Senior Level Information Systems Analyst Jobs

Senior level information systems analyst jobs place experienced analysts in charge of enterprise architecture decisions, system integration roadmaps, and the cross-functional projects that translate business strategy into working technology. Hiring is concentrated across Aerospace & Defense, Technology & Software, and Healthcare & Medical Services, with 75% of openings offering remote or hybrid arrangements and employers like MTSI, AMERICAN SYSTEMS, and Penn State Health hiring at this level now.

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Overview

Open roles21
Top stateMaryland
Top employerMTSI
Top cityFort Meade, MD
Work type50% Remote
Top industryAerospace

Showing 5 of 21+ Senior Level Information Systems Analyst jobs

Kyndryl
HR Information Systems Product Owner - Core HCM
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Kyndryl
Added 3d ago
HR Information Systems Product Owner - Core HCM
Kyndryl
Florida
Compliance & Risk
Cybersecurity Operations
Security & Protective Services
$117k - $266k/yr
Remote (US)
Bachelor's degree
10,000+

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University Health
Information Systems Project Manager
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University Health
Added 1w ago
Information Systems Project Manager
University Health
San Antonio, Texas
Data Science
Health Informatics
Healthcare Administration
$27 - $44/hr
Managed care
10,000+

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UT Southwestern Medical Center
Laboratory Information Systems Manager
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UT Southwestern Medical Center
Added 1w ago
Laboratory Information Systems Manager
UT Southwestern Medical Center
Dallas, Texas
Healthcare Administration
Project & Program Management
Compliance & Legal
On-Site
Bachelor's
10,000+

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Harrisburg University
Professor Information Systems Engineering Man
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Harrisburg University
Added 1mo ago
Professor Information Systems Engineering Man
Harrisburg University
Harrisburg, Pennsylvania
Business Operations
$90k - $110k/yr
Doctoral degree in engineering

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MTSI
Cyber Security Engineer - Information Systems Security Engineer (ISSE) - Senior Principal
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MTSI
Added 3mo ago
Cyber Security Engineer - Information Systems Security Engineer (ISSE) - Senior Principal
MTSI
Wright-Patterson AFB, Ohio
Cloud Architecture
Solutions Architecture
Technical Product & Program Management
Master's degree in cybersecurity
1,001-5,000

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Senior Level Information Systems Analyst Job Market

Who's Hiring

MTSI
MTSI3 open roles
AMERICAN SYSTEMS
AMERICAN SYSTEMS3 open roles
Penn State Health
Penn State Health2 open roles

Top Industries Hiring

  • Aerospace & Defense
  • Technology & Software
  • Healthcare & Medical Services
  • Education
  • Consulting & Professional Services

Senior Level Information Systems Analyst Jobs: Frequently Asked Questions

How do I get a senior level information systems analyst job?

Employers hiring at the senior level look for candidates who have owned full system lifecycles, not just contributed to them. Demonstrating that you have led requirements gathering, driven architecture decisions, and delivered measurable improvements to enterprise systems gives you a clear edge. Strong candidates also show experience mentoring junior analysts and communicating technical tradeoffs to non-technical stakeholders.

Which companies hire senior level information systems analysts?

Companies hiring senior level information systems analysts right now include MTSI, AMERICAN SYSTEMS, and Penn State Health, based on current listings on Migrate Mate as of September 2026. Hiring at this level tends to concentrate in large enterprises, government contractors, and consulting firms that maintain complex, mission-critical information systems requiring experienced oversight.

Are there remote senior level information systems analyst jobs?

Yes, remote and hybrid opportunities are well represented at this level. About 75% of senior level information systems analyst openings are remote or hybrid as of September 2026, reflecting how many organizations trust senior analysts to lead systems work independently. On-site roles are most common in sectors where security, compliance, or infrastructure access is required.

What makes an information systems analyst role senior level?

Senior level roles are defined by ownership and scope rather than task execution. A senior information systems analyst is expected to lead system design and integration initiatives, set technical standards for their team, and advise business leaders on technology investments. Mentoring analysts at earlier career stages and managing vendor or stakeholder relationships are also standard expectations at this level.

Which industries hire the most senior level information systems analysts?

Senior level information systems analyst roles concentrate in Aerospace & Defense, Technology & Software, and Healthcare & Medical Services, based on current listings on Migrate Mate as of September 2026. These sectors drive demand because they operate large, interconnected systems that require experienced analysts to maintain reliability, manage upgrades, and ensure alignment between technology capabilities and evolving business requirements.