Principal Process Development Engineer Jobs
Principal Process Development Engineer jobs are open across semiconductor manufacturing, pharmaceuticals, biotechnology, and specialty chemicals, from mid-level process engineer to staff and principal, with specializations in process scale-up, yield optimization, and advanced materials integration. Find a role that fits below and apply directly.
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Join Amgen’s Mission of Serving Patients
At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.
Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Senior Principal Scientist, Commercial Drug Products & Life Cycle Management
What you will do
Let’s do this. Let’s change the world. In this vital role you will be part of Amgen’s Process Development organization, Drug Product Technologies unit that continuously strives to be a technical leader in delivering superior, robust drug product manufacturing processes, high-quality CMC sections, and ensuring supply of commercial products. Drug Product Team leaders (DPTLs) play a central role in this process by serving as single point of accountability for individual drug product programs for technical activities specific to formulation, aseptic drug product process design and validation, integrated development of combination products, process improvements, life cycle changes, regulatory submissions, annual product reviews, etc. DPTLs are part of an integrated operations team and lead a technical team responsible for delivering drug product process transfers, process optimization, process trouble shooting, timely closure of non-conformance investigations and change control assessments to ensure supply of commercial drug products. We are seeking an Sr. Principal Scientist to lead commercial drug product programs as DPTL and lead a scientific team that supports advancing the commercial drug product programs in our portfolio.
- Serve as a leader on Drug Product Commercialization Teams responsible for planning, designing, executing, and documenting laboratory studies related to drug product design, formulation, and process development in support of commercialization and lifecycle management of parenteral presentations.
- Lead a team of scientists focused on late-stage drug product process development and tech transfer and coach staff with emphasis on people-centered leadership.
- Provide support, as needed, to clinical and commercial fill/finish manufacturing operations through process capability analysis, troubleshooting, root cause analysis, and product impact assessments for non-conformance investigations and process changes/improvements.
- Drive continuous improvement in the drug product development process through technological innovation and application of first principles in process engineering.
- Participate and lead global cross-functional teams working effectively in a highly matrixed team environment to influence and drive change, efficiency, and foster strong relationships.
- Author and review guideline documents, technical protocols, reports, product impact assessments, regulatory submissions, and developing responses to regulatory questions.
- Deliver progress reports and presentations to ensure management awareness and engagement of the status, progress, and future program and functional needs.
- Actively utilize advanced IS systems to improve drug product design through faster data availability, leveraging historical information, analyzing large data sets, and statistical analysis.
- Ability to travel domestically and internationally up to 10% of the time.
What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a leader with these qualifications.
Basic Qualifications:
- Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 3 years of engineering or science experience OR
- Master’s degree and 6 years of engineering or science experience OR
- Bachelor’s degree and 8 years of engineering or science experience
Preferred Qualifications:
- Advanced degree in Pharmaceutics, Biotechnology, Engineering or related discipline and industry experience in pharmaceuticals/biotechnology
- Demonstrated knowledge of drug product commercialization and integrated combination product development with hands-on experience with end-to-end development for liquid, lyophilized and/or oral solid dosage drug products in various presentations
- Demonstrated experience in process transfers, control strategy, authoring MAs, developing robust responses to regulatory questions, supporting validation activities and PAIs at commercial sites
- Understanding of physical/chemical stability of proteins and how process related stress impacts product quality, specifically, the impact of freezing and drying to short- and long-term stability
- Strong knowledge about developing processes with single-use manufacturing equipment
- Aseptic processing experience and familiarity with cGMPs, ICH guidelines
- Experience that includes elements of new product development, process characterization, equipment design and implementation, technical transfers to global manufacturing sites, statistical process control (SPC), and statistical design and analysis of experiments
- Strong problem solving and effective cross-functional communication skills
- Proven ability to learn and act on dynamic information at a rapid pace
- Ability to participate in global cross-functional teams and work effectively in a highly matrixed environment to lead change, efficiency, and strong cross functional relationships
What you can expect of us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.
and make a lasting impact with the Amgen team.
careers.amgen.com
In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
Application deadline
Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
Sponsorship
Sponsorship for this role is not guaranteed.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer. We make all employment decisions without regard to race, color, religion, sex or any other characteristic protected by applicable law.
