Rare Disease Business Manager Jobs in USA with Visa Sponsorship
Rare Disease Business Managers lead commercial strategy for specialty therapeutics, a field where employers routinely sponsor H-1B and O-1 visas for candidates with biotech or pharma backgrounds. Competition for qualified talent is tight enough that sponsorship is common, even for mid-level roles. For detailed occupation requirements, see the O*NET profile.
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About the role:
The Rare Disease Business Manager (RDBM) is responsible for driving sales and territory growth through effective execution of sales strategies and tactics in a rare neurological sleep disorder, called narcolepsy type 1. This role involves collaboration with their Regional Business Leader and other cross-functional, customer-facing teams to ensure healthcare providers (HCPs) are well educated and that appropriate patients have access to a new therapeutic option, once approved by federal agencies.
Reporting into a Regional Business Leader, the RDBM will support a new product introduction in a new therapeutic area for Takeda. Strong execution, insights gathering, and building our Company’s reputation will be critical to our success. The role will establish and build impactful relationships with targeted HCPs and accounts within their geographic territory. Following regulatory approval, the Rare Disease Business Manager will play a key role in generating demand for a new therapeutic option by focusing on educating and informing healthcare professionals by providing clinical information and in-depth knowledge of the product, the orexin system, and narcolepsy type 1.
How you will contribute:
- Results Focused: Demonstrates a strong sense of urgency to drive results and achieve strong performance by delivering a high level of sales effort will be necessary for a successful rare disease product introduction.
- Clinical Expertise: Possesses and delivers exceptional disease state, product knowledge, and selling skills in working with HCPs to support product education and drive demand.
- Sales Strategy and Execution: Following approval, drive sales by implementing sales and marketing plans, leveraging strong selling skills utilizing approved, on-label materials to achieve monthly, quarterly, and annual sales goals. Execute brand strategies and manage all business-related activities within the assigned geographic territory, focusing on achieving sales goals and advancing the diagnosis and treatment of NT1.
- Specialty Customer Engagement: Builds strong relationships with, and educates healthcare professionals (HCPs), including sleep specialists, neurologists, pulmonologists, sleep centers and associated clinic staff, on disease state and approved Takeda orexin therapies.
- Strategic Analysis and Territory Planning: Strategically analyze local, regional, and national business trends and apply data to assess business opportunities and strategic priorities. Leverage market insights to appropriately tailor regional and local business strategies to market trends and customer needs.
- Communication Skills: Strong communication skills will be critical in discussions with specialty HCPs and accounts for a rare disease therapy. Utilize CRM system to document account profiles, develop pre-call plans and record post-call activities.
- Financial Responsibility: Manage a territory budget in a manner that is consistent with all Takeda compliance policies.
- Cross-Functional Collaboration: Partner with internal teams such as Patient Access, Market Access, Marketing to align on strategies and tactics that support customer and business outcomes. Collaborate with Sales and Marketing leadership to provide feedback that further supports sales tactics and performance. Foster a collaborative culture of accountability and engagement with cross-functional team members to enhance performance and impact.
- Compliance and Ethical Standards: Exemplify Takeda’s patient-first values and commitment to upholding high standards of customer satisfaction. Adhere strictly to all Takeda compliance policies, guidelines, training and relevant laws and regulations. Demonstrate leadership and integrity by seeking clarification when uncertain on compliance matters.
Minimum Qualifications:
Required:
- Bachelor’s degree – BS/BA.
- 3+ years of successful selling experience in pharmaceutical, biotech or medical device and/or relevant clinical or industry experience; OR 2+ years of successful selling experience at Takeda.
- Excellent verbal and written communication skills.
- Proven ability to navigate complex selling environment and influence across various decision makers in key accounts.
- Strong business acumen and strategic planning skills to identify and execute on selling opportunities.
- Demonstrated territory planning, strategic account management and prioritization skills. Ability to interpret analytical data to create effective sales strategies.
- Strong collaborative skills and ability to work within a matrix of cross functional partners on behalf of the customers served.
