Application Engineer Jobs in San Francisco, CA
Application Engineer jobs in San Francisco are concentrated in SoMa, the Financial District, and Mission Bay, driven by enterprise software, cloud infrastructure, and life sciences employers. Companies currently hiring include AMIGO, Abridge, and ivo. Find a role that fits below and apply directly.
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About Amigo
Amigo partners with healthcare organizations to deploy robust AI infrastructure that directly serves patients and providers. Our agents handle clinical workflows and patient engagement across the entire journey: pre-visit intake, care navigation, post-visit care plans, patient monitoring, and more.
We're fresh off our Series A backed by Tier 1 investors like Madrona, General Catalyst, and Optum Ventures. Our work is validated with leading academic medical institutions. Our agents have reached 3M+ patient encounters and are on track to 10x this year.
About this role
As a Staff Application Engineer at Amigo, you'll build the applications that clinical teams, researchers, and customers use every day: real-time oversight of live agent conversations, natural language research over healthcare data, and tools for designing agent behavior without code. You'll own features end to end, from the database to the UI, in systems that handle sensitive patient data. The bar for correctness and reliability is high.
What you might work on
Building real-time interfaces for clinical oversight of live agent conversations
Owning a feature end to end, from schema to API to UI
Designing tools that let non-engineers shape agent behavior safely
Making healthcare data explorable through natural language
Hardening the reliability and performance of applications clinicians depend on
Working with designers, clinicians, and customers to get the details right
You may be a fit if
You've shipped production full-stack features end to end and owned the outcome
You're strong across the stack, from data modeling and APIs to modern front-end work
You sweat correctness and reliability, especially where sensitive data is involved
You have good product instincts and care how things feel to use
You're low ego, direct, and hold yourself to a high bar
You can work on site in San Francisco
Nice to have
Experience in a regulated or high-reliability domain (healthcare, finance, legal)
Experience with real-time or streaming interfaces
Background with design systems or complex UI state
Experience with production AI or ML products
Benefits (available to Full-Time Employees)
Health & Wellness
Comprehensive health, dental, and vision insurance
Daily catered lunch and dinner
Mental health support and wellness coaching
Flexible wellness stipend for fitness, therapy, or personal growth
Growth & Development
Annual learning budget for courses, books, or conferences
Conference attendance budget for professional development
Annual team offsite
Academic collaboration opportunities
Unlimited PTO
Our Core Values
Patients Win, We Win
If patients aren't getting better care, we haven't earned the right to scale. Every internal decision gets pressure-tested: does this make patients' lives better? If we can't draw the line, we question why we're doing it.
High Standards, High Care
We hold a high bar for the team because patients are counting on us to get this right. But high standards only work with genuine investment in each other. You can take risks, admit mistakes, and challenge ideas—not despite our standards, but because of them.
Thoughtful Urgency
We move fast by default, but speed without judgment is recklessness. The discipline is knowing which decisions are reversible vs. not. In healthcare AI, the companies that win will be fast everywhere they can be and careful everywhere they must be. We build the muscle to do both.
Intensely Measured
We instrument patient outcomes, provider ROI, system performance, and clinical accuracy. But data without action is surveillance. Every metric should have an owner, a threshold, and a response plan. If we're measuring something but never acting on it, we stop measuring it.
Who Builds With Us
Low ego: Politics and territory don't interest you. The best ideas win, regardless of who has them.
Direct: You say the hard thing, challenge ideas openly, and commit fully once decided.
High agency: You thrive on trust rather than instruction. When you see something is broken, you fix it. You don’t file tickets and wait for someone else.
Bar of excellence: You hold yourself to a bar most people wouldn't, and you want teammates who do the same.
Skeptical: You push back on rules that don’t make sense and question assumptions that haven’t earned their place.
Compensation Range: $260K - $300K
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Find Application Engineer JobsApplication Engineer Job Market in San Francisco
Who's Hiring
- AMIGO28

- Abridge28

- ivo14

- BRAIN14

- OpenAI14

Top Industries Hiring
- Technology & Software98
- Science & Research28
- Energy14
- Insurance14
- Manufacturing14
Application Engineer Jobs in San Francisco: Frequently Asked Questions
How do I get a application engineer job in San Francisco?
Target the enterprise software, cloud, and biotech companies concentrated in SoMa, Mission Bay, and the Financial District, where demand for application engineers is highest. Hands-on experience with APIs, systems integration, or customer-facing technical implementations gives you a clear edge. Candidates who can demonstrate pre-sales or post-sales technical support experience tend to move quickly through hiring pipelines at San Francisco's fast-moving tech and life sciences firms.
Which companies hire application engineers in San Francisco?
San Francisco application engineer roles are posted by AMIGO, Abridge, and ivo and others right now, based on current listings on Migrate Mate as of August 2026. The city draws a mix of large enterprise software vendors, early-stage startups, and medical device or biotech firms, all of which rely on application engineers to bridge technical products and customer needs.
Are there remote application engineer jobs in San Francisco?
Yes, though availability depends heavily on the role: customer-facing and integration-heavy positions typically require on-site or hybrid presence, while more analytical or documentation-focused work can run fully remote. About 75% of application engineer openings tied to San Francisco are remote or hybrid as of August 2026. Product support and pre-sales engineering roles at San Francisco software companies represent the largest share of those flexible arrangements.
How can I get a application engineer job in San Francisco with little or no experience?
The most realistic entry path in San Francisco is through junior technical support or solutions engineer roles at mid-stage SaaS companies in SoMa or the Financial District, where structured onboarding is more common. Bootcamp graduates and candidates with strong API or scripting fundamentals are regularly considered for associate-level positions. Targeting companies that sell complex software to enterprise clients gives you the best chance, since those teams need people who can learn a product deeply and explain it clearly.
Which industries hire the most application engineers in San Francisco?
The sectors hiring the most application engineers in San Francisco are Technology & Software, Science & Research, and Energy, based on current listings on Migrate Mate as of August 2026. San Francisco's dense concentration of enterprise software headquarters, cloud infrastructure companies, and life sciences campuses in Mission Bay creates sustained, year-round demand for technical roles that sit between product and customer.
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