Application Engineer Jobs in San Francisco, CA

Application Engineer jobs in San Francisco are concentrated in SoMa, the Financial District, and Mission Bay, driven by enterprise software, cloud infrastructure, and life sciences employers. Companies currently hiring include AMIGO, Abridge, and ivo. Find a role that fits below and apply directly.

Find Application Engineer Jobs

Overview

Open roles252+
Top employerAMIGO
Work type58% Hybrid
Companies hiring16

Showing 5 of 252+ Application Engineer jobs

AMIGO
Staff Software Engineer - Application [NYC or SF]
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AMIGO
Added 2w ago
Staff Software Engineer - Application [NYC or SF]
AMIGO
San Francisco, California
Engineering (Non-Software)
Mechanical Engineering
Specialized Engineering
$260k - $300k/yr
2-10

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AMIGO
Senior Software Engineer - Application [NYC or SF]
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AMIGO
Added 2w ago
Senior Software Engineer - Application [NYC or SF]
AMIGO
San Francisco, California
Backend Engineering
Full-stack Engineering
Software Engineering
$220k - $260k/yr
2-10

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Heartflow
Application Security Engineer
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Heartflow
Added 1mo ago
Application Security Engineer
Heartflow
San Francisco, California
Cybersecurity
Software Engineering
Security Engineering
$145k - $180k/yr
Hybrid
Bachelor's

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Zeta Global
Senior Application Security Engineer
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Zeta Global
Added 1mo ago
Senior Application Security Engineer
Zeta Global
San Francisco, California
AI (Artificial Intelligence)
Data Science
Software Engineering
Remote (US)
Bachelor's degree
1,001-5,000

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Abridge
Senior Application Security Engineer
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Abridge
Added 1mo ago
Senior Application Security Engineer
Abridge
San Francisco, California
Cybersecurity
Technical Product & Program Management
Security Engineering
Technical Program Management
$214k - $252k/yr
On-Site
None

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See All 252+ Application Engineer Jobs in San Francisco

Find roles in San Francisco that match your experience and apply in just a few clicks.

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Application Engineer Job Market in San Francisco

Who's Hiring

  • AMIGO
    AMIGO28
  • Abridge
    Abridge28
  • ivo
    ivo14
  • BRAIN
    BRAIN14
  • OpenAI
    OpenAI14

Top Industries Hiring

  • Technology & Software98
  • Science & Research28
  • Energy14
  • Insurance14
  • Manufacturing14

Application Engineer Jobs in San Francisco: Frequently Asked Questions

How do I get a application engineer job in San Francisco?

Target the enterprise software, cloud, and biotech companies concentrated in SoMa, Mission Bay, and the Financial District, where demand for application engineers is highest. Hands-on experience with APIs, systems integration, or customer-facing technical implementations gives you a clear edge. Candidates who can demonstrate pre-sales or post-sales technical support experience tend to move quickly through hiring pipelines at San Francisco's fast-moving tech and life sciences firms.

Which companies hire application engineers in San Francisco?

San Francisco application engineer roles are posted by AMIGO, Abridge, and ivo and others right now, based on current listings on Migrate Mate as of August 2026. The city draws a mix of large enterprise software vendors, early-stage startups, and medical device or biotech firms, all of which rely on application engineers to bridge technical products and customer needs.

Are there remote application engineer jobs in San Francisco?

Yes, though availability depends heavily on the role: customer-facing and integration-heavy positions typically require on-site or hybrid presence, while more analytical or documentation-focused work can run fully remote. About 75% of application engineer openings tied to San Francisco are remote or hybrid as of August 2026. Product support and pre-sales engineering roles at San Francisco software companies represent the largest share of those flexible arrangements.

How can I get a application engineer job in San Francisco with little or no experience?

The most realistic entry path in San Francisco is through junior technical support or solutions engineer roles at mid-stage SaaS companies in SoMa or the Financial District, where structured onboarding is more common. Bootcamp graduates and candidates with strong API or scripting fundamentals are regularly considered for associate-level positions. Targeting companies that sell complex software to enterprise clients gives you the best chance, since those teams need people who can learn a product deeply and explain it clearly.

Which industries hire the most application engineers in San Francisco?

The sectors hiring the most application engineers in San Francisco are Technology & Software, Science & Research, and Energy, based on current listings on Migrate Mate as of August 2026. San Francisco's dense concentration of enterprise software headquarters, cloud infrastructure companies, and life sciences campuses in Mission Bay creates sustained, year-round demand for technical roles that sit between product and customer.

See All 252+ Application Engineer Jobs in San Francisco

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