Senior Cloud Infrastructure Engineer Jobs in USA with Visa Sponsorship
Senior Cloud Infrastructure Engineers are among the most consistently sponsored roles in tech. Employers routinely file H-1B visa and O-1 visa petitions for this specialty occupation, and the work aligns squarely with USCIS degree requirements in computer science, information systems, or a closely related field. For detailed occupation requirements, see the O*NET profile.
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Get Access To All JobsINTRODUCTION
Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists-accredited. Personalis is based in Fremont, California.
SUMMARY
We are seeking a highly skilled Senior Cloud Infrastructure Engineer to architect, implement, and support cloud-first infrastructure platforms across AWS, Azure, and hybrid environments. This role will be responsible for designing scalable, secure, and highly available cloud infrastructure, managing containerized platforms, automating infrastructure deployments, and supporting critical enterprise and laboratory systems.
The ideal candidate has deep expertise in cloud technologies, Kubernetes, Docker, Infrastructure as Code (IaC), DevOps practices, and cloud security. This individual will work closely with software engineering, bioinformatics, security, laboratory operations, and compliance teams to ensure reliable and compliant infrastructure services supporting business-critical applications.
ONSITE: Monday, Tuesday, and Thursday
Responsibilities:
- Design, deploy, and manage enterprise cloud infrastructure primarily within AWS and/or Azure environments.
- Architect highly available, scalable, secure, and cost-effective cloud solutions.
- Implement cloud networking, identity management, storage, compute, monitoring, and security services.
- Support integration between cloud and on-premises infrastructure environments.
- Manage hybrid networking, VPNs, Direct Connect, ExpressRoute, and secure connectivity solutions.
- Support virtualization platforms and legacy infrastructure during cloud transformation initiatives.
- Design, deploy, and manage Kubernetes clusters in cloud and hybrid environments.
- Administer container orchestration platforms including Amazon EKS, Azure AKS, or self-managed Kubernetes environments.
- Build and maintain containerized application platforms using Docker.
- Automate infrastructure provisioning, configuration management, and deployment processes.
- Support and optimize CI/CD pipelines using GitHub Actions, GitLab CI, Azure DevOps, Jenkins, or similar platforms.
- Implement automated monitoring, alerting, scaling, backup, and recovery solutions.
- Partner with Security and Compliance teams to support HIPAA/CLIA/CAP/FDA requirements, where applicable.
- Ensure secure management of Protected Health Information (PHI) and sensitive business data.
- Partner with software engineering teams to optimize cloud-native application architectures.
REQUIRED QUALIFICATIONS:
- Bachelor's degree in Computer Science, Information Technology, Engineering, or related field.
- 7+ years of infrastructure engineering experience.
- 5+ years of hands-on cloud engineering experience in AWS, Azure, or GCP.
- 3+ years of Kubernetes administration and container platform management experience.
- Strong experience with Docker and containerized application deployment.
- Experience implementing Infrastructure as Code using Terraform or equivalent tools.
- Experience with Linux systems administration and cloud networking.
- Strong scripting and automation skills using Python, PowerShell, Bash, or similar languages.
- Experience supporting production-critical environments with high availability requirements.
TECHNICAL SKILLS:
- AWS (EC2, EKS, RDS, S3, IAM, VPC, Route53, CloudWatch, Lambda)
- Azure (AKS, Virtual Networks, Azure AD, Storage, Monitor, Key Vault)
- Multi-cloud and hybrid-cloud architectures
- Kubernetes, Docker, Helm, EKS, Terraform, Ansible and other adjacent cloud services
- Monitoring services like Splunk, Datadog or other cloud-native monitoring tools
KEY COMPETENCIES:
- Cloud Architecture & Engineering
- Kubernetes Administration
- Docker & Container Platforms
- Infrastructure Automation
- DevOps & CI/CD
- Cloud Security & Compliance
- Site Reliability Engineering (SRE)
- Disaster Recovery & Business Continuity
- Technical Leadership
- Problem Solving & Incident Management
SUCCESS METRICS:
- Cloud platform availability and reliability.
- Kubernetes cluster health and operational efficiency.
- Infrastructure automation coverage and deployment success rates.
