Associate Director Clinical Operations Jobs in Massachusetts
Associate Director Clinical Operations jobs in Massachusetts are concentrated in one of the most active life sciences and clinical research markets in the country, with demand across biopharmaceutical sponsors, contract research organizations, and academic medical centers at every level from senior manager through director. The greatest density of openings is in the Greater Boston area, Cambridge, and Worcester, where anchor employers such as Biogen, Pfizer's local research operations, and Massachusetts General Hospital Brigham Health system consistently recruit for this role. The most in-demand specialties are oncology trials, rare disease programs, and Phase I through III oversight for complex multi-site studies. Find a role that fits below and apply directly.
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Showing 5 of 7+ Associate Director Clinical Operations jobs
Join Us in Tackling Autoimmune Disease at Its Root
At Vor, we believe science can do more than manage symptoms. It can change the course of disease. By advancing telitacicept, a first- and potentially best-in-class dual BAFF/APRIL inhibitor, we are silencing upstream survival signals and stopping downstream autoimmune cascades. Together, we are addressing disease at its root cause and rewriting what is possible for patients worldwide.
When you join Vor, you’re not just working on a medicine. You’re part of a mission to redefine the future of autoimmune care.
Why Work at Vor?
Impact: Contribute directly to a medicine with best-in-disease Phase 3 results in myasthenia gravis and expansion into multiple autoimmune diseases.
Growth: Be part of a rapidly scaling company with opportunities to grow your career in science, clinical development, commercial strategy, and beyond.
Innovation: Work on a platform with potential beyond one indication — a therapy that has already shown consistent results across lupus, IgA nephropathy, and Sjögren’s syndrome.
Belonging: Join a culture where every voice is heard, and where our shared mission unites us across functions and geographies.
Who we are looking for:
Vor Biopharma is seeking an Associate Director of Clinical Operations to manage our autoimmune programs. The ideal candidate will initiate and lead clinical trials across all phases, including overseeing CROs and vendors and working cross-functionally on clinical operations strategy and related initiatives. The successful candidate will report to the Vice President, Clinical Operations. The Associate Director will also work collaboratively across the therapeutic area and cross-functional teams on the overall development programs and related studies to ensure the successful execution of assigned projects.
Experience and knowledge of end-to-end management of clinical trial operations, knowledge of the pharmaceutical industry, and an understanding of clinical drug development and clinical trials operations are essential.
Key areas of responsibilities:
- Accountable for delivery of assigned clinical program/studies budget, timelines, and resource management with a focus on quality, including making recommendations and decisions regarding operational strategies to support study and/or program objectives
- Ensure clinical trials comply with ICH/GCP guidelines, regulations, and company SOPs
- Develop operational strategy and clinical operations plans to support the execution of the Clinical Development Plan
- Support the selection, oversight, and management of CROs and other vendors
- Oversee site feasibility/capability assessments in collaboration with the CRO and cross-functional team
- Review and provide clinical operations input into relevant clinical documents such as the protocol, investigator brochure, regulatory documents, clinical study reports, and other documents and plans as appropriate
- Manage the cross-functional team and CRO/vendor(s) related to all aspects of clinical trial operations
- Assist in forecasting clinical trial material and ancillary supplies
- Represent Clinical Operations on cross-functional project teams and vendor/CRO operational meetings and ensure compliance with operational standards and procedures
- Ensure timely review of protocol deviations and assess the impact on study data
- Along with other Clinical Development personnel, represent Vor Biopharma externally to Investigators, site staff, and Key Opinion Leaders
- Perform and document study level Sponsor Oversight of outsourced clinical activities
- Communicate study status, cost, and issues to ensure timely decision-making by senior management
- Oversee/collaborate and contribute to inspection readiness activities that support audits and regulatory inspections related to clinical trial conduct
- Develop and foster strong, collaborative relationships with key stakeholders both within and external to Vor Biopharma
- Support program level deliverables/activities at the discretion of the Head of Clinical Operations
- Provide oversight and mentorship to assigned Clinical Trial Managers and Clinical Trial Associates by providing clinical operations and functional area expertise
- Oversee or conduct routine completeness checks of the Trial Master File (TMF) to ensure compliance with ICH/GCP and company SOPs and ensure all appropriate documents are filed
- Participate and respond to Quality Assurance and/or regulatory authority inspection audits
- Facilitate the development of trial budgets and execution of clinical trial agreements and other relevant documents in conjunction with CRO and appropriate internal stakeholders
- Manage the clinical trial budget and provide financial reporting and projections to Finance
- Lead creation of scope of work and budgets and escalate vendor performance issues to Head of Clinical Operations and Outsourcing as necessary
Qualifications:
- BA or BS in a scientific, life science, or health-related discipline; advanced degree preferred
- Minimum of 8 years of experience in clinical research with at least 5 years of managing trials in the biotech/pharma industry and/or prior CRO experience
- Experience in setup, execution, and oversight/operational management of autoimmune trial experience - Sjogren's and/or Myasthenia Gravis experience preferred
- Experience working on late-stage studies (Phase II, III)
- Excellent communication, writing, and presentation skills with strong problem-solving ability and attention to detail
- Strong initiative and a can-do attitude, excellent organizational skills, ability to prioritize deliverables/tasks to meet deadlines, and proven effectiveness in a fast-moving and growing biotech environment
- Solid working knowledge of ICH/GCP guidelines and the application to the conduct of clinical trials
- Proficient in MS Office Suite and understanding of Clinical Trial Management System, eTMF, and EDC systems, as required
- Ability/willingness to travel as required
- Proven track record of effective leadership and team-building skills in the context of a multi-disciplinary team in the biotech or pharmaceutical industry
The salary range for this position is expected to be between $195,000 and $220,000 per year. Individual pay may vary based on multiple factors including but not limited to relevant job-related skills, experience, education or training, market factors, and work location.
