Internal Medicine Nurse Practitioner Jobs in Missouri
Internal Medicine Nurse Practitioner jobs in Missouri are open across Chesterfield, St Louis, and Columbia and other Missouri metros, with employers like SSM Health, St. Luke's Hospital (MO), and Cox Monett Hospital hiring at every experience level. Find a role that fits below and apply directly.
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Build Your Career in a Physician-Forward Environment at St. Luke’s Hospital
At St. Luke’s Hospital, we are more than just a healthcare system—we are a community of dedicated professionals committed to delivering exceptional, patient-centered care. As an independent, award-winning health system, we have been recognized nationally for our outstanding patient experience and unmatched quality of care. St. Luke’s Hospital for over a decade has been recognized for “Outstanding Patient Experience” by HealthGrades.
Position Summary:
Elevate Your Career with a Premier Physician-Led, only independent system in St. Louis. St. Luke’s Medical Group, a highly respected, physician-driven healthcare organization, is expanding to meet the growing demand for high-quality outpatient primary care. We are actively recruiting board-certified or board-eligible Internal Medicine and Family Medicine physicians to join our team in St. Louis’ thriving western and southern suburbs. This is more than just a job, it’s an opportunity to build a rewarding career in a supportive, patient-centered environment where your voice matters.
Why Choose St. Luke’s Medical Group?
- Physician-Led, Patient-Focused: We foster autonomy, collaboration, and leadership opportunities for our physicians.
- Flexible Scheduling & Work-Life Balance: Enjoy control over your schedule with call coverage provided on evenings and weekends, so you have more time for what matters most.
- Lucrative Compensation & Growth Potential: Competitive base salary + productivity incentives, plus marketing support to help grow your practice.
- Robust Benefits from Day One: Comprehensive medical, dental, vision, and retirement plans with employer match, PTO
- Malpractice coverage with tail
- Student loan assistance and CME Dollars
- Built-In Success with Strong Referral Networks: Leverage direct access to St. Luke’s specialists, urgent care centers, and hospital services for seamless patient care.
- Cutting-Edge Technology & Support: Work efficiently with Cerner EMR and AI tools that directly input into the EMR and a dedicated clinical team that maximizes patient interaction time.
Your Role & What to Expect:
- 100% outpatient primary care with no inpatient responsibilities
- Well-supported practice environment with experienced clinical staff
- Strategic growth locations in high-demand suburban communities
- Opportunities to shape the future of care through leadership and innovation
Education, Experience, & Licensing Requirements:
Education: MD/DO
Experience: Team-oriented, patient-focused physician with a commitment to excellence. Strong communication skills
Licensure: BC/BE in Specialty, ACLS and BLS Certified, DEA License, and Missouri Board of Registration of the Healing Arts.
Benefits for a Better You:
- Day one benefits package
- Pension Plan & 401K
- Competitive compensation
- FSA & HSA options
- PTO programs available
- Education & Loan Assistance
- Signing Bonus
- Resident Stipend
- CME Allowance & Time Off
Be a Part of Something Bigger
For over 150 years, St. Luke’s Hospital has been a nationally recognized, independent, nonprofit health system, dedicated to providing exceptional, compassionate care. We are consistently recognized for our outstanding patient experience, ensuring that every physician has the resources and support needed to deliver top-quality care.
If you’re looking for a rewarding career with excellent support, competitive compensation, and a culture that values physician input, we invite you to apply today
See All 13 Internal Medicine Nurse Practitioner Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
Find JobsInternal Medicine Nurse Practitioner Jobs by City in Missouri
Where Missouri roles are concentrated, by current openings.
Internal Medicine Nurse Practitioner Job Market in Missouri
A snapshot from current Missouri openings, updated as new roles post.
Who's Hiring
- SSM Health5

- St. Luke's Hospital (MO)3

- Cox Monett Hospital1

- Mercy1

- Mosaic Life Care1

Top Industries Hiring
- Healthcare & Medical Services12
- Education1
- Insurance1
What Missouri Employers Look For
The qualifications that appear most often in internal medicine nurse practitioner jobs across Missouri.
- Active APRN license with adult or family nurse practitioner board certification (ANCC or AANP)
- Master of Science in Nursing or Doctor of Nursing Practice degree from an accredited program
- DEA registration and state prescriptive authority for controlled substances
- Minimum one to three years of clinical experience in internal medicine or primary care
- Proficiency with electronic health record systems such as Epic, Cerner, or Meditech
- Basic Life Support and Advanced Cardiovascular Life Support certification
Internal Medicine Nurse Practitioner Jobs in Missouri: Frequently Asked Questions
How many internal medicine nurse practitioner jobs are there in Missouri?
There are 13+ internal medicine nurse practitioner openings in Missouri on Migrate Mate as of June 2026, with the most roles in Chesterfield, St Louis, and Columbia. New positions post regularly as employers across Missouri hire.
How much do internal medicine nurse practitioners make in Missouri?
Internal medicine nurse practitioners in Missouri earn a median of about $129,930 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $100,650 for the lowest 10% to over $162,060 for the top 10%. Pay rises with experience, specialty, and employer.
Which Missouri cities have the most internal medicine nurse practitioner jobs?
Chesterfield, St Louis, and Columbia have the most internal medicine nurse practitioner openings in Missouri right now, with additional roles spread across smaller metros statewide.
Which companies hire internal medicine nurse practitioners in Missouri?
Employers hiring internal medicine nurse practitioners in Missouri include SSM Health, St. Luke's Hospital (MO), and Cox Monett Hospital, based on current listings on Migrate Mate as of June 2026.
Are there remote internal medicine nurse practitioner jobs in Missouri?
Yes. About 0% of internal medicine nurse practitioner openings tied to Missouri are remote or hybrid as of June 2026. The rest are on-site roles based in Missouri metros.
How do I apply for internal medicine nurse practitioner jobs in Missouri?
You can apply to internal medicine nurse practitioner jobs in Missouri directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred Missouri location, then apply to each one that fits.
See All 13 Internal Medicine Nurse Practitioner Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
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