Senior AI Product Manager Jobs in San Francisco, CA
Senior AI Product Manager jobs in San Francisco are in high demand, concentrated in SoMa, the Financial District, and Mission Bay across AI infrastructure, enterprise software, and consumer technology. Employers hiring right now include Innovaccer, Meta, and CRUSOE. See the openings below and apply to the ones that match your experience.
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The Position
Why Genentech
We’re passionate about delivering on Our Promise to improve the lives of patients and create healthier communities for all. We foster a culture of inclusivity, integrity and creativity while boldly pursuing answers to the world’s most complex health challenges and transforming society.
Who We Are
Our Data, Digital and Analytics (DDA) team is dedicated to solving complex healthcare challenges and improving patient outcomes. Data, Digital and Analytics empowers business partners across Commercial, Medical, and Government Affairs (CMG) to make impactful decisions by leveraging data, analytics, business products, and AI/ML to enable fast, targeted actions in rapidly evolving business contexts.
Data, Digital and Analytics fosters a unified understanding of customers, actions, and outcomes by integrating analytics and insights seamlessly into CMG’s evolving digital, data, and automation platforms, creating scalable solutions and eliminating silos.
In Data, Digital and Analytics, you will work as a trusted, objective advisor and expert, recommending critical decisions and actions to be taken with credibility and a focus on driving measurable impact. You will be part of a thriving culture built on collaboration and innovation.
The Opportunity
As an AI & Digital Data Product Manager, you will drive execution from strategy through implementation for a designated portfolio of advanced AI/ML pipelines and digital data products. Reporting directly to the Director AI & Digital Data Products, you will own the full product lifecycle, spearhead digital transformation initiatives, translate complex business needs into actionable roadmaps, and collaborate within cross-functional data squads to deliver scalable AI and digital data solutions.
Product Lifecycle Ownership: Manage execution from digital product strategy through implementation for a portfolio of AI and Analytical Data Products, driving roadmap development, release management, and continuous optimization.
Agile Collaboration & Digital Transformation: Champion a digital product operating model mindset, participating in agile routines and collaborating within cross-functional AI and data squads to deliver iterative value.
Stakeholder Liaison: Act as the primary point of contact for inquiries and digital demand requests, effectively bridging the gap between business stakeholders, AI/ML researchers, and the data product technology team.
Data Standards & AI Quality: Partner with data owners and cross-functional teams to define and enforce data standards, ensuring AI model readiness, data quality, testing, usability, and seamless workflow integration.
Architectural Guidance & Advanced Strategy: Guide the team in adhering to data mesh, data fabric, Semantic Layer concepts, advanced digital product strategy, and FAIR (Findable, Accessible, Interoperable, Reusable) data principles.
Backlog Management: Maintain and prioritize the AI and digital data product backlog for your designated portfolio to ensure it efficiently addresses the requirements of evolving business use cases.
Performance Monitoring: Monitor and measure data product performance in collaboration with IT partners, identifying opportunities to optimize value delivery to end users.
Who you are
You possess a Bachelor's degree in Business, Technology, Operations, Marketing, Data Science, Information Systems, Business Analytics, Computer Science, or a related field.
You have 3+ years of combined experience in AI & digital data product management, data management, AI/ML product development, software development, or equivalent experience, with a proven track record in digital transformation and driving execution from strategy to implementation.
You demonstrate strong technical fluency with data systems, SQL, AI/ML frameworks, and cloud-based data platforms (e.g., AWS, GCP, Azure) to inform digital product decisions.
You possess working knowledge of Semantic Layer concepts, data governance frameworks, and FAIR data principles.
You have proven experience collaborating with Legal, Compliance, and Privacy teams to ensure adherence to governance and regulatory standards.
Preferred
Advanced degree such as an MBA or related graduate-level qualification.
Professional experience in data management, technical project management, or business analysis within the pharmaceutical, biotechnology, finance, CPG, or management consulting industries.
Experience with AI-driven products, omnichannel/digital marketing solutions, or CRM systems.
Expertise in driving product enhancements based on measurement, optimization insights, and data usage metrics.
Strong problem-solving abilities and adaptability to navigate ambiguous or evolving environments.
Location
This role is based in South San Francisco and offers a hybrid schedule working 3 day per week on campus
No relocation benefits are available for this posting
The expected salary range for this position based on the primary location of South San Francisco, CA is $125,200 - $232,600. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
See All 334+ Senior AI Product Manager Jobs in San Francisco
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Find JobsSenior AI Product Manager Job Market in San Francisco
Who's Hiring
- Innovaccer21

- Meta11

- CRUSOE11

- Okta11

- Sigma Computing11

Top Industries Hiring
- Technology & Software77
- Science & Research7
- Banking & Financial Services7
- Education4
- Healthcare & Medical Services4
Senior AI Product Manager Jobs in San Francisco: Frequently Asked Questions
How do I get a senior ai product manager job in San Francisco?
Target AI-native companies, enterprise software firms, and fintech platforms in SoMa, Mission Bay, and the Financial District, where most senior ai product manager roles concentrate. Candidates with hands-on experience shipping AI or machine learning features have a clear edge in this market. Building a portfolio of shipped AI products and engaging with San Francisco's dense network of product-focused meetups and tech communities helps differentiate your application.
Which companies hire senior ai product managers in San Francisco?
Employers hiring senior ai product managers in San Francisco right now include Innovaccer, Meta, and CRUSOE, based on current listings on Migrate Mate as of September 2026. San Francisco's hiring base skews toward AI-native startups, established enterprise software companies, and consumer tech platforms with large product organizations.
Are there remote senior ai product manager jobs in San Francisco?
Yes, though many senior ai product manager roles in San Francisco require regular in-person collaboration given how closely the work intersects with engineering and design teams. About 74% of senior ai product manager openings tied to San Francisco are remote or hybrid as of September 2026, with fully remote options most common at later-stage startups and large enterprise tech companies. Strategic and roadmap-focused work tends to be the most remote-friendly portion of the role.
How can I get a senior ai product manager job in San Francisco with little or no experience?
The most realistic entry path in San Francisco is moving laterally from a technical role, such as software engineering or data science, into an associate or mid-level AI product manager position at a startup or growth-stage company in SoMa or Mission Bay. San Francisco's high density of AI startups means many teams prefer candidates with engineering depth over traditional product backgrounds. Contributing to open-source AI projects and building a portfolio of AI-adjacent work strengthens your candidacy significantly.
Which industries hire the most senior ai product managers in San Francisco?
Most senior ai product manager openings in San Francisco sit in Technology & Software, Science & Research, and Banking & Financial Services, per current listings on Migrate Mate as of September 2026. San Francisco's concentration of AI research labs, enterprise SaaS companies, and consumer technology platforms makes these sectors the primary drivers of local demand for this role.
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