Remote Advanced Systems Engineer Jobs
Remote advanced systems engineer jobs are in active demand across the U.S., with remote-first firms and distributed engineering teams hiring for roles in defense, aerospace, telecommunications, and enterprise software. Employers hiring remotely right now include Southern California Edison, Lee Health, and Everforth ECS. Scan the live roles below and apply to whichever ones fit.
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In this role, you will collaborate with the ARPA-H Program Manager and team to effectuate bold ARPA-H research initiatives, support the development, funding, and management of new and existing R&D programs to meet ARPA-H's mission to accelerate better health outcomes for everyone.
The ideal candidate will be able to assist, support, and provide advice to the Program Manager to further the development and progress of new and existing programs. The candidate will be tasked to support the development and management of new and existing programs.
More specifically, the candidate should be comfortable working across disciplines and assessing the integration of biological systems with autonomous experimentation, high-throughput screening, sensors, instrumentation, and other advanced research platforms.
The candidate should have strong logical and critical thinking skills and be able to critically review scientific and technical data. The candidate will be expected to integrate into an existing team to support current ARPA-H efforts and be able to operate independently and in a group environment in support of technical R&D efforts. This is a remote position.
These SETA duties include but are not limited to:
- Conduct thorough scientific evaluation of the current R&D landscape to identify gaps in research portfolios to address critical needs that are aligned with the ARPA-H mission.
- Monitor and track performers progress toward established metrics.
- Read and digest complex information and develop briefings for technical and non-technical audiences.
- Other tasks include some basic administrative tasks such as collecting, sorting, analyzing, and writing internal programmatic reports/briefings on relevant topics in a health-related field.
- Some CONUS travel is expected (~10-20%) as needed to fully support the program(s) and Program Manager.
- Must be able to obtain a federal government Public Trust clearance.
- Candidates should have experience in biomedical engineering strategy as well as a PhD in biomedical sciences with a preference for one of the following or related fields:
- Biomedical Engineering, Biochemistry, Biomaterials, Cell Biology, Regenerative Medicine, and Cancer Biology.
- The ideal candidate will have at least:
- Five years of industry (e.g., biotechnology or biopharmaceutical companies) experience;
- 2-3 years of prior Government SETA experience; and
- Some experience with regulatory affairs in regenerative medicine.
- The ideal candidate will bring advanced scientific or engineering expertise in areas such as tissue engineering, regenerative medicine, organoids, microphysiological systems (organ-on-chip), aging biology, or related biomedical sciences.
- The ideal candidate must have strong PowerPoint and Excel skills, which include proficiency with keyboard shortcuts and ability to create PPT slides and Excel files on the fly during a meeting in a high-pressure environment.
- Strong oral and written communication skills are required.
- Professional curiosity, continuous drive for learning, and the ability to focus on assigned tasks are critical attributes of the ideal candidate
Req Benefits:
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Who's Hiring

Top Industries Hiring
- Electronics & Hardware
What Employers Look For
The qualifications that appear most often in remote advanced systems engineer jobs.
- Bachelor's or master's degree in systems engineering, electrical engineering, or a related technical field
- Experience with Model-Based Systems Engineering tools such as DOORS, Cameo, or Rhapsody
- Proficiency in requirements management and verification and validation processes
- Familiarity with MIL-STD, DO-178, or other domain-specific standards and compliance frameworks
- Active or adjudicable security clearance, depending on program and contract
- Experience with interface control documents and system-of-systems integration planning
Tips for Your Remote Advanced Systems Engineer Job Search
Apply early to remote roles that fit
Migrate Mate lists remote advanced systems engineer openings from across the U.S. in one place, so you can find roles that match your background and apply directly without sifting through unrelated postings.
Demonstrate async communication in your application
Remote employers for this role screen hard for written clarity. Submit cover materials that are structured, precise, and free of ambiguity. Treat every written touchpoint as a preview of how you'll coordinate on distributed engineering teams.
Build a visible systems engineering portfolio
Remote hiring managers can't observe you in a lab or office, so your work needs to speak for itself. Document architecture decisions, requirements traceability work, and integration outcomes in a shareable format, whether that's a personal site, a GitHub repository, or a structured PDF.
Prepare for remote-specific technical interviews
Remote advanced systems engineer interviews often include whiteboard-style architecture reviews over video, collaborative diagramming in tools like Lucidchart or Miro, and scenario questions about coordinating trade studies across distributed teams. Practice explaining design decisions clearly without in-person cues.
Remote Advanced Systems Engineer Jobs: Frequently Asked Questions
How do I get a remote advanced systems engineer job?
Remote advanced systems engineers get hired by targeting companies that run distributed engineering teams, particularly in defense contracting, aerospace, enterprise software, and telecommunications. Remote employers screen heavily for self-direction, strong written communication, and the ability to coordinate across time zones without hand-holding. Proficiency in systems modeling tools, requirements management platforms, and documentation practices gives candidates a clear edge over those with equivalent technical skills but no remote work history.
Which companies hire remote advanced systems engineers?
Employers currently hiring remote advanced systems engineers include Southern California Edison, Lee Health, and Everforth ECS, per current remote listings on Migrate Mate as of November 2026. Remote openings for this role are most common at remote-first defense contractors, distributed aerospace firms, and enterprise software companies running geographically dispersed engineering organizations.
Can you get a remote advanced systems engineer job with no experience?
Yes, but remote entry-level roles are harder to land because employers expect you to work independently from day one with minimal oversight. Companies most likely to hire junior remote advanced systems engineers include smaller defense contractors and software firms with structured onboarding. Showing a portfolio of systems architecture work, contributions to open engineering projects, or certifications in systems engineering methodologies opens doors when direct experience is limited.
Do you need a degree for remote advanced systems engineer jobs?
Usually, but not always. Most remote employers in defense, aerospace, and enterprise software list a bachelor's degree in systems engineering, electrical engineering, or a related field as a baseline requirement. Remote hiring managers also weigh demonstrated systems design work, relevant certifications like INCOSE CSEP, and a portfolio showing complex integration or architecture decisions, particularly for candidates whose degree is in an adjacent field.
Which industries hire the most remote advanced systems engineers?
Remote advanced systems engineer roles concentrate in Electronics & Hardware, based on current remote listings on Migrate Mate as of November 2026. These sectors hire advanced systems engineers remotely because their engineering organizations are built around distributed teams coordinating across multiple facilities, programs, and time zones.
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