Senior ML Engineer Jobs in San Diego, CA

Senior ML Engineer jobs in San Diego are concentrated in defense technology, biotech, and enterprise software, with the heaviest hiring in Sorrento Valley, UTC, and the Torrey Pines corridor. Employers actively posting roles include Qualcomm, ASML, and Apple. See the openings below and apply to the ones that match your experience.

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Overview

Open roles758+
Top employerQualcomm
Work type82% On-site
Top credentialDoctoral degree in Computer Science
Companies hiring13

Showing 5 of 758+ Senior ML Engineer jobs

Machine Learning Engineer, Evaluation and Quality, Creativity Apps
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Added 3d ago
Machine Learning Engineer, Evaluation and Quality, Creativity Apps
Apple
San Diego, California
Data Engineering
Data Science
ML (Machine Learning)
Software Engineering
$142k - $263k/yr
Bachelor's degree
10,000+

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Researcher - Artificial Intelligence and Machine Learning
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Added 1w ago
Researcher - Artificial Intelligence and Machine Learning
University of San Diego
San Diego, California
Data Science & Analytics
Quality Assurance & Testing (QA Testing)
Software Engineering
$20 - $40/hr
Bachelor's degree in electrical engineering
1,001-5,000

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Senior Machine Learning Engineer – End-to-End Autonomous Driving
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Added 1w ago
Senior Machine Learning Engineer – End-to-End Autonomous Driving
Qualcomm
San Diego, California
Engineering (Non-Software)
Mechanical Engineering
Specialized Engineering
$141k - $211k/yr
Doctoral degree in Computer Science
10,000+

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Senior Staff Engineer, Machine Learning Engineering ( Agentic AI SW )
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Added 3w ago
Senior Staff Engineer, Machine Learning Engineering ( Agentic AI SW )
Qualcomm
San Diego, California
Business Operations
Program Management
Project Management
$194k - $292k/yr
Doctoral degree in Computer Science
10,000+

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Senior Staff Engineer, Machine Learning Engineering ( On-device SW )
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Added 1mo ago
Senior Staff Engineer, Machine Learning Engineering ( On-device SW )
Qualcomm
San Diego, California
Electrical Engineering
Engineering (Non-Software)
Project & Program Management
$194k - $292k/yr
Doctoral degree in Computer Science
10,000+

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See All 758+ Senior ML Engineer Jobs in San Diego

Find roles in San Diego that match your experience and apply in just a few clicks.

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Senior ML Engineer Job Market in San Diego

Who's Hiring

  • Qualcomm433
  • ASML27
  • Apple27
  • Google27
  • Intuit27

Top Industries Hiring

  • Electronics & Hardware162
  • Telecommunications108
  • Technology & Software108
  • Science & Research27
  • Media & Entertainment27

Senior ML Engineer Jobs in San Diego: Frequently Asked Questions

How do I get a senior ml engineer job in San Diego?

Target San Diego's three dominant hiring clusters: defense and national security contractors in Kearny Mesa and Sorrento Valley, life sciences and biotech companies along the Torrey Pines corridor, and enterprise software firms in UTC and downtown. Candidates with experience in computer vision, NLP, or predictive modeling stand out here. A portfolio demonstrating deployed models in regulated or mission-critical environments gives you a clear edge in this market.

Which companies hire senior ml engineers in San Diego?

Companies currently hiring senior ml engineers in San Diego include Qualcomm, ASML, and Apple, per current listings on Migrate Mate as of November 2026. San Diego's employer base skews toward defense primes, genomics and precision medicine firms, and growth-stage software companies, many of which maintain dedicated ML teams on-site.

Are there remote senior ml engineer jobs in San Diego?

Yes, though senior ml engineer roles trend toward hybrid arrangements rather than fully remote, since production deployment and cross-functional collaboration often require in-person coordination. About 18% of senior ml engineer openings tied to San Diego are remote or hybrid as of November 2026. Research and modeling-focused roles at biotech and software companies offer the most remote flexibility locally.

How can I get a senior ml engineer job in San Diego with little or no experience?

The most realistic entry path in San Diego is through associate or mid-level ML or data science roles at biotech companies along the Torrey Pines corridor or at defense contractors in Kearny Mesa, where structured engineering teams offer mentorship and internal advancement. Contributing to open-source ML projects, completing a research internship at UC San Diego, or building domain-specific portfolio work in genomics or sensor data strengthens a candidacy for local openings.

Which industries hire the most senior ml engineers in San Diego?

San Diego senior ml engineer roles concentrate in Electronics & Hardware, Telecommunications, and Technology & Software, based on current listings on Migrate Mate as of November 2026. The region's deep roots in defense contracting, genomic research, and wireless technology create sustained and specialized demand for senior ML talent across those sectors.

See All 758+ Senior ML Engineer Jobs in San Diego

Find roles in San Diego that match your experience and apply in just a few clicks.

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