Registered Nurse Operating Room Jobs in St. Louis, MO

Registered Nurse Operating Room jobs in St. Louis are concentrated around the Central West End medical corridor, Barnes-Jewish and Cortex districts, and the South City hospital campuses, with demand running strong across academic medical centers, health systems, and surgical specialty centers. Employers hiring right now include BJC HealthCare, Mercy, and American Traveler. Scan the live roles below and apply to whichever ones fit.

Find Jobs

Overview

Open roles70
Top employerBJC HealthCare
Top credentialNursing Diploma
Companies hiring5

Showing 5 of 70+ Registered Nurse Operating Room jobs

Surgical Technologist - Main Operating Room
We won't show you this job again
Added 4d ago
Surgical Technologist - Main Operating Room
Mercy
St. Louis, Missouri
Healthcare Administration
Patient Services & Wellbeing
Public Health
BLS Certification
10,000+

Have you applied for this role?

RN First Assistant - Main Operating Room
We won't show you this job again
Added 4d ago
RN First Assistant - Main Operating Room
Mercy
St. Louis, Missouri
Healthcare Administration
Patient Services & Wellbeing
Public Health
10,000+

Have you applied for this role?

Surgical Technologist First Assistant - Main Operating Room
We won't show you this job again
Added 4d ago
Surgical Technologist First Assistant - Main Operating Room
Mercy
St. Louis, Missouri
Engineering (Non-Software)
Manufacturing Engineering
Robotics Engineering
BLS Certification
10,000+

Have you applied for this role?

Travel RN - Operating Room
We won't show you this job again
Added 4d ago
Travel RN - Operating Room
American Traveler
St. Louis, Missouri
Healthcare Administration
Nursing
Patient Services & Wellbeing
BLS Certification
501-1,000

Have you applied for this role?

Operating Room Registered Nurse Full Time
We won't show you this job again
Added 5d ago
Operating Room Registered Nurse Full Time
United Surgical Partners
St. Louis, Missouri
Healthcare Administration
Nursing
Patient Services & Wellbeing
ACLS Certification
10,000+

Have you applied for this role?

See All 70 Registered Nurse Operating Room Jobs in St. Louis

Find roles in St. Louis that match your experience and apply in just a few clicks.

Find Jobs

Registered Nurse Operating Room Job Market in St. Louis

Who's Hiring

  • BJC HealthCare34
  • Mercy21
  • American Traveler8
  • SSM Health5
  • United Surgical Partners3

Registered Nurse Operating Room Jobs in St. Louis: Frequently Asked Questions

How do I get a registered nurse operating room job in St. Louis?

St. Louis hiring concentrates in its academic medical systems and large health network affiliates, particularly around the Central West End and midtown hospital campuses. Candidates with scrub and circulating experience across general, cardiac, or orthopedic surgery move fastest here. Perioperative certifications like CNOR sharpen your competitiveness with the larger systems. Reaching out to surgical staffing coordinators directly at St. Louis health networks often surfaces openings before they appear publicly.

Which companies hire registered nurse operating rooms in St. Louis?

St. Louis registered nurse operating room roles are posted by BJC HealthCare, Mercy, and American Traveler and others right now, based on current listings on Migrate Mate as of November 2026. The local market is anchored by large academic health systems, regional hospital networks, and ambulatory surgical centers spread throughout the city and its western suburbs.

How can I get a registered nurse operating room job in St. Louis with little or no experience?

The most realistic entry path in St. Louis is through a perioperative nurse residency or OR internship offered by the city's larger academic health systems, which are designed specifically for RNs without prior surgical experience. Starting in a medical-surgical unit at a St. Louis community hospital and requesting elective procedure exposure builds the clinical foundation employers look for. Volunteering for weekend on-call coverage during training also demonstrates commitment that local hiring managers notice.

See All 70 Registered Nurse Operating Room Jobs in St. Louis

Find roles in St. Louis that match your experience and apply in just a few clicks.

Find Jobs