Lead Clinical Data Manager Jobs
Lead Clinical Data Manager jobs are open across pharmaceutical, biotech, and medical device companies, at every level from senior data manager to director, with specializations in regulatory submissions, database validation, and clinical trial oversight. Scan the live roles below and apply to whichever ones fit.
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Showing 5 of 46+ Lead Clinical Data Manager jobs
Standard Job Description
Join Lockheed Martin’s Data and AI Enablement organization and accelerate the company’s AI transformation. As the manager of the Enterprise Control Tower’s technical team, you will play a key role in leading the build of the corporation’s data foundation to enable use of AI agents in some of our most important cross-functional analytics applications. You will develop strategy for the team’s operations, manage customer relationships, lead the creation and deployment of critical data products, support the build and operationalization of application ontologies, oversee the team’s engineering operations and manage and grow our organization’s talent. If you have a passion for making business impact through cutting-edge technology, this role is for you.
Key Responsibilities
- Work with functional partners to create enterprise data products and ontologies that provide maximal value to the corporation.
- Build relationships with key stakeholders to ensure their support for the team’s mission.
- Ensure data product alignment with enterprise ontology standards and guardrails.
- Work with functional partners to produce validation tests for data products and enterprise ontologies.
- Identify/report/mitigate technical risks and develop strategies to enable team to overcome obstacles in building the corporation’s data foundations.
- Manage technical requirements, lead technical designs, lead technical governance of overall Enterprise Control Tower suite of applications.
- Optimize team operations to maximize quality and efficiency, and to ensure delivery deadlines are met.
- Plan and manage application budgets and staffing.
- Optimize the work experience of our team’s architects and engineers, and enable them to grow their careers in the directions they wish.
- Identify and hire new talent for the team.
- Must be a US citizen
Basic Qualifications
- Bachelor’s (or higher) in Computer Science, Systems Engineering, Information Management, or a related field.
- 8 + years of experience working in data engineering/analysis/science, with at least 2 years of experience working in management.
- 3 + years of experience delivering concrete business value through technical ownership of portions of an enterprise data platforms.
- Proven ability to influence stakeholders and motivate action through superior communication and relationship building skills
- Demonstrated ability to apply strategic thinking to solve programmatic issues.
- Demonstrated ability to deliver business value through optimizing engineering operations and plans.
Desired Skills
- Experience in Operations or Supply Chain business functions.
- Experience productizing data sets for enterprise consumption.
- Experience operationalizing ontologies, taxonomies, or knowledge graphs that enable AI agent operations.
- Experience facilitating cross-functional workshops.
- Experience with use case-driven software development.
- Excellent interpersonal and collaboration skills for cross‑functional teamwork and internal‑customer support.
- Master’s degree or advanced technical training.
- Experience with Databricks and/or medallion data architectures.
- Experience implementing data access controls in complex systems.
- Hands-on experience using genAI to solve business problems.
Pay Information
GeoZone Definition: GeoZones are geographic groupings created by Lockheed Martin to align compensation ranges with regional labor markets and cost-of-labor differences across the United States. Locations are assigned a Geo Zone based on the primary work location of the role.
-
Full-time salary range (GEOZONE 1): $185400.00 - $344400.00
- Includes metropolitan areas such as Sunnyvale CA; Pal Alto, CA; New York City metropolitan area; Newark, New Jersey; etc.
-
Full-time salary range (GEOZONE 2): $166900.00 - $309900.00
- Includes metropolitan areas such as Denver, CO; King of Prussia, PA; Stratford, CT; Moorestown, NJ; etc.
-
Full-time salary range (GEOZONE 3): $148300.00 - $275500.00
- Includes metropolitan areas such as Dallas–Fort Worth, TX; Orlando, FL; Grand Prairie, TX; Marietta, GA; etc.
-
Full-time salary range (GEOZONE 4): $133500.00 - $247900.00
- Includes metropolitan areas such as Camden, AR; Lexington, KY; Lufkin, TX; etc.
At Lockheed Martin, we know mission success starts with taking care of our people. Our Total Rewards program is designed to attract top talent, support your well-being, and help you grow—both professionally and personally.
The salary range for this position is as listed on the requisition. Please note that the salary information listed is a general guideline only.
Lockheed Martin considers factors such as (but not limited to) scope and responsibilities of the position, candidate's work experience, education/ training, key skills as well as market(work location) and business considerations when extending an offer.
Benefits offered: Medical, Dental, Vision, Flexible work arrangements and schedules (e.g., 4x10), 401(k) match, Paid time off, Holidays, Parental Leave, EAP, Flexible Spending Accounts, Education Assistance, Life Insurance, Short-Term Disability, and Long-Term Disability.
- Annual short-term and/or long-term incentive compensation programs may be offered depending on the position. Payments under these annual programs are not guaranteed and can vary from year to year and are tied to a range of performance metrics.
