AI Engineer Jobs in Missouri
AI Engineer jobs in Missouri are in active demand, with strong concentrations in financial services, healthcare technology, and defense contracting across Kansas City, St. Louis, and Columbia. Major employers with a lasting footprint hiring ai engineers in Missouri include Cerner (now Oracle Health), Edward Jones, and Boeing Defense. The most sought-after specialties in the state are machine learning infrastructure, natural language processing, and AI-driven analytics. Find a role that fits below and apply directly.
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Our Purpose
Mastercard powers economies and empowers people in 200+ countries and territories worldwide. Together with our customers, we’re helping build a sustainable economy where everyone can prosper. We support a wide range of digital payments choices, making transactions secure, simple, smart and accessible. Our technology and innovation, partnerships and networks combine to deliver a unique set of products and services that help people, businesses and governments realize their greatest potential.
Title and Summary
Lead AI Platform Engineer Who is Mastercard?Mastercard powers economies and empowers people in 200+ countries and territories worldwide. Together with our customers, we are helping build a sustainable economy where everyone can prosper. We support digital payment choices that make transactions secure, simple, smart, and accessible. Our technology, innovation, partnerships, and networks deliver products and services that help people, businesses, and governments realize their greatest potential.
Overview
The AI Platform Engineering team builds, operates, and evolves Mastercard's enterprise AI platforms. Our mission is to provide scalable, secure, and reliable AI infrastructure that enables teams across Mastercard to accelerate the development and deployment of AI-powered solutions.
As a Lead AI Engineer, you will provide technical leadership in designing, implementing, and operating the foundational platforms supporting AI and machine learning workloads across the enterprise. Working at the intersection of platform engineering, cloud infrastructure, MLOps, and AI operations, you will deliver capabilities that enable teams to safely develop, deploy, observe, and scale AI solutions across public and private cloud environments.
You will help shape the platforms, tooling, operational practices, and infrastructure supporting the next generation of AI capabilities at Mastercard. You will address complex challenges involving scalability, reliability, observability, governance, automation, and customer enablement while influencing stakeholders and contributing to Mastercard's long-term AI platform direction.
About the Role
As a Lead AI Engineer, AI Platform Engineering, you will serve as a developing subject matter expert responsible for advancing the architecture, engineering, automation, and operational excellence of Mastercard's AI platforms. You will lead the technical design and delivery of complex capabilities, improve existing products and processes, and influence decisions across engineering, infrastructure, security, architecture, and governance teams.
The ideal candidate combines advanced software engineering and cloud platform expertise with experience supporting production AI and machine learning systems. You are passionate about technical leadership, automation, reliability, and building platforms that empower others to innovate. You are comfortable operating through influence, reviewing technical work, mentoring engineers, and translating complex requirements into scalable solutions.
Responsibilities
- Lead the design, development, and operation of enterprise platforms supporting machine learning, generative AI, agentic AI, and advanced analytics workloads.
- Translate business, engineering, and operational requirements into scalable platform solutions and implementation approaches.
- Design and maintain advanced AI and machine learning systems that meet enterprise requirements for security, reliability, availability, scalability, and performance.
- Own technical delivery across public and private cloud environments, identifying dependencies, resolving complex challenges, and influencing cross-functional decisions.
- Build and optimize services and workflows that simplify onboarding, development, deployment, operations, and lifecycle management for AI solutions.
- Develop infrastructure, tooling, and services supporting model training, evaluation, fine-tuning, deployment, inference, monitoring, and governance.
- Lead the implementation of repeatable, scalable, and secure MLOps capabilities and AI development workflows.
- Build and optimize data ingestion, preprocessing, and feature engineering workflows supporting model training and inference.
- Design observability capabilities including telemetry, performance monitoring, logging, alerting, operational analytics, model monitoring, and drift detection.
- Ensure the operational stability and scalability of AI platforms, driving improvements to reliability, resilience, efficiency, security, and customer experience.
- Lead troubleshooting, root cause analysis, and incident response for complex platform issues and translate lessons learned into sustainable improvements.
- Influence platform architecture through design discussions, reviews, prototypes, tradeoff analysis, and technical recommendations.
- Partner with engineering and product teams to understand requirements, guide solution design, enable adoption, and accelerate delivery of AI-powered products.
- Collaborate with infrastructure, security, architecture, risk, and governance teams to align capabilities with enterprise standards, controls, ethical guidelines, and regulatory requirements.
- Evaluate emerging AI technologies and industry trends and recommend improvements to Mastercard's AI ecosystem and roadmap.
- Drive engineering best practices across Infrastructure as Code, CI/CD, automated testing, secure development, documentation, and operational excellence.
- Guide and mentor engineers through design guidance, technical reviews, problem-solving support, and knowledge sharing.
All About You
Required Qualifications
- Experience designing, building, and operating cloud-native platforms or large-scale distributed systems in enterprise environments.
- Strong experience delivering solutions across public and private cloud environments.
- Experience deploying and managing containerized workloads using Kubernetes or OpenShift.
- Advanced software engineering and automation experience using Python.
- Experience leading the technical design and delivery of complex initiatives involving multiple teams or stakeholders.
