Senior ML Engineer Jobs in San Francisco, CA

Senior ML Engineer jobs in San Francisco are in high demand, concentrated in SoMa, Mission Bay, and the Financial District across AI infrastructure, enterprise software, and biotech. Employers hiring right now include Uber, DoorDash, and Pinterest. See the openings below and apply to the ones that match your experience.

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Overview

Open roles758+
Top employerUber
Work type50% Hybrid
Top credentialMaster's degree
Companies hiring94

Showing 5 of 758+ Senior ML Engineer jobs

Principal Machine Learning Engineer
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Added 1d ago
Principal Machine Learning Engineer
Atlassian
San Francisco, California
Electrical Engineering
Engineering (Non-Software)
Quality Assurance & Testing (QA Testing)
$196k - $309k/yr
Remote (US)
10,000+

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Machine Learning Engineer, Applied AI Intern (Summer 2027)
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Added 3d ago
Machine Learning Engineer, Applied AI Intern (Summer 2027)
BRAIN
San Francisco, California
AI (Artificial Intelligence)
Data Science
ML (Machine Learning)
Hybrid
201-500

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Senior Machine Learning Engineer - Pricing
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Added 5d ago
Senior Machine Learning Engineer - Pricing
Uber
San Francisco, California
Data Science
Data Science & Analytics
ML (Machine Learning)
$202k - $224k/yr
Doctoral degree in Computer Science
10,000+

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Staff Machine Learning Engineer
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Added 5d ago
Staff Machine Learning Engineer
Integral Ad Science
San Francisco, California
Electrical Engineering
Engineering (Non-Software)
Quality Assurance & Testing (QA Testing)
Specialized Engineering
$135k - $232k/yr
Master's degree
501-1,000

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Senior Machine Learning Engineer
We won't show you this job again
Added 5d ago
Senior Machine Learning Engineer
Atlassian
San Francisco, California
Electrical Engineering
Engineering (Non-Software)
Quality Assurance & Testing (QA Testing)
Remote (US)
Master's degree
10,000+

Have you applied for this role?

See All 758+ Senior ML Engineer Jobs in San Francisco

Find roles in San Francisco that match your experience and apply in just a few clicks.

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Senior ML Engineer Job Market in San Francisco

Who's Hiring

  • Uber52
  • DoorDash39
  • Pinterest39
  • Lila Sciences30
  • Anthropic22

Top Industries Hiring

  • Technology & Software139
  • Artificial Intelligence22
  • Biotechnology & Pharmaceuticals22
  • Science & Research17
  • Banking & Financial Services13

Senior ML Engineer Jobs in San Francisco: Frequently Asked Questions

How do I get a senior ml engineer job in San Francisco?

San Francisco's senior ML engineer market centers on AI-native startups in SoMa, large tech platforms headquartered in the city, and biotech firms in Mission Bay. Candidates who stand out have production-level experience with large-scale model deployment, a public portfolio of applied ML work, and fluency with the MLOps tooling those sectors use. Networking through local ML meetups and research seminars also gives you a concrete edge over remote applicants.

Which companies hire senior ml engineers in San Francisco?

Employers hiring senior ml engineers in San Francisco right now include Uber, DoorDash, and Pinterest, based on current listings on Migrate Mate as of November 2026. The local market mixes AI-focused startups, established enterprise software companies, and research-driven biotech firms, all of which maintain dedicated ML engineering teams in the city.

Are there remote senior ml engineer jobs in San Francisco?

Yes, though availability depends on the role. Senior ML engineers working on model research, data pipelines, and evaluation frameworks tend to work remotely more often than those supporting on-premise infrastructure or hardware-adjacent teams. About 70% of senior ml engineer openings tied to San Francisco are remote or hybrid as of November 2026, with the highest share coming from enterprise software and AI platform companies headquartered here.

How can I get a senior ml engineer job in San Francisco with little or no experience?

The most realistic entry path in San Francisco is moving into a junior ML engineer or ML platform engineer role at one of the city's many mid-stage AI startups, which tend to have faster promotion tracks than large tech companies. Contributing to open-source ML projects, completing applied capstone work through local university programs such as UC Berkeley or UCSF data science initiatives, and attending Bay Area ML research events all help you build the portfolio and local connections that San Francisco employers expect before considering a promotion to the senior level.

Which industries hire the most senior ml engineers in San Francisco?

San Francisco senior ml engineer roles concentrate in Technology & Software, Artificial Intelligence, and Biotechnology & Pharmaceuticals, based on current listings on Migrate Mate as of November 2026. San Francisco's density of AI-native companies, enterprise cloud platforms, and research-oriented biotech firms creates sustained demand for ML talent well beyond what most other U.S. cities generate.

See All 758+ Senior ML Engineer Jobs in San Francisco

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