- For (Washington state applicants only) Non-represented full-time employees: accrue at least 10 hours per month of Paid Time Off (PTO) to be used for incidental absences and other reasons; receive at least 90 hours for holidays. Represented full time employees accrue 6.67 hours of Vacation per month; accrue up to 52 hours of sick leave annually; receive at least 96 hours for holidays. PTO, Vacation, sick leave, and holiday hours are prorated based on start date during the calendar year.
Standard Job Description
Join Lockheed Martin’s Data and AI Enablement organization and accelerate the company’s AI transformation. As the manager of the Enterprise Control Tower’s technical team, you will play a key role in leading the build of the corporation’s data foundation to enable use of AI agents in some of our most important cross-functional analytics applications. You will develop strategy for the team’s operations, manage customer relationships, lead the creation and deployment of critical data products, support the build and operationalization of application ontologies, oversee the team’s engineering operations and manage and grow our organization’s talent. If you have a passion for making business impact through cutting-edge technology, this role is for you.
Key Responsibilities
- Work with functional partners to create enterprise data products and ontologies that provide maximal value to the corporation.
- Build relationships with key stakeholders to ensure their support for the team’s mission.
- Ensure data product alignment with enterprise ontology standards and guardrails.
- Work with functional partners to produce validation tests for data products and enterprise ontologies.
- Identify/report/mitigate technical risks and develop strategies to enable team to overcome obstacles in building the corporation’s data foundations.
- Manage technical requirements, lead technical designs, lead technical governance of overall Enterprise Control Tower suite of applications.
- Optimize team operations to maximize quality and efficiency, and to ensure delivery deadlines are met.
- Plan and manage application budgets and staffing.
- Optimize the work experience of our team’s architects and engineers, and enable them to grow their careers in the directions they wish.
- Identify and hire new talent for the team.
- Must be a US citizen
Basic Qualifications
- Bachelor’s (or higher) in Computer Science, Systems Engineering, Information Management, or a related field.
- 8 + years of experience working in data engineering/analysis/science, with at least 2 years of experience working in management.
- 3 + years of experience delivering concrete business value through technical ownership of portions of an enterprise data platforms.
- Proven ability to influence stakeholders and motivate action through superior communication and relationship building skills
- Demonstrated ability to apply strategic thinking to solve programmatic issues.
- Demonstrated ability to deliver business value through optimizing engineering operations and plans.
Desired Skills
- Experience in Operations or Supply Chain business functions.
- Experience productizing data sets for enterprise consumption.
- Experience operationalizing ontologies, taxonomies, or knowledge graphs that enable AI agent operations.
- Experience facilitating cross-functional workshops.
- Experience with use case-driven software development.
- Excellent interpersonal and collaboration skills for cross‑functional teamwork and internal‑customer support.
- Master’s degree or advanced technical training.
- Experience with Databricks and/or medallion data architectures.
- Experience implementing data access controls in complex systems.
- Hands-on experience using genAI to solve business problems.
Pay Information
GeoZone Definition: GeoZones are geographic groupings created by Lockheed Martin to align compensation ranges with regional labor markets and cost-of-labor differences across the United States. Locations are assigned a Geo Zone based on the primary work location of the role.
-
Full-time salary range (GEOZONE 1): $185400.00 - $344400.00
- Includes metropolitan areas such as Sunnyvale CA; Pal Alto, CA; New York City metropolitan area; Newark, New Jersey; etc.
-
Full-time salary range (GEOZONE 2): $166900.00 - $309900.00
- Includes metropolitan areas such as Denver, CO; King of Prussia, PA; Stratford, CT; Moorestown, NJ; etc.
-
Full-time salary range (GEOZONE 3): $148300.00 - $275500.00
- Includes metropolitan areas such as Dallas–Fort Worth, TX; Orlando, FL; Grand Prairie, TX; Marietta, GA; etc.
-
Full-time salary range (GEOZONE 4): $133500.00 - $247900.00
- Includes metropolitan areas such as Camden, AR; Lexington, KY; Lufkin, TX; etc.
At Lockheed Martin, we know mission success starts with taking care of our people. Our Total Rewards program is designed to attract top talent, support your well-being, and help you grow—both professionally and personally.
The salary range for this position is as listed on the requisition. Please note that the salary information listed is a general guideline only.
Lockheed Martin considers factors such as (but not limited to) scope and responsibilities of the position, candidate's work experience, education/ training, key skills as well as market(work location) and business considerations when extending an offer.
Benefits offered: Medical, Dental, Vision, Flexible work arrangements and schedules (e.g., 4x10), 401(k) match, Paid time off, Holidays, Parental Leave, EAP, Flexible Spending Accounts, Education Assistance, Life Insurance, Short-Term Disability, and Long-Term Disability.
- Annual short-term and/or long-term incentive compensation programs may be offered depending on the position. Payments under these annual programs are not guaranteed and can vary from year to year and are tied to a range of performance metrics.