We provide reasonable accommodations to applicants and employees with disabilities, consistent with legal requirements. Please contact us to request accommodation.
Join Amgen’s Mission of Serving Patients
At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.
Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Senior Principal Scientist, Commercial Drug Products & Life Cycle Management
What you will do
Let’s do this. Let’s change the world. In this vital role you will be part of Amgen’s Process Development organization, Drug Product Technologies unit that continuously strives to be a technical leader in delivering superior, robust drug product manufacturing processes, high-quality CMC sections, and ensuring supply of commercial products. Drug Product Team leaders (DPTLs) play a central role in this process by serving as single point of accountability for individual drug product programs for technical activities specific to formulation, aseptic drug product process design and validation, integrated development of combination products, process improvements, life cycle changes, regulatory submissions, annual product reviews, etc. DPTLs are part of an integrated operations team and lead a technical team responsible for delivering drug product process transfers, process optimization, process trouble shooting, timely closure of non-conformance investigations and change control assessments to ensure supply of commercial drug products. We are seeking an Sr. Principal Scientist to lead commercial drug product programs as DPTL and lead a scientific team that supports advancing the commercial drug product programs in our portfolio.
- Serve as a leader on Drug Product Commercialization Teams responsible for planning, designing, executing, and documenting laboratory studies related to drug product design, formulation, and process development in support of commercialization and lifecycle management of parenteral presentations.
- Lead a team of scientists focused on late-stage drug product process development and tech transfer and coach staff with emphasis on people-centered leadership.
- Provide support, as needed, to clinical and commercial fill/finish manufacturing operations through process capability analysis, troubleshooting, root cause analysis, and product impact assessments for non-conformance investigations and process changes/improvements.
- Drive continuous improvement in the drug product development process through technological innovation and application of first principles in process engineering.
- Participate and lead global cross-functional teams working effectively in a highly matrixed team environment to influence and drive change, efficiency, and foster strong relationships.
- Author and review guideline documents, technical protocols, reports, product impact assessments, regulatory submissions, and developing responses to regulatory questions.
- Deliver progress reports and presentations to ensure management awareness and engagement of the status, progress, and future program and functional needs.
- Actively utilize advanced IS systems to improve drug product design through faster data availability, leveraging historical information, analyzing large data sets, and statistical analysis.
- Ability to travel domestically and internationally up to 10% of the time.
What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a leader with these qualifications.
Basic Qualifications:
- Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 3 years of engineering or science experience OR
- Master’s degree and 6 years of engineering or science experience OR
- Bachelor’s degree and 8 years of engineering or science experience
Preferred Qualifications:
- Advanced degree in Pharmaceutics, Biotechnology, Engineering or related discipline and industry experience in pharmaceuticals/biotechnology
- Demonstrated knowledge of drug product commercialization and integrated combination product development with hands-on experience with end-to-end development for liquid, lyophilized and/or oral solid dosage drug products in various presentations
- Demonstrated experience in process transfers, control strategy, authoring MAs, developing robust responses to regulatory questions, supporting validation activities and PAIs at commercial sites
- Understanding of physical/chemical stability of proteins and how process related stress impacts product quality, specifically, the impact of freezing and drying to short- and long-term stability
- Strong knowledge about developing processes with single-use manufacturing equipment
- Aseptic processing experience and familiarity with cGMPs, ICH guidelines
- Experience that includes elements of new product development, process characterization, equipment design and implementation, technical transfers to global manufacturing sites, statistical process control (SPC), and statistical design and analysis of experiments
- Strong problem solving and effective cross-functional communication skills
- Proven ability to learn and act on dynamic information at a rapid pace
- Ability to participate in global cross-functional teams and work effectively in a highly matrixed environment to lead change, efficiency, and strong cross functional relationships
What you can expect of us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.
and make a lasting impact with the Amgen team.
careers.amgen.com
In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
Application deadline
Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
Sponsorship
Sponsorship for this role is not guaranteed.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer. We make all employment decisions without regard to race, color, religion, sex or any other characteristic protected by applicable law.
We provide reasonable accommodations to applicants and employees with disabilities, consistent with legal requirements. Please contact us to request accommodation.
