project management role or similar
- Experience in clinical study budget planning, and program implementation
- Experience with both direct line management and dotted line reporting
- Experience in developing feasibility questionnaires
- Experience with protocol and ICF development and review
- Experience in clinical study start-up
- Experience with rare disease / difficult to recruit populations a plus
- Experience identifying and managing multiple CROs, vendors, budgets, KPIs
- Comprehensive regulatory knowledge, including ICH and GCPs
- Exceptional organizational skills and ability to deal with competing priorities
- Strong analytical reasoning and problem-solving ability
- Excellent PowerPoint slide development and presentation skills
- Ability to multi-task, work independently and as part of a multidisciplinary team, exercise sound judgement and escalate issues when necessary
What Now?
We’re always looking for solution-oriented, critical thinkers.
So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.
LI-Hybrid
This position is hybrid, you will be expected to work on site at one of Sarepta’s facilities in the United States and/or attend Company-sponsored in-person events from time to time.
The targeted salary range for this position is $160,800 - $201,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.
Candidates must be authorized to work in the U.S.
Sarepta Therapeutics offers a competitive compensation and benefit package.
Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.
Why Sarepta? Why Now?
The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.
We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.
What Sarepta Offers
At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:
- Physical and Emotional Wellness
- Financial Wellness
- Support for Caregivers
For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us
The Importance of the Role
The Associate Director, Clinical Operations Program Lead, Study Start-up and Feasibility will report to the Director, Patient Recruitment and Start-Up Strategy and lead a team to drive the strategy and implementation of feasibility and study start-up across all clinical programs.
The Opportunity to Make a Difference
We are seeking an associate director-level candidate with clinical operations experience, with specific expertise in feasibility and study start-up, who is interested in applying their experience to develop, build out, and implement innovative feasibility and study start-up activities within Sarepta that positively impact our clinical programs.
The Associate Director, Clinical Operations Program Lead, Study Start-up and Feasibility will report to the Director, Patient Recruitment and Start-Up Strategy and will lead a team to drive the strategy and implementation of country and site feasibility for our studies and support the internalization of country and site feasibility. The candidate will drive study start-up activities and be responsible for oversight of timelines and goals with respect to our clinical studies. The candidate will be responsible for directing and overseeing the success of Sarepta’s clinical trial feasibility process, leading the development of feasibility and start-up strategies, including study-specific plans, and directing and overseeing the success of Sarepta’s clinical trial start-up activities.
This is a highly cross-functional position, requiring collaboration with internal teams, CROs, and vendors. The candidate must be comfortable working directly with clinical trial sites.
The contribution of the candidate directly supports the goals of the Development Operations organization under R&D.
This is a great opportunity for an individual with an operational background and innovative mindset to help us accelerate study execution to support Sarepta’s goal of Patient’s First.
More about You
Primary Responsibilities Include:
- Develop and implement feasibility and start-up strategies to support the success of Sarepta’s clinical studies.
- Oversee study feasibility activities, including country, site, and investigator selection for participation in Sarepta clinical studies.
- Gather cross-functional, country-level input to inform robust feasibility strategies.
- Develop and manage integrated feasibility and site start-up timelines, and report on progress, including plans to address potential timing risks or gaps.
- Establish study-specific meetings to review clinical trial feasibility data and start-up activities with study leads, MSLs, and the CRO; report metrics to broader teams, including senior management.
- Lead calls with Sarepta and CRO partners to manage feasibility and study start-up activities and ensure study timelines are achieved.
- Foster a culture of innovation by developing new ideas and programs to advance feasibility and support departmental growth.
- Provide guidance and mentorship to junior members of the Study Start-up and Feasibility team.
- Create reporting tools to measure ongoing activities, as well as key performance, quality, and effectiveness indicators.
- Partner with Clinical Operations, CRO teams, and other key stakeholders to implement innovative feasibility initiatives, including data collection within CTMS.
- Support and/or lead the development of charters and SOPs related to Study Start-up and Feasibility.
- May have direct reports.
Desired Education and Skills:
- BA/BS degree in a related field; 10+ years related experience in the pharmaceutical or biotech industry within a clinical operations or project management role or similar
- Experience in clinical study budget planning, and program implementation
- Experience with both direct line management and dotted line reporting
- Experience in developing feasibility questionnaires
- Experience with protocol and ICF development and review
- Experience in clinical study start-up
- Experience with rare disease / difficult to recruit populations a plus
- Experience identifying and managing multiple CROs, vendors, budgets, KPIs
- Comprehensive regulatory knowledge, including ICH and GCPs
- Exceptional organizational skills and ability to deal with competing priorities
- Strong analytical reasoning and problem-solving ability
- Excellent PowerPoint slide development and presentation skills
- Ability to multi-task, work independently and as part of a multidisciplinary team, exercise sound judgement and escalate issues when necessary
What Now?