- Compliance with HIPAA, CLIA, CAP, and security requirements.
- Cloud cost optimization and resource utilization.
- Incident response and recovery performance.
- Successful delivery of cloud modernization initiatives.
- Security and audit readiness.
The hiring range for this position is $150,000 to $180,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.
Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.
Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.
Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.)
INTRODUCTION
Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists-accredited. Personalis is based in Fremont, California.
SUMMARY
We are seeking a highly skilled Senior Cloud Infrastructure Engineer to architect, implement, and support cloud-first infrastructure platforms across AWS, Azure, and hybrid environments. This role will be responsible for designing scalable, secure, and highly available cloud infrastructure, managing containerized platforms, automating infrastructure deployments, and supporting critical enterprise and laboratory systems.
The ideal candidate has deep expertise in cloud technologies, Kubernetes, Docker, Infrastructure as Code (IaC), DevOps practices, and cloud security. This individual will work closely with software engineering, bioinformatics, security, laboratory operations, and compliance teams to ensure reliable and compliant infrastructure services supporting business-critical applications.
ONSITE: Monday, Tuesday, and Thursday
Responsibilities:
- Design, deploy, and manage enterprise cloud infrastructure primarily within AWS and/or Azure environments.
- Architect highly available, scalable, secure, and cost-effective cloud solutions.
- Implement cloud networking, identity management, storage, compute, monitoring, and security services.
- Support integration between cloud and on-premises infrastructure environments.
- Manage hybrid networking, VPNs, Direct Connect, ExpressRoute, and secure connectivity solutions.
- Support virtualization platforms and legacy infrastructure during cloud transformation initiatives.
- Design, deploy, and manage Kubernetes clusters in cloud and hybrid environments.
- Administer container orchestration platforms including Amazon EKS, Azure AKS, or self-managed Kubernetes environments.
- Build and maintain containerized application platforms using Docker.
- Automate infrastructure provisioning, configuration management, and deployment processes.
- Support and optimize CI/CD pipelines using GitHub Actions, GitLab CI, Azure DevOps, Jenkins, or similar platforms.
- Implement automated monitoring, alerting, scaling, backup, and recovery solutions.
- Partner with Security and Compliance teams to support HIPAA/CLIA/CAP/FDA requirements, where applicable.
- Ensure secure management of Protected Health Information (PHI) and sensitive business data.
- Partner with software engineering teams to optimize cloud-native application architectures.
REQUIRED QUALIFICATIONS:
- Bachelor's degree in Computer Science, Information Technology, Engineering, or related field.
- 7+ years of infrastructure engineering experience.
- 5+ years of hands-on cloud engineering experience in AWS, Azure, or GCP.
- 3+ years of Kubernetes administration and container platform management experience.
- Strong experience with Docker and containerized application deployment.
- Experience implementing Infrastructure as Code using Terraform or equivalent tools.
- Experience with Linux systems administration and cloud networking.
- Strong scripting and automation skills using Python, PowerShell, Bash, or similar languages.
- Experience supporting production-critical environments with high availability requirements.
TECHNICAL SKILLS:
- AWS (EC2, EKS, RDS, S3, IAM, VPC, Route53, CloudWatch, Lambda)
- Azure (AKS, Virtual Networks, Azure AD, Storage, Monitor, Key Vault)
- Multi-cloud and hybrid-cloud architectures
- Kubernetes, Docker, Helm, EKS, Terraform, Ansible and other adjacent cloud services
- Monitoring services like Splunk, Datadog or other cloud-native monitoring tools
KEY COMPETENCIES:
- Cloud Architecture & Engineering
- Kubernetes Administration
- Docker & Container Platforms
- Infrastructure Automation
- DevOps & CI/CD
- Cloud Security & Compliance
- Site Reliability Engineering (SRE)
- Disaster Recovery & Business Continuity
- Technical Leadership
- Problem Solving & Incident Management
SUCCESS METRICS:
- Cloud platform availability and reliability.
- Kubernetes cluster health and operational efficiency.
- Infrastructure automation coverage and deployment success rates.
- Compliance with HIPAA, CLIA, CAP, and security requirements.
- Cloud cost optimization and resource utilization.
