Software Design Engineer Jobs in St. Louis, MO

Software Design Engineer jobs in St. Louis are concentrated in the Cortex Innovation Community, downtown Clayton, and the Midtown tech corridor, with strong demand from employers in defense technology, healthcare IT, and enterprise software. Companies hiring right now include Energizer, Cushman & Wakefield, and LUZCO Technologies. See the openings below and apply to the ones that match your experience.

Find Software Design Engineer Jobs

Overview

Open roles43
Top employerEnergizer
Work type54% Hybrid
Top credentialBachelor's degree
Companies hiring28

Showing 5 of 43+ Software Design Engineer jobs

Washington University in St. Louis
Senior Creative Director, Design (Hybrid) - Medicine Marketing & Communications
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Washington University in St. Louis
New 12h ago
Senior Creative Director, Design (Hybrid) - Medicine Marketing & Communications
Washington University in St. Louis
St. Louis, Missouri
Business Development
Marketing
Sales
$96k - $169k/yr
Hybrid
Bachelor's degree in communications
10,000+

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SSM Health
Regional Director, Planning, Design and Construction
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SSM Health
New 20h ago
Regional Director, Planning, Design and Construction
SSM Health
St. Louis, Missouri
Construction Management
Program Management
Project Management
Bachelor's degree in construction management
10,000+

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Cushman & Wakefield
Sr. Project Design Manager
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Cushman & Wakefield
Added 1d ago
Sr. Project Design Manager
Cushman & Wakefield
St. Louis, Missouri
Construction Management
Program Management
Project & Program Management
Project Management
$85k - $100k/yr
Hybrid
Bachelor's degree in interior design
10,000+

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Cushman & Wakefield
Project Design Manager
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Cushman & Wakefield
Added 1d ago
Project Design Manager
Cushman & Wakefield
St. Louis, Missouri
Construction Management
Engineering (Non-Software)
Project Management
$81k - $95k/yr
Remote (US)
Bachelor's degree in interior design
10,000+

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Washington University in St. Louis
Education Specialist (Hybrid) - Instructional Design Studio
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Washington University in St. Louis
Added 2d ago
Education Specialist (Hybrid) - Instructional Design Studio
Washington University in St. Louis
St. Louis, Missouri
Corporate Training
Instructional Design
Learning & Development
$58k - $100k/yr
Hybrid
Associate's degree
10,000+

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See All 43 Software Design Engineer Jobs in St. Louis

Find roles in St. Louis that match your experience and apply in just a few clicks.

Find Software Design Engineer Jobs

Software Design Engineer Job Market in St. Louis

Who's Hiring

Energizer
Energizer4 open roles
Cushman & Wakefield
Cushman & Wakefield4 open roles
LUZCO Technologies
LUZCO Technologies3 open roles

Top Industries Hiring

  • Construction & Real Estate
  • Consulting & Professional Services
  • Manufacturing
  • Retail
  • Education

Software Design Engineer Jobs in St. Louis: Frequently Asked Questions

How do I get a software design engineer job in St. Louis?

Focus your search on the Cortex Innovation Community and Clayton, where defense contractors, healthcare technology firms, and enterprise software companies cluster. Employers in the Boeing and Centene ecosystems hire software design engineers regularly, as do the growing number of Series B and C startups in the Midtown corridor. Candidates with embedded systems, systems architecture, or medical device software experience tend to stand out in the St. Louis market.

Which companies hire software design engineers in St. Louis?

St. Louis software design engineer roles are posted by Energizer, Cushman & Wakefield, and LUZCO Technologies and others right now, based on current listings on Migrate Mate as of July 2026. The St. Louis market draws from a broad base of large defense contractors, regional health systems, financial technology firms, and a growing cohort of venture-backed software startups anchored in the Cortex district.

Are there remote software design engineer jobs in St. Louis?

Yes, though many software design engineer roles involve collaborative design reviews, hardware integration, or lab access that favors in-person or hybrid arrangements. About 73% of software design engineer openings tied to St. Louis are remote or hybrid as of July 2026, with remote work most common for roles focused on software architecture, UX design systems, and backend platform engineering rather than embedded or hardware-adjacent work.

How can I get a software design engineer job in St. Louis with little or no experience?

The most realistic entry path in St. Louis is through associate or junior engineer roles at mid-size defense and aerospace contractors, which often hire recent graduates from Washington University, Saint Louis University, and Missouri S&T. Internship-to-hire pipelines at regional health technology companies are another strong avenue. Building a portfolio that demonstrates systems thinking, UI component work, or embedded software projects gives candidates a clear edge locally.

Which industries hire the most software design engineers in St. Louis?

St. Louis software design engineer roles concentrate in Construction & Real Estate, Consulting & Professional Services, and Manufacturing, based on current listings on Migrate Mate as of July 2026. Defense and aerospace anchor much of the demand given Boeing's long presence in the region, while healthcare IT growth from major health systems and a maturing fintech sector have added significant software design hiring over the past several years.

See All 43 Software Design Engineer Jobs in St. Louis

Find roles in St. Louis that match your experience and apply in just a few clicks.

Find Software Design Engineer Jobs