We’re always looking for solution-oriented, critical thinkers.
So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.
LI-Hybrid
This position is hybrid, you will be expected to work on site at one of Sarepta’s facilities in the United States and/or attend Company-sponsored in-person events from time to time.
The targeted salary range for this position is $160,800 - $201,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.
Candidates must be authorized to work in the U.S.
Sarepta Therapeutics offers a competitive compensation and benefit package.
Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.
See all Green Card Clinical Operations Lead Jobs
Sign up for free to unlock all listings, filter by visa type, and get alerts for new Green Card Clinical Operations Lead Jobs.
Get Access To All JobsTips for Finding Green Card Sponsorship in Clinical Operations Lead
Document your CRA and CRC credentials early
PERM requires your employer to verify your qualifications meet the job's minimum requirements. Gather transcripts, clinical research certifications like ACRP or SOCRA credentials, and employment records before your employer begins the labor certification filing.
Target employers with active PERM filing history
Not all CROs or biotech firms sponsor green cards regularly. Search OFLC PERM disclosure data to identify which organizations have certified Clinical Operations roles before, then prioritize those companies in your job search.
Clarify EB-2 versus EB-3 fit with your hiring manager
If the posted role requires a master's degree in a clinical or life sciences field, ask whether the employer will file under EB-2. That classification can meaningfully shorten your green card timeline depending on your country of birth.
Use Migrate Mate to find green card sponsoring roles
Filtering job boards manually for sponsorship willingness wastes time. Migrate Mate surfaces Clinical Operations Lead openings specifically at employers with PERM and I-140 sponsorship history, so you apply where the pathway already exists.
Negotiate the PERM job description before signing your offer
The labor certification locks in the role's minimum requirements. If your offer letter describes duties too narrowly or lists overly specific software requirements, ask HR to align the PERM job description with standard SOC occupational language before filing begins.
Understand how DOL audit risk affects your filing timeline
PERM applications for managerial clinical roles face higher DOL audit rates because of their hybrid oversight responsibilities. Ask your employer's immigration counsel whether they'll use a supervised or assisted recruitment approach to reduce audit exposure and processing delays.
Green Card Clinical Operations Lead: Frequently Asked Questions
Does a Clinical Operations Lead role qualify for EB-2 or EB-3 green card sponsorship?
Most Clinical Operations Lead positions qualify for EB-3 as skilled professional roles requiring at least a bachelor's degree in a clinical, biological, or health sciences field. If your employer structures the role to require a master's degree or you hold an advanced degree central to the duties, EB-2 may apply. Your employer's immigration counsel determines the category based on the actual job requirements, not your personal credentials alone.
How does PERM green card sponsorship differ from H-1B sponsorship for this role?
H-1B visa is a temporary status with a three-year initial period, annual cap exposure, and lottery risk. PERM-based green card sponsorship is a permanent residency pathway with no annual cap at the EB-3 level for most countries other than India and China. The trade-off is timeline: PERM labor certification, I-140 approval, and adjustment of status typically take two to four years for most nationalities, but the outcome is lawful permanent residency rather than another renewal cycle.
What does the PERM labor certification process actually require from my employer?
Your employer must conduct a supervised recruitment campaign documenting that no qualified U.S. worker is available for the role at the prevailing wage. DOL sets the prevailing wage based on your job title, duties, and work location using OFLC Wage Search data. For Clinical Operations Lead roles, employers typically run advertisements, post with state workforce agencies, and compile rejection logs before filing the ETA Form 9089 with DOL.
How do I find Clinical Operations Lead jobs where the employer will sponsor a green card?
Most job postings don't specify PERM sponsorship willingness. Migrate Mate filters roles specifically by employers with verified green card sponsorship history, including PERM filings for clinical operations titles. Searching that way means you're applying to companies that have already navigated the process, not hoping a recruiter will bring it up after the offer stage.
Can I switch employers after my I-140 is approved without losing my green card progress?
Yes, under AC21 portability rules, you can change employers after your I-140 has been approved and your adjustment of status application has been pending for at least 180 days, provided the new role is in the same or a similar occupational classification. Clinical operations management roles typically qualify as same or similar to each other. USCIS evaluates portability claims on the SOC code and duties, so document the overlap carefully before making a move.