Senior ML Engineer Jobs in San Francisco, CA

Senior ML Engineer jobs in San Francisco are in high demand, concentrated in SoMa, Mission Bay, and the Financial District across AI infrastructure, enterprise software, and biotech. Employers hiring right now include Pinterest, Genentech, and OpenAI. See the openings below and apply to the ones that match your experience.

Find Senior ML Engineer Jobs

Overview

Open roles353+
Top employerPinterest
Work type47% On-site
Top credentialBachelor's
Companies hiring100+

Showing 5 of 353+ Senior ML Engineer jobs

Oracle
Lead Principal Machine Learning Engineer
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Oracle
Added 1d ago
Lead Principal Machine Learning Engineer
Oracle
San Francisco, California
Specialized Engineering
Engineering (Non-Software)
On-Site
Bachelor's
10,000+

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AppFolio
Staff Machine Learning Engineer
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AppFolio
Added 1d ago
Staff Machine Learning Engineer
AppFolio
San Francisco, California
Software Engineering
Data Science & Analytics
AI (Artificial Intelligence)
ML (Machine Learning)
Data Science
Property Management
On-Site
None
1,001-5,000

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General Motors (GM)
Senior Machine Learning Engineer II
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General Motors (GM)
Added 2d ago
Senior Machine Learning Engineer II
General Motors (GM)
San Francisco, California
Software Engineering
Data Science & Analytics
AI (Artificial Intelligence)
ML (Machine Learning)
Data Science
$290k - $360k/yr
Hybrid
Master's
10,000+

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Airbnb
Staff Machine Learning Engineer
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Airbnb
Added 3d ago
Staff Machine Learning Engineer
Airbnb
San Francisco, California
Software Engineering
Data Science & Analytics
AI (Artificial Intelligence)
ML (Machine Learning)
Data Science
$260k/yr
Remote (US)
Master's

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Airbnb
Machine Learning Engineer
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Airbnb
Added 3d ago
Machine Learning Engineer
Airbnb
San Francisco, California
Software Engineering
Data Science & Analytics
AI (Artificial Intelligence)
ML (Machine Learning)
Data Science
$180k/yr
On-Site
Doctorate

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See All 353+ Senior ML Engineer Jobs in San Francisco

Find roles in San Francisco that match your experience and apply in just a few clicks.

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Senior ML Engineer Job Market in San Francisco

Who's Hiring

  • Pinterest
    Pinterest39
  • Genentech
    Genentech14
  • OpenAI
    OpenAI13
  • Lyft
    Lyft11
  • DoorDash
    DoorDash11

Top Industries Hiring

  • Technology & Software203
  • Science & Research20
  • Artificial Intelligence20
  • Retail15
  • Fintech13

Senior ML Engineer Jobs in San Francisco: Frequently Asked Questions

How do I get a senior ml engineer job in San Francisco?

San Francisco's senior ML engineer market centers on AI-native startups in SoMa, large tech platforms headquartered in the city, and biotech firms in Mission Bay. Candidates who stand out have production-level experience with large-scale model deployment, a public portfolio of applied ML work, and fluency with the MLOps tooling those sectors use. Networking through local ML meetups and research seminars also gives you a concrete edge over remote applicants.

Which companies hire senior ml engineers in San Francisco?

Employers hiring senior ml engineers in San Francisco right now include Pinterest, Genentech, and OpenAI, based on current listings on Migrate Mate as of June 2026. The local market mixes AI-focused startups, established enterprise software companies, and research-driven biotech firms, all of which maintain dedicated ML engineering teams in the city.

Are there remote senior ml engineer jobs in San Francisco?

Yes, though availability depends on the role. Senior ML engineers working on model research, data pipelines, and evaluation frameworks tend to work remotely more often than those supporting on-premise infrastructure or hardware-adjacent teams. About 53% of senior ml engineer openings tied to San Francisco are remote or hybrid as of June 2026, with the highest share coming from enterprise software and AI platform companies headquartered here.

How can I get a senior ml engineer job in San Francisco with little or no experience?

The most realistic entry path in San Francisco is moving into a junior ML engineer or ML platform engineer role at one of the city's many mid-stage AI startups, which tend to have faster promotion tracks than large tech companies. Contributing to open-source ML projects, completing applied capstone work through local university programs such as UC Berkeley or UCSF data science initiatives, and attending Bay Area ML research events all help you build the portfolio and local connections that San Francisco employers expect before considering a promotion to the senior level.

Which industries hire the most senior ml engineers in San Francisco?

San Francisco senior ml engineer roles concentrate in Technology & Software, Science & Research, and Artificial Intelligence, based on current listings on Migrate Mate as of June 2026. San Francisco's density of AI-native companies, enterprise cloud platforms, and research-oriented biotech firms creates sustained demand for ML talent well beyond what most other U.S. cities generate.

See All 353+ Senior ML Engineer Jobs in San Francisco

Find roles in San Francisco that match your experience and apply in just a few clicks.

Find Senior ML Engineer Jobs