Senior Level Rare Disease Business Manager Jobs

Senior level rare disease business manager jobs place experienced professionals in charge of market strategy, cross-functional execution, and the commercial outcomes that define a therapy's performance in complex patient populations. Openings concentrate in Medical Devices, Biotechnology & Pharmaceuticals, and Healthcare & Medical Services, with a mix of on-site, remote, and hybrid roles available from employers like Takeda Pharmaceuticals, Biogen, and Ambry Genetics hiring at this level now.

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Overview

Open roles12
Top stateMassachusetts
Top employerTakeda Pharmaceuticals
Top cityCambridge, MA
Work type86% Remote
Top industryMedical Devices

Showing 5 of 12+ Senior Level Rare Disease Business Manager jobs

IPSEN
Associate Director, HCP Marketing, Rare Disease
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IPSEN
New 1m ago
Associate Director, HCP Marketing, Rare Disease
IPSEN
Cambridge, Massachusetts
Brand Marketing
Creative & Design
Marketing
$194k - $220k/yr
Master's degree in business administration
5,001-10,000

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Shionogi Inc.
Senior Director Portfolio Strategy and Execution (Rare Disease)
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Shionogi Inc.
New 1m ago
Senior Director Portfolio Strategy and Execution (Rare Disease)
Shionogi Inc.
Florham Park, New Jersey
Account Management
Business Operations
Customer Success
Partnerships & Business Development
$270k - $300k/yr
Master's degree in business administration
201-500

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Takeda Pharmaceuticals
Rare Disease Business Manager- Alpha 1 (Detroit)
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Takeda Pharmaceuticals
New 1m ago
Rare Disease Business Manager- Alpha 1 (Detroit)
Takeda Pharmaceuticals
Michigan
Brand & Social Media
Marketing
Partnerships & Business Development
Sales
$66.11 - $90.91/hr
Remote (US)
Bachelor's degree
10,000+

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Takeda Pharmaceuticals
Rare Disease Business Manager, Alpha 1 (Tampa, FL)
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Takeda Pharmaceuticals
New 1m ago
Rare Disease Business Manager, Alpha 1 (Tampa, FL)
Takeda Pharmaceuticals
Florida
Project & Program Management
Solutions Engineering & Architecture
Technical Program Management
$63.51 - $87.31/hr
Remote (US)
Bachelor's degree
10,000+

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Biogen
Associate Director, Rare Disease Market Access Strategy
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Biogen
New 1m ago
Associate Director, Rare Disease Market Access Strategy
Biogen
Cambridge, Massachusetts
Account Management
Business Development
Sales
$171k - $236k/yr
Master's degree in business administration
5,001-10,000

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Senior Level Rare Disease Business Manager Job Market

Who's Hiring

  • Takeda Pharmaceuticals
    Takeda Pharmaceuticals3
  • Biogen
    Biogen2
  • Ambry Genetics
    Ambry Genetics2
  • Amgen
    Amgen1
  • IPSEN
    IPSEN1

Top Industries Hiring

  • Medical Devices3
  • Biotechnology & Pharmaceuticals3
  • Healthcare & Medical Services2
  • Science & Research1
  • Technology & Software1

Senior Level Rare Disease Business Manager Jobs: Frequently Asked Questions

How do I get a senior level rare disease business manager job?

Employers at this level look for candidates who have owned a geographic territory or product launch in a rare or specialty disease space, not just contributed to one. Demonstrating that you have influenced payer access strategy, led cross-functional account teams, and navigated complex patient identification challenges gives you a clear edge. A strong network within patient advocacy and key opinion leader communities also matters significantly at the senior stage.

Which companies hire senior level rare disease business managers?

Companies hiring senior level rare disease business managers right now include Takeda Pharmaceuticals, Biogen, and Ambry Genetics, based on current listings on Migrate Mate as of July 2026. Hiring at this level covers dedicated rare disease biotechs, specialty pharma divisions within large biopharmaceutical companies, and emerging gene therapy and cell therapy organizations scaling their commercial teams.

Are there remote senior level rare disease business manager jobs?

Yes, though many roles require regional travel given the field-based nature of rare disease commercial work. About 86% of senior level rare disease business manager openings are remote or hybrid as of July 2026, reflecting how companies balance home-office flexibility with the expectation that senior managers are present with key accounts and medical centers.

What makes a rare disease business manager role senior level?

Senior level roles carry full ownership of a defined territory, product, or account segment rather than executing someone else's plan. Expectations include setting local strategy, coaching junior field colleagues, managing complex stakeholder relationships across medical, payer, and patient advocacy channels, and reporting directly on business performance. The scope is broader, the autonomy is greater, and accountability for commercial results sits clearly with you.

Which industries hire the most senior level rare disease business managers?

Senior Level rare disease business manager roles concentrate in Medical Devices, Biotechnology & Pharmaceuticals, and Healthcare & Medical Services, based on current listings on Migrate Mate as of July 2026. These sectors drive hiring at this level because they are actively commercializing approved rare disease therapies or expanding into new indications that require experienced field leaders who can build markets with limited patient populations.