Senior ML Engineer Jobs in San Francisco, CA
Senior ML Engineer jobs in San Francisco are in high demand, concentrated in SoMa, Mission Bay, and the Financial District across AI infrastructure, enterprise software, and biotech. Employers hiring right now include Pinterest, Genentech, and OpenAI. See the openings below and apply to the ones that match your experience.
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INTRODUCTION
The Senior Principal AI Agent / ML Software Engineer is a Senior Staff-level, hands-on technical leadership role responsible for defining, building, and operating next-generation AI systems on Oracle Cloud Infrastructure (OCI). This person will set architecture and engineering direction for production-grade agentic AI platforms, autonomous workflows, scalable inference infrastructure, and enterprise AI applications used in large-scale, business-critical environments.
This role requires a proven engineer who can translate ambiguous product and platform goals into durable technical strategy, lead multi-team execution without direct authority, and remain deeply hands-on in design, code, reviews, operations, and incident follow-up. The ideal candidate combines deep distributed systems experience with practical AI-native engineering, including orchestration of LLMs, tools, APIs, memory, retrieval, evaluation, guardrails, and cloud services. The expectation is to ship, scale, and operate reliable, secure, observable, and cost-aware AI platform systems while raising the technical bar for engineers across the organization.
Responsibilities
- Serve as a senior technical owner for OCI AI platform capabilities, including agent execution, inference systems, model serving, AI workflow orchestration, evaluation, and observability.
- Design, architect, and deliver scalable agentic AI systems capable of reasoning, planning, tool use, workflow execution, multi-step task orchestration, and safe human-in-the-loop escalation.
- Build production-grade services for tool calling, agent memory, context management, Model Context Protocol (MCP) integration, vector retrieval, multi-agent coordination, policy enforcement, and evaluation.
- Lead architecture across distributed services optimized for low latency, high throughput, GPU efficiency, reliability, cost, operability, and secure multi-tenant operation.
- Define service boundaries, APIs, data models, state management, consistency tradeoffs, failure modes, SLIs/SLOs, rollout strategies, and operational readiness criteria for AI platform services.
- Drive technical strategy across infrastructure, platform, security, data, and application engineering teams, converting broad goals into executable multi-quarter plans and measurable milestones.
- Integrate AI agents securely and reliably with enterprise APIs, cloud services, databases, identity systems, secrets management, and external systems.
- Establish AgentOps and LLMOps practices for tracing, monitoring, eval suites, regression testing, experimentation, safety guardrails, prompt/tool versioning, and production reliability.
- Evaluate and operationalize emerging technologies in generative AI, agentic workflows, inference optimization, long-context systems, reasoning models, AI developer tooling, and agentic-first development.
- Drive engineering excellence through code reviews, design reviews, test strategy, deployment automation, incident analysis, documentation, and AI-assisted development practices using tools such as Codex, Claude Code, Cursor, Copilot, or similar systems.
- Mentor Staff and senior engineers, raise architectural standards, and influence engineering practices across OCI without requiring direct management authority.
- Own critical production outcomes, including reliability, performance, security posture, cost efficiency, and supportability for the systems delivered.
REQUIRED QUALIFICATIONS
- Bachelor's, Master's, or Ph.D. in Computer Science, AI/ML, Engineering, or a related field, or equivalent practical experience.
- 12+ years of professional software engineering experience, including significant ownership of production systems; or equivalent experience demonstrating Senior Staff / Principal-level impact.
- Proven track record as a Staff, Senior Staff, Principal, or equivalent technical leader influencing architecture and execution across multiple teams.
- Deep experience designing, building, and operating high-scale distributed systems, cloud services, infrastructure platforms, or AI/ML platform services.
- Hands-on experience with production AI systems, agentic AI applications, autonomous workflows, tool-using agents, multi-step orchestration, or multi-agent systems.
- Practical experience with orchestration frameworks such as LangGraph, LangChain, CrewAI, AutoGen, LlamaIndex, or similar ecosystems.
- Deep understanding of LLM application patterns, including prompt design, structured outputs, function/tool calling, context management, RAG, memory, tool safety, and evaluation.
- Strong programming skills in Python and ability to contribute high-quality production code, reviews, tests, and debugging in complex distributed environments.
- Strong expertise with Kubernetes, Docker, cloud-native infrastructure, service-to-service communication, scalability, fault tolerance, observability, and performance analysis.
- Experience defining SLIs/SLOs, production readiness criteria, incident response practices, monitoring, tracing, experiments, and reliability programs for AI or distributed systems.
- Strong understanding of AI safety, governance, security, and operational risks for autonomous or semi-autonomous systems, including data handling, access control, auditability, and human accountability.
- Excellent written and verbal communication, with demonstrated ability to lead technical direction, resolve ambiguity, and influence senior stakeholders.
PREFERRED QUALIFICATIONS
- Experience optimizing large-scale GPU inference or training workloads for latency, throughput, utilization, availability, and cost.
- Experience building or operating model serving, inference gateways, agent runtimes, workflow engines, developer platforms, or internal AI productivity platforms.
- Experience integrating AI systems with enterprise APIs, databases, cloud services, vector databases, embeddings, retrieval systems, identity systems, and policy enforcement layers.
- Experience with LLM fine-tuning, long-context systems, reasoning models, model routing, caching, batching, quantization, or emerging generative AI research.
- Experience building evaluation frameworks for agentic systems, including offline evals, online experiments, golden tasks, adversarial testing, regression gates, and observability dashboards.
- Experience using AI-assisted software development tools such as Codex, Claude Code, Cursor, Copilot, or similar systems in large-scale engineering environments.
- Track record of defining architectural standards, platform capabilities, or engineering practices adopted across multiple teams or organizations.
- Experience in enterprise, cloud infrastructure, regulated, security-sensitive, or mission-critical environments.
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Find Senior ML Engineer JobsSenior ML Engineer Job Market in San Francisco
Who's Hiring
- Pinterest39

