Production Engineer Jobs in San Francisco, CA
Production Engineer jobs in San Francisco concentrate across semiconductor design, advanced manufacturing, and cloud infrastructure, with demand anchored in SoMa, the Mission Bay biotech corridor, and the Dogpatch industrial district. Employers hiring right now include FluidStack, Salesforce, and Guild. Find a role that fits below and apply directly.
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POSITION SUMMARY:
The Bioinformatics Production Analyst performs basic data analysis to provide bioinformatics support for Horizon Carrier Screening and future platform sequencing tests, while actively participating in production pipeline improvements. In this role, the analyst plays a pivotal part in ensuring Natera provides high-quality carrier screening and sequencing products.
PRIMARY RESPONSIBILITIES:
- Data Analysis & Processing: Analyze high-throughput DNA sequencing data and perform basic data analysis to support product development, validation studies, and incoming experiment analysis requests.
- Pipeline Improvement & Support: Help move data through the analysis pipeline while proactively identifying and implementing improvements to production workflows.
- Troubleshooting: Investigate and resolve technical issues related to data quality, analysis pipelines, and system integration.
- Cross-Functional Collaboration: Communicate effectively and work collaboratively with cross-functional teams, including biology, software engineering, lab operations, and medical/legal affairs.
- Documentation: Produce high-quality written documentation, including formal study plans and technical reports.
- Compliance & PHI Safety: Regularly handle Protected Health Information (PHI) in both paper and electronic formats, ensuring strict adherence to data privacy technologies and protocols.
- Training & Certification: Complete required HIPAA/PHI privacy, security, and General Policies and Procedures Compliance training within the first 30 days of hire, and maintain current status on all ongoing company training requirements.
QUALIFICATIONS:
Minimum Qualifications:
- Bachelor's degree in Biomedical Engineering, Computer Science, Bioinformatics, or a related equivalent field.
- 2+ years of relevant professional experience.
Preferred Qualifications:
- Master's degree in a relevant scientific or technical discipline.
- Previous professional experience within the biotechnology, diagnostics, or pharmaceutical industry.
KNOWLEDGE, SKILLS, AND ABILITIES:
- Experience using Python for data analysis and plotting preferred.
- Experience using Linux command-line tools and relational databases (SQL) preferred, knowledge of data visualization tools/platforms a plus (plotly).
- Knowledge of genomics, relevant NGS analyses (mapping, variant calling, etc.), and NGS file types is required. e.g. Know how to run pipelines and knowledge of pipeline platforms/languages (WDL, Nextflow).
- Ability to produce high quality written documentation for varying audiences, e.g. validation reports
- Familiarity with Large Language Models (LLMs), such as Claude Code, and how to leverage them to streamline workflows and tasks.
- Ability to work independently while managing multiple objectives and timelines.
- Desire to work in a fast-paced environment with potential for high impact in a small team.
- Team player, self-motivated, and detail-oriented.
OUR OPPORTUNITY
Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women's health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.
The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you'll work hard and grow quickly. Working alongside the elite of the industry, you'll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.
WHAT WE OFFER
Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!
For more information, visit www.natera.com.
Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.
All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.
If you are based in California, we encourage you to read this important information for California residents.
Link: https://www.natera.com/notice-of-data-collection-california-residents/
Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.
- BBB announcement on job scams
- FBI Cyber Crime resource page
POSITION SUMMARY:
The Bioinformatics Production Analyst performs basic data analysis to provide bioinformatics support for Horizon Carrier Screening and future platform sequencing tests, while actively participating in production pipeline improvements. In this role, the analyst plays a pivotal part in ensuring Natera provides high-quality carrier screening and sequencing products.
PRIMARY RESPONSIBILITIES:
- Data Analysis & Processing: Analyze high-throughput DNA sequencing data and perform basic data analysis to support product development, validation studies, and incoming experiment analysis requests.
- Pipeline Improvement & Support: Help move data through the analysis pipeline while proactively identifying and implementing improvements to production workflows.
- Troubleshooting: Investigate and resolve technical issues related to data quality, analysis pipelines, and system integration.
- Cross-Functional Collaboration: Communicate effectively and work collaboratively with cross-functional teams, including biology, software engineering, lab operations, and medical/legal affairs.
- Documentation: Produce high-quality written documentation, including formal study plans and technical reports.
- Compliance & PHI Safety: Regularly handle Protected Health Information (PHI) in both paper and electronic formats, ensuring strict adherence to data privacy technologies and protocols.
