Software Systems Engineer Jobs in San Francisco, CA

Software Systems Engineer jobs in San Francisco are concentrated in SoMa, Mission Bay, and the Financial District, driven by demand across cloud infrastructure, embedded systems, and defense technology. Employers actively hiring include OpenAI, GAMMA, and CRUSOE. Scan the live roles below and apply to whichever ones fit.

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Overview

Open roles235+
Top employerOpenAI
Work type50% Hybrid
Companies hiring24

Showing 5 of 235+ Software Systems Engineer jobs

Verse
Software Engineer, Distributed Systems
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Verse
Added 3d ago
Software Engineer, Distributed Systems
Verse
San Francisco, California
Cloud & DevOps
Cloud Engineering
DevOps
Solutions Engineering & Architecture
$160k - $194k/yr
Hybrid
Bachelor's degree
11-50

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Meta
Software Engineer, Systems ML
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Meta
Added 5d ago
Software Engineer, Systems ML
Meta
San Francisco, California
Biotech & Life Sciences
Clinical Trials & Medical Research
Data Science
Research & Academia
$184k - $257k/yr
Bachelor's degree
10,000+

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CRUSOE
Principal Systems Software Engineer
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CRUSOE
Added 1w ago
Principal Systems Software Engineer
CRUSOE
San Francisco, California
Cloud Engineering
Cybersecurity
Systems Administration
$260k - $340k/yr
Master's degree
1,001-5,000

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Google
Software Engineer III, Agentic AI Systems, Cloud Security
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Google
Added 1w ago
Software Engineer III, Agentic AI Systems, Cloud Security
Google
San Francisco, California
Clinical Support
Healthcare Administration
Medical Assistant
$147k - $210k/yr
Master's degree
10,000+

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Kohlberg Kravis Roberts & Co.
Software Engineer - Investment Systems New
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Kohlberg Kravis Roberts & Co.
Added 1w ago
Software Engineer - Investment Systems New
Kohlberg Kravis Roberts & Co.
San Francisco, California
Software Engineering
Solutions Engineering & Architecture
Specialized Engineering
Technical Program Management
$14k - $170k/yr
Hybrid
Bachelor's degree in engineering

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See All 235+ Software Systems Engineer Jobs in San Francisco

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Software Systems Engineer Job Market in San Francisco

Who's Hiring

  • OpenAI
    OpenAI57
  • GAMMA
    GAMMA19
  • CRUSOE
    CRUSOE19
  • Google
    Google13
  • Meta
    Meta6

Top Industries Hiring

  • Science & Research70
  • Technology & Software64
  • Artificial Intelligence13
  • Banking & Financial Services13

Software Systems Engineer Jobs in San Francisco: Frequently Asked Questions

How do I get a software systems engineer job in San Francisco?

Focus your search on San Francisco's strongest hiring sectors: cloud platforms, cybersecurity, biotech infrastructure, and hardware-software integration. SoMa and Mission Bay concentrate the most openings, with Dogpatch and the Civic Center corridor also active. Candidates who can demonstrate systems-level thinking alongside software skills, particularly in distributed systems or real-time processing, stand out in this market. Networking through local engineering meetups and open-source contributions visible on public repositories also carries weight with San Francisco hiring teams.

Which companies hire software systems engineers in San Francisco?

Companies currently hiring software systems engineers in San Francisco include OpenAI, GAMMA, and CRUSOE, per current listings on Migrate Mate as of August 2026. San Francisco's employer mix skews toward high-growth tech firms, enterprise software companies, and federally contracted defense and infrastructure organizations with local offices.

Are there remote software systems engineer jobs in San Francisco?

Yes, though availability depends heavily on the role: software systems engineers working on cloud architecture, platform reliability, or developer tooling tend to find remote options more readily than those working on embedded hardware or physical lab systems. About 65% of software systems engineer openings tied to San Francisco are remote or hybrid as of August 2026, with hybrid arrangements most common at enterprise firms headquartered in SoMa and the Financial District.

How can I get a software systems engineer job in San Francisco with little or no experience?

The most realistic entry path in San Francisco is targeting associate systems engineer or platform reliability roles at mid-stage startups in SoMa and Mission Bay, which tend to hire more broadly than large enterprise employers. Building a portfolio around open-source infrastructure projects or contributing to developer tooling used by San Francisco companies gets attention. Local coding bootcamps with employer partnerships and university co-op programs tied to Bay Area technology firms also create direct entry points that bypass traditional experience requirements.

Which industries hire the most software systems engineers in San Francisco?

The sectors hiring the most software systems engineers in San Francisco are Science & Research, Technology & Software, and Artificial Intelligence, based on current listings on Migrate Mate as of August 2026. San Francisco's concentration of cloud-native companies, biotech campuses in Mission Bay, and defense contractors with Bay Area offices drives consistent demand across each of these sectors.

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