Head of Software Jobs
Head of Software jobs are open across technology, fintech, healthtech, and enterprise SaaS, from engineering lead to VP-level, with specializations in platform engineering, product-led development, and distributed systems. Scan the live roles below and apply to whichever ones fit.
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A-Alpha Bio is an early-stage, rapidly growing biotechnology platform company headquartered in Seattle, WA. We are focused on building the foundational data layer for AI-driven protein engineering. We provide biopharma companies and model builders with access to ground truth experimental datasets, including affinity and structure, for training, benchmarking and validating AI protein models. In parallel, we apply our data and models directly with select partners to engineer next-generation dual-specific and molecular glue therapeutics, and to discover and optimize differentiated biologics.
Candidates local to Seattle are preferred, but remote applicants are welcome to apply. Candidates must reside in the United States.
Starting Salary Range: $190,000 - $232,000 annually
Exemption Status: Exempt
Location Expectations: Remote-Eligible (travel to Seattle HQ on a quarterly basis)
Reporting To: SVP, Data Science
Role Description
A-Alpha Bio is seeking a Head of Product to own our Atlas software platform: the web application, SDK, and APIs through which customers design experiments, access licensed datasets, and integrate them into machine learning workflows. In this role, you'll turn the vision set by our commercial leadership into a platform that delivers on that vision: owning product definition and delivery, as well as technical adoption and utilization. This is a hands-on, player-coach role and the first product hire for Atlas.
Key Responsibilities
From Strategy to Platform
- Translate the business vision and roadmap owned by our commercial team into a platform roadmap and a software experience.
- Bring platform feasibility, cost, and sequencing into commercial planning early enough to make an impact.
- Define and track platform and UX adoption and utilization metrics, such as active users, API and SDK usage, and integration depth.
- Define what we build versus buy, keeping a small team focused on maximizing platform value for customers.
Developer Experience
- Treat the data contract as a product: stable schemas, versioning, deprecation, and documentation.
- Design the path from first API call to production use, with samples, references, and self-serve tooling.
- Run discovery with platform users (engineering and scientific customers), turning their needs into requirements.
Product Definition & Delivery
- Communicate with engineering staff while iterating on experiment submission, data access and delivery, search, etc.
- Own platform releases across engineering, data science, laboratory systems, and provider integrations on a predictable cadence.
- Partner with engineering on architecture, scalability, and reliability tradeoffs.
Access, Security, & Integrations
- Own entitlements and access control, mapped exactly to customer agreements and robust under enterprise security review.
- Define requirements for provider and LIMS integrations that keep data flowing reliably into the platform.
Instrumentation & Team
- Build product analytics and usage telemetry from a near-standing start.
- Partner with the SVP, Data Science on hiring and scoping the team that will deliver on product, platform, and UX/design.
Qualifications & Experience
Required
- Bachelor's degree in computer science, engineering, or a related discipline with 8+ years of software product or technical program management experience, including 3+ years owning a developer-facing platform, API, or data product end-to-end; or an equivalent combination of education and experience.
- Track record of building and scaling software platforms for technical users, with measurable growth in adoption and usage.
- Experience owning API and SDK product decisions, including design, versioning and deprecation, and UX research and implementation.
- Ability to engage credibly with engineers on architecture, data systems, and technical tradeoffs, as well as directly with customers on UX.
- Track record of delivering a predictable cadence against external dependencies and partner timelines.
- Ability to operate hands-on, writing specs and shipping without a supporting product organization.
Preferred
- Work experience as a software engineer.
- Familiarity with life sciences, drug discovery, or laboratory data environments.
- Experience with data platforms or ML developer tooling, and familiarity with how ML teams consume training data.
- Experience with open-source engagement and productization.
- Experience with multi-tenant SaaS, entitlements, and enterprise security and procurement review.
- Experience at a startup or early-stage company, ideally as an early product hire.
- Hands-on experience with AI tools such as LLMs and agents for specification, prototyping, and analysis.
In 2018, A-Alpha Bio spun out of the University of Washington's Institute for Protein Design and Center for Synthetic Biology – both communities filled with brilliant and highly entrepreneurial scientists. Since the company's inception, we have built and scaled AlphaSeq, our high-throughput platform for quantitatively measuring protein-protein interactions at unprecedented scale. What began as a technology for generating large, standardized affinity datasets has grown into a broader data engine for AI-driven protein engineering. New members of the team should expect a fast-paced, highly dynamic, and interdisciplinary work environment. We are building a diverse, meritocratic, and supportive team that shares our values of speaking the truth, shooting for the moon, taking the reins, playing for the team, and improving the world.