- Training & Certification: Complete required HIPAA/PHI privacy, security, and General Policies and Procedures Compliance training within the first 30 days of hire, and maintain current status on all ongoing company training requirements.
QUALIFICATIONS:
Minimum Qualifications:
- Bachelor's degree in Biomedical Engineering, Computer Science, Bioinformatics, or a related equivalent field.
- 2+ years of relevant professional experience.
Preferred Qualifications:
- Master's degree in a relevant scientific or technical discipline.
- Previous professional experience within the biotechnology, diagnostics, or pharmaceutical industry.
KNOWLEDGE, SKILLS, AND ABILITIES:
- Experience using Python for data analysis and plotting preferred.
- Experience using Linux command-line tools and relational databases (SQL) preferred, knowledge of data visualization tools/platforms a plus (plotly).
- Knowledge of genomics, relevant NGS analyses (mapping, variant calling, etc.), and NGS file types is required. e.g. Know how to run pipelines and knowledge of pipeline platforms/languages (WDL, Nextflow).
- Ability to produce high quality written documentation for varying audiences, e.g. validation reports
- Familiarity with Large Language Models (LLMs), such as Claude Code, and how to leverage them to streamline workflows and tasks.
- Ability to work independently while managing multiple objectives and timelines.
- Desire to work in a fast-paced environment with potential for high impact in a small team.
- Team player, self-motivated, and detail-oriented.
OUR OPPORTUNITY
Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women's health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.
The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you'll work hard and grow quickly. Working alongside the elite of the industry, you'll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.
WHAT WE OFFER
Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!
For more information, visit www.natera.com.
Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.
All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.
If you are based in California, we encourage you to read this important information for California residents.
Link: https://www.natera.com/notice-of-data-collection-california-residents/
Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.
- BBB announcement on job scams
- FBI Cyber Crime resource page
See All 18 Production Engineer Jobs in San Francisco
Find roles in San Francisco that match your experience and apply in just a few clicks.
Find Production Engineer JobsProduction Engineer Job Market in San Francisco
Who's Hiring
- FluidStack3
- Salesforce2
- Guild1
- Google1
- Natera1
Top Industries Hiring
- Technology & Software10
- Science & Research2
- Education1
- Agriculture & Farming1
- Artificial Intelligence1
Production Engineer Jobs in San Francisco: Frequently Asked Questions
How do I get a production engineer job in San Francisco?
Target San Francisco's strongest hiring sectors: semiconductor and hardware companies in SoMa, biotech manufacturers in Mission Bay, and cloud infrastructure teams in the Financial District. Hands-on experience with yield optimization, process control, or reliability engineering stands out here. Networking through local IEEE chapters and Bay Area manufacturing meetups gives candidates a real edge in a market where referrals move faster than cold applications.
Which companies hire production engineers in San Francisco?
San Francisco production engineer roles are posted by FluidStack, Salesforce, and Guild and others right now, based on current listings on Migrate Mate as of June 2026. The local market skews toward high-tech hardware firms, biotech device manufacturers, and software-defined infrastructure companies, many of which maintain production and reliability engineering teams directly in the city rather than offshoring them to the wider Bay Area.
Are there remote production engineer jobs in San Francisco?
Yes, though availability depends heavily on the role type: hands-on process and manufacturing positions rarely go fully remote, while reliability, DevOps-adjacent, and analytical production engineering roles are far more flexible. About 29% of production engineer openings tied to San Francisco are remote or hybrid as of June 2026. The most remote-friendly work in this market tends to be software production engineering at cloud and SaaS companies based in SoMa and the Financial District.
How can I get a production engineer job in San Francisco with little or no experience?
The most realistic entry path in San Francisco is targeting associate or junior production engineer roles at mid-size hardware and biotech startups in Mission Bay and Dogpatch, which hire more entry-level talent than large established manufacturers. Internships at UCSF-affiliated medtech companies or contract roles at semiconductor firms in SoMa build the hands-on process experience local employers prioritize. A strong capstone project demonstrating yield analysis or process improvement is noticed in this market.
Which industries hire the most production engineers in San Francisco?
Most production engineer openings in San Francisco sit in Technology & Software, Science & Research, and Education, per current listings on Migrate Mate as of June 2026. San Francisco's concentration of hardware startups, biotech device manufacturers in Mission Bay, and cloud infrastructure companies creates consistent demand across both physical process engineering and software reliability engineering, making the city's market broader than most coastal metros of comparable size.
Related Jobs in California
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