- For (Washington state applicants only) Non-represented full-time employees: accrue at least 10 hours per month of Paid Time Off (PTO) to be used for incidental absences and other reasons; receive at least 90 hours for holidays. Represented full time employees accrue 6.67 hours of Vacation per month; accrue up to 52 hours of sick leave annually; receive at least 96 hours for holidays. PTO, Vacation, sick leave, and holiday hours are prorated based on start date during the calendar year.
Lead Clinical Data Manager Jobs by Experience Level
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Find JobsLead Clinical Data Manager Job Market
Who's Hiring
Top Industries Hiring
- Consulting & Professional Services
- Energy
- Retail
- Technology & Software
- E-Commerce & Online Marketplaces
What Employers Look For
The qualifications that appear most often in lead clinical data manager jobs.
- Bachelor's or master's degree in life sciences, health informatics, or a related field
- 5 or more years of clinical data management experience across multiple trial phases
- Proficiency with EDC platforms such as Medidata Rave, Veeva Vault, or Oracle Clinical
- Deep knowledge of CDISC standards including CDASH, SDTM, and ADAM
- Experience authoring and reviewing data management plans and edit check specifications
- Familiarity with ICH E6 GCP guidelines and FDA or EMA regulatory submission requirements
Tips for Your Lead Clinical Data Manager Job Search
Tailor your resume for therapeutic areas
Hiring managers in oncology, rare disease, and cardiovascular trials expect you to call out the specific therapeutic areas you've managed data for. Generic clinical data management experience reads weaker than a resume that names your phase and indication history directly.
Highlight your CDISC and CDASH expertise
Most lead clinical data manager postings require demonstrated CDISC standards experience, especially CDASH and SDTM. List the specific domains you've built or validated and name the EDC platforms you've used, since reviewers scan for these before reading anything else.
Apply early to roles that fit
Migrate Mate lists lead clinical data manager openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Target postings that name your EDC platform
Many roles are built around Medidata Rave, Veeva Vault, or Oracle Clinical. Filtering for openings that name the system you know best positions you as a faster ramp-up, which matters especially at the lead level where you'll be configuring, not just entering data.
Prepare a data discrepancy case study
Interviewers at the lead level routinely ask how you've handled a critical data quality issue under a regulatory deadline. Walk in with a real example that covers how you identified the discrepancy, escalated it, resolved it, and documented the outcome for audit purposes.
Negotiate scope alongside compensation
At the lead level, your leverage isn't just salary. Ask explicitly about how many protocols you'll own, whether you'll manage junior data managers, and what the database lock timeline looks like. Scope clarity upfront protects you from being spread too thin after you start.
Lead Clinical Data Manager Jobs: Frequently Asked Questions
Which companies are hiring the most lead clinical data managers?
The companies hiring the most lead clinical data managers right now include Katalyst Healthcares & Life Sciences, Amazon, and Gilead Sciences, with the largest share of openings in Texas, Illinois, and California, based on current listings on Migrate Mate as of November 2026. CROs and large pharmaceutical sponsors tend to post the most volume, particularly during active enrollment phases of late-stage trials.
How many lead clinical data manager jobs are remote?
About 94% of lead clinical data manager openings are fully remote or hybrid as of November 2026, reflecting how thoroughly remote work has taken hold in clinical data roles since database management and EDC work can be done entirely off-site. Protocol setup, edit check programming, and data review meetings are the sub-areas most commonly listed as remote-eligible.
How do you become a lead clinical data manager?
Start with a degree in life sciences, health informatics, or a related field, then build hands-on experience as a clinical data coordinator or data manager on sponsored trials. Progress through increasing protocol complexity, earn proficiency in CDISC standards and at least one major EDC platform, take ownership of data management plans, and demonstrate you can lead database lock activities and mentor junior staff.
Can you get hired as a lead clinical data manager with limited experience?
Moving directly into a lead role with little experience is difficult, but candidates who have strong EDC platform expertise and have independently owned a data management plan on a small or Phase I study sometimes make the jump earlier. Targeting smaller CROs or biotech sponsors that run lean teams can open doors that large pharma companies typically keep closed until you have several years of progressively independent work behind you.
What does the lead clinical data manager interview process look like?
Most processes start with a recruiter screen focused on therapeutic area background and EDC platform experience, followed by a technical interview where you walk through how you've built or validated a data management plan and handled edit check issues. A panel interview with clinical operations and biostatistics stakeholders often follows, and some sponsors include a short written or practical exercise around database design or discrepancy resolution before an offer is extended.
Where can I find and apply to lead clinical data manager jobs?
You can find and apply to lead clinical data manager jobs on Migrate Mate, which lists current openings from across the United States. Search the roles available, find the ones that match your experience and therapeutic area background, and apply directly to each listing that fits.
See All 46 Lead Clinical Data Manager Jobs
Find roles that match your experience and apply in just a few clicks.
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