Systems Engineer Jobs in San Diego, CA
Systems Engineer jobs in San Diego, California are available now at employers like Apple, Northrop Grumman, and Qualcomm and other local employers, from entry level to senior. Find a role that fits below and apply directly.
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The Company
Dexcom Corporation (NASDAQ DXCM) is a pioneer and global leader in continuous glucose monitoring (CGM). Dexcom began as a small company with a big dream: To forever change how diabetes is managed. To unlock information and insights that drive better health outcomes. Here we are 25 years later, having pioneered an industry. And we're just getting started. We are broadening our vision beyond diabetes to empower people to take control of health. That means personalized, actionable insights aimed at solving important health challenges. To continue what we've started: Improving human health.
We are driven by thousands of ambitious, passionate people worldwide who are willing to fight like warriors to earn the trust of our customers by listening, serving with integrity, thinking big, and being dependable. We've already changed millions of lives and we're ready to change millions more. Our future ambition is to become a leading consumer health technology company while continuing to develop solutions for serious health conditions. We'll get there by constantly reinventing unique biosensing-technology experiences. Though we've come a long way from our small company days, our dreams are bigger than ever. The opportunity to improve health on a global scale stands before us.
Meet the team:
This position will report to the IT Directory Manufacturing and Smart Factory and will lead strategy, development, and support of our manufacturing systems landscape. This role is critical to driving operational excellence and ensuring compliance with regulatory standards in a highly controlled environment. High degree of visibility and pivotal to Dexcom’s overall success, the IT Sr. Manager will guide a team of high-performing IT/OT team members in all aspects of system strategy and lifecycle for our core manufacturing systems, working collaboratively with colleagues around the world as part of a global IT organization.
Where you come in:
- Drive strategic initiatives, partnering with business stakeholders to translate strategic priorities into executable initiatives, requirements, and solution roadmaps
- Analyze complex business problems and identify technology-enabled solutions to drive scalability, efficiency, and value realization
- Identify opportunities to automate and optimize with standalone or embedded AI Agents
- Collaborate with IT and technical teams to design, develop, test, and implement solutions aligned to business needs
- Act as the voice of the business, translating requirements into user stories, functional designs, and test scenarios
- Support testing, validation, and deployment activities, ensuring solutions meet quality, compliance, and business requirements
- Work cross-functionally with Operations, Quality, Supply Chain, and IT teams to ensure alignment and drive execution in a matrixed environment
- Identify process improvement, automation, and digital enablement opportunities to support enterprise transformation initiatives
- Support development of business cases, cost-benefit analyses, and ROI tracking for strategic initiatives
- Facilitate workshops, drive stakeholder alignment, and ensure clear communication across business and IT teams
What makes you successful:
- 10+ years of experience in all aspects of manufacturing systems management, including strategy, development, and support.
- Experience with Machine Learning, Predictive Maintenance, and AI for Manufacturing. GCP, Agentic AI, Gemini Enterprise / Vertix strongly preferred.
- Proven track record in system architecture, integration, and lifecycle management within regulated environments.
- Deep understanding of FDA requirements for validated systems, including GMP/GxP, ISO 13485, FDA 21 CFR Parts 11 and 820, and electronic records/e-signatures compliance.
- Excellent leadership, communication, and stakeholder management skills.
- Six Sigma experience / certification strongly preferred.
What you’ll get:
- A front row seat to life changing CGM technology. Learn about our brave #dexcomwarriors community.
- A full and comprehensive benefits program.
- Growth opportunities within the arena of Medical Affairs.
- Access to career development through in-house learning programs and/or qualified tuition reimbursement.
- An exciting and innovative, industry-leading organization committed to our employees, customers, and the communities we serve.
Travel Required:
- 0-5%
Experience and Education Requirements:
Typically requires a Bachelor’s degree in a technical discipline, and a minimum of 8-12 years related experience or Master’s degree and 5-7 years equivalent industry experience or a PhD and 2-4 years of experience.
Flex Workplace:
Your primary location will be a home office. You will not have an assigned workstation and will work with your manager to determine office visit needs. You must live within commuting distance of your assigned Dexcom site (typically 75 miles/120km).
Please note: The information contained herein is not intended to be an all-inclusive list of the duties and responsibilities of the job, nor are they intended to be an all-inclusive list of the skills and abilities required to do the job. Management may, at its discretion, assign or reassign duties and responsibilities to this job at any time. The duties and responsibilities in this job description may be subject to change at any time due to reasonable accommodation or other reasons. Reasonable accommodations may be made to enable individuals with disabilities to perform essential functions.
An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. Dexcom’s AAP may be viewed upon request by contacting Talent Acquisition at talentacquisition@dexcom.com.
If you are an individual with a disability and would like to request a reasonable accommodation as part of the employment selection process, please contact Dexcom Talent Acquisition at talentacquisition@dexcom.com.
Meritain, an Aetna Company, creates and publishes the Machine-Readable Files on behalf of Dexcom. To link to the Machine-Readable Files, please click on the URL provided: https://health1.meritain.com/app/public/#/one/insurerCode=MERITAIN_I&brandCode=MERITAINOVER/machine-readable-transparency-in-coverage?reportingEntityType=TPA_19874&lock=true
To all Staffing and Recruiting Agencies: Our Careers Site is only for individuals seeking a job at Dexcom. Only authorized staffing and recruiting agencies may use this site or to submit profiles, applications or resumes on specific requisitions. Dexcom does not accept unsolicited resumes or applications from agencies. Please do not forward resumes to the Talent Acquisition team, Dexcom employees or any other company location. Dexcom is not responsible for any fees related to unsolicited resumes/applications.
Salary:
$135,100.00 - $225,100.00
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Find Systems Engineer JobsSystems Engineer Job Market in San Diego
Who's Hiring
- Apple26

- Northrop Grumman26

- Qualcomm25

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Systems Engineer Jobs in San Diego: Frequently Asked Questions
How many systems engineer jobs are there in San Diego?
There are 296+ systems engineer openings in San Diego, California on Migrate Mate as of June 2026. New positions post regularly as San Diego employers hire.
Which companies hire systems engineers in San Diego?
San Diego systems engineer roles are posted by Apple, Northrop Grumman, and Qualcomm and others right now, based on current listings on Migrate Mate as of June 2026.
Are there remote systems engineer jobs in San Diego?
Yes. About 16% of systems engineer openings tied to San Diego are remote or hybrid as of June 2026. The rest are on-site roles based in and around San Diego.
Which industries hire the most systems engineers in San Diego?
San Diego systems engineer roles concentrate in Electronics & Hardware, Technology & Software, and Consulting & Professional Services, based on current listings on Migrate Mate as of June 2026.
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