Senior Level Principal Full Stack Engineer Jobs

About Cleerly

We're Cleerly – a healthcare company that's revolutionizing how heart disease is diagnosed, treated, and tracked. We were founded in 2017 by one of the world's leading cardiologists and are a growing team of world-class engineering, operations, medical affairs, marketing, and sales leaders. We raised $223M in Series C funding in 2022 which has enabled rapid growth and continued support of our mission. In December 2024 we received an additional $106M in a Series C extension funding. Most of our teams work remotely and have access to our offices in Denver, Colorado, New York, New York, Dallas, Texas, and Lisbon, Portugal with some roles requiring you to be on-site in a location.

Cleerly has created a new standard of care for heart disease through value-based, AI-driven precision diagnostic solutions with the goal of helping prevent heart attacks. Our technology goes beyond traditional measures of heart disease by enabling comprehensive quantification and characterization of atherosclerosis, or plaque buildup, in each of the heart arteries. Cleerly's solutions are supported by more than a decade of performing some of the world's largest clinical trials to identify important findings beyond symptoms that increase a person's risk of heart attacks.

At Cleerly, we collaborate digitally and use a wide variety of systems. Our people use Google Workspace (GMail, Drive, Docs, Sheets, Slides), Slack, Confluence/Jira, and Zoom Video; prior experience in these areas is a plus. Role or department specific technology needs may vary and will be listed as requirements in the job description.

While we are mostly a remote company, travel is required for some team meetings and cross function projects typically once per month or once per quarter; for some roles like sales or external facing roles travel could be up to 90% of the time.

Cleerly is committed to providing safe and effective medical software that meets customer needs and our intended use. The adherence to all applicable regulatory and statutory requirements establishes a clear framework for setting measurable quality objectives. Our commitment to continually improving our products and processes proactively manages risks, ensuring ongoing compliance throughout the entire software lifecycle. Understanding this role's relevance and importance is critical to achieving Cleerly's quality objectives.

About the Opportunity

We are seeking a hands-on Staff Full-Stack Software Engineer to help build and own core components of Cleerly's clinical platform. This is a high-impact individual contributor role spanning both frontend and backend — you will work across the stack, from the React/TypeScript interfaces clinicians use to the Python and Java services and AWS infrastructure that power them.

Our platform connects to hospital systems, processes cardiac CT studies through our FDA-cleared AI, and delivers quantified clinical results back to cardiologists and health systems. You will own meaningful parts of that pipeline end to end.

We are open to candidates who lean either frontend or backend, provided you are genuinely comfortable working across the full stack. What matters most is engineering depth, the ability to own platform components independently, and enthusiasm for building software that directly affects patient care.

This is not an architecture-and-delegate role. We need someone who writes production code, debugs production issues, and takes personal ownership of the systems they build.

What You'll Own

Frontend and Clinical Interfaces

• Build and own React/TypeScript interfaces used by cardiologists, radiologists, and clinical teams to review cases, interpret results, and finalize reports
• Design clear, high-usability clinical interfaces that handle complex multi-source data with strong information hierarchy and rigorous edge-case handling
• Implement workflow features including case status, review queues, exception handling, edits, and sign-off flows
• Implement secure viewer launch flows — opening the Cleerly viewer, embedded HTML5 components, or external viewers via deep-link or SDK integration

Backend Services and APIs

• Design, build, and own backend services in Python or Java that power the clinical platform — REST APIs, data processing, and integration layers
• Design data models, API contracts, and service boundaries that support a scalable, maintainable platform
• Ensure audit-safe data handling, PHI protection, and data integrity across all services
• Contribute to platform reliability through observability, monitoring, error handling, and performance optimization

Cloud Infrastructure and Platform

• Build and operate cloud-native services on AWS — ECS, Lambda, SQS, S3, RDS, CloudWatch — in a regulated healthcare environment
• Contribute to infrastructure as code, CI/CD pipelines, and deployment automation
• Help scale platform components as Cleerly expands to additional clinical sites and health systems

Clinical System Integration

• Work with FHIR and HL7 standards for structured clinical outputs and EHR write-back
• Partner with Backend, Viewer, and CoreLab teams to ensure clinical workflows function reliably end to end
• Integrate with third-party clinical systems, reporting engines, and dictation tools as needed