- Experience implementing CI/CD pipelines, Infrastructure as Code, automated testing, and modern DevOps practices.
- Experience designing or supporting production AI, machine learning, data platforms, or distributed systems.
- Strong understanding of MLOps, model lifecycle management, production inference, and AI system operations.
- Experience implementing telemetry, monitoring, logging, alerting, and operational analytics.
- Ability to diagnose complex issues, lead root cause analysis, and implement sustainable corrective actions.
- Ability to assess architectural options, explain technical tradeoffs, and influence cross-functional decisions.
- Ability to communicate effectively with technical and non-technical stakeholders.
- Experience guiding, mentoring, or reviewing the work of other engineers.
Preferred Qualifications
- Experience with enterprise generative AI platforms and large language model workloads.
- Experience with model evaluation, fine-tuning, guardrails, responsible AI controls, and model governance.
- Experience with model observability, drift detection, telemetry, and operational analytics.
- Experience with AI serving infrastructure, inference platforms, or AI gateways.
- Experience supporting GPU-based workloads and accelerated computing environments.
- Experience with OpenShift, Kubernetes, Docker, Helm, GitOps, and Infrastructure as Code.
- Experience with enterprise platform engineering, developer enablement, and self-service capabilities.
- Familiarity with vector databases, retrieval-augmented generation, AI gateways, agentic systems, and model routing.
- Experience operating in regulated environments requiring strong security, governance, risk management, resiliency, and compliance controls.
Corporate Security Responsibility
All activities involving access to Mastercard assets, information, and networks comes with an inherent risk to the organization and, therefore, it is expected that every person working for, or on behalf of, Mastercard is responsible for information security and must:
Abide by Mastercard’s security policies and practices;
Ensure the confidentiality and integrity of the information being accessed;
Report any suspected information security violation or breach, and
Complete all periodic mandatory security trainings in accordance with Mastercard’s guidelines.
THIS POSTING RELECTS ONE OR MORE CURRENT VACANCIES ON OUR TEAM, AND MASTERCARD INTENDS TO FILL THIS POSITION BY 01/26/2027. If the fill date has passed, Mastercard intends to fill this position as soon as possible.
Pay Ranges
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AI Engineer Job Market in Missouri
A snapshot from current Missouri openings, updated as new roles post.
Who's Hiring



What Missouri Employers Look For
The qualifications that appear most often in AI engineer jobs across Missouri.
- Bachelor's or master's degree in computer science, data science, or a related field
- Proficiency in Python and machine learning frameworks such as TensorFlow or PyTorch
- Experience designing, training, and deploying production-grade machine learning models
- Familiarity with cloud platforms including AWS, Azure, or Google Cloud for AI workloads
- Strong understanding of data pipelines, feature engineering, and model evaluation techniques
- Ability to communicate AI concepts and results clearly to non-technical stakeholders
AI Engineer Jobs in Missouri: Frequently Asked Questions
How do you become a ai engineer in Missouri?
AI engineering in Missouri has no state-issued license or registration requirement, so the path centers on education and demonstrated skills. Most Missouri employers expect at least a bachelor's degree in computer science, data science, or a closely related field, with a master's preferred for research-heavy roles. Building a portfolio of deployed projects and earning cloud or machine learning certifications from providers like AWS or Google strengthens a candidate's profile with Missouri employers considerably.
Which companies hire ai engineers in Missouri?
Employers hiring ai engineers in Missouri right now include Mastercard, Clayco, and Jack Henry & Associates, based on current listings on Migrate Mate as of November 2026. Missouri's concentration of financial services firms in St. Louis and healthcare technology companies in Kansas City means those two sectors consistently account for a large share of the state's ai engineer openings.
Which Missouri cities have the most ai engineer jobs?
St. Louis, O'Fallon, and Kansas City have the most ai engineer openings in Missouri. Kansas City and St. Louis drive the bulk of demand through their large financial services, healthcare, and defense employer bases, while Columbia benefits from the University of Missouri's research ecosystem and the technology firms that cluster around it.
Are there remote ai engineer jobs in Missouri?
Yes, and more than most fields. About 70% of ai engineer openings tied to Missouri are remote or hybrid as of November 2026, reflecting the desk-based, software-driven nature of the work. Roles focused on model development, data pipeline engineering, and research tend to be the most remote-friendly, while positions requiring close collaboration with hardware teams or embedded systems are more likely to require on-site presence.
How can I get hired as a ai engineer in Missouri with little or no experience?
The most realistic entry path is through a data analyst or software engineering role at a Missouri employer that uses machine learning internally, then transitioning into AI work as you build relevant skills. Large Missouri employers in healthcare technology and financial services often run new-graduate rotational programs where early-career hires contribute to AI projects alongside experienced engineers. Building a public portfolio of machine learning projects and earning a recognized cloud or AI certification gives candidates a concrete edge when applying to those programs.
Where can I find and apply to ai engineer jobs in Missouri?
You can find and apply to ai engineer jobs in Missouri on Migrate Mate, which lists current Missouri openings across industries and experience levels. Find roles that fit your background and apply directly without needing to create a profile or sign up first.
See All 23 AI Engineer Jobs in Missouri
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