Software Systems Engineer Jobs in San Francisco, CA

Software Systems Engineer jobs in San Francisco are concentrated in SoMa, Mission Bay, and the Financial District, driven by demand across cloud infrastructure, embedded systems, and defense technology. Employers actively hiring include OpenAI, Databricks, and CRUSOE. Scan the live roles below and apply to whichever ones fit.

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Overview

Open roles33
Top employerOpenAI
Work type68% On-site
Companies hiring21

Showing 5 of 33+ Software Systems Engineer jobs

US PharmaLab Inc.
Embedded Software Engineer – Computer Vision & Imaging Systems
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US PharmaLab Inc.
Added 3d ago
Embedded Software Engineer – Computer Vision & Imaging Systems
US PharmaLab Inc.
San Francisco, California
Software Engineering
Embedded Systems Engineering
Backend Engineering
$130k - $180k/yr
On-Site
201-500

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US PharmaLab Inc.
Lead Software Engineer (Robotics) – Rust / Real-Time Systems
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US PharmaLab Inc.
Added 3d ago
Lead Software Engineer (Robotics) – Rust / Real-Time Systems
US PharmaLab Inc.
San Francisco, California
Software Engineering
Cloud & DevOps
Technical Product & Program Management
Backend Engineering
Cloud Engineering
Technical Program Management
$160k - $250k/yr
On-Site
Bachelor's
201-500

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S
Senior Software Engineer, Engine & Distributed Systems
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S
Added 1w ago
Senior Software Engineer, Engine & Distributed Systems
StackAI
San Francisco, California
Software Engineering
Cloud & DevOps
Backend Engineering
$202k - $230k/yr

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Homebase
Senior Software Engineer, AI Systems
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Homebase
Added 1w ago
Senior Software Engineer, AI Systems
Homebase
San Francisco, California
Software Engineering
Data Science & Analytics
Technical Product & Program Management
AI (Artificial Intelligence)
Data Science
Backend Engineering
$168k - $200k/yr
201-500

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Databricks
Staff Software Engineer - Distributed Data Systems
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Databricks
Added 1w ago
Staff Software Engineer - Distributed Data Systems
Databricks
San Francisco, California
On-Site
Bachelor's

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See All 33 Software Systems Engineer Jobs in San Francisco

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Software Systems Engineer Job Market in San Francisco

Who's Hiring

  • OpenAI
    OpenAI8
  • Databricks
    Databricks3
  • CRUSOE
    CRUSOE2
  • Rippling
    Rippling2
  • US PharmaLab
    US PharmaLab2

Top Industries Hiring

  • Technology & Software12
  • Science & Research9
  • Banking & Financial Services3
  • Artificial Intelligence2
  • Biotechnology & Pharmaceuticals2

Software Systems Engineer Jobs in San Francisco: Frequently Asked Questions

How do I get a software systems engineer job in San Francisco?

Focus your search on San Francisco's strongest hiring sectors: cloud platforms, cybersecurity, biotech infrastructure, and hardware-software integration. SoMa and Mission Bay concentrate the most openings, with Dogpatch and the Civic Center corridor also active. Candidates who can demonstrate systems-level thinking alongside software skills, particularly in distributed systems or real-time processing, stand out in this market. Networking through local engineering meetups and open-source contributions visible on public repositories also carries weight with San Francisco hiring teams.

Which companies hire software systems engineers in San Francisco?

Companies currently hiring software systems engineers in San Francisco include OpenAI, Databricks, and CRUSOE, per current listings on Migrate Mate as of June 2026. San Francisco's employer mix skews toward high-growth tech firms, enterprise software companies, and federally contracted defense and infrastructure organizations with local offices.

Are there remote software systems engineer jobs in San Francisco?

Yes, though availability depends heavily on the role: software systems engineers working on cloud architecture, platform reliability, or developer tooling tend to find remote options more readily than those working on embedded hardware or physical lab systems. About 32% of software systems engineer openings tied to San Francisco are remote or hybrid as of June 2026, with hybrid arrangements most common at enterprise firms headquartered in SoMa and the Financial District.

How can I get a software systems engineer job in San Francisco with little or no experience?

The most realistic entry path in San Francisco is targeting associate systems engineer or platform reliability roles at mid-stage startups in SoMa and Mission Bay, which tend to hire more broadly than large enterprise employers. Building a portfolio around open-source infrastructure projects or contributing to developer tooling used by San Francisco companies gets attention. Local coding bootcamps with employer partnerships and university co-op programs tied to Bay Area technology firms also create direct entry points that bypass traditional experience requirements.

Which industries hire the most software systems engineers in San Francisco?

The sectors hiring the most software systems engineers in San Francisco are Technology & Software, Science & Research, and Banking & Financial Services, based on current listings on Migrate Mate as of June 2026. San Francisco's concentration of cloud-native companies, biotech campuses in Mission Bay, and defense contractors with Bay Area offices drives consistent demand across each of these sectors.

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