Senior ML Engineer Jobs in San Mateo, CA

Senior ML Engineer jobs in San Mateo are concentrated in the Hillsdale and Bay Meadows districts as well as the city's growing biotech and fintech corridors, with strong demand across financial services, healthcare technology, and enterprise software. Employers hiring right now include Roblox, BigHat Biosciences, and Sony Interactive Entertainment. See the openings below and apply to the ones that match your experience.

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Overview

Open roles758+
Top employerRoblox
Work type87% Hybrid
Top credentialBachelor's
Companies hiring10

Showing 5 of 758+ Senior ML Engineer jobs

Senior Principal Engineer, Data & Machine Learning
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Added 1w ago
Senior Principal Engineer, Data & Machine Learning
Sony Interactive Entertainment
San Mateo, California
Software Engineering
Solutions Architecture
Technical Product & Program Management
$304k - $456k/yr
Hybrid
Master's degree in computer science
1,001-5,000

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Machine Learning Engineer
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Added 1w ago
Machine Learning Engineer
Chooch
San Mateo, California
Data Engineering
Data Science
ML (Machine Learning)
Software Engineering
$120k - $180k/yr
Hybrid
Bachelor's degree in electrical engineering

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Machine Learning Intern - Master's
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Added 2w ago
Machine Learning Intern - Master's
Sony Interactive Entertainment
San Mateo, California
AI (Artificial Intelligence)
Data Science
ML (Machine Learning)
Hybrid
1,001-5,000

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Machine Learning Intern - PhD
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Added 2w ago
Machine Learning Intern - PhD
Sony Interactive Entertainment
San Mateo, California
AI (Artificial Intelligence)
Data Science
ML (Machine Learning)
Hybrid
1,001-5,000

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Director of Machine Learning
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Added 2w ago
Director of Machine Learning
BigHat Biosciences
San Mateo, California
AI (Artificial Intelligence)
Data Science
Software Engineering
$250k - $335k/yr
Hybrid
Doctoral degree in Computer Science

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See All 758+ Senior ML Engineer Jobs in San Mateo

Find roles in San Mateo that match your experience and apply in just a few clicks.

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Senior ML Engineer Job Market in San Mateo

Who's Hiring

  • Roblox310
  • BigHat Biosciences103
  • Sony Interactive Entertainment103
  • Chooch34
  • Upstart34

Top Industries Hiring

  • Technology & Software
  • Artificial Intelligence

Senior ML Engineer Jobs in San Mateo: Frequently Asked Questions

How do I get a senior ml engineer job in San Mateo?

The strongest path into San Mateo's senior ml engineer market is through the city's dense cluster of fintech companies, healthcare technology firms, and enterprise software shops concentrated in the Bay Meadows and Hillsdale areas. Candidates who bring experience with production model deployment, ML infrastructure, or recommendation systems have a clear edge locally, as San Mateo employers tend to hire for applied, revenue-driving ML work rather than pure research.

Which companies hire senior ml engineers in San Mateo?

Employers hiring senior ml engineers in San Mateo right now include Roblox, BigHat Biosciences, and Sony Interactive Entertainment, based on current listings on Migrate Mate as of November 2026. The local employer base skews toward mid-sized technology companies and established financial services firms, many of which have built in-house ML teams to support product and data initiatives.

Are there remote senior ml engineer jobs in San Mateo?

Yes, senior ml engineer roles are among the more remote-friendly positions in technology because the core work revolves around code, data pipelines, and model training rather than physical presence. About 93% of senior ml engineer openings tied to San Mateo are remote or hybrid as of November 2026, reflecting how broadly the local tech sector adopted flexible arrangements. Roles focused on experimentation, model evaluation, and research tend to offer the most location flexibility.

How can I get a senior ml engineer job in San Mateo with little or no experience?

The most realistic entry path in San Mateo is targeting ML engineer or data scientist roles at the city's mid-sized fintech and healthtech companies, which often hire candidates who can demonstrate strong project work even without extensive industry tenure. Contributing to open-source ML projects, building a portfolio on public datasets relevant to financial or clinical domains, and pursuing internships at San Mateo's product-driven technology firms all help candidates break in locally.

Which industries hire the most senior ml engineers in San Mateo?

Most senior ml engineer openings in San Mateo sit in Technology & Software and Artificial Intelligence, per current listings on Migrate Mate as of November 2026. San Mateo's position between Silicon Valley and San Francisco makes it a natural home for fintech platforms and enterprise software companies that rely heavily on production machine learning to power their core products.

See All 758+ Senior ML Engineer Jobs in San Mateo

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