At Vor, we support our team with robust benefits, including comprehensive health coverage, flexible paid time off, generous parental leave, and a competitive 401(k). From education assistance to wellness resources and financial security, we invest in your well-being so you can thrive at work and beyond.
As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
Please visit our website at https://www.vorbio.com/ for more information.
Join Us in Tackling Autoimmune Disease at Its Root
At Vor, we believe science can do more than manage symptoms. It can change the course of disease. By advancing telitacicept, a first- and potentially best-in-class dual BAFF/APRIL inhibitor, we are silencing upstream survival signals and stopping downstream autoimmune cascades. Together, we are addressing disease at its root cause and rewriting what is possible for patients worldwide.
When you join Vor, you’re not just working on a medicine. You’re part of a mission to redefine the future of autoimmune care.
Why Work at Vor?
Impact: Contribute directly to a medicine with best-in-disease Phase 3 results in myasthenia gravis and expansion into multiple autoimmune diseases.
Growth: Be part of a rapidly scaling company with opportunities to grow your career in science, clinical development, commercial strategy, and beyond.
Innovation: Work on a platform with potential beyond one indication — a therapy that has already shown consistent results across lupus, IgA nephropathy, and Sjögren’s syndrome.
Belonging: Join a culture where every voice is heard, and where our shared mission unites us across functions and geographies.
Who we are looking for:
Vor Biopharma is seeking an Associate Director of Clinical Operations to manage our autoimmune programs. The ideal candidate will initiate and lead clinical trials across all phases, including overseeing CROs and vendors and working cross-functionally on clinical operations strategy and related initiatives. The successful candidate will report to the Vice President, Clinical Operations. The Associate Director will also work collaboratively across the therapeutic area and cross-functional teams on the overall development programs and related studies to ensure the successful execution of assigned projects.
Experience and knowledge of end-to-end management of clinical trial operations, knowledge of the pharmaceutical industry, and an understanding of clinical drug development and clinical trials operations are essential.
Key areas of responsibilities:
- Accountable for delivery of assigned clinical program/studies budget, timelines, and resource management with a focus on quality, including making recommendations and decisions regarding operational strategies to support study and/or program objectives
- Ensure clinical trials comply with ICH/GCP guidelines, regulations, and company SOPs
- Develop operational strategy and clinical operations plans to support the execution of the Clinical Development Plan
- Support the selection, oversight, and management of CROs and other vendors
- Oversee site feasibility/capability assessments in collaboration with the CRO and cross-functional team
- Review and provide clinical operations input into relevant clinical documents such as the protocol, investigator brochure, regulatory documents, clinical study reports, and other documents and plans as appropriate
- Manage the cross-functional team and CRO/vendor(s) related to all aspects of clinical trial operations
- Assist in forecasting clinical trial material and ancillary supplies
- Represent Clinical Operations on cross-functional project teams and vendor/CRO operational meetings and ensure compliance with operational standards and procedures
- Ensure timely review of protocol deviations and assess the impact on study data
- Along with other Clinical Development personnel, represent Vor Biopharma externally to Investigators, site staff, and Key Opinion Leaders
- Perform and document study level Sponsor Oversight of outsourced clinical activities
- Communicate study status, cost, and issues to ensure timely decision-making by senior management
- Oversee/collaborate and contribute to inspection readiness activities that support audits and regulatory inspections related to clinical trial conduct
- Develop and foster strong, collaborative relationships with key stakeholders both within and external to Vor Biopharma
- Support program level deliverables/activities at the discretion of the Head of Clinical Operations
- Provide oversight and mentorship to assigned Clinical Trial Managers and Clinical Trial Associates by providing clinical operations and functional area expertise
- Oversee or conduct routine completeness checks of the Trial Master File (TMF) to ensure compliance with ICH/GCP and company SOPs and ensure all appropriate documents are filed
- Participate and respond to Quality Assurance and/or regulatory authority inspection audits
- Facilitate the development of trial budgets and execution of clinical trial agreements and other relevant documents in conjunction with CRO and appropriate internal stakeholders
- Manage the clinical trial budget and provide financial reporting and projections to Finance
- Lead creation of scope of work and budgets and escalate vendor performance issues to Head of Clinical Operations and Outsourcing as necessary
Qualifications:
- BA or BS in a scientific, life science, or health-related discipline; advanced degree preferred
- Minimum of 8 years of experience in clinical research with at least 5 years of managing trials in the biotech/pharma industry and/or prior CRO experience
- Experience in setup, execution, and oversight/operational management of autoimmune trial experience - Sjogren's and/or Myasthenia Gravis experience preferred
- Experience working on late-stage studies (Phase II, III)
- Excellent communication, writing, and presentation skills with strong problem-solving ability and attention to detail
- Strong initiative and a can-do attitude, excellent organizational skills, ability to prioritize deliverables/tasks to meet deadlines, and proven effectiveness in a fast-moving and growing biotech environment
- Solid working knowledge of ICH/GCP guidelines and the application to the conduct of clinical trials
- Proficient in MS Office Suite and understanding of Clinical Trial Management System, eTMF, and EDC systems, as required
- Ability/willingness to travel as required
- Proven track record of effective leadership and team-building skills in the context of a multi-disciplinary team in the biotech or pharmaceutical industry
The salary range for this position is expected to be between $195,000 and $220,000 per year. Individual pay may vary based on multiple factors including but not limited to relevant job-related skills, experience, education or training, market factors, and work location.