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Who's Hiring
Top Industries Hiring
- Science & Research
- Electronics & Hardware
What Employers Look For
The qualifications that appear most often in principal process development engineer jobs.
- Bachelor's or master's degree in chemical engineering, materials science, or a related field
- 7-plus years of hands-on process development or process engineering experience
- Demonstrated expertise in design of experiments, statistical process control, and DOE methodologies
- Experience transferring processes from development scale to full commercial manufacturing
- Proficiency with process characterization tools and relevant unit operations for the specific industry
- Strong cross-functional collaboration with R&D, quality, and manufacturing engineering teams
Tips for Your Principal Process Development Engineer Job Search
Quantify process improvements on your resume
Hiring managers for principal-level roles expect metrics, not descriptions. Replace 'improved yield' with specific outcomes tied to your process changes: cycle time reductions, defect rate shifts, or throughput gains you drove from initial characterization through full-scale implementation.
Highlight scale-up experience explicitly
Many process development engineers at the senior level have lab or pilot experience but limited commercial-scale transfer work. If you've led the transition from R&D to manufacturing scale, name the technology node, batch size, or production volume to separate your resume from generic applicants.
Apply early to roles that fit
Migrate Mate lists principal process development engineer openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Target postings by equipment and process type
Principal roles are often equipment- or unit-operation-specific. Search using terms like CVD, ALD, lithography, fermentation, or lyophilization alongside the job title to surface openings where your domain expertise is a direct fit rather than a stretch.
Prepare a process narrative for your interview
Interviewers at this level expect you to walk through a full development cycle you owned, from defining process requirements and designing experiments through DOE analysis, process qualification, and handoff to manufacturing. Practice telling that story in under ten minutes with clear decision points.
Negotiate scope alongside compensation
Principal roles vary widely in whether you own the full process development roadmap or execute within a constrained charter. Before accepting an offer, clarify budget authority, headcount you'll influence, and whether the role includes external partner or supplier management, since these shape actual seniority more than the title does.
Principal Process Development Engineer Jobs: Frequently Asked Questions
Which companies are hiring the most principal process development engineers?
The companies hiring the most principal process development engineers right now include Northrop Grumman, Merck, and AbbVie, with the largest share of openings in California, Massachusetts, and Utah, based on current listings on Migrate Mate as of November 2026. Semiconductor fabs, large pharmaceutical manufacturers, and specialty chemical producers consistently represent the highest volume of postings at this level.
How many principal process development engineer jobs are remote?
About 29% of principal process development engineer openings are fully remote or hybrid as of November 2026, reflecting the lab- and equipment-dependent nature of most process development work. Data analysis, process modeling, and technical documentation roles within this title carry the highest share of remote or hybrid arrangements compared to hands-on characterization and scale-up positions.
How do you become a principal process development engineer?
Start with a degree in chemical engineering, materials science, or a closely related discipline, then build hands-on process development experience in a relevant industry such as semiconductors, pharmaceuticals, or specialty chemicals. Progress by owning increasingly complex scale-up projects, developing expertise in DOE and statistical process control, and demonstrating the ability to lead cross-functional teams through process qualification and technology transfer milestones.
Can you get hired as a principal process development engineer without direct principal-level experience?
Yes, candidates coming from a senior engineer title can move into a principal role if they can show they have been operating at that scope already. Document any process development cycles you led end-to-end, any manufacturing transfers you drove independently, and any situations where you set technical direction for a team rather than executed someone else's plan. Titles vary by company, so the substance of your work matters more than your current level.
What does the principal process development engineer interview process look like?
Expect a multi-stage process that typically opens with a recruiter screen focused on background and experience level, followed by a technical phone or video interview covering process fundamentals, DOE methodology, and a walkthrough of a development project you owned. Finalists usually complete an on-site or virtual panel with process engineering, R&D, and manufacturing stakeholders, and are often asked to present a past project in detail, including how you handled process failures and made go or no-go decisions.
Where can I find and apply to principal process development engineer jobs?
You can find and apply to principal process development engineer jobs on Migrate Mate, which lists current openings from across the United States. Find roles that match your background and apply directly to each listing from the page.
See All 24 Principal Process Development Engineer Jobs
Find roles that match your experience and apply in just a few clicks.
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