- Understanding of payer access and reimbursement at territory, regional, and state levels.
- Adaptability to changing market conditions and customer needs.
- Demonstrated learning agility with ability to successfully develop and compliantly apply clinical expertise and selling skills.
- Must reside within the territory or within close proximity to assigned geography.
Preferred
- 5+ years of pharmaceutical sales experience, preferably in rare disease or sleep disorders.
- Sales experience with pharmaceutical or biologic products requiring coordination with patient access and market access teams.
- Relevant clinical or industry experience.
- Consultative / needs-based selling skills.
- Experience working in a highly regulated marketplace.
- Adept at leveraging emerging technologies, digital tools, and openness to AI-enabled processes.
Licenses/Certifications
Valid Driver's License
Travel Requirements
- Ability to drive and/or fly to accounts and occasional business meetings.
- Some overnight travel of up to 25-50% may be required depending on geographic assignment.
TRAINING REQUIREMENTS:
- This position and continued employment is contingent upon the employee successfully passing mandatory product training which includes written and oral examinations.
- External Takeda Hires Only: During that training period, the employee will be classified as a non-exempt employee and will be eligible for overtime during the training period only in accordance with applicable federal and/or state law but the employee will not be eligible for any Takeda related sales incentive programs and/or other production based bonuses. The training period will consist of live instruction, independent study, role play, and other training related activities which should take no more than 8 hours per day and 40 hours total in a workweek.
- After successful passage of the mandatory product training examinations, the employee will be transitioned to exempt status and will no longer be eligible for overtime. They will then be paid on a bi-weekly basis and eligible to participate in various Takeda related sales incentive programs and/or contests.
Takeda Compensation and Benefits Summary
We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
For Location:
Pennsylvania - Virtual
U.S. Hourly Wage Range:
$66.11 - $90.91
The estimated hourly wage range reflects an anticipated range for this position. The actual hourly wage offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual hourly wage offered will be in accordance with state or local minimum wage requirements for the job location.
U.S. based employees may be eligible for short-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.
EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations
Pennsylvania - Virtual
Worker Type
Employee
Worker Sub-Type
Regular
Time Type
Full time
Job Exempt
No
LI-Remote
Job Description
About the role:
The Rare Disease Business Manager (RDBM) is responsible for driving sales and territory growth through effective execution of sales strategies and tactics in a rare neurological sleep disorder, called narcolepsy type 1. This role involves collaboration with their Regional Business Leader and other cross-functional, customer-facing teams to ensure healthcare providers (HCPs) are well educated and that appropriate patients have access to a new therapeutic option, once approved by federal agencies.
Reporting into a Regional Business Leader, the RDBM will support a new product introduction in a new therapeutic area for Takeda. Strong execution, insights gathering, and building our Company’s reputation will be critical to our success. The role will establish and build impactful relationships with targeted HCPs and accounts within their geographic territory. Following regulatory approval, the Rare Disease Business Manager will play a key role in generating demand for a new therapeutic option by focusing on educating and informing healthcare professionals by providing clinical information and in-depth knowledge of the product, the orexin system, and narcolepsy type 1.
How you will contribute:
- Results Focused: Demonstrates a strong sense of urgency to drive results and achieve strong performance by delivering a high level of sales effort will be necessary for a successful rare disease product introduction.
- Clinical Expertise: Possesses and delivers exceptional disease state, product knowledge, and selling skills in working with HCPs to support product education and drive demand.
- Sales Strategy and Execution: Following approval, drive sales by implementing sales and marketing plans, leveraging strong selling skills utilizing approved, on-label materials to achieve monthly, quarterly, and annual sales goals. Execute brand strategies and manage all business-related activities within the assigned geographic territory, focusing on achieving sales goals and advancing the diagnosis and treatment of NT1.
- Specialty Customer Engagement: Builds strong relationships with, and educates healthcare professionals (HCPs), including sleep specialists, neurologists, pulmonologists, sleep centers and associated clinic staff, on disease state and approved Takeda orexin therapies.
- Strategic Analysis and Territory Planning: Strategically analyze local, regional, and national business trends and apply data to assess business opportunities and strategic priorities. Leverage market insights to appropriately tailor regional and local business strategies to market trends and customer needs.
- Communication Skills: Strong communication skills will be critical in discussions with specialty HCPs and accounts for a rare disease therapy. Utilize CRM system to document account profiles, develop pre-call plans and record post-call activities.
- Financial Responsibility: Manage a territory budget in a manner that is consistent with all Takeda compliance policies.
- Cross-Functional Collaboration: Partner with internal teams such as Patient Access, Market Access, Marketing to align on strategies and tactics that support customer and business outcomes. Collaborate with Sales and Marketing leadership to provide feedback that further supports sales tactics and performance. Foster a collaborative culture of accountability and engagement with cross-functional team members to enhance performance and impact.
- Compliance and Ethical Standards: Exemplify Takeda’s patient-first values and commitment to upholding high standards of customer satisfaction. Adhere strictly to all Takeda compliance policies, guidelines, training and relevant laws and regulations. Demonstrate leadership and integrity by seeking clarification when uncertain on compliance matters.
Minimum Qualifications:
Required:
- Bachelor’s degree – BS/BA.
- 3+ years of successful selling experience in pharmaceutical, biotech or medical device and/or relevant clinical or industry experience; OR 2+ years of successful selling experience at Takeda.
- Excellent verbal and written communication skills.
- Proven ability to navigate complex selling environment and influence across various decision makers in key accounts.
- Strong business acumen and strategic planning skills to identify and execute on selling opportunities.
- Demonstrated territory planning, strategic account management and prioritization skills. Ability to interpret analytical data to create effective sales strategies.
- Strong collaborative skills and ability to work within a matrix of cross functional partners on behalf of the customers served.
- Understanding of payer access and reimbursement at territory, regional, and state levels.
- Adaptability to changing market conditions and customer needs.
- Demonstrated learning agility with ability to successfully develop and compliantly apply clinical expertise and selling skills.
- Must reside within the territory or within close proximity to assigned geography.
Preferred
- 5+ years of pharmaceutical sales experience, preferably in rare disease or sleep disorders.
- Sales experience with pharmaceutical or biologic products requiring coordination with patient access and market access teams.
- Relevant clinical or industry experience.
- Consultative / needs-based selling skills.
- Experience working in a highly regulated marketplace.
- Adept at leveraging emerging technologies, digital tools, and openness to AI-enabled processes.
Licenses/Certifications
Valid Driver's License
Travel Requirements
- Ability to drive and/or fly to accounts and occasional business meetings.
- Some overnight travel of up to 25-50% may be required depending on geographic assignment.
TRAINING REQUIREMENTS:
- This position and continued employment is contingent upon the employee successfully passing mandatory product training which includes written and oral examinations.
- External Takeda Hires Only: During that training period, the employee will be classified as a non-exempt employee and will be eligible for overtime during the training period only in accordance with applicable federal and/or state law but the employee will not be eligible for any Takeda related sales incentive programs and/or other production based bonuses. The training period will consist of live instruction, independent study, role play, and other training related activities which should take no more than 8 hours per day and 40 hours total in a workweek.
- After successful passage of the mandatory product training examinations, the employee will be transitioned to exempt status and will no longer be eligible for overtime. They will then be paid on a bi-weekly basis and eligible to participate in various Takeda related sales incentive programs and/or contests.
Takeda Compensation and Benefits Summary
We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
For Location:
Pennsylvania - Virtual
U.S. Hourly Wage Range:
$66.11 - $90.91
The estimated hourly wage range reflects an anticipated range for this position. The actual hourly wage offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual hourly wage offered will be in accordance with state or local minimum wage requirements for the job location.
U.S. based employees may be eligible for short-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.
EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations
Pennsylvania - Virtual
Worker Type
Employee
Worker Sub-Type
Regular
Time Type
Full time
Job Exempt
No
LI-Remote
How to Get Visa Sponsorship as a Rare Disease Business Manager
Target biotech and rare disease specialty pharma employers
Companies like Sanofi Genzyme, BioMarin, and Alexion have established immigration programs and routinely sponsor H-1B visas for commercial roles. Smaller rare disease biotechs often sponsor too, especially when filling niche therapeutic area expertise.
Lead with your rare disease or orphan drug experience
Employers justify H-1B specialty occupation status more easily when your background directly matches the therapeutic area. Patient advocacy experience, KOL relationships, and payer access knowledge in rare disease make your sponsorship case significantly stronger.
Understand how your degree field affects your petition
H-1B approval requires a degree in a field directly related to the role. Life sciences, pharmacy, health economics, or business degrees with biotech concentration typically satisfy this. A general business degree alone may require additional documentation.
Ask about sponsorship early, but frame it as logistics, not a red flag
Bring up visa sponsorship after demonstrating your value, ideally in the second interview or offer stage. Frame it as a straightforward process your previous employers have navigated, not as a complication requiring special consideration from the hiring team.
Consider O-1A if your rare disease track record is strong
If you have publications, speaker engagements, rare disease awards, or a history of leading high-impact launches, the O-1A visa may be worth exploring. It bypasses the H-1B lottery and is approved at higher rates for demonstrably accomplished candidates.
Use Migrate Mate to filter specifically for sponsoring employers
Not every job posting that sounds like a match will offer sponsorship. Migrate Mate surfaces roles from employers with active visa sponsorship histories, so you spend your time on opportunities that are actually accessible given your immigration situation.
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Get Access To All JobsFrequently Asked Questions
Can a Rare Disease Business Manager role qualify for H-1B sponsorship?
Yes, provided the employer can demonstrate the position requires a bachelor's degree or higher in a specific specialty. Rare Disease Business Manager roles typically qualify because they require specialized knowledge in life sciences, health economics, or pharmaceutical commercialization. USCIS scrutinizes business roles more than clinical ones, so a well-documented job description and a degree in a directly related field strengthen the petition considerably.
Which visa types are most relevant for this role?
The H-1B is the most common path, particularly for candidates already in the U.S. on OPT or another nonimmigrant status. The O-1A is worth considering if you have a strong record of rare disease launches, speaking engagements, or peer-reviewed contributions. Australians may qualify for the E-3, which has no lottery and faster processing. Browse currently open roles on Migrate Mate to see which visa types sponsoring employers in this space support.
Does my degree field matter for getting sponsored in this role?
It matters significantly. USCIS requires that the offered position qualifies as a specialty occupation and that your degree is in a field directly related to it. Life sciences, pharmaceutical sciences, health economics, public health, and business degrees with biotech or healthcare concentration are the strongest fits. A general MBA or unrelated bachelor's degree may require additional evidence, such as advanced coursework or professional certifications, to support the specialty occupation argument.
How selective are rare disease pharma companies about sponsoring commercial roles?
Selectivity varies by company size and pipeline stage. Established rare disease companies with large commercial teams, such as those focused on enzyme replacement therapies or gene therapies, have mature HR and legal infrastructure for sponsorship. Earlier-stage biotechs may sponsor on a case-by-case basis when the candidate has a specific therapeutic area background they cannot easily hire domestically. Your leverage increases when you bring existing payer relationships, patient advocacy networks, or formulary access experience in the specific disease area.
What happens to my visa status if the rare disease product I'm hired to commercialize gets a setback?
Your H-1B status is tied to the employer, not the specific product. If the company restructures your role rather than terminating you, your status generally remains valid as long as you maintain a qualifying position. If you're laid off, you have a 60-day grace period to find a new sponsoring employer, change status, or depart. Some rare disease biotechs include severance provisions that account for immigration status, so it's worth clarifying this before accepting an offer.
What is the prevailing wage requirement for sponsored Rare Disease Business Manager jobs?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.
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