A-Alpha Bio is headquartered in a custom designed lab and office space in downtown Seattle's Belltown neighborhood. We are fortunate to be situated in a region that is renowned for its premier outdoor activities, including hiking, biking, climbing, skiing, kayaking, sailing, and more. At A-Alpha, you'll find many who love the outdoors, but also gamers, amateur chefs, explorers, sports fans, bakers, crafters, photographers, brewers, jetsetters, animal lovers, and artists. Whatever your passions, you belong at A-Alpha Bio!
A-Alpha Bio is an early-stage, rapidly growing biotechnology platform company headquartered in Seattle, WA. We are focused on building the foundational data layer for AI-driven protein engineering. We provide biopharma companies and model builders with access to ground truth experimental datasets, including affinity and structure, for training, benchmarking and validating AI protein models. In parallel, we apply our data and models directly with select partners to engineer next-generation dual-specific and molecular glue therapeutics, and to discover and optimize differentiated biologics.
Candidates local to Seattle are preferred, but remote applicants are welcome to apply. Candidates must reside in the United States.
Starting Salary Range: $190,000 - $232,000 annually
Exemption Status: Exempt
Location Expectations: Remote-Eligible (travel to Seattle HQ on a quarterly basis)
Reporting To: SVP, Data Science
Role Description
A-Alpha Bio is seeking a Head of Product to own our Atlas software platform: the web application, SDK, and APIs through which customers design experiments, access licensed datasets, and integrate them into machine learning workflows. In this role, you'll turn the vision set by our commercial leadership into a platform that delivers on that vision: owning product definition and delivery, as well as technical adoption and utilization. This is a hands-on, player-coach role and the first product hire for Atlas.
Key Responsibilities
From Strategy to Platform
- Translate the business vision and roadmap owned by our commercial team into a platform roadmap and a software experience.
- Bring platform feasibility, cost, and sequencing into commercial planning early enough to make an impact.
- Define and track platform and UX adoption and utilization metrics, such as active users, API and SDK usage, and integration depth.
- Define what we build versus buy, keeping a small team focused on maximizing platform value for customers.
Developer Experience
- Treat the data contract as a product: stable schemas, versioning, deprecation, and documentation.
- Design the path from first API call to production use, with samples, references, and self-serve tooling.
- Run discovery with platform users (engineering and scientific customers), turning their needs into requirements.
Product Definition & Delivery
- Communicate with engineering staff while iterating on experiment submission, data access and delivery, search, etc.
- Own platform releases across engineering, data science, laboratory systems, and provider integrations on a predictable cadence.
- Partner with engineering on architecture, scalability, and reliability tradeoffs.
Access, Security, & Integrations
- Own entitlements and access control, mapped exactly to customer agreements and robust under enterprise security review.
- Define requirements for provider and LIMS integrations that keep data flowing reliably into the platform.
Instrumentation & Team
- Build product analytics and usage telemetry from a near-standing start.
- Partner with the SVP, Data Science on hiring and scoping the team that will deliver on product, platform, and UX/design.
Qualifications & Experience
Required
- Bachelor's degree in computer science, engineering, or a related discipline with 8+ years of software product or technical program management experience, including 3+ years owning a developer-facing platform, API, or data product end-to-end; or an equivalent combination of education and experience.
- Track record of building and scaling software platforms for technical users, with measurable growth in adoption and usage.
- Experience owning API and SDK product decisions, including design, versioning and deprecation, and UX research and implementation.
- Ability to engage credibly with engineers on architecture, data systems, and technical tradeoffs, as well as directly with customers on UX.
- Track record of delivering a predictable cadence against external dependencies and partner timelines.
- Ability to operate hands-on, writing specs and shipping without a supporting product organization.
Preferred
- Work experience as a software engineer.
- Familiarity with life sciences, drug discovery, or laboratory data environments.
- Experience with data platforms or ML developer tooling, and familiarity with how ML teams consume training data.
- Experience with open-source engagement and productization.
- Experience with multi-tenant SaaS, entitlements, and enterprise security and procurement review.
- Experience at a startup or early-stage company, ideally as an early product hire.
- Hands-on experience with AI tools such as LLMs and agents for specification, prototyping, and analysis.