- Genentech14

- OpenAI13

- Lyft11

- DoorDash11

Top Industries Hiring
- Technology & Software203
- Science & Research20
- Artificial Intelligence20
- Retail15
- Fintech13
Senior ML Engineer Jobs in San Francisco: Frequently Asked Questions
How do I get a senior ml engineer job in San Francisco?
San Francisco's senior ML engineer market centers on AI-native startups in SoMa, large tech platforms headquartered in the city, and biotech firms in Mission Bay. Candidates who stand out have production-level experience with large-scale model deployment, a public portfolio of applied ML work, and fluency with the MLOps tooling those sectors use. Networking through local ML meetups and research seminars also gives you a concrete edge over remote applicants.
Which companies hire senior ml engineers in San Francisco?
Employers hiring senior ml engineers in San Francisco right now include Pinterest, Genentech, and OpenAI, based on current listings on Migrate Mate as of June 2026. The local market mixes AI-focused startups, established enterprise software companies, and research-driven biotech firms, all of which maintain dedicated ML engineering teams in the city.
Are there remote senior ml engineer jobs in San Francisco?
Yes, though availability depends on the role. Senior ML engineers working on model research, data pipelines, and evaluation frameworks tend to work remotely more often than those supporting on-premise infrastructure or hardware-adjacent teams. About 53% of senior ml engineer openings tied to San Francisco are remote or hybrid as of June 2026, with the highest share coming from enterprise software and AI platform companies headquartered here.
How can I get a senior ml engineer job in San Francisco with little or no experience?
The most realistic entry path in San Francisco is moving into a junior ML engineer or ML platform engineer role at one of the city's many mid-stage AI startups, which tend to have faster promotion tracks than large tech companies. Contributing to open-source ML projects, completing applied capstone work through local university programs such as UC Berkeley or UCSF data science initiatives, and attending Bay Area ML research events all help you build the portfolio and local connections that San Francisco employers expect before considering a promotion to the senior level.
Which industries hire the most senior ml engineers in San Francisco?
San Francisco senior ml engineer roles concentrate in Technology & Software, Science & Research, and Artificial Intelligence, based on current listings on Migrate Mate as of June 2026. San Francisco's density of AI-native companies, enterprise cloud platforms, and research-oriented biotech firms creates sustained demand for ML talent well beyond what most other U.S. cities generate.
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