Technical Leadership

• Make and defend independent architectural decisions across the stack
• Provide technical leadership through code reviews, design reviews, and mentoring
• Collaborate directly with clinical stakeholders — cardiologists, radiologists, and CoreLab teams — to shape workflows that impact patient care
• Contribute to regulated software delivery: requirements traceability, change impact analysis, and validation support

What We're Looking For

Required

• 8+ years of professional software engineering experience with demonstrable depth across the stack
• Strong React and TypeScript — you are genuinely comfortable owning complex production interfaces
• Strong backend engineering in Python or Java — you write and own production services, not just scripts
• AWS production experience — you have built and operated cloud-native services, not just deployed to a VM
• Solid API design and integration skills — you can design and consume APIs, handle edge cases, and reason about data integrity end to end
• Experience working in healthcare, regulated, or otherwise high-stakes software environments
• Strong testing discipline — rigorous handling of edge cases, error states, partial results, and latency
• Ability to operate in a regulated environment — requirements traceability, change impact analysis, validation support
• Independent technical judgment — you can own platform components and make sound decisions without constant oversight

Nice to Have

• Experience building clinician-facing interfaces — radiology, cardiology, or clinical workflow applications
• FDA-regulated medical device or SaMD experience (510k, De Novo, IEC 62304)
• DICOM knowledge — C-STORE, C-FIND, DICOMweb, structured reporting, or medical imaging data handling
• Working knowledge of at least one healthcare interoperability standard (FHIR or HL7 v2), or the ability to ramp quickly
• Experience embedding or launching medical viewers (OHIF/Cornerstone, HTML5 viewers, iframes)
• Prior integration with commercial reporting or dictation tools (Nuance, M*Modal)
• Spring framework, Kubernetes, Docker, or Terraform experience
• Experience with AI/ML platforms or integrating model outputs into production applications

Why This Role

This is a role for an engineer who wants genuine ownership across the stack in a system where the output directly affects patient care. You'll build interfaces clinicians rely on, the services behind them, and the cloud infrastructure that keeps it all running. If you've built full-stack products in healthcare, regulated, or high-stakes environments and want to apply that experience to one of the most important problems in cardiovascular medicine, we'd like to talk.

Why You Should Apply

PURPOSE: Cleerly's purpose is to create a world without heart attacks. With our new paradigm for precision heart care, we will leave big footprints in the sands of time. Help us make that a reality.

COMMUNITY: We are building a truly world-class team of talented problem solvers. While we have diverse backgrounds, we are united in our commitment to each other, to our customers, and to the patients our technology serves.

GROWTH: We prioritize learning and growth. As a rapid-growth company there is always space for new challenges and responsibilities — and through Cleerly U, we invest in the development of our team.

OWNERSHIP: Everyone on the team contributes to our success, so everyone has equity in the company through our employee stock option incentive plan.

BENEFITS: Cleerly offers a variety of medical, dental, and vision plans designed to fit you and your family's needs. Our 401(k) program helps you invest in the future.

Job duties, activities, and responsibilities are subject to change by our company.

The base salary range for this role varies by location and is aligned to market benchmarks.

• Candidates located in higher-cost labor markets, including California, Washington, New York, New Jersey, Connecticut, Massachusetts, and Washington, DC represent the middle to high end of the range, while candidates located in all other U.S. locations represent the low to middle end of the range.
• Final compensation is determined based on location, experience, skills, and internal equity.

This role is eligible for a 15% target annual bonus, resulting in the following base salary and Total Target Compensation (TTC) ranges:

• Base Salary: $175,000 - $201,000
• TTC: $200,000 - $231,000

Total Target Compensation (TTC): Total Cash Compensation (including base pay, variable pay, commission, bonuses, etc.) Additionally, stock options, paid benefits, and employee perks are part of your total rewards.

Working at Cleerly takes HEART. Discover our Core Values:

• H: Humility - be a servant leader
• E: Excellence - deliver world-changing results
• A: Accountability - do what you say; expect the same from others
• R: Remarkable - inspire & innovate with impact
• T: Teamwork - together we win

Don't meet 100 percent of the qualifications? Apply anyway and help us diversify our candidate pool and workforce. We value experience, whether gained formally or informally on the job or through other experiences. Job duties, activities and responsibilities are subject to change by our company.

OUR COMPANY IS AN EQUAL OPPORTUNITY EMPLOYER. We do not discriminate on the basis of race, color, national origin, ancestry, citizenship status, protected veteran status, religion, physical or mental disability, marital status, sex, sexual orientation, gender identity or expression, age, or any other basis protected by law, ordinance, or regulation.