At Vor, we support our team with robust benefits, including comprehensive health coverage, flexible paid time off, generous parental leave, and a competitive 401(k). From education assistance to wellness resources and financial security, we invest in your well-being so you can thrive at work and beyond.
As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
Please visit our website at https://www.vorbio.com/ for more information.
See All 7 Associate Director Clinical Operations Jobs in Massachusetts
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Find JobsAssociate Director Clinical Operations Jobs by City in Massachusetts
Where Massachusetts roles are concentrated, by current openings.
Associate Director Clinical Operations Job Market in Massachusetts
A snapshot from current Massachusetts openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Science & Research
What Massachusetts Employers Look For
The qualifications that appear most often in associate director clinical operations jobs across Massachusetts.
- Bachelor's or advanced degree in life sciences, nursing, or a related clinical field
- Minimum five to eight years of clinical trial operations experience at a sponsor or CRO
- Demonstrated experience managing multi-site or global Phase II or Phase III studies
- Strong working knowledge of ICH-GCP guidelines and FDA regulatory requirements
- Experience leading and mentoring cross-functional clinical operations teams
- Proficiency with clinical trial management systems such as Medidata Rave or Veeva Vault
Associate Director Clinical Operations Jobs in Massachusetts: Frequently Asked Questions
How do you become a associate director clinical operations in Massachusetts?
Most associate directors of clinical operations in Massachusetts reach the role by building several years of progressive experience in clinical trial management, typically starting as a clinical research associate or trial manager. Massachusetts does not require a state-issued license specific to this role, but employers in the Greater Boston and Cambridge life sciences corridor strongly favor candidates with a bachelor's or advanced degree in a clinical or scientific field, GCP certification, and a documented record of leading multi-site studies through a sponsor or contract research organization.
Which companies hire associate director clinical operationss in Massachusetts?
Employers hiring associate director clinical operationss in Massachusetts right now include Flagship Pioneering, Vor Bio, and Cogent Biosciences, based on current listings on Migrate Mate as of August 2026. Massachusetts's dense concentration of biopharmaceutical headquarters and academic medical centers in the Greater Boston and Cambridge area makes it one of the most consistently active hiring markets for this role nationwide.
Which Massachusetts cities have the most associate director clinical operations jobs?
The cities with the most associate director clinical operations openings in Massachusetts are Boston, Waltham, and Cambridge. Greater Boston and Cambridge dominate because of the concentration of biopharmaceutical company headquarters, contract research organizations, and major academic medical centers there, while Worcester draws openings tied to UMass Memorial Health and regional hospital research programs.
Are there remote associate director clinical operations jobs in Massachusetts?
Yes, and more than many clinical roles, since associate directors of clinical operations spend a significant portion of their time on strategy, vendor oversight, and team management that can be done remotely. About 33% of associate director clinical operations openings tied to Massachusetts are remote or hybrid as of August 2026, reflecting the desk-heavy nature of much of this leadership work. Site monitoring and audit responsibilities still typically require travel or an on-site presence.
How can I get hired as a associate director clinical operations in Massachusetts with little or no experience?
The most realistic entry path is through a clinical research associate or clinical trial coordinator role at a contract research organization or mid-size biopharmaceutical company in the Greater Boston area, then building toward a trial manager position before targeting associate director openings. Large Massachusetts employers such as Biogen and PPD operate structured development programs for early-career clinical operations staff. Earning a GCP certification and gaining hands-on experience on at least one Phase II or III study significantly strengthens a candidacy for the next step up.
Where can I find and apply to associate director clinical operations jobs in Massachusetts?
You can find and apply to associate director clinical operations jobs in Massachusetts on Migrate Mate, which lists current openings from employers across the state. Search the listings for roles that match your experience level and therapeutic area focus, then apply directly to the ones that fit.
See All 7 Associate Director Clinical Operations Jobs in Massachusetts
Find roles in Massachusetts that match your experience and apply in just a few clicks.
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