In 2018, A-Alpha Bio spun out of the University of Washington's Institute for Protein Design and Center for Synthetic Biology – both communities filled with brilliant and highly entrepreneurial scientists. Since the company's inception, we have built and scaled AlphaSeq, our high-throughput platform for quantitatively measuring protein-protein interactions at unprecedented scale. What began as a technology for generating large, standardized affinity datasets has grown into a broader data engine for AI-driven protein engineering. New members of the team should expect a fast-paced, highly dynamic, and interdisciplinary work environment. We are building a diverse, meritocratic, and supportive team that shares our values of speaking the truth, shooting for the moon, taking the reins, playing for the team, and improving the world.
A-Alpha Bio is headquartered in a custom designed lab and office space in downtown Seattle's Belltown neighborhood. We are fortunate to be situated in a region that is renowned for its premier outdoor activities, including hiking, biking, climbing, skiing, kayaking, sailing, and more. At A-Alpha, you'll find many who love the outdoors, but also gamers, amateur chefs, explorers, sports fans, bakers, crafters, photographers, brewers, jetsetters, animal lovers, and artists. Whatever your passions, you belong at A-Alpha Bio!
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Find Head of Software JobsHead of Software Job Market
Who's Hiring
Top Industries Hiring
- Banking & Financial Services
- Biotechnology & Pharmaceuticals
What Employers Look For
The qualifications that appear most often in head of software jobs.
- 7 or more years of software engineering experience including people management
- Demonstrated experience leading and scaling engineering teams of 10 or more
- Proficiency in modern cloud platforms such as AWS, GCP, or Azure
- Strong background in agile delivery practices and software development lifecycle
- Experience partnering with product and design leaders on roadmap planning
- Bachelor's degree in computer science, software engineering, or a related technical field
Tips for Your Head of Software Job Search
Quantify engineering org impact on your resume
Head of software roles require proof you've grown and managed teams, not just shipped code. Replace vague descriptions with concrete outcomes: team size you scaled, delivery velocity improvements, or infrastructure cost reductions you drove as the engineering lead.
Apply early to roles that fit
Migrate Mate lists head of software openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Tailor applications to company growth stage
A head of software at a Series B startup owns entirely different problems than one at a public enterprise. Read the job description for signals like 'build from scratch' or 'scale existing systems' and mirror that language in your resume summary and cover letter.
Prepare a cross-functional leadership narrative
Interviewers for head of software roles probe how you align engineering with product, design, and business goals. Prepare two or three stories where you resolved competing priorities across departments, not just technical decisions made within your own team.
Negotiate scope alongside compensation
Head of software candidates often focus only on base pay, but reporting structure, headcount authority, and budget ownership directly affect your ability to do the job. Clarify these before accepting an offer so there are no surprises in your first 90 days.
Follow up with a post-interview technical brief
After a final-round interview, send a one-page written summary of how you'd approach the team's most pressing engineering challenge. It's uncommon at this level and signals exactly the ownership mindset companies expect from a head of software.
Head of Software Jobs: Frequently Asked Questions
Which companies are hiring the most head of softwares?
The companies hiring the most head of softwares right now include KBKG, m3usa, and A-Alpha Bio, with the largest share of openings in California, Texas, and Georgia, based on current listings on Migrate Mate as of November 2026. Demand is especially strong at growth-stage technology companies and established enterprises modernizing their engineering organizations.
How many head of software jobs are remote?
About 67% of head of software openings are fully remote or hybrid as of November 2026, reflecting persistent flexibility at senior engineering leadership levels. Sub-areas like platform engineering, developer tooling, and distributed systems tend to have the highest share of remote-friendly roles, while consumer product and hardware-adjacent teams more often require in-office presence.
How do you become a head of software?
Most people reach a head of software role by progressing from individual contributor engineer to tech lead, then to engineering manager overseeing a team, and eventually to a director or head-level position with cross-team scope. Building credibility requires shipping meaningful products, developing other engineers, and demonstrating that you can align technical decisions with business outcomes over time.
Can you get a head of software job with limited leadership experience?
It's possible at smaller companies or early-stage startups where the first engineering leader builds the team from the ground up. If your formal management experience is limited, strengthen your case by highlighting informal leadership such as leading cross-functional projects, mentoring junior engineers, or owning an architectural decision that had significant business impact.
What does the head of software interview process look like?
The process typically starts with a recruiter screen, followed by a hiring manager conversation focused on your leadership philosophy and engineering background. Later rounds usually include a technical depth discussion with senior engineers, a cross-functional interview with product or design partners, and a final presentation to an executive where you outline how you'd approach the team's strategic challenges.
Where can I find and apply to head of software jobs?
You can find and apply to head of software jobs on Migrate Mate, which lists current openings from across the United States. Search the listings to find roles that match your experience and location preferences, then apply directly to each one that fits.
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