- Incident response and recovery performance.
- Successful delivery of cloud modernization initiatives.
- Security and audit readiness.
The hiring range for this position is $150,000 to $180,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.
Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.
Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.
Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.)
See all 178+ Senior Cloud Infrastructure Engineer Jobs
Sign up for free to unlock all listings, filter by visa type, and get alerts for new Senior Cloud Infrastructure Engineer roles.
Get Access To All JobsTips for Finding Visa Sponsorship as a Senior Cloud Infrastructure Engineer
Confirm the role qualifies as a specialty occupation
Cloud infrastructure engineering requires at least a bachelor's degree in computer science, computer engineering, or a related field. Roles framed as general IT support or systems administration may not meet USCIS specialty occupation standards, even if the work overlaps.
Target employers with an H-1B filing history
Large cloud-heavy employers, including hyperscalers, financial institutions, and enterprise SaaS companies, file H-1B petitions regularly. Prioritizing employers with documented sponsorship history significantly reduces the risk of an offer falling apart at the visa stage.
Get your job description to reflect the degree requirement
USCIS scrutinizes whether the position genuinely requires a specific bachelor's degree. Make sure your offer letter and job description explicitly state that a degree in computer science, information systems, or equivalent is required, not merely preferred.
Understand how cloud certifications factor into your application
AWS, Azure, and GCP certifications strengthen your profile but do not substitute for a qualifying degree. If your degree is in an unrelated field, a combination of education and years of directly relevant experience may still support a successful H-1B petition.
Account for premium processing in your start date planning
Standard H-1B adjudication can take several months. Premium processing guarantees a response within 15 business days and is worth requesting if your start date is firm or your current status has a hard expiration.
Prepare documentation of your technical scope upfront
For cloud infrastructure roles, USCIS may issue RFEs questioning whether the position requires a degree versus general IT experience. Having architecture diagrams, project scopes, and evidence of specialized responsibilities ready strengthens your employer's response significantly.
Frequently Asked Questions
Do Senior Cloud Infrastructure Engineer roles qualify for H-1B sponsorship?
Yes. Senior Cloud Infrastructure Engineer is consistently approved as a specialty occupation under the H-1B visa because the role requires at minimum a bachelor's degree in computer science, information systems, or a closely related field. USCIS has approved this job title across thousands of petitions. Roles that bundle infrastructure work with general helpdesk or non-specialized IT duties can attract RFEs, so job description specificity matters.
What degree do I need for an employer to sponsor me in this role?
Most H-1B petitions for this role cite a bachelor's degree in computer science, computer engineering, information technology, or information systems as the qualifying credential. Australian three-year bachelor's degrees are generally accepted as equivalent to U.S. four-year degrees. If your degree is in a different field, relevant coursework combined with documented work experience may still support a petition, though the case requires stronger supporting evidence.
Are there visa options other than H-1B for cloud infrastructure engineers?
Yes. Australian citizens can pursue the E-3 visa, which has no lottery and allows two-year renewable periods. Canadians and Mexicans may qualify under TN visa status if the role fits a covered USMCA occupation. Engineers with a strong publication record, open-source contributions, or industry recognition may also be competitive for the O-1A, which has no cap or lottery and can be filed at any time of year.
How hard is it to find employers willing to sponsor this role?
Sponsorship willingness is higher for Senior Cloud Infrastructure Engineers than for most other roles because demand consistently outpaces the available domestic talent pool. Hyperscalers, enterprise software companies, financial services firms, and managed service providers are the most active sponsors. Migrate Mate filters job listings specifically by visa sponsorship availability, so you can focus only on employers who have already committed to sponsoring this role.
Can I use work experience instead of a degree to qualify for H-1B sponsorship?
In limited cases, yes. USCIS allows three years of specialized work experience to substitute for one year of education, meaning a two-year degree plus six years of directly relevant cloud infrastructure experience could potentially satisfy the requirement. However, experience-substitution cases face higher scrutiny, and the experience must be specific to the specialty, not general IT work. An immigration attorney should evaluate your profile before your employer commits to filing.
What is the prevailing wage requirement for sponsored Senior Cloud Infrastructure